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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Pertanian Indonesia ACTA VETERINARIA INDONESIANA Hemera Zoa Jurnal Sain Veteriner Jurnal Veteriner Indonesian Journal of Pharmaceutical Science and Technology JSFK (Jurnal Sains Farmasi & Klinis) ARSHI Veterinary Letters Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Health Sains Jurnal Buana Farma Britain International of Exact Sciences Journal (BIoEx Journal) Indonesian Journal of Biological Pharmacy Jurnal Sylva Lestari Eduvest - Journal of Universal Studies Jurnal Veteriner dan Biomedis Current Biomedicine
Bayu Febram Prasetyo
Sub-Divisi Farmasi Veteriner, Sekolah Kedokteran Hewan Dan Biomedis, IPB University, Bogor, Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

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Effect of Boswellic Acid Administration on Blood Biochemical Profile of Sprague Dawley Rats in Cyclophosphamide-Induced Cardiotoxicity Conditions Miranti Fardesiana Putri; Ietje Wientarsih; Bayu Febram Prasetyo; Vetnizah Juniantito
Britain International of Exact Sciences (BIoEx) Journal Vol 4 No 2 (2022): Britain International of Exact Sciences Journal, May
Publisher : Britain International for Academic Research (BIAR) Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/bioex.v4i2.660

Abstract

Cyclophosphamide (CP) is a chemotherapeutic agent that belongs to the alkylating agent group that is widely used in the treatment of cancer. Cardiotoxicity is often a side effect of using CP in medical therapy. In this study, 24 Sprague Dawley rats were randomly divided into 4 groups. Group 1 (K1) was given injection with aqua pro injection intraperitoneally (IP) once a week for 21 days. Group 2 (K2) was given IP CP with a dose of 50 mg/kg BW, once a week for 21 days. Group 3 (K3) was given boswellic acid extract at a dose of 250 mg/kg BW orally, every day for 21 days. Group 4 (K4) was given boswellic acid nanoparticles at a dose of 250 mg/kg BW orally, every day for 21 days. During the treatment the body weight of the rats was weighed every day. At the end of the treatment, the rats were euthanized and blood samples were taken for blood biochemical evaluation, namely CPK, LDH, AST, and ALT. The results showed that the levels of CPK, LDH, AST, and ALT in K2 were significantly higher (p<0.05) than K1, K3 and K4. Statistically, the results of CPK, LDH, AST and ALT in K3 and K4 were not significantly different (p<0.05) compared to K1. The two groups (K3 and K4) were not significantly different (p<0.05) but on average the CPK, LDH, AST, and ALT results in K4 had lower scores than K3. This can indicate the protective effect of boswellic acid and boswellic acid nanoparticles on the heart against cyclophosphamide-induced cardiotoxicity.
Studi Penggunaan Obat Anti Ektoparasit di Salah Satu Klinik Hewan Kota Bogor Tahun 2017 dan 2018 Bayu Febram Prasetyo; Harry Soehartono; Rahmalia Dini Hanifa
Jurnal Veteriner Vol 23 No 2 (2022)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (94.798 KB) | DOI: 10.19087/jveteriner.2022.23.2.259

