Garuda - Garba Rujukan Digital

MSMEs’ go digital assistance as an effort to support MSMEs’ upgrading program in Banyuasin Regency Dwi Mirani; Januar Eko Aryansah; Farisha Sestri Musdalifah; Muhammad Yusuf Abror; Krisna Murti
Community Empowerment Vol 7 No 4 (2022)
Publisher : Universitas Muhammadiyah Magelang

The Covid-19 pandemic has had a significant impact on Indonesian economic activities, including micro, small, and medium enterprises (MSMEs). MSME actors need a variety of innovations to survive this pandemic, one of which is adapting by moving their business to the digital realm. The majority of the people in Sungai Pinang Village, Rambutan District, Banyuasin Regency, South Sumatra, are farmers, laborers, and entrepreneurs. However, businesspeople in this village are still unfamiliar with how to use technology to digitally market their products. This service program aims to introduce MSME actors to digital marketing and assist them in doing so. Visitations and counseling about digital marketing, as well as direct practice marketing products through digital channels, are the method of this program. Then, after interviewing MSME actors who had participated in the program, follow-up activities were carried out. The outcomes of this program include increased business actors' knowledge and enthusiasm for using digital marketing in sales.

Efek Pemberian Ekstrak Daun Kelor (Moringaoleifera) dalam Proses Menyusui Indri Seta Septadina; Krisna Murti; Neliza Utari
Sriwijaya Journal of Medicine Vol. 1 No. 1 (2018): Vol 1, No 1, 2018
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v1i1.8

Pemberian ASI ekslusif selama 6 bulan merupakan salah satu strategi global untuk meningkatkan pertumbuhan, perkembangan, kesehatan dan kelangsungan hidup bayi. Meskipun banyak manfaat pemberian ASI ekslusif bagi bayi, ibu, keluarga, dan masyarakat namun cakupannya masih rendah diberbagai negara termasuk Indonesia.Air Susu Ibudiproduksi dari hasil kerjasama antara rangsangan mekanik faktor hormonal dan saraf. Salah satu hormon yangmempengaruhi adalah hormon estrogen. Hormon estrogen adalah hormon seks yang diproduksi oleh rahim untukmerangsang pertumbuhan organ seks seperti payudara dan rambut pubik serta mengatur siklus menstruasi. Hormonestrogen juga berperan menjaga tekstur dan fungsi payudara. Kehamilan pada seorang perempuan, membuat kelenjarpayudara akan makin berkembang oleh pengaruh hormon estrogen, somatomamotropin dan prolaktin. Proses tersebutdipengaruhi oleh hormon estrogen dan progesteron.Estrogen secara signifikan memacu sintesis dan pelepasan prolaktinoleh hipofisa, efek ini tergantung pada durasi dan dosis pemberian.Di Indonesia tanaman kelor merupakan bahanmakanan lokal yang memiliki potensi untuk dikembangkan dalam kuliner ibu menyusui karena mengandung senyawafitosterol yang berfungsi meningkatkan dan memperlancar produksi ASI (efek laktogogum).Pada tulisan ini akandibahas mengenai beberapa fakta mengenai pengaruh pemberian ekstrak daun kelor (Moringa oleifera) peningkatankuantitas dan kualitas ASI pada proses menyusui. Banyaknya kandungan nutrisi di dalam daun kelor (Moringa oleifera)salah satunya seperti senyawa fitosterol (efek laktogogum) dalam meningkatkan kadar hormon menyusui dan zat besidapat memberikan dampak positif bagi kesehatan bayi karena ASI merupakan makanan alamiah bayi paling utama danterbaik.

Product photography assistance for micro, small, and medium enterprises in Banyuasin, South Sumatra Farisha Sestri Musdalifah; Krisna Murti; Annisa Rahmawati; Januar Eko Aryansah; Harry Yogsunandar
Community Empowerment Vol 7 No 10 (2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/ce.7586

In this digital era, online trade transactions have become a new culture. Small business owners in Sungai Pinang Village are familiar with technology and have been assisted in expanding the market to the online realm via smartphones. However, the challenge experienced by small business actors is that there are not proper and not attractive product photos to upload to social media and online stores, so they cannot attract the attention of potential consumers. This community empowerment activity aims to assist small business actors in being able to take photos of their business products in marketing and promoting their products digitally. There are 30 business owners attended the workshop with various types of business products. Small business participants were given materials about marketing, promotion, and basic knowledge of product photography. They also participated in workshops and mentoring on making attractive product photos so the photos could be promoted online. In addition, there are follow-up activities by monitoring the social media of small business owners to see the implementation of uploaded product photos in promoting their products. The result of this event is an increase in the general knowledge of small business owners about the basics of product photography so that it can be applied when marketing and promoting their business products online.

