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Journal : As-syifaa Jurnal Farmasi

EFEK ANTI INFLAMASI IN VITRO EKSTRAK ETANOL DAUN KARET KEBO (Ficus elastica) DENGAN METODE STABILISASI MEMBRAN Red Blood Cell (RBCs) Suhaenah, Asriani; Widiastuti, Harti; Aprianti, Tiara
As-Syifaa Jurnal Farmasi Vol 17, No 1 (2025): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v17i1.1299

Abstract

The rubber kebo plant (Ficus elastica) is traditionally known to have various benefits, including as an anti-inflammatory agent. This study aimed to evaluate the anti-inflammatory effect of ethanol extract of rubber kebo leaves using the red blood cell (RBCs) membrane stabilisation method in vitro. Kebo rubber leaves were extracted by a maceration method using 96% ethanol, and anti-inflammatory activity was tested by measuring the stability of RBCs membrane against hypotonic solution-induced haemolysis. The results showed that ethanol extract of rubber kebo leaves had anti-inflammatory activity with a percentage of membrane stabilisation of 31.156% at a concentration of 40 ppm and reached 51.998% at a concentration of 200 ppm. This activity is caused by the content of secondary metabolites such as flavonoids and tannins that work by stabilising the red blood cell membrane. Compared to the positive control of diclofenate sodium, the extract showed competitive effectiveness, albeit lower