Abstract

The anti-ectoparasitic drug is the type of medication used to treat infections caused by various kinds of ectoparasites. The use of this drug needs to be evaluated through the drug use evaluation program (EPO) to ensure the rational and effective application of this drug. The purpose of this research is to examine the anti-ectoparasitic drugs that are often used and its effectivity in cases of infections caused by ectoparasites, in this study that is infection caused by Ctenocephalides felis fleas which cause the Flea Allergic Dermatitis and Sarcoptes scabiei mites which cause Scabies in cats and dog. This is a descriptive study using medical records from 127 patients who have infections caused by ectoparasites. The evaluation of this drug use is done descriptively by comparing data results and literatures. This study showed the use of anti-ectoparasitic drugs in animals with Flea Allergic Dermatitis in 20 times applications; 15 times using Imidacloprid 10% combined with Moxidectin 2.5% and 5 times using anti-ectoparasit ivermectin, while in animals with scabies the drug are used 107 times; 76 times using anti-ectoparasitic ivermectin, 26 times using Permethrin 5% and 5 times using Imidacloprid 10% combined with Moxidectin 2.5%. Imidacloprid 10% combined with Moxidectin 2.5% is the most used anti-ectoparasitic drugs to treat cases of Flea Allergic Dermatitis, while ivermectin is most used to treat cases of Scabies. Keywords: anti ectoparasite, evaluation of drug use, ivermectin, Imidacloprid 10% and Moxidectin 2.5%
Evaluation of Drug Uses for Calicivirus and Panleukopenia Treatment in Bogor Animal Clinic on 2017 and 2018 Muhammad Agung Nulhakim; Bayu Febram Prasetyo; Rini Madyastuti Purwono
Eduvest - Journal of Universal Studies Vol. 1 No. 9 (2021): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1937.038 KB) | DOI: 10.59188/eduvest.v1i9.202

Abstract

Drug therapy in cases of infections by viruses is only to prevent secondary infections. The use of drugs for each action must be evaluated through a drug use evaluation program (EPO) in order to guarantee a rational and effective drug. This study aims to examine the drugs in case for handling and the effectiveness of drug use in cases of infections caused by viruses, in this study the therapeutic use of drugs in cases of feline calicivirus and feline panleukopenia. This research is a descriptive study using data from 543 patients who came to get treatment of clinic in Bogor City during 2017 and 2018, 29 of which were infected with feline calicivirus and 32 infected with feline panleukopenia. Evaluation of drug use in these two viral diseases is done descriptively by comparing research data with literature. The results showed the use of drugs in the case of feline calicivirus there were 12 types of drug treatment, while in the case of feline panleukopenia there were 9 types of drug treatment. The use of drugs most often used is based on the records of veterinary clinical records, namely the preparation of metronidazole combined with cefadroxil to handle cases of feline calicivirus and metronidazole alone to handle cases of feline panleukopenia.
Pengaruh Penambahan Tepung Protein Maggot Black Soldier Fly (Hermetia illucens) terhadap Palatabilitas Pakan Kucing Komersial Bayu Febram Prasetyo; Dedi Rahmat Setiadi; Handri Dwi Agung
Jurnal Sain Veteriner Vol 41, No 2 (2023): Agustus
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.81730

Abstract

Larva Black Soldier Fly (BSF) spesies Hermetia illucens mengandung nutrisi protein yang berpotensi menjadi sumber pakan alternatif hewan peliharaan yang ramah lingkungan, berkelanjutan, dan memiliki komposisi nutrisi yang ideal. Namun, laporan penggunaannya masih belum diketahui sebagai bahan pakan kucing. Uji palatabilitas pakan komersial dengan penambahan tepung protein maggot bertujuan untuk mengetahui daya terima pakan yang dikonsumsi. Uji palatabilitas dilakukan dengan metode monadik atau single bowl pada kucing domestik jantan dalam dua tahap, adaptasi pakan dan pemberian pakan uji pada empat kelompok perlakuan (0,25%, 50%, dan 75%) dengan penambahan tepung maggot, yang masing-masing terdiri dari 3 ekor kucing. Hasil pengujian diperoleh dari jumlah konsumsi pakan harian dengan cara jumlah pakan yang diberikan dikurangi dengan jumlah sisa pakan. Hasil penelitian menunjukkan bahwa tidak terdapat perbedaan yang nyata (P>0,05) pada perlakuan P1 119±15,36 (g/hari) dan 204±26,31 (kkal/hari) pada jumlah konsumsi pakan dan jumlah kebutuhan kucing harian. Dapat disimpulkan bahwa tepung protein maggot BSF dapat menjadi sumber bahan pakan kucing.
PENGHAMBATAN ENZIM TIROSINASE dan AKTIVITAS ANTIOKSIDAN EKSTRAK BUNGA TELANG (Clitoria ternatea) MENGGUNAKAN METODE DPPH Bayu Febram Prasetyo; Amrozi; Nur Anisa BS
Jurnal Buana Farma Vol. 4 No. 1 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i1.942