LANGERHANS CELLS HISTIOCYTOSIS Krisna Murti; Maria Ulfa
JURNAL KEDOKTERAN DAN KESEHATAN Vol 10, No 1 (2023)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V10I1.20142

Langerhans cell histiocytosis (LCH) merupakan salah satu penyakit terbanyak dari histiositosis dengan 2,0–5,4 kasus/100 juta populasi diseluruh dunia usia<15 tahun dan jarang terjadi pada dewasa. Penyakit ini bermanifestasi sebagai spektrum klinik dengan gejala bervariasi mulai dari ringan, tersebar diseluruh tubuh, bahkan bisa mengancam nyawa penderitanya. Klinisi dan ahli patologi dapat mengenali manifestasi klinis dan gambaran mikroskopik LCH, sehingga dapat menegakkan diagnosis LCH secara akurat. Diagnosis akurat bermanfaat untuk penatalaksaan yang adekuat bagi pasien. Metode yang digunakan adalah literature review. Data diperoleh dari buku dan artikel internasional hasil penelitian dan pemikiran para peneliti dan praktisi. Pasien LCH distratifikasi dalam kategori resiko berdasarkan keberlanjutan penyakit dan berat ringannya disfungsi organ; yaitu pasien dengan single-system disease, biasanya hanya memerlukan terapi lokal atau observasi saja. Pasien dengan multy-system disease yaitu penyakit yang lebih berat yang juga melibatkan multi organ membutuhkan terapi sistemik. Efek jangka panjang banyak terjadi pada pasien dengan keterlibatan multy-system disease dan pasien dengan reaktivasi penyakit beberapa kali. Efek jangka panjang yang dilaporkan yang tersering adalah diabetes insipidus dan orthopedic abnormalities (20%). Gambaran mikroskopik sel-sel tumor LCH berupa sel-sel bentuk oval, berinti satu dengan bentuk inti berlobus seperti biji kopi atau bentuk ginjal atau groove dan sitoplasma eosinofilik mengandung Birbeck granules yang dapat dideteksi dengan marker anti- CD1a dan Langerin (CD207). LCH dapat di diagnosis secara akurat dengan mengenali gambaran klinis dan gambaran mikroskopik. Penderita dapat ditangani secara tepat dan adekuat, sehingga mengurangi morbiditas, mortalitas dan komplikasi.

Effects of Fluoride Exposure During Pregnancy in Mice Brain Neurogenesis (Mus musculus) Siti Sarahdeaz Fazzaura Putri; Irfannuddin Irfannuddin; Krisna Murti; Yudianita Kesuma; Hardi Darmawan; Noriyuki Koibuchi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 17 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i17.720

Background: Fluoride is a type of micromineral found in teeth and bones. This mineral is also found in nature, such as in soil, water, plants, rocks, and even air. Fluoride can cross the placental barrier and diffuse into the cord blood, with a range from 60% to 91% of maternal fluoride. Maternal fluoride exposure during pregnancy and lactation can affect learning ability, memory, and expression of glutamate receptors. This study aimed to determine the effect of fluoride exposure during pregnancy and lactation on brain neurogenesis in vivo. Methods: In vivo, experimental study using mice (Mus musculus) C57BL/6 as many as 60 brood mice (20 males and 40 females) and as many as 30 offspring mice. Mice broodstock were first mated to produce offspring. During pregnancy, the female mice were exposed to fluoride (NaF). Exposure of broodstock mice to NaF was divided into 0 mg/L, 50 mg/L, 100 mg/L, and 150 mg/L exposure groups. Expression of PSD-95 protein was carried out by immunohistochemical examination of mouse brain tissue. Data analysis was carried out with the help of SPSS using univariate and bivariate methods. Results: There was a decrease in the expression of PSD-95 with increasing exposure to NaF doses during pregnancy and lactation. Giving NaF at a dose of 50 mg/L did not decrease PSD-95 expression because the results were not different from the control. In contrast, the administration of NaF doses that can reduce the expression of PSD-95 are doses of 100 and 150 mg/L. Conclusion: Fluoride exposure during pregnancy contributed to a decrease in mice brain neurogenesis, as indicated by the expression of the PSD-95 protein in the hippocampus area.

