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All Journal MediaTor: Jurnal Komunikasi Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya MetaKom : Jurnal Kajian Komunikasi Majalah Kedokteran Sriwijaya Molecular and Cellular Biomedical Sciences (MCBS) MetaCommunication; Journal Of Communication Studies SRIWIJAYA JOURNAL OF MEDICINE Majalah Patologi Indonesia Jurnal Riset Komunikasi Bricolage : Jurnal Magister Ilmu Komunikasi Jurnal Aisyah : Jurnal Ilmu Kesehatan Indonesian Journal of Global Health research