Abstract

Clitoria ternatea or known as the butterfly pea is widely used in the health sector due to its efficacy as antidiabetic, anti-inflammatory, antimicrobial, anticancer, analgesic, antipyretic, and antioxidants. The purpose of this research is to examine the antioxidants and tyrosinase inhibitor activities of butterfly pea ethanol extract as well as to identify the phytochemical content. Antioxidants activities are determined by the DPPH method. The results of this study indicates that butterfly pea extract has very weak antioxidant activities with an IC50 value more than 200 ppm. The results of the tyrosinase inhibitor activities showed that the butterfly pea extract did not inhibit the tyrosinase enzyme. Based on the screening phytochemical tests, the chemical components contained in butterfly pea extract are flavonoids, tannins, saponins, and steroids. Bunga telang flower extract has very weak antioxidant activity and tyrosinase inhibitor testing showed antioxidant flower extract by DPPH method. Tyrosinase inhibitor assay results showed white Bungatelang extract has no activity to inhibit tyrosinase enzyme.
Acute toxicity test of avocado (Persea americana) oil in mice Bhila, Aisya Salsa; Andriyanto, Andriyanto; Prasetyo, Bayu Febram
Current Biomedicine Vol. 2 No. 2 (2024): July
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.2.2.55-60

Abstract

Background: Avocado (Persea americana) fruit has a high oil content, so it is widely used in the pharmaceutical and cosmetic industries. Objective: This study aims to determine the toxicity of avocado oil in mice using the lethal dose (LD50) method so that it can be used as a reference for further testing. Methods: This study used a total of 20 DDY strain female mice, which were divided into 5 groups: one control group and four treatment groups that were fed with avocado oil with 5, 10, 15, and 20 g/kg BW doses orally. The mortalities of experimental mice were observed for 14 days after treatment. Other parameters observed in this study were physiological response, body weight, absolute organ weight, and relative organ weight. Results: There was a change in behavior, and the obtained LD50 value was 25.4 g/kg BW. Observation of physiological responses, body weight, absolute organ weights, and relative organ weights showed no significant differences. Conclusion: It was concluded that avocado oil is considered relatively harmless and safe to use.
Uji Resistansi Antibiotik Bakteri Vibrio Parahaemolyticus dari Udang Putih (Litopaneus Vannamei) Serta Identifikasi Gen Penyandi Resistan Ampisilin Ramadhaniah, Vetty; Agustin Indrawati; Bayu Febram Prasetyo
Acta VETERINARIA Indonesiana Vol. 12 No. 2 (2024): Juli 2024
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.12.2.97-105

