Article Per Year (5 Year)
p-Index From 2021 - 2026
2.319
P-Index
This Author published in this journals
All Journal HAYATI Journal of Biosciences Indonesian Journal of Pharmaceutical Science and Technology Indonesian Journal of Biotechnology Health Notions Jurnal Biodjati Al-Kimia Chimica et Natura Acta Jurnal Pendidikan Kimia (JPKim) Indonesian Journal of Chemistry Jurnal Ilmiah Berkala: Sains dan Terapan Kimia Jurnal Sains dan Teknologi Farmasi Indonesia al Kimiya : Jurnal Ilmu Kimia dan Terapan Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan
Muhammad Yusuf
Departemen Kimia, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

Published : 27 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Health Notions

 1 
A Computational Study of Fab CHK152 with CHK265 as Anti Chikungunya Virus for Rapid Test Components Korry Novitriani; Ade Rizki Ridwan Firdaus; Bacthi Alisjahbana; Shabarni Gaffar; Muhammad Yusuf; Toto Subroto
Health Notions Vol 7, No 5 (2023): May
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/hn70502

Abstract

The symptoms of chikungunya disease are generally similar to the symptoms of other viral diseases, except that chikungunya disease can cause joint disorders and even paralysis. Incorrect initial diagnosis will result in inappropriate treatment of the disease Thus it is necessary to study the identified antibodies that can neutralize and protect the body from alphavirus infections, including chikungunya. There are several antibodies that can neutralize chikungunya including CHK152 which neutralizes virus by inhibiting fusion with stabilizing the surface area of the virus, hindering the exposure of the fusion-loop, likely neutralizing infection by blocking fusion. Otherwise CHK265 inhibits the life cycle of the virus in a way neutralize infection by blocking entry at a post-attachment pre-fusion step. The low energy of binding between antigen-antibodies will stabilize the interaction of both. Therefore, this aims to find the best affinity energy for antibodies to be used in the rapid diagnostic component of anti-chikungunya virus (CHIKV). The binding energies were calculated using FireDock an efficient method for the refinement and rescoring of rigid-body docking solutions, through rearrangement of the interface sidechains and adjustment of the relative orientation of the molecules.The results of this study  obtained energy scores from CKH152 and CHK265 are -125.78 and -29.94, indicate that CHK265 antibody affinity energy is higher than CHK152. It can be concluded that the best affinity energy for CHIKV diagnostic component is CHK152.Keywords: energy affinity; CHK152; CHK265; E1E2 CHIKV; molecular docking
Co-Authors Abdul Mutalib Abdul Mutalib Abdul Mutalib Abdul Mutholib Ade Rizki Ridwan Firdaus Ade Rizqi Ridwan Firdaus Agus Safari Agus Safari Agus Safari Ahmad Fariz Maulana Ahsanul Chaliqin Gayo Anceu Murniati Angga Himas Setyawan Anita Yuwita Anneke Noviyanti Anni Anggraeni Anni Anggraeni Anni Anggraeni Annisyaban Fatiha Azzahra Ari Hardianto Arum Kurnia Sari Ashary Fathul Hafidh Bachti Alisjahbana Bacthi Alisjahbana Baroroh, Umi Basti Andriyoko Bayu Shiddiq Widhi Pratama Bevi Lidya Clara Claudia Desy Linasari Dewi Astriany Dewi Astriany Dewi Ratih Handayani Dhiya Salsabila Elsa Destiana Endah Wulandari Farhan Azhwin Maulana Fauzian Giansyah Fauziyah, Hanifa Ghina Nur Fadhilah Henry Chandra Herman Herman Hesein H. Bahti Hesti Lina Wiraswati Husein Hernadi Bahti Idar Idar Idar Idar Ika Wiani Imam Adi Wicaksono Iman Permana Maksum Iman Rahayu Irkham Irkham Irma Mardiah Khomaini Hasan Khomairi Hasan Korry Novitriani Korry Novitriani, Korry Leonardus Wiydatmoko Mamlikatu Ilmi Azizah Martalena Ramli Mia Tria Novianti Mia Widyaningsih Muchtaridi Muchtaridi Muhamad Abidin Muhamad Abidin Muhammad Fadhlillah Nisa Fauziah Novianti, Mia Tria Nur Asni Setiani Nurul Aida Fathya Opik Taupiqurrohman R. Ukun M.S. Soedjanaatmadja Rahmaniar Mulyani Ratna Sari Dewi Ratna Sari Dewi Regaputra Satria Janitra Retna Putri Fauzia Rima Handiyani Rina Fajri Nuwarda Rista Awalia Rudi Hartono Saadah D. Rachman Saadah D. Rachman Saadah Diana Rachman Safri Ishmayana Safri Ishmayana Safri Ishmayana Safri Ishmayana Safri Ishmayana Santhy Wyantuti Sari Syahruni Sari Syahruni Saronom Silaban Shabarni Gaffar Shabarni Gaffar Shabarni Gaffar Shabarni Gaffar Shabarni Gaffar Shinta Kusumawardani Shinta Kusumawardani Siti Soidah Soni Muhsinin Sukma Nuswantara Sylvi Qurrotul Aini Taufik Ramdani Tohari Toto Subroto Toto Subroto Toto Subroto Toto Subroto Toto Subroto Umi Baroroh Umi Baroroh Wahyu Widayat Wanda Destiarani Yani Suryani Yeni Wahyuni Hartati Yeni Wahyuni Hartati Yurika Sastyarina Yurika Sastyarina Zelika Mega Ramadhania Zuhrotun Nafisah Zuhrotun Nafisah