Effects of Fluoride Exposure During Pregnancy in Mice Brain Neurogenesis (Mus musculus) Siti Sarahdeaz Fazzaura Putri; Irfannuddin Irfannuddin; Krisna Murti; Yudianita Kesuma; Hardi Darmawan; Noriyuki Koibuchi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 17 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i17.720

Background: Fluoride is a type of micromineral found in teeth and bones. This mineral is also found in nature, such as in soil, water, plants, rocks, and even air. Fluoride can cross the placental barrier and diffuse into the cord blood, with a range from 60% to 91% of maternal fluoride. Maternal fluoride exposure during pregnancy and lactation can affect learning ability, memory, and expression of glutamate receptors. This study aimed to determine the effect of fluoride exposure during pregnancy and lactation on brain neurogenesis in vivo. Methods: In vivo, experimental study using mice (Mus musculus) C57BL/6 as many as 60 brood mice (20 males and 40 females) and as many as 30 offspring mice. Mice broodstock were first mated to produce offspring. During pregnancy, the female mice were exposed to fluoride (NaF). Exposure of broodstock mice to NaF was divided into 0 mg/L, 50 mg/L, 100 mg/L, and 150 mg/L exposure groups. Expression of PSD-95 protein was carried out by immunohistochemical examination of mouse brain tissue. Data analysis was carried out with the help of SPSS using univariate and bivariate methods. Results: There was a decrease in the expression of PSD-95 with increasing exposure to NaF doses during pregnancy and lactation. Giving NaF at a dose of 50 mg/L did not decrease PSD-95 expression because the results were not different from the control. In contrast, the administration of NaF doses that can reduce the expression of PSD-95 are doses of 100 and 150 mg/L. Conclusion: Fluoride exposure during pregnancy contributed to a decrease in mice brain neurogenesis, as indicated by the expression of the PSD-95 protein in the hippocampus area.

Perempuan dan perilaku berkelanjutan dalam komunitas online pecinta barang lokal Krisna Murti; Raden Ayu Wulantari; Nurly Meilinda; Anang Dwi Santoso
Bricolage : Jurnal Magister Ilmu Komunikasi Vol 8, No 2 (2022): Accredited by Kemenristekdikti RI SK No. 36/E/KPT/2019
Publisher : Universitas Bunda Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30813/bricolage.v8i2.3248

Scholars discovered that the majority of studies studying why women engage in sustainable fashion practices focused on environmental incentive, personal drive, or hedonistic motivation. In fact, women may anticipate the social value of fashion to be associated with the concept of self-improvement rather than the dimension of conservatism. This study aims to determine whether women's fashion consumption serves as a signifier of social identity, class, or position, as well as the degree to which the social value of fashion is embedded inside the product itself. The thesis to be demonstrated in this study is that women are agents of sustainable behavior to transmit sustainable habits because women are grassroots agents with the most influence in daily life. This research is based on a constructivist paradigm with a qualitative method that enables researchers to comprehend how behavior from the perspective of research subjects (women) with their subjective understanding underpins the sustainable behavior that they practice. Seven female agents were interviewed via Zoom meetings or WhatsApp video calls to collect the primary data. This study finds that sustainable fashion consumption has a social value. The social value of sustainable fashion consumption is inherent in the purchase or consumption of these products, as well as in the location where these items are purchased. The implication of this study is that a campaign to promote sustainable fashion consumption may incorporate social values.

DIFFUSE LARGE B CELL LYMPHOMA Krisna Murti
Majalah Kedokteran Sriwijaya Vol 53, No 3 (2021): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/mks.v53i3.20435

Diffuse large B cell lymphoma is a neoplasm arising from B lymphocytes and having a diffuse growth pattern. The nuclei cells showed a medium or similar or larger than the sizes of normal macrophages. This entity is the most common type of non-Hodgkin lymphoma (NHL) with incidence 30-40% from all NHL types. In Indonesia DLBCL cases was 68.2%, much higher than that in western countries (37%) and slightly higher than in other Asian countries (30-60%). Another data showed that in Indonesia there was 16.125 new NHL cases in 2020. This entity has diversity of molecular pathogenesis causes DLBCL showed some heterogeneity and similarities of clinical sign and symptoms, morphology and immunopheno types with other non-Hodgkin lymphomas. Therefore, some other molecular analysis such mutation events should be performed to achieve a correct diagnosis. All clinical data, morphologic immunhistochemical foundings have to be collected and analyzed and some additional molecular examination should be also conducted such as FISH analysis, PCR-based assay to exclude differential diagnosis. Some patients can be cured with a standard regimen Rituximab-Cyclophosphamide, Doxorubicin, Vincristine, and Prednisolone (R-CHOP). However, 40% of patients is refractory or relapse.