Abstract

Penyakit vibriosis pada udang putih (Litopaneus vannamei) sangat ditakuti oleh pembudidaya pada tahun 2009 karena diduga dapat menimbulkan early mortality syndrome (EMS). Penyakit ini menyebabkan kematian massal pada usia muda. Umumnya vibriosis pada udang dicegah dan diobati dengan menggunakan antibiotik. Penggunaan antibiotik yang tidak tepat dapat menyebabkan resistansi multi-antibiotik. Penelitian ini dilakukan untuk mengetahui tingkat resistansi antibiotik terhadap bakteri Vibrio parahaemolyticus di udang putih dan mengidentifikasi keberadaan gen resistan terhadap ampisilin. Isolat bakteri V. parahaemolyticus diuji resistansi terhadap antibiotik ampisilin, oksitetrasiklin, kloramfenikol, enrofloksasin, dan eritromisin. Penelitian ini dilakukan menggunakan metode difusi cakram Kirby-Bauer dengan tabel Clinical and Laboratory Standards Institute (CLSI). Hasil uji resistansi menunjukkan bahwa 30 isolat V. parahemolyticus sensitif terhadap enrofloxacin (94%), dan kloramfenikol (97%). Adapun hasil uji terhadap ampisilin menunjukkan adanaya resistan (77%). Bakteri yang resistan terhadap ampisilin diuji terhadap keberadaan gen yang mengkode protein BlaTEM yaitu dengan hasil persentase 100% (dari 6 sampel) pada amplikon 516 bp. Dapat disimpulkan bahwa isolat V. parahaemolyticus resistan terhadap ampisilin terhadap gen BlaTEM.
Potensi Minyak Rosemari pada Waktu Kematian Caplak secara In Vitro Prasetyo, Bayu Febram; Hadi, Upik Kesumawati; Winarto, Tytha Nadhifa
Indonesian Journal of Biological Pharmacy Vol 2, No 3 (2022): IJBP (Desember)
Publisher : Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijbp.v2i3.41493

Abstract

Minyak esensial rosemari telah banyak digunakan di berbagai bidang karena manfaatnya bagi kesehatan. Salah satu manfaat yang kurang diketahui adalah sifat antiparasitnya. Penelitian ini bertujuan menganalisis pengaruh pemberian minyak esensial rosemari terhadap waktu kematian caplak Rhipicephalus sanguineus. Pada penelitian ini, 50 ekor caplak dibagi menjadi 5 kelompok dan masing-masing kelompok mendapatkan 5 perlakuan yang berbeda yaitu minyak esensial rosemari konsentrasi 10%, 15%, dan 20% serta antiparasit komersial yang mengandung fipronil 3% sebagai kontrol positif dan minyak kelapa murni sebagai kontrol negatif. Kelompok caplak diamati dalam 3 kali periode masing-masing 30 menit. Kelompok perlakuan minyak esensial rosemari konsentrasi 10% memiliki LT50 pada 2 jam 27 menit, kelompok perlakuan minyak esensial rosemari konsentrasi 15% memiliki LT50 pada 1 jam 10 menit, dan kelompok perlakuan minyak esensial rosemari konsentrasi 20% memiliki LT50 pada menit ke-34. Hasil penelitian ini menyimpulkan bahwa minyak esensial rosemari dalam konsentrasi 20% hampir sama efektifnya dengan antiparasit komersial yang mengandung bahan aktif fipronil 3% yang memiliki sifat akarisidal.
Uji Aktivitas Antioksidan dan Daya Hambat Enzim Tirosinase Ekstrak Etanol Azolla filiculoides Lam. Prasetyo, Bayu Febram
JSFK (Jurnal Sains Farmasi & Klinis) Vol 8 No 1 (2021): J Sains Farm Klin 8(1), April 2021
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.8.1.53-59.2021

Abstract

Azolla (Azolla filiculoides Lam.) merupakan tanaman paku air dari famili Azollaceae. Azolla filiculoides digunakan sebagai pakan alami dengan ketersediaannya melimpah di alam yang belum termanfaatkan secara optimal. Tanaman ini dapat bersimbiosis dengan Cyanobacteria. Azolla memiliki senyawa bioaktif yang berfungsi sebagai antioksidan dan inhibitor tirosinase. Tujuan dari penelitian ini adalah untuk menguji aktivitas antioksidan menggunakan metode DPPH (2.2-difenil 1-pikrihidrasil ) dan daya hambat tirosinase pada ekstrak etanol Azolla filiculoides. Ekstraksi menggunakan metode maserasi dan pelarut etanol 96%. Hasil uji fitokimia menunjukkan bahwa ekstrak etanol Azolla mengandung senyawa flavonoid, tanin, saponin, steroid dan triterpenoid. Kandungan fitokimia tersebut berpotensi sebagai antioksidan dan inhibitor tirosinase, terutama senyawa flavonoid dan tanin. Uji aktivitas antioksidan menunjukkan bahwa ekstrak etanol Azolla filiculoides memiliki aktivitas antioksidan yang kuat dengan nilai IC50 sebesar 23.00 ppm. Uji aktivitas inhibisi tirosinase ekstrak azolla menunjukkan daya hambat yang lebih efektif pada aktivitas diphenolase (IC50 996.60 ppm) dibandingkan aktivitas monophenolase (IC50 1893.09 ppm).
Canine Atopic Dermatitis (CAD) di Rumah Sakit Hewan Pendidikan IPB University Prasetyo, Bayu Febram; Firdausi, Zalfaa Nurr; Rahmadani, Satria Tegar; Fadia, Sindy Siti; Adinda, Nada; Amanda, Marsha; Zheng, Lee Xiang; Natawiria, Maria Stella Linda
Jurnal Veteriner dan Biomedis Vol. 3 No. 1 (2025): Maret
Publisher : Sekolah Kedokteran Hewan dan Biomedis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jvetbiomed.3.1.23-29.

