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Isolation of Antioxidant Compounds from Mangiferaindica L. Leaves Fitria Fitria; Sri Fatmawati; Taslim Ersam
IPTEK Journal of Proceedings Series No 1 (2015): 1st International Seminar on Science and Technology (ISST) 2015
Publisher : Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j23546026.y2015i1.1155

Abstract

The free radical scavenging activity of Mangiferaindica L. Leaves had been performed. The methanol extract showed the highest 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) free radical scavenging activity among other extracts. Bioassay guided fractionation was performed and yielded three isolated compounds. Their structures were identified as mangiferin (1), friedelin (2) and lupeol (3). Mangiferin exhibited free radical scavenging activity, with an IC50 value of 12.12 µg/mL in vitro.
ISOLASI DAN IDENTIFIKASI SENYAWA α-MANGOSTIN DARI EKSTRAK KAYU DAN KULIT AKAR Garcinia tetrandra Pierre Ahmad Ubaidillah Ihsany; Taslim ersam
Akta Kimia Indonesia Vol 3, No 1 (2018)
Publisher : LPPM, Institut Teknologi Sepuluh Nopember

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (727.866 KB) | DOI: 10.12962/j25493736.v3i1.3099

Abstract

Satu senyawa santon berhasil diisolasi dari ekstrak pekat metilen klorida kayu dan kulit akar dari Garcinia tetrandra yaitu α-Mangostin (1). Metode ekstraksi menggunakan pelarut metilen klorida dan fraksinasi dilakukan dengan kromatografi cair vakum, kromatografi kolom gravitasi dan kromatografi sistem radial atau kromatotron serta kromatografi kolom sephadex. Penentuan struktur dilakukan dengan memanfaatkan data dari spektrum UV-Vis, FT-IR, 1H-NMR dan 13C-NMR
ISOLATION, STRUCTURE ANALYSIS, AND ANTIBACTERIAL ACTIVITY OF BIFLAVONOID GB-1 FROM Garcinia tetranda Pierre Novi Sulistyaningrum; Taslim Ersam
Widyariset Vol 15, No 3 (2012): Widyariset
Publisher : Pusbindiklat - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/widyariset.15.3.2012.637–644

Abstract

Garcinia tetranda Pierre (Clusiaceae) was reported as source of flavonoid which has various bioactivities forhealth. Pure compound has been isolated by repeat chromatography techniques (Vacuum Column Chromatography,preparative TLC and TLC). UV, IR, 1H-NMR and 13C-NMR spectroscopic data of isolated compound (isolate)compared with the compound which was found before, and showed same as biflavonoid GB-1 data. Antibacterialassay against Salmonella typhi showed lower activity than chloramphenicol. Biflavonoid GB-1 compound foundin this study is different to the previous study, which all of compounds were classified as xanthones. Therefore,result of this study improves compound variability of Garcinia tetranda. However GB-1 is not potentially used asGram-negative antibacterial agent, especially against Salmonella typhi.
Antioxidant Activity of Moringa oleifera Extracts Wiwit Denny Fitriana; Taslim Ersam; Kuniyoshi Shimizu; Sri Fatmawati
Indonesian Journal of Chemistry Vol 16, No 3 (2016)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (301.518 KB) | DOI: 10.22146/ijc.21145

Abstract

Moringa oleifera have been evaluated for its antioxidant activity. M. oleifera leaves were extracted with methanol, ethyl acetate, dichloromethane and n-hexane. The antioxidant activity of extracts were evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity assay and an improved 2,2’-azino-bis-[3-ethylbenzothiazoline sulphonate] (ABTS) radical cation decolorization assay in vitro. Trolox was used as standard with IC50 5.89 μg/mL in DPPH assay and 3.06 μg/mL in ABTS assay. The methanol extract showed the highest free radical scavenging activity with IC50 value of 49.30 μg/mL in DPPH assay and 11.73 μg/mL in ABTS assay. This study provided that M. oleifera leaves possess antioxidant.
New Prenylated Stilbenes and Antioxidant Activities of Cajanus cajan (L.) Millsp. (Pigeon pea) Taslim Ersam; Sri Fatmawati; Dini Nur Fauzia
Indonesian Journal of Chemistry Vol 16, No 2 (2016)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (303.492 KB) | DOI: 10.22146/ijc.21158

