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All Journal Jurnal Ilmu Dasar Journal of the Medical Sciences (Berkala Ilmu Kedokteran) e-Journal Pustaka Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Pengembangan Pendidikan Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia STOMATOGNATIC- Jurnal Kedokteran Gigi Journal of Agromedicine and Medical Sciences Al-Kimia SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan JURNAL PENGABDIAN KEPADA MASYARAKAT JFIOnline Jurnal Ilmu Kefarmasian Indonesia Poltekita : Jurnal Ilmu Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Fifteen Aprila Fajrin
Fakultas Farmasi Universitas Jember
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : e-Journal Pustaka Kesehatan

 1 
Analisis HKSA dan Docking Aktivitas Inhibisi Turunan HEPT terhadap Enzim Reverse Transcriptase HIV (QSAR and Docking of Inhibition Activity of HEPT Derivatives Against Enzym Reverse Transcriptase HIV) Ani Riani Hasana; Ayik Rosita; Fifteen Aprila Fajrin
Pustaka Kesehatan Vol 1 No 1 (2013)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

This study describes the analysis of QSAR and Docking based on the inhibition activity of the enzyme Reverse Transcriptase HIV by 1-[(2-hydroxyethoxy) metil]-6-(phenylthio) timin (HEPT) derivatives. QSAR modeling using 85 compounds HEPT derivatives have calculated the value of biological activity in vitro inhibition of the value of log1/C, then made a linear regression equation against QSAR parameters like as lipophilic, electronic and steric to obtained maximum results correlation r2 by method Multiple Linear Regression (MLR). Docking used to determine the predictive ability of the inhibitor affinity value when HEPT derivatives interacting with the enzyme Reverse Transcriptase HIV. QSAR study results that play a role in the activity is the refractive index parameter (η), molar volume (MV), Parachor (Pc), I2 (parameter which indicates the presence of Sulphur in position R2) and ISP (parameter which indicates the presence of Sulphur in position X). Best equation obtained with compound 75 has a value of R=0.9135, R2adj=0.8064, RMSE=0.5104, and F=69.4881. Docking study results indicate derivatives with the number 80 has the smallest affinity by -11.3 kcal / mol. Keywords: docking, reverse transcriptase enzyme , HEPT, MLR, QSAR.
Uji Antifertilitas Kombinasi Fraksi Kloroform Biji Pepaya (Carica papaya Linn.) dengan Fraksi Metanol Biji Saga (Abrus precatorius Linn.) terhadap Spermatogenesis Tikus Jantan Galur Wistar (Antifertility Study from Combination of Chloroform Fractions o Zainah Rajab; Siti Muslichah; Fifteen Aprila Fajrin
Pustaka Kesehatan Vol 3 No 2 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Chloroform fraction of Carica papaya seed (FKCP) and methanol fraction of Abrus precatorius seed (FMAB) have antifertility activity. This study aims to determine the antifertility activity combination of FKCP and FMAB in spermatogenesis and its reversibility on wistar male rats. This research used 40 wistar male rats that were divided into 5 groups, eight animals each group. Grup P0 (control) was administered by CMC Na 1%, group P1 was administered by combination of FKCP dose of 100 mg/kg BW and FMAB dose of 75 mg/kg BW, group P2 was administered by combination of FKCP dose of 100 mg/kg BW and FMAB dose of 50 mg/kg BW, group P3 was administered by combination of FKCP dose of 50 mg/kg BW and FMAB dose of 75 mg/kg BW, grup P4 was administered by combination of FKCP dose of 50 mg/kg BW and FMAB dose of 50 mg/kg BW for 28 days. Reversibility of spermatogenesis was observed in all group after 28 days of withdrawal of treatment. The results showed degenerative changes in the seminiferous tubules of rats given FKCP and FMAB. Conclusion of this research is the combination of these fractions reduced spermatogenesis, but it was reversible. Keywords: antifertility, saga seed, papaya seed, spermatogenesis, reversibility.
Penetapan Kadar Fenol Total dan Pengujian Aktivitas Antioksidan Minyak Jahe Gajah (Zingiber officinale var. officinale) (Determination of Total Phenolic Content and Antioxidant Activity of Jahe Gajah (Zingiber officinale var. officinale) Oil) Tsabit Barki; Nia Kristiningrum; Endah Puspitasari; Fifteen Aprila Fajrin
Pustaka Kesehatan Vol 5 No 3 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v5i3.5897