Abstract

Canine Atopic Dermatitis (CAD) adalah penyakit kulit kronis yang dipengaruhi oleh faktor genetik dan lingkungan. Studi kasus ini membahas penanganan seekor anjing Siberian Husky berusia 7 tahun yang didiagnosis dengan CAD di Rumah Sakit Hewan Pendidikan IPB University. Gejala utama yang dialami meliputi pruritus, eritema, dan lesi kulit yang disebabkan oleh infeksi sekunder. Terapi yang diberikan termasuk penggunaan prednisolon sebagai antiinflamasi, Transfer Factor untuk mendukung sistem imun, dan produk topikal seperti Allerdone untuk mengatasi gatal. Selain itu, sampo antibakteri dan antijamur, serta suplemen kulit Coatex, diberikan untuk mengelola kondisi kulit. Edukasi terhadap pemilik mengenai pengelolaan jangka panjang sangat penting untuk menjaga kualitas hidup anjing dan mengurangi beban psikologis serta finansial pemilik. Studi ini menekankan pentingnya pendekatan terapi multimodal dalam menangani CAD.
Co-Authors Adinda, Nada Affan Zufar Agustin Indrawati Ahmad Kurniawan Amanda, Marsha Amrozi Andriyanto Andriyanto ANGGARA ALDOBRATA Anisa Rahma, Anisa Anisa, Rahma Ath-Thaariq, Affan Aufar Aziziah, Nurul Madinah Bachmid, Salma Safitri Baharun, Rasyid Bambang Pontjo Priosoeryanto Bhila, Aisya Salsa Budiono, Novericko Ginger Dedi Rahmat Setiadi Diaz, Fariz Arrachman Dondhin Sajuthi Dondin Sajuthi Eva Harlina Fadia, Sindy Siti Farra Sasmita Fikram, Muhammad Fikri Hanifah Firdausi, Zalfaa Nurr Fitri, Arni Diana Ghazali, Farhan Rizqy Hamidi, Zikri Handri Dwi Agung Hikmarizky, Firda IETJE WIENTARSIH Khamidah, Nabila Nurrisma Lina Noviyanti Sutardi Madyastuti, Rini May, Ng U Mifthadillah, Sekar Ayu Miranti Fardesiana Putri Mufida, Anis Arifatu Muhammad Agung Nulhakim Natawiria, Maria Stella Linda Nur Anisa BS Nurdiansyah, Rio Dwi Haryadi Prayogo, Yanico Hadi Rahmadani, Satria Tegar Rahmalia Dini Hanifa Ramadhaniah, Vetty Rasyid, Baharun Rita Kartika Sari Rizal Arifin Akbari Saragih, Adrian SUPRIYONO Upik Kesumawati Hadi Vetnizah Juniantito Wasrin Syafii Winarto, Tytha Nadhifa Wulandari, Nenis Rahma Zheng, Lee Xiang