Abstract

New Prenylated stilbene derivatives, 3-hydroxy-4-prenyl-5-methoxy-stilbene acid (1) and 5,4'-dihydroxy-3-methoxy-2-prenyl-stilbene (2) had been isolated from methanol extract of Cajanus cajan (L.) Millsp. (Pigeon pea), a member of family fabaceae. The aim of this present work was to evaluate its in vitro antioxidant activity using 2,2-diphenyl-1-picryhydrazyl (DPPH) radical-scavenging. Isolation of compounds was achieved by extraction (maceration) and chromatographic technique. The structures of the compounds were determined based on UV, IR, 1H-NMR and 13C-NMR spectra and also by comparing with the previously reported data. Antioxidant activities (IC50) of 1 and 2 were 413.68 μg/mL and 271.53 μg/mL, respectively.
Antioxidant Activity of Syzygium polyanthum Extracts Mutia Devi Hidayati; Taslim Ersam; Kuniyoshi Shimizu; Sri Fatmawati
Indonesian Journal of Chemistry Vol 17, No 1 (2017)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (263.1 KB) | DOI: 10.22146/ijc.23545

Abstract

Antioxidant activities of Syzygium polyanthum leaves extracts (methanol, ethyl acetate, dichloromethane and n-hexane) were evaluated by using DPPH (2,2-diphenyl-2-picrylhydrazyl) and ABTS (2,2’-azinobis (3-ethylbenzothiazole-6-sulfonic acid) methods. The methanol extract showed the highest antioxidant activity of DPPH assay among extract with IC50 value of 44.35 mg/mL. In addition, methanol extract also showed the highest antioxidant activity of ABTS assay among extracts with IC50 value of 17.69 mg/mL. This study indicated that the methanol extract of S. polyanthum leaves is potential as antioxidant.
A Novel Selective and Sensitive Electrochemical Sensor for Insulin Detection Zulkarnain Zulkarnain; Suprapto Suprapto; Taslim Ersam; Fredy Kurniawan
Indonesian Journal of Electrical Engineering and Computer Science Vol 3, No 3: September 2016
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijeecs.v3.i3.pp496-502

Abstract

A novel selective and sensitive electrochemical sensor for insulin detection has been fabricated and investigated. The electrochemical sensor was made from a mixture of silica gel, chitosan and nickel hydroxide (Ni(OH)2) nanoparticles, which was mounted on a silver wire and covered by a glass tube (silica gel/chitosan/Ni(OH)2 nanoparticles paste electrode). The sensor was characterized using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The anodic and cathodic currents of the silica gel/chitosan paste electrode with Ni(OH)2 are 580 mA and -750 mA, respectively. Without Ni(OH)2, however, the currents are 150 mA and -250 mA, respectively. The sensitivity and limit of detection of the silica gel/chitosan/Ni(OH)2 nanoparticle paste electrode for insulin detection are 5573 × 10­5pA/pMcm2 and 0.25 pM, respectively. The sensor also shows good reproducibility of measurement for 35 days with an RSD of 0.29%. The fabricated electrodes also show good reproducibility, with an RSD of 1.39%.
Isolasi Senyawa Aromatik Diterpenoid dan Bioaktivitas Antioksidan dari Batang Tumbuhan Mimba (Azadirachta indica) Asal Pulau Poteran Madura Prima Lukis; Taslim Ersam
Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya Vol 3 No 2 (2022): Desember 2022
Publisher : Fakultas Sains, Teknologi, dan Analsisi Institut ilmu Kesehatan Bhakti Wiyata

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56399/jst.v3i2.59

Abstract

Chemical composition comparison of n-hexane extract and essential oil kemenyan toba (Styrax sumatrana) sap from Tobasa North Sumatera by GC-MS and in silico study its compound as antiinflammatory Kamilia Mustikasari; Mardi Santoso; Nadia Sasanti; Maria Dewi Astuti; Taslim Ersam; Noer Komari
Jurnal Riset Industri Hasil Hutan Vol 14, No 2 (2022)
Publisher : Kementerian Perindustrian

