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All Journal Jurnal Wiyata : Penelitian Sains dan Kesehatan Bioscientist : Jurnal Ilmiah Biologi JOURNAL OF COMMUNITY ENGAGEMENT AND EMPOWERMENT JUSTER: Jurnal Sains dan Terapan Jurnal Pharma Bhakta
DWI WAHYUNI
Fakultas Farmasi Institut Ilmu Kesehatan Bhakti Wiyata Kediri
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Energy Environmental Science Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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ANALGETIC ASSAY OF TREMBESI LEAVES (Samanea saman (Jacq.) Merr.) KRISNA KHARISMA PERTIWI; DWI WAHYUNI; ROSA J HESTURINI; AGUSTINA DWI LESTARI
Jurnal Wiyata Penelitian Sains dan Kesehatan Vol 7, No 2 (2020)
Publisher : LP2M IIK (Lembaga Penelitian dan Pengabdian Masyarakat Institut Ilmu Kesehatan) Bhakti Wiy

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Abstract

Background: Trembesi (Samanea saman (Jacq.) Merr.) is a plant of the genus Samanea spread in tropical areainclude Indonesia. This plant have some chemical ingredients such as flavonoids, alkaloids, tannins, saponins,  and steroids or triterpenoids. Objective: To know the analgesic activity and the effective dose of ethanol extract of leaves of trembesi  in white male mice (Mus musculus L.). Method: This research is experimental with Post-Test Only Control Group Design techniques. Analgesic activity test was performed by chemical induction method using acetic acid in vivo with a negative control treatment (CMC-Na 0,5%), a positive control (aspirin 500mg), dose of ethanol extract of trembesi 150, 300 and 600 mg/kgBB. Data were analyzed with Hendersoth and Forsaith equation to determine the amount of stretching by mice. Analysis by One Way ANOVA test and LSD test. Results: The results showed the analgesic power percent ethanol extract of trembesi leaves are respectively 16.6%, 45.8% and 69.6%. Conclusions: The dose of ethanol extract of trembesi leaves have analgesic activity with the most effective dose is 600 mg/kgBB is equivalent to 500mg of aspirin (p=0.560).
Karakterisasi Spesies Averrhoa yang Tumbuh di Kota Kediri Berdasarkan Pendekatan Palinologi Dwi Wahyuni; Hari Untarto Swandono
Bioscientist : Jurnal Ilmiah Biologi Vol 8, No 2 (2020): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bjib.v8i2.2939

Abstract

Averrhoa is a member of the Oxalidaceae family and has four types, namely Averrhoa carambola, Averrhoa bilimbi, Averrhoa leucopetala, Averrhoa  dolichocarpa.. Among the four types of averhoa, the most commonly found growing and planted in Kediri's yards were Averrhoa carambola and Averrhoa bilimbi. Cultivation of this plant is usually done by vegetative and generative with seeds. Pollen has long been used as an indicator in plant taxonomy, because in pollen there are many secret characters. This study aims to determine characterization Averrhoa species that grow in Kediri City based on a palinological approach. The result of this research is Averrhoa pollen that grows in Kediri City has almost the same characteristics, namely very small size, spheroidal Prolate shape, trizonocolpate aperture and isopolar polarity. The similarity is so great because the environmental conditions in which these two types of plants grow are the same. The difference in the character of pollen that grows in Kediri City lies in its ornamentation. In Averrhoa carambola ornate Perforate-Foveolate and Averrhoa bilimbi with reticulate character. This difference in ornament is due to the fact that these two types of plants have different species.
Upcycle Limbah Sabut Kelapa Sebagai Upaya Penambahan Pendapatan di Era Pandemi Dwi Wahyuni; Herelinda Mawardika
Journal of Community Engagement and Empowerment Vol 4, No 1 (2022)
Publisher : Institut Ilmu Kesehatah Bhakti Wiyata Kediri