Abstract

Jahe gajah (Zingiber officinale var. officinale) is one of export commodity plant in Indonesia. Part of jahe gajah often to be used is the rhizome, that content lots of essentials oil. One of the essential oil content is a phenolic compound. Phenolic compound is a natural product function as antioxidant reducing oxidative damage in the body that cause inflammation. The aim of this study was to determine the total phenolic content and antioxidant activity of jahe gajah oil. The total phenol content was determined using Folin-Ciocalteu method and the antioxidant activity assay was done using DPPH method. The total phenol content for jahe gajah oil was 0.626 ± 0.022 mg GAE/g . The IC50 of jahe gajah oil was 5,766 ± 0,087 µl/ml. Antioxidant activity from jahe gajah oil was suggested to be contributed by the phenolic compound and result from synergistic action of all constituents. Keywords: essential oil, aktivitas antioxidant, phenolic content
Ekstrak n-Heksana Daun Maja (Aegle marmelos) Menurunkan Kadar LDL Mencit Diabetes yang Diinduksi Aloksan (n-Hexane Extract of Maja Leaves (Aegle marmelos) Decreases LDL Levels on Diabetic Mice Induced by Alloxan) Lesti Eko Pangestuti; Fifteen Aprila Fajrin; Diana Holidah
Pustaka Kesehatan Vol 3 No 1 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Diabetes mellitus is a metabolic disorder which characterized by hyperglicaemia due to abnormalities of carbohydrate, fat an protein metabolism resulting from defects in insulin secretion, insulin action or both. Metabolic disorders are caused by diabetes induce lipolysis, resulting in changes in the levels of LDL in the blood. This research aims to know the effect of n-hexane extract of maja leaves in LDL levels in diabetic mice. Test animals were induced by alloxan 210 mg/kg BW intraperitoneally. Twenty five mice were divided into 5 groups, control negative group (CMC Na 1%), control positive group (glibenclamide suspension 0.65 mg/kg BW), and the treatment group was given 3 suspension of of n-hexane extract of maja leaves (dose of 200 mg/kg BW, 400 mg/kg BW, and 800 mg/kg BW) for 14 days. The result showed that the decrease of LDL level due to N-hexane extracts of maja leaves dose 200 mg/kg BW, 400 mg/kg BW, and 800 mg/kg BW was -10,54%; 9,07%; 31,69%; respectively. N-hexane extracts of maja leaves decreases LDL levels on diabetic mice induced by alloxan with the best activity indicated by doses 800 mg/kg BW. Keywords: Aegle marmelos, n-hexane, diabetes melitus, LDL, alloxan
Uji Toksisitas Subkronik Jamu Asam Urat pada Hati Mencit Galur Balb-C (Subchronic Toxicity Study of Jamu Asam Urat in Liver of Balb-C Mice) M Nuril Huda; Diana Holidah; Fifteen Aprila Fajrin
Pustaka Kesehatan Vol 5 No 1 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v5i1.3952

Abstract

Jamu asam urat is one of the most-consumed herbal medicine product to threat gout arthritis. This study aimed to determine of jamu asam urat effect for long-term consumption on mice's liver. Mice were divided into 4 groups of 10 each group. A control group was administered with aquadest and 3 treatment groups were administered with jamu sample per oral in dose of 1,800 (D1); 3,600 (D2); and 7,200 mg/kg BW (D3) in 28 days. The examination included GPT and GOT serum level measurement and liver histopathology. The result showed that GPT serum level was 34.33 ± 2.48 U/L (D1), 41.20 ± 1.94 U/L (D2), and 46.32 ± 2.84 U/L (D3), while GOT serum was 44.60 ± 2.94 U/L (D1), 55.53 ± 3.22 U/L (D2), and 63.31 ± 2.63 U/L (D3), respectively. Parenchymatous degeneration and necrosis in liver were found in histopathology examination. Increase of GPT, GOT level, and parenchymatous degeneration liver changes at D1 and D2 counted as mild degeneration, meanwhile necrosis change at D3 counted as moderate degeneration but it did'nt greatly affect liver function. Thus jamu asam urat is still save to be consumed. Keywords: subchronic toxicity, jamu asam urat, GPT, GOT, liver histopathology
Efektivitas Penggunaan Insulin pada Penderita Diabetes Melitus dengan Kehamilan di Rawat Inap RSD dr. Soebandi Jember Tahun 2012-2013 (Effectivity of Insulin Usage on Diabetic Mellitus Gestational Hospitalized Patient at RSD dr. Soebandi Jember in 2012-20 Riza Rastri Wihardiyanti; Prihwanto Budi Subagio; Fifteen Aprila Fajrin
Pustaka Kesehatan Vol 3 No 3 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Gestational diabetes melitus is a diseases that are frequently happen to pregnant women, and is happen to be one of the causes of mortality on mother and fetus. The use of drugs during pregnancy should be prudentially considered for pregnant women, since they are not allowed to consume anti-diabetic drug (OAD) and just allowed to use insulin as therapy. The purpose of this study was to describe the use of insulin, as well as assessing the effectiveness of insulin therapy in patients with gestational diabetes mellitus in RSD dr. Soebandi Jember. The sample in this study was taken from 23 patients. We found that the disease affect 7.69% patients of 20-24 years of age, 11.54% patients of 25-29 years of age, 26.92% patients of 30-34 years of age, 30.77% patients of 35-39 years of age, 7.69% patients of 40-44 years of age and 15.38% patients of above 45 years of age. The insulin used in the sampling is Actrapid for 10 patients and Novorapid for 4 patients. It is known that the effectiveness of insulin based on blood glucose random levels with insulin Actrapid and Novorapid in sub-cutaneous do not have significant differences. Keywords: diabetic mellitus gestational, insulin, antidiabetic drugs
Co-Authors A Nurrochmad AE Nugroho Ajeng Merdeka Putri Alfarisy, Fariz Kustiawan Annisa Shalihah Atmawati, Siti Dwiana Ayik Rosita Puspaningtyas1 Dian Agung Pangaribowo Diana Chusna Mufida Diana Holidah Dianasari, Dewi Dianasari, Dewi Dwi Koko Pratoko Endah Puspitasari Fransiska M. Christianty Hadi Paramu Hasana, Ani Riani Ika Puspita Dewi Ika Puspita Dewi Imam Susilo Junaidi Khotib Kartika Senjarini Laily Ilman Widuri, Laily Ilman Lelyta - Septiandini Lesti Eko Pangestuti M Nuril Huda Muhammadiy, Noer Sidqi My, Truong Nhat Nia Kristiningrum Prihwanto Budi Subagio R Susilowati Rahmayanti, Fina Rahmayanti, Finas Restanto, Didik Pudji Riza Rastri Wihardiyanti Song, Le Huu Tsabit Barki Velavan, Thirumalaisamy P. Wardhani, Firdha Aprillia Yuli Witono Zainah Rajab