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24111/jrihh.v14i2.7220

Abstract

The sap of kemenyan toba (Styrax sumatrana) is often used as a binder for perfumes, raw materials for cosmetics and medicines, so it is widely traded. However, not many studies have reported about its chemical composition. The process of extracting chemical compounds from kemenyan toba (S. sumatrana) sap quality one was carried out by maceration method using n-hexane and water distillation. The result of maceration was 25.3% of the n-Hexane extract, while the distillation yielded 0.13% (w/w) of a pale-yellow oil. The results of the GC-MS analysis showed that only benzoic acid was present in the extracts and essential oils. n-Hexane extract consists of styrene compounds, cinnamic acid, benzyl benzoate, 1,4-diphenyl-1.4-butanedione, benzyl cinnamates, methyl styrene, and cinnamyl cinnamate. In comparison, essential oil consists of 3-methylpentan-2-one, methyl palmitate, methyl stearate, methyl trans-9.10-epoxystearate, dioctyl hexanedioic, methyl oleic, and methyl-13.16-Octadecanoic. The in-silico test results of several compounds as antiinflammatory showed that the compounds cinnamyl cinnamate had potential as an anti-inflammatory.
Membangun Industri Halal dalam Mendukung Masterplan Ekonomi Syariah Indonesia melalui Program Gerakan Menuju Sertifikasi Halal (GEMESH) Herdayanto Sulistyo Putro; Yatim Lailun Ni'mah; Susi Agustina Wilujeng; Susy Budi Astuti; Aunurohim; Taslim Ersam; Mardi Santoso; Lukman Atmaja; Adityo Pratomo Putro; Anisa Rahma Maharani; Ananda Krisna Aldianita; Cicilia Puspa Rini; Dheva Noveilya; Imelda Priskila Simanjuntak; M Daffa Aditya; Nabilah Dita Anaqah; Ni Kadek Githa Kartika Gunadyani; Nor Farida; Ruzain Rafie Sukma Putra; Vanuella Tresnaning Budi; Yaqdhan Nufal Rafi; Ardi Lukman Hakim; Fiqey Indriati Eka Sari
Sewagati Vol 7 No 4 (2023)
Publisher : Pusat Publikasi ITS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12962/j26139960.v7i4.544

Abstract

Berkembangnya era globalisasi serta perdagangan masyarakat ekonomi ASEAN, kebutuhan akan produk halal semakin besar dan diminati. Upaya Pemerintah dalam mendorong Indonesia menjadi produsen produk halal yakni membuat UU Nomor 33 Tahun 2014 Tentang Jaminan Produk Halal. Sifat sertifikasi halal yang semula sukarela menjadi wajib bagi pelaku usaha. Sehingga, UMKM juga diwajibkan untuk menerapkan Sistem Jaminan Halal agar mutu dan kualitas produk menjadi lebih baik di mata konsumen. Kondisi ini dimanfaatkan oleh Tim Pengabdi melalui GEMESH (Gerakan Menuju Sertifikasi Halal) yang telah membentuk suatu Kawasan Halal di Taman Indah, Sidoarjo. Tim Pengabdi memfasilitasi UMKM pangan dalam meningkatkan kesadaran akan pentingnya kaidah halal serta membantu proses sertifikasi halal produknya melalui kampanye GEMESH yang diintegrasikan dengan kegiatan KKN mahasiswa meliputi sosialisasi, diklat penyelia halal, seminar dan pelatihan proses produksi halal, hingga pendampingan proses sertifikasi halal serta dengan website gemeshalal.in untuk mendukung keberlanjutan kampanye GEMESH. Terdapat 1 UMKM yang telah verval berkas sertifikasi halal dan 3 UMKM lainnya belum tersertifikasi karena harus melakukan perbaikan data dalam pengajuan pendaftaran sertifikasi halal.