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Tujuan: Kegiatan ini bertujuan untuk memanfaatkan limbah sabut kelapa menjadi produk yang bernilai ekonomis, dan pada akhirnya akan menambah pendapatan bagi masyarakat serta untuk meminimalisir terjadinya polusi estetika.  Metode: Pengabdian masyarakat yang dilakukan menggunakan metode penyuluhan/sosialisasi tentang pemanfaatan  limbah sabut kelapa dan pelatihan/praktik tentang pembuatan cocopot. Pengumpulan sampel berupa limbah sabut kelapa dan data yang diperoleh dianalisi menggunakan analisis deskriptif kualitatif.  Hasil: Warga yang mengikuti penyuluhan  dan pelatihan sebanyak lima orang. Materi yang diberikan dalam pelatihan meliputi pengeringan dan penguraian sabut kelapa menjadi cocofiber, pembuatan pola/cetakan, pengisian cetakan dan finishing. Kegiatan ini mendapatkan tanggapan positif dan warga sangat antusias yang ditandai dengan keaktifan mereka saat melakukan praktik langsung pembuatan cocopot. Kegiatan diakhiri dengan penjelasan tentang teknik pemasaran baik secara online maupun langsung. Warga yang mengikuti kegiatan ini sangat antusias sekali dan mereka dapat membuat cocopot sendiri. Kesimpulan:  Warga dapat memanfaatkan limbah sabut kelapa menjadi produk bernilai ekonomis berupa cocopot secara mandiri. Selain itu  dapat  menambah wawasan masyarakat mengenai hasil olahan sabut kelapa dan membuka peluang usaha yang dapat dilakukan dari rumah dimasa pandemi COVID-19, serta lingkungan menjadi lebih bersih dan sehat.
Karakterisasi Makroskopis Dan Mikroskopis Jeruk Purut (Citrus hystrix DC) Sebagai Bahan Alam Berkhasisat Obat Dwi Wahyuni; Herlinda Mawardika; Winda Aulia Riski; Shita Ayu Pitaloka
JUSTER : Jurnal Sains dan Terapan Vol. 2 No. 2 (2023): JUSTER: Jurnal Sains dan Terapan
Publisher : Jompa Research and Development

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Abstract

Tanaman jeruk purut (Cytrus hystrix DC) banyak dibudidayakan oleh masyarakat tetapi pemanfaatannya masih sangat kurang padahal mengandung senyawa metabolit yang sangat bermanfaat. Buah dan daun jeruk purut (Cytrus hystrix DC) sejak dahulu sudah dikenal oleh masyarakat untuk digunakan sebagai obat tradisional. Secara umum pemanfaatannya dilakukan dengan teknik sederhana berdasarkan pengetahuan empiris Pemanfaatan bahan alam harus terlebih dahulu melewati tahap pengujian untuk menentukan komponen seluler secara spesifik sebagai pedoman standarisasi suatu tanaman obat. Tujuan: untuk mengetahui karakter  makroskopis dan mikroskopis pada daun, dan buah jeruk purut (Cytrus hystrix DC) .Metodepenelitian yang digunakan adalah kualitatif deskriptif. Hasil penelitian berdasarkan karakter makroskopis dan mikroskopis menunjukkan hasil bahwa karakter-karakter tersebut tidak terlalu berbeda dengan karakter yang ada di buku Materia Medika Indonesia. Terdapat fragmen spesifik berupa stomata type anomositik, sel litokis, kristal kalsium oksalat bentuk prisma. Tidak kalah penting  adanya kelenjar minyak atsiri yang merupakan bagian dari struktur sekretori yang berpotensi sebagai obat. Struktur sekretori tersebut dapat diindikasikan mengandung senyawa metabolit sekunder yang baik untuk perkembangan fitofarmakologi dalam bidang kesehatan, maupun pengobatan herbal.
UJI EFEKTIVITAS REPELLENT EKSTRAK DAUN JERUKPURUT (Citrus hytrix) TERHADAP NYAMUK Aedes aegypti Dwi Wahyuni; Sholikatin Nafi'ah
JURNAL PHARMA BHAKTA Vol 1 No 2 (2021): Desember 2021
Publisher : FAKULTAS FARMASI, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

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Abstract

Daun jeruk purut (Citrus hystrix D.C) merupakan tanaman dari keluarga Rutaceae yang memberikan manfaat bagi kesehatan. Daun jeruk purut mengandung senyawa flavonoid, alkaloid, saponin, tanin, steroid, dan terpenoid yang dapat digunakaan sebagai repellent. Tujuan dari penelitian ini untuk mengetahui efektivitas ekstrak daun jeruk purut dalam menolak nyamuk. Ekstraksi dilakukan dengan metode maserasi menggunakan pelarut etanol 96%. Uji repellent menggunakan enam kelompok perlakuan. Kelompok 1 diberikan alkohol 70% yang merupakan kontrol negatif, kelompok 2,3,4, dan 5 diberikan ekstrak daun jeruk purut dengan kosentrasi 10%, 20%, 30%, dan 40%, kelompok 6 diberikan soffell varian jeruk yang merupakan kontrol positif. Uji repellent dilakukan dalam waktu 30 detik untuk menghitung nyamuk yang hinggap pada lengan probandus. Hasil penelitian menunjukkan ekstrak daun jeruk purut megandung senyawa metabolit sekunder berupa flavonoid, alkaloid, saponin, tanin, steroid, dan terpenoid. Ekstrak daun jeruk memiliki daya proteksi dalam menolak nyamuk. Hasil pengamatan terdapat perbedaan pemberian tiap kosentrasi dan kontrol yang bermakna (p<0,05). Kesimpulan dari penelitian ini adalah ekstrak stanol Jerukpurut memiliki efektivitas sebagai penolak nyamuk.
Penetapan Kadar Kuersetin pada Obat Herbal yang Mengandung Ekstrak Tempuyung (Sonchus arvensis) Menggunakan KLT Densitometri Asih Imulda Hari Purwani; Krisna Kharisma Pertiwi; Dwi Wahyuni; Rachma Nurhayati
Bioscientist : Jurnal Ilmiah Biologi Vol 12, No 1 (2024): June
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i1.11260

Abstract

Quercetin are the main marker compounds in extracts of Sonchus arvensis which show nephrolithiasis activity. For quality control of herbal medicines, Densitometric Thin Layer Chromatography (TLC) method has been developed in this study using quercetin as phytochemical markers. Objective: Determination for quercetin in herbal medicines. Determination of quercetin by determining the composition of the mobile phase, the wavelength of the analysis, the saturation time, the elution distance and the volume of the spot. The parameters observed in the optimization method and stability test are area, retardation factor (Rf), peak shape and resolution (Rs). The composition of selected mobile phase which results good separation and symmetrical peak shape is chloroform: methanol: dichloromethane: acetonitrile: formic acid (6: 2: 2: 0.05: 0.05 v/v/v/v/v) with a wavelength of 335 nm, time of saturation is 30 minutes, elution distance is 8 cm, volume of spots is 10 µL and Rf 0.48. In this study, it was shown that there were no factors that had a significant effect so that the method could be applied for the determination of quercetin levels in herbal medicines.The research data showed that the range of levels on quercetin 3.26%.
Karakterisasi dan Uji Aktivitas Antimikroba Bakteri Kandidat Probiotik dari Terasi Udang Rebon Herlinda Mawardika; Krisna Kharisma Pertiwi; Dwi Wahyuni; Qosania Wilda Aulia
Bioscientist : Jurnal Ilmiah Biologi Vol 11, No 2 (2023): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v11i2.8981

Abstract

Probiotics are live microorganisms that are widely used to help maintain a healthy digestive system. Some compounds secreted by these bacteria have a bactericidal effect on pathogenic and putrefactive bacteria. Various types of probiotic bacteria can be obtained from fermented foods and drinks. This research aims to characterize bacteria from rebon shrimp paste in Macajah Village, Tanjung Bumi District, Bangkalan Regency, East Java Province which have potential as probiotics and test their antimicrobial activity against pathogenic bacteria. Bacteria were isolated using the Pour Plate technique using de Man Rogosa Sharpe Agar media. The bacterial isolates were then characterized by observing colony morphology, cells and biochemical properties. Next, antibacterial activity was tested using the well diffusion method. The results showed that the four bacteria obtained from the samples were gram positive, round and rod shaped, catalase negative, homofermentative, grew at a temperature of 37-45°C, survived at NaCl concentrations of 4 and 6.5%, low pH, and bile salts. According to the characterization results, three bacterial isolates belonged to the genus Enterococcus and one other isolate belonged to the genus Bacillus. Bacillus isolate is a potential probiotic candidate, because it has inhibitory activity against Escherichia coli and Staphylococcus aureus.
Karakterisasi dan Potensi Ekstrak Daun Paitan (Tithonia diversifolia) sebagai Penolak Nyamuk Aedes aegypti Dwi Wahyuni; Hari Untarto Swandono; Herlinda Mawardika; Mega Yuliya Prana
Bioscientist : Jurnal Ilmiah Biologi Vol 11, No 2 (2023): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v11i2.8844

Abstract

The paitan plant (Tithonia diversifolia) contains alkaloids, saponins, flavonoids, tannins and phenolics which have the potential to prevent Dengue Hemorrhagic Fever (DHF). This plant also has various insecticidal activities. In society, there are many mentions of the paitan plant, so people need to know the characteristics of this paitan plant. The aim of this research is to determine the morphological characterization and specific fragments of the paitan plant, as well as to determine the activity and effective concentration of the ethanol extract of paitan leaves as a repellent for the Aedes aegypti mosquito. Two types of methods were used, namely descriptive qualitative for observing morphology, specific fragments, pollen, and phytochemical screening, and experimental methods for mosquito repellent testing, and calculating the protective power of the ethanol extract of paitan leaves. The results obtained are flowers consisting of two shapes, namely ribbon flowers in the outer circle, infertile, and tube shapes in the inner circle. Stomata are anomocytic type, while trichomes are non-glandular multicellular type. Pollen characteristics, namely small size, colpate, number 3, aperture shaped trizonocolpate with echinate ornamentation. The screening results for the ethanol extract of paitan leaves were positive for containing metabolite compounds, such as flavonoids, alkaloids, tannins, saponins, terpenoids and phenolics. The results of the mosquito repellent test showed that the higher the concentration of the extract, the fewer mosquitoes that landed. Calculation of protective power shows that the most effective concentration in repelling mosquitoes is 15%, namely 93.64%. The conclusion is that paitan (Tithonia diversifolia) leaf extract has potential activity as a repellent against Aedes aegypti mosquitoes with the most effective concentration being 15%.
Uji Aktivitas Antioksidan Esktrak Kasar dan Terpurifikasi Daun Salam (Syzygium polyanthum) Krisna Pertiwi; Dwi Wahyuni; Rosa Juwita Hesturini
JUSTER : Jurnal Sains dan Terapan Vol. 4 No. 2 (2025): JUSTER: Jurnal Sains dan Terapan
Publisher : Jompa Research and Development

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Abstract

Bay leaves (Syzygium polyanthum) are one of Indonesia’s biological resources that have long been utilized, particularly as a cooking spice and in traditional therapy. Current use by the public is still largely based on empirical evidence, and scientific validation is still needed to support its application. The aim of this study was to determine the antioxidant capacity of both crude and purified bay leaf extracts. Extraction was carried out using the maceration method with 96% ethanol as the solvent. Purification of the extract was performed using a liquid-liquid extraction method with a solvent ratio of ethanol to n-hexane = 1:1. Phytochemical screening was conducted on both the crude and purified extracts. Antioxidant activity was evaluated using the DPPH method. Free radical scavenging was measured by UV-Vis spectrophotometry at the maximum wavelength. The results of phytochemical screening indicated that both crude and purified extracts contained alkaloids, flavonoids, tannins, and saponins. The maximum absorbance wavelength was found at λ = 514 nm. The antioxidant activity (IC₅₀) of the crude and purified bay leaf extracts was 15.120 ± 0.039 ppm and 13.293 ± 0.039 ppm, respectively. These results indicate that bay leaves possess strong antioxidant potential.
Formulasi dan Uji Stabilitas Lotion Repelen Daun Paitan: Pendekatan Fisikokimia Untuk Pengendalian Aedes aegypti Dwi Wahyuni; Arshy Prodyanatasari; Asih Imulda Hari Purwani; Anik Andayani; Hari Untarto Swandono; Pavitra Meilina Imanda’ar
JUSTER : Jurnal Sains dan Terapan Vol. 5 No. 1 (2026): JUSTER: Jurnal Sains dan Terapan
Publisher : Jompa Research and Development

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57218/juster.v5i1.2281

Abstract

Tingginya kasus DBD di Indonesia mendorong inovasi lotion anti nyamuk yang aman. Urgensi penelitian muncul dari risiko iritasi kulit akibat penggunaan produk sintetis berbasis DEET. Gap penelitian terletak pada belum adanya formulasi lotion berbasis ekstrak daun paitan yang dilengkapi dengan data uji stabilitas fisik dan efektivitasnya sebagai penolak nyamuk Aedes aegypti. Penelitian ini bertujuan memformulasikan lotion ekstrak etanol daun paitan konsentrasi 15% dan mengevaluasi karakteristik fisik, stabilitas, serta efektivitasnya sebagai penolak nyamuk Aedes aegypti. Penelitian ini merupakan penelitian eksperimental, meliputi ekstraksi daun paitan, formulasi lotion, dan uji stabilitas menggunakan metode freeze and thaw. Parameter uji meliputi organoleptis, homogenitas, pH, jenis emulsi, kemampuan daya lekat dan sebarnya, serta efektivitas repellent. Hasil evaluasi terlihat bahwa sediaan lotion memenuhi semua persyaratan uji karakteristik fisik. Uji efektivitas pada manusia menunjukkan daya proteksi yang sangat tinggi, yaitu 97% sebelum uji stabilitas dan 93% setelahnya, meskipun terjadi sedikit perubahan pada semua parameter fisik pasca uji stabilitas. Lotion ekstrak etanol daun paitan 15% memenuhi syarat karakteristik sediaan topikal dan efektif sebagai penolak nyamuk Aedes aegypti dengan daya proteksi tinggi (97% sebelum dan 93% setelah uji stabilitas).
Co-Authors AGUSTINA DWI LESTARI Arshy Prodyanatasari Arti Wahyu Utami Asih Imulda Hari Purwani Asih Imulda Hari Purwani Bramantyo Hari Untarto Swandono Hari Untarto Swandono Herelinda Mawardika Herlinda Mawardika Jihan Nabilla KRISNA KHARISMA PERTIWI Krisna Pertiwi Mega Yuliya Prana Nanik Pujiastuti Pavitra Meilina Imanda’ar Puput Setiawati Qosania Wilda Aulia Rachma Nurhayati Rifkarosita Putri Ginaris ROSA J HESTURINI Rosa Juwita Hesturini Shita Ayu Pitaloka Sholikatin Nafi'ah Winda Aulia Riski Zulfania Shandra Fatikha