ADVANCE STAGE OF HODGKIN LYMPHOMA SHOWS HIGH DENSITY OF PLASMA CELLS BUT LOW ANGIOGENESIS Krisna Murti; Neti Neti; Iche Andriyani Liberty
Majalah Kedokteran Sriwijaya Vol 55, No 1 (2023): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/mks.v55i1.21035

BackgroundTumor microenvironmental of classical Hodgkin lymphoma (cHL) containing plasma cells and angiogenesis, however their exact roles remained indeterminate. Plasma cells are important prognostic factors of various malignancies. Angiogenesis can be assessed by evaluating of micro vessel density (MVD). Higher MVD is associated with a poor prognosis in various type of malignancies. The objectives of this study were to investigate the density of plasma cells and MVD in the microenvironment of cHL and to determine the association of both components with the stage of cHL.Materials and methodsThe selected 37 paraffin blocks of cHL cases were sectioned. The clinical staging was performed using modification of Ann Arbor staging system. To assess the density of plasma and endothelial cells, anti-CD138 and anti-CD34 antibodies were employed by immunohistochemistry. The association of plasma cells’densities and MVD with cHL stages was measured by statistical analysis using t-test by STATA version 15 with significant consideration if p <0.05.ResultsIn our cohort cHL was occurred in slightly older patients (?40 years; 53.33%), more in male (60%), and majority with nodal location (86.67%). The subtypes was dominated by lymphocyte rich (43.33%); followed by nodular sclerosing (30%) and mixed cellularity (26.67%), while lymphocyte depleted was not found. Statistical analysis revealed that higher density of plasma cells was significantly correlated to the patient higher stages (p=0.0003). While density of micro vessels is not significant correlation (p=0.5564) to the stages of cHLConclusionHigh densities of plasma cells but not angiogenesis correlate to advance stage of Hodgkin lymphoma.

STATUS ANEMIA TIDAK BERHUBUNGAN DENGAN SUBTIPE DIFFUSE LARGE B-CELL LYMPHOMA Angga Febriyanto; Krisna Murti; Soilia Fertilita
JURNAL KEDOKTERAN DAN KESEHATAN Vol 10, No 3 (2023)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V10I3.22336

AbstrakDiffuse large B-cell lymphoma (DLBCL) merupakan neoplasma sel-B sedang atau besar yang pola pertumbuhanya secara difus dengan inti besar. Sekitar 30-40 % kasus limfoma merupakan DLBCL. Berdasarkan fiturmolekuler dan cell of origin (COO), DLBCL dibagi menjadi subtipegerminal center B-cell (GCB) dan activated B-cell (ABC) / non-germinal center B-cell (non-GCB). Anemia menjadi salah satu kondisi klinis yang seringmenyertai limfoma. Anemia pada limfoma dikaitkan dengan prognostik yang lebihburuk. Tujuan penelitian ini untuk mengetahui hubungan subtipe molekular DLBCL dengan anemia. Penelitian ini adalah jenis penelitian cross-sectional, dengan sampel adalah semua pasien yang terdiagnosis DLBCL di RSUP Dr. Mohammad Hoesin Palembang tahun 2017-2021 sesuai kriteria yang ditentukan. Data Hb yang diambil adalah hasil pemeriksaan Hb paling awal pasien sebelum dilakukan biopsi. Dari 93 sampel, kasus DLBCL tinggi pada kelompokusia<60 tahun (64,5%), jenis kelaminlaki-laki (58,1%), lokasi ekstranodal (72%), varian sentroblastik (75,3%), dan subtipe non-GCB (75,3%). Anemia terjadi pada 76,3% kasus. Derajat mild (69%) memiliki proporsi yang paling tinggi. Tidak terdapat hubungan yang signifikan antara subtipe molekular DLBCL baik dengan status anemia (p= 0,97) maupun dengan derajat anemia (p= 0,97). Berdasarkan hasil penelitian, tidak terdapat hubungan yang bermakna subtipe molekular DLBCL dengan status anemia dan derajat anemia.Kata Kunci: DLBCL, SubtipeMolekular, GCB, Non-GCB, Anemia.

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