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All Journal HAYATI Journal of Biosciences Jurnal Sains dan Seni ITS IPTEK Journal of Proceedings Series Matematika dan Sains Widyariset Jurnal Riset Industri Hasil Hutan PENA SAINS Indonesian Journal of Chemistry Akta Kimia Indonesia Indonesian Journal of Electrical Engineering and Computer Science Widyariset Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya Sewagati Jurnal Kefarmasian Indonesia Journal of Tropical Pharmacy and Chemistry
Taslim Ersam
Departemen Kimia, Institut Teknologi Sepuluh Nopember
Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Other

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Isolasi Biflavonoid Baru dari Garcinia tetranda Pierre Berdasarkan Jalur Biogenesis dan Aktivitas terhadap Antibakteri Sulistyaningrum, Novi; Ersam, Taslim
Jurnal Kefarmasian Indonesia VOLUME 2, NOMOR 1, FEBRUARI 2012
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v2i1.3716

Abstract

Garcinia tetranda Pierre (Clusiaceae) is a plant that is widely used to treat various diseases and its chemical compounds has not been much studied. Compound isolation using the three methods of chromatography (Vacuum Liquid Chromatography Column (VLCC), preparative Thin Layer Chromatography (pTLC) and TLC) generate novel compound 5,7,4 ', 5'', 7'', 3''', 4 '''-heptahidroksi-2'''-methoxy-flavanon [ 3,8 ]-flavone'' which is different from the compounds that had been found previously in Garcinia tetranda Pierre. Structure identification was conducted using UV, IR and NMR spectroscopic data and by comparing the 13C and 1H-NMR data of the isolate compound and known biflavonoid compounds. Biogenesis pathway analysis of the new compound showing relationship with molecular compounds which have previously been found in Garcinia. Antibacterial test of the novel compound using Kirby-Bauer agar diffusion methode against Gram-negative bacteria Salmonella typhi showed that the compound is not potentially used as antibacterial agent compared to chloramphenicol.
Mekanisme Aksi ?-Mangostin dari Garcinia Tetranda Pierre terhadap P.falciparum Secara In Vitro Hadi Kuncoro; Aty Widyawaruyanti; Taslim Ersam
Journal of Tropical Pharmacy and Chemistry Vol. 1 No. 1 (2010): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v1i1.6

Abstract

ABSTRACT Development stage of parasite resistance assay and the Globin accumulation using SDS-PAGE Method has been done to parasite P. falciparum by giving α-mangostin from G. tetranda. α-Mangostin cause delays in the development stage of the parasite P. falciparum from stage schizont to stage trofozoit and cause parasite death after 48 hour. Swelling of the parasite of abnormal parasite food vacuole occurred after administration of α-Mangostin show from the results of SDS-PAGE. Key word : α- Mangostin, G. tetranda, P. falciparum, globin accumulation ABSTRAK Telah dilakukan pengujian hambatan perkembangan stadium parasit dan akumulasi globin menggunakan metode SDS- PAGE terhadap P. falciparum dengan pemberian α-Mangostin dari G. tetranda. Diketahui α-Mangostin menyebabkan penundaan perkembangan parasit P. falciparum dari stadium trofozoit menjadi stadium skizon dan menyebabkan parasit mati setelah jam ke 48. Pembengkakan vakuola makanan parasit yang abnormal terjadi setelah pemberian α- Mangostin terlihat dari hasil SDS-PAGE. Kata Kunci : α-Mangostin, G. tetranda, P. falciparum, , akumulasi globin
Co-Authors Adi Setyo Purnomo Adityo Pratomo Putro Ahmad Ubaidillah Ihsany Amalia Zafitri Amelinda Pratiwi Ananda Krisna Aldianita Anisa Rahma Maharani Ardi Lukman Hakim Aty Widyawaruyanti Aunurohim Aunurohim Cicilia Puspa Rini Dahlena Ariyani Dheva Noveilya Dini Nur Fauzia Fadlan, Arif Fatati Nurmalasari Fatimatul Munawaroh Fatimatul Munawaroh Fatmawati Inneke Putri Fiqey Indriati Eka Sari Fitria Fitria Fredy Kurniawan Fuji Ridha Kharomah Hadi Kuncoro Healthy Kainama Herdayanto Sulistyo Putro Hesti Selfiana Dwi Jayanti Ika Febriana Syafitri Imelda Priskila Simanjuntak Kamilia Mustikasari Karneg, Syahdam Khoiriyah Umami Kholifatu Rosyidah Kuniyoshi Shimizu Kuniyoshi Shimizu Laila Khamsatul Muharrami, Laila Khamsatul Lita Amalia Lukman Atmaja M Daffa Aditya Mardi Santoso Maria Dewi Astuti Mutia Devi Hidayati Nabilah Dita Anaqah Nadia Sasanti Ni Kadek Githa Kartika Gunadyani Noer Komari Nor Farida Novi Sulistyaningrum Novi Sulistyaningrum Novi Sulistyaningrum Nurbariyah Nurlatifah Nurlatifah Pieter Kakisina Prima Lukis Putri, Devi Anggraini Rafsanjani, Ega Rocky Maulana Rahma Rahayu Dinarlita Retno Purbowati Retno Purbowati Rizaldy Nizzah Kurniawan Ruzain Rafie Sukma Putra Sri Banun Titi Istiqomah Sri Fatmawati Suprapto Suprapto Susi Agustina Wilujeng Susy Budi Astuti Vanuella Tresnaning Budi Wiwit Denny Fitriana Yaqdhan Nufal Rafi Yatim Lailun Ni’mah Zulkarnain Zulkarnain