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All Journal Jurnal Pengolahan Hasil Perikanan Indonesia Jurnal Ilmu dan Teknologi Kelautan Tropis Alotrop Jurnal Pendidikan dan Ilmu Kimia Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology Jurnal Sosial Ekonomi Kelautan dan Perikanan JURNAL PERIKANAN TROPIS Jurnal Pengabdian Masyarakat: Darma Bakti Teuku Umar Jurnal Laot Ilmu Kelautan Marine Kreatif Journal of Aceh Aquatic Sciences Nawadeepa: Jurnal Pengabdian Masyarakat
Mohamad Gazali
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Public Health Social Sciences Transportation Other

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The Anticancer Potency of Pandanus odoratissimus Extracts In Human Breast Cancer (MCF-7) Cell Line Andriani, Yosie; Yahya, Rodhiyah; Gazali, Mohamad; Amir, Hermansyah; Subhan, Beginer
Jurnal Laot Ilmu Kelautan Vol 6, No 1 (2024): Jurnal Laot Ilmu Kelautan
Publisher : Universitas Teuku Umar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35308/jlik.v6i1.9275

Abstract

The development of novel chemical entities, novel pharmaceuticals, and novel drug leads frequently involves the use of natural sources. One of the most well-known plants, Pandanus odoratissimus (Pandanaceae), is native to Malaysia and has long been used in Ayurvedic medicine to treat a variety of illnesses. The purpose of this study is to determine P odoratissimus's antioxidant and anticancer properties against MCF-7 human breast cancer cell lines. The 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity was used to assess antioxidant activity, and among the other extracts, core exhibited the highest antioxidant value. An MTT assay was used to assess the effects of plant components on MCF-7 cell lines (3-(4, 5-dimethylthiazolyl)-2, 5-diphenyl-tetrazolium bromide). The concentration of samples was shown to considerably boost the antioxidant activities in P. odoratissimus extracts. Our findings demonstrated that, after receiving treatment for 72 hours, sample treated cancer cells experienced a decline in cell viability. The IC50 value of 88.00 mg/ml indicates that the extracts have a poor cytotoxic impact and have no promise as anticancer agents against MCF-7, which is why it’s killing efficiency in cancer cells is regarded as lower.
Pemanfaatan Buah Mangrove Sonneratia alba Sebagai Sirup Alami di Desa Lhok Bubon, Aceh Barat Salsabila, Farah; Gazali, Mohamad; Anggraini, Deri; Ropita, Ropita; Mardalena, Selvi; Alfarisi, Irnu; Syafitri, Rina; Zuriat, Zuriat
Marine Kreatif Vol 8, No 1 (2024): Marine Kreatif
Publisher : Universitas Teuku Umar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35308/mk.v8i1.9790

Abstract

Mangrove memiliki banyak manfaat dan dapat dijadikan sebagai sumber pangan fungsional. Mangrove merupakan jenis tanaman dikotil yang hidup di habitat air laut dan air payau. Tujuan dari pelaksanaan pengabdian masyarakat adalah untuk mentransferkan keterampilan dan pengetahuan dalam memproduksi sirup buah pedada (Sonneratia alba) kepada masyarakat pesisir Lhok Bubon Aceh Barat. Metode pelaksanaan kegiatan pengabdian masyarakat meliputi sosialisasi, persiapan bahan baku, dan pelatihan kepada masyarakat pesisir di Lhok Bubon Aceh Barat. Pelaksanaan kegiatan pengabdian kepada masyarakat dilaksanakan dengan melibatkan Wanita pesisir Lhok Bubon yang menghasilkan produk sirup buah pedada yang berasal dari mangrove S. alba. Outcomes yang diharapkan dalam kegiatan ini adalah pemanfaatan secara berkelanjutan mangrove S. alba sebagai sirup alami yang dapat meningkatkan pendapatan masyarakat pesisir.
Aktivitas inhibisi tirosinase ekstrak etanol rumput laut Ulva lactuca secara in vitro: In vitro tyrosinase inhibitory activity of ethanol extract of seaweed Ulva lactuca Gazali, Mohamad; Suhardani, Mila Novalita; Husni, Amir; Nurjanah, Nurjanah; Zuriat, Zuriat; Hasanah, Uswatun; Syafitri, Rina
Jurnal Pengolahan Hasil Perikanan Indonesia Vol. 27 No. 7 (2024): Jurnal Pengolahan Hasil Perikanan Indonesia 27(7)
Publisher : Department of Aquatic Product Technology IPB University in collaboration with Masyarakat Pengolahan Hasil Perikanan Indonesia (MPHPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17844/jphpi.v27i7.53399

Abstract

Ulva lactuca kaya senyawa bioaktif yang bermanfaat bagi manusia dan organisme lainnya. Tujuan penelitian ini adalah untuk menentukan aktivitas inhibisi tirosinase pada ekstrak etanol rumput laut U. lactuca secara in vitro. Penelitian ini dilakukan secara bertahap, yaitu proses maserasi U. lactuca dengan pelarut etanol. Ekstrak difraksinasi cair-cair dengan pelarut n-heksana, kloroform, dan air. Ekstrak etanol dan fraksi diuji total fenol, total flavonoid, dan aktivitas inhibisi tirosinase. Nilai total fenol dan flavonoid tertinggi didapatkan dari fraksi n-heksana dengan nilai 9,43±0,27 mgGAE/g dan 9,20±0,49 mgQE/g. Aktivitas inhibisi tirosinase tertinggi diperoleh dari fraksi n-heksan dengan nilai IC50 127,74±6,47 µg/mL. Senyawa aktif yang berperan penting dalam aktivitas inhibisi tirosinase pada ekstrak etanol dan fraksi n-heksana meliputi kalkon, asam ferulat, asam 4-nitrocinamat, asam 4-aminobenzoat, derivat 2TMS, asam 4-hidroksibenzoat, 4-tert-butylfenol, 1-tetradekanol, ester metil asam n-heksadekanoat, asam palmitat, 2-(2-Aminofenil)-1H-benzimidazol, dan asam 5-metilsalisilat. Fraksi n-heksana U. lactuca dapat digunakan sebagai inhibitor tirosinase alami.
Antioxidant and Anti-Arthritic Activities of Green Seaweed Halimeda tuna Methanolic Extract Gazali, Mohamad; Fatimah, Aden Nurin; Husni, Amir; Nurjanah, Nurjanah; Zuriat, Zuriat; Syafitri, Rina
Squalen, Buletin Pascapanen dan Bioteknologi Kelautan dan Perikanan Vol 19, No 1 (2024): May 2024
Publisher : :Agency for Marine and Fisheries Research and Human Resources, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15578/squalen.841

Abstract

Seaweed contains various bioactive compounds rich in pharmacological potentials, such as antioxidants and anti-arthritic. This study aims to determine the antioxidant and anti-arthritic activities of the methanolic extract of Halimeda tuna. Halimeda tuna samples were extracted using the maceration method and methanol. The methanol extract was tested for antioxidant (2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP)) and anti-arthritic activity using denatured bovine serum albumin (BSA). The methanol extract was also subjected to phytochemical and Gas Chromatography-Mass Spectrometry (GC-MS) analysis. Research results revealed that the extract yield was 0.50 ± 0.06%. Phytochemical analysis showed that H. tuna methanolic extract contained flavonoids, steroids, and alkaloids. GC-MS analysis showed that H. tuna methanolic extract contained steroids, fatty alcohols, and fatty acids. The antioxidant activity tests revealed an IC50 value of 299.98 ± 121.15 ppm and a FRAP value of 200.02 ± 8.50 M/g, categorized as a weak antioxidant. Anti-arthritic activity of H. tuna methanolic extract showed an IC50 value of 877.29 ± 209.84 ppm. The anti-arthritic activity of H. tuna methanolic extract was lower than sodium diclofenac as a standard drug. The extract of H. tuna has antioxidant and anti-arthritic activities; hence, further exploration is needed as an alternative potential in the pharmacological field.
Program Pengenalan Metode Ekstraksi Sargassum sp Sebagai Fitoimunostimulan Bagi Ikan Nila di Balai Perikanan Budidaya Air Payau Ujong Batee, Aceh Besar Zuriat, Zuriat; Gazali, Mohamad; Syafitri, Rina; Zuraidah, Syarifah; Amarullah, T; Wahyuni, Sri
Marine Kreatif Vol 8, No 2 (2024): Marine Kreatif
Publisher : Universitas Teuku Umar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35308/mk.v8i2.10247

Abstract

Alga cokelat Sargassum sp memiliki potensi untuk dapat dijadikan sebagai sumber pakan antiobiotik bagi komoditas budidaya ikan nila. Sargassum sp merupakan salah satu organisme laut yang tersebar pada zona intertidal pada kedalam 1-3 m yang masih tembus penetrasi Cahaya matahari. Tujuan dari pelaksanaan pengabdian masyarakat adalah untuk memperkenalkan metode ekstraksi Sargassum sp sebagai fitoimunostimulan bagi ikan nila di Balai Perikanan Air Payau Ujong Batee, Aceh Besar. Metode pelaksanaan kegiatan pengabdian masyarakat meliputi sosialisasi, penyerahan bahan baku Sargassum sp, dan pengenalan invensi paten sederhana dan hasil riset kepada stakeholder. Pelaksanaan kegiatan pengabdian kepada masyarakat dilaksanakan dengan melibatkan stakeholder memberikan dampak dan respon positif untuk meningkatkan produktivitas ikan nila (Oreochromis niloticus). Outcomes yang diharapkan dalam kegiatan ini adalah implementasi paten sederhana berkaitan dengan metode ekstraksi Sargassum sp sebagai fitoimmunostimulan pada ikan nila (O. niloticus).
SYSTEMATIC LITERATURE REVIEW OF TRENDS AND DEVELOPMENT IN ANTIHYPERTENSIVE EFFECT OF SEAWEED RESEARCH: SCIENTOMETRIC ANALYSIS Mohamad Gazali; Yosie Andriani; Jasnizat Saidin; Noraznawati Ismail
ALOTROP Vol. 8 No. 2 (2024): Alotrop 2024
Publisher : University of Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/alo.v8i2.36875

Abstract

Hypertension is the most alarming disease that causes cardiovascular risk for human health Worldwide. Thus, the author has explored marine natural marine macroalgae that possess antihypertension activity to lower blood pressure. Marine macroalgae or seaweed tropical marine organisms from marine biodiversity that are distributed widely in the subtropic and tropical oceans. Marine macroalgae have a significant role in preventing hypertension risk with a unique biochemical compound that is not contained in a terrestrial plant. However, antihypertension of seaweed research using scientometric analysis is limited. This study collected scientific information from relevant literature to determine the recent development and trends regarding antihypertension of seaweed research Worldwide. Many researchers, academia, and practitioners will have a wide understanding of the recent novelty finding in seaweed prospect to prevent antihypertension disease with a scientometric analysis approach to interpret data using CiteSpace. The literature review using scientometric analysis regarding antihypertension of seaweed research from 1991 until 2022. The result showed Suetsuna K is the most influential author (sigma score =1.52, centrality score =0.24 and degree score =51). Advances in Food and Nutrition Research is the leading journal. The most popular keywords in common cluster related antihypertension of seaweed research area are seaweed, hypertension, algae, in vitro, and dietary fiber. On the other hand, various stakeholders need to know the development and trends of a marine drug for antihypertensive effect from various seaweeds or marine macroalgae.
Tyrosinase Inhibitory Activity of Methanolic Extract and Fractions from Green Seaweed Ulva lactuca Gazali, Mohamad; Maknun, Fazidatul Lu’luil; Husni, Amir; Nurjanah, Nurjanah; Nursid, Muhammad; Hasanah, Uswatun; Zuriat, Zuriat; Syafitri, Rina
Squalen, Buletin Pascapanen dan Bioteknologi Kelautan dan Perikanan Vol 20, No 1 (2025): May 2025
Publisher : :Agency for Marine and Fisheries Research and Human Resources, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15578/squalen.915

Abstract

Ulva lactuca, a widely available green seaweed, has demonstrated promising bioactivity as a tyrosinase inhibitor. This study aimed to evaluate the tyrosinase inhibitory activity of U. lactuca extracts and identify the active compounds responsible. The seaweed was extracted using methanol via maceration, followed by partitioning with hexane, chloroform, and water. Total phenolic and flavonoid contents were determined using UV-VIS spectrophotometry, and tyrosinase inhibition was assessed in vitro. Among the tested fractions, the hexane fraction exhibited the highest tyrosinase inhibitory activity with an IC50 value of 584.34 ± 35.07 µg/mL, classifying it as an active inhibitor. Although this activity was weaker than kojic acid (IC50 = 11.07 ± 0.86 µg/mL), the hexane fraction showed relatively high phenolic (11.66 ± 0.53 mg GAE/g) and flavonoid (9.75 ± 0.30 mg QE/g) contents. Gas Chromatography-Mass Spectrometry (GC-MS) analysis identified several bioactive compounds, notably 2,4-dimethoxycinnamic acid, chalcone, and derivatives such as 2,6-dihydroxybenzoic acid and phloretin. These findings highlight the potential of U. lactuca, particularly its hexane fraction, as a source of natural tyrosinase inhibitors. This opens avenues for its application in the pharmaceutical and cosmetic industries, especially in formulations targeting hyperpigmentation and skin brightening.
Antifouling properties of green seaweed Halimeda opuntia from the Coast of Aceh, Indonesia: Sifat antifouling Halimeda opuntia dari Pesisir Aceh, Indonesia Gazali, Mohamad; Ismail, Noraznawati; Saidin, Jasnizat; Bakar, Kamariah; Siong, Julius Yong Fu
Jurnal Pengolahan Hasil Perikanan Indonesia Vol. 28 No. 6 (2025): Jurnal Pengolahan Hasil Perikanan Indonesia 28(6)
Publisher : Department of Aquatic Product Technology IPB University in collaboration with Masyarakat Pengolahan Hasil Perikanan Indonesia (MPHPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17844/jphpi.v28i6.63699

Abstract

Biofouling merupakan tantangan yang dihadapi dalam sektor maritim dan mendorong para peneliti untuk mengeksplorasi secara berkelanjutan dengan mencari solusi berupa antifouling yang ramah lingkungan dan berasal dari organisme laut. Penelitian ini bertujuan menentukan konsentrasi terbaik ekstrak H. opuntia berdasarkan aktivitas antifouling. Metode penelitian ini meliputi uji antibiofilm, sitotoksisitas, antibakteri, anti-quorum sensing, dan uji in situ. Hasil penelitian menunjukkan bahwa ekstrak metanol H. opuntia memiliki aktivitas antibiofilm lebih tinggi dengan nilai IC50 sebesar 0,020 mg/mL. Uji sitotoksisitas menunjukkan toksisitas terendah terhadap sel L6, dengan nilai IC50 sebesar 70,79 µg/mL. Secara mekanistik, ekstrak metanol H. opuntia tidak memiliki efek bakterisidal melawan bakteri Pseudomonas aeruginosa, tetapi dapat menghalangi mekanisme komunikasi bakteri melalui aktivitas quorum quenching, yang dibuktikan dengan pembentukan zona buram tidak berwarna dalam uji tersebut. Uji in situ yang dilakukan di perairan Pulau Redang dan Kuala Kemaman, Malaysia menunjukkan panel yang dilapisi dengan formulasi 5% H. opuntia menunjukkan kinerja antifouling yang superior selama tiga bulan percobaan, dengan tingkat penutupan fouling masing-masing sebesar 11,19% dan 9,10%. Penelitian selanjutnya diperlukan berkaitan dengan sifat antifouling dengan melakukan identifikasi senyawa aktif, evaluasi efektivitas jangka panjang, dan menentukan efisiensi biaya untuk produksi massal.
Freshwater Fish and Challenge of Supply Chain for Production Enhancement: West Southern Region of Aceh Province, Indonesia Zuriat, Zuriat; Amarullah, T; gazali, mohamad; Ali, M; Irham, Muhammad
Jurnal Sosial Ekonomi Kelautan dan Perikanan Vol 20, No 1 (2025): JUNI 2025
Publisher : Balai Besar Riset Sosial Eonomi Kelautan dan Perikanan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15578/jsekp.v20i1.13653

Abstract

This research aims to analyze the supply chain and marketing chain of freshwater fish in the West-Southern Region of Aceh Province, Indonesia. The research activities took place from May to July 2022, with data collection continuing in 2023. The determination of data collection locations used purposive methods, and data collection was conducted through survey methods. Data were obtained from fish traders in four  markets: Ujong Baroh Meulaboh Fish Market, Blang Pidie Market, Nagan Raya Market, and Krueng Sabe Fish Market. Data analysis was conducted descriptively. The research results indicate that the supply chain includes fish farmers, partner traders, collector traders, retailers, and consumers, and there are two supply chains based on regions: inter-insular and intra-region. The dominant types of freshwater fish supply are catfish and tilapia. Tilapia has a higher price compared to catfish. Tilapia is dominant in the Ujong Baroh market, while catfish is dominant in the Blang Pidie  market. It has become a substitute when sea fish are scarce or expensive in the market. Based on the value chain analysis, a margin ranging from 10% to 30% was obtained. Partner traders play a significant role in production activities and the supply chain due to cooperation in input-output factors. Challenges in the freshwater fish supply consist of seeds and feed, with seeds mostly supplied from outside West-South, accounting for more than 80%.. Addressing freshwater fish supply challenges in Southwest Aceh requires an integrated supply chain approach enhancing hatchery systems and fry distribution upstream, improving aquaculture infrastructure and feed subsidies at the production level, and establishing collection centers, cold storage, and modern markets in key districts to strengthen distribution, stabilize prices, and improve food security.
Eksplorasi Senyawa Bioaktif Alga Cokelat Sargassum sp. Agardh sebagai Antioksidan dari Pesisir Barat Aceh Gazali, Mohamad; Nurjanah, Nurjanah; Zamani, Neviaty P.
Jurnal Pengolahan Hasil Perikanan Indonesia Vol. 21 No. 1 (2018): Jurnal Pengolahan Hasil Perikanan Indonesia 21(1)
Publisher : Department of Aquatic Product Technology IPB University in collaboration with Masyarakat Pengolahan Hasil Perikanan Indonesia (MPHPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (254.776 KB) | DOI: 10.17844/jphpi.v21i1.21543

Abstract

Alga cokelat merupakan salah satu jenis makroalga laut yang mendominasi kawasan pesisir Barat Aceh. Penelitian ini bertujuan untuk melakukan eksplorasi senyawa bioaktif alga cokelat Sargassum sp. sebagai sumber antioksidan. Penelitian dilakukan secara deskriptif. Pengujian terdiri dari analisis proksimat, senyawa aktif, total fenol, aktivitas antioksidan metode DPPH dan perhitungan rendemen ekstrak. Hasil penelitian menunjukkan komposisi kimia yang paling dominan terdiri dari kadar abu 52,74% dan kadar karbohidrat 23,77%. Rendemen ekstrak Sargasuum sp. dengan pelarut etanol 0,565%, etil asetat 0,420% dan n-heksan 0,265%. Kadar total fenol etanol ektrak 563,22 mg GAE/g, etil asetat ekstrak 13,48 mg GAE/g, n-heksan ekstrak 30,610 mg GAE/g. Aktivitas antioksidan etanol ekstrak dengan IC50 = 239,51mg/L, etil asetat ekstrak 68,89 mg/L dan n-heksan ekstrak 148.16 mg/L. Ekstrak Sargassum sp. terdeteksi mengandung fenol, alkaloid dan triterpenoid.
Co-Authors Afrizal Hendri Alfarisi, Irnu Ali, M Amarullah, T Amarullah, Teuku Amir Husni Arfriani Maifizar Bakar, Kamariah Beginer Subhan Deri Anggraini Endah Anisa Rahma, Endah Anisa Eri Safutra Farah Salsabila, Farah Fatimah, Aden Nurin Hasni, Jusnaini Hayatun Nufus Hermansyah Amir, Hermansyah Husna, Faizatul Ismail, Noraznawati Jasnizat Saidin Khairul Samuki Mai Suriani Maknun, Fazidatul Lu’luil Mardalena, Selvi Muhammad Agam Thahir Muhammad Irham Muhammad Nurdin Muhammad Nursid Mulyono S. Baskoro Muzakkir Muzakkir N. Nurjanah Nabila Ukhty NEVIATY PUTRI ZAMANI Noraznawati Ismail Nurjanah Nurul Najmi Oktavinanda, Giovanni Rahmatillah, Refanja Rina Syafitri, Rina Ropita, Ropita Saidin, Jasnizat Siong, Julius Yong Fu Sri Wahyuni Suhardani, Mila Novalita Syarifah Zuaridah Syarifah Zuraidah Teuku Amarullah Uswatun Hasanah Yahya, Rodhiyah Yosie Andriani Zuaridah, Syarifah Zuriat Zuriat Zuriat Zuriat Zuriat, Zuriat Zuriat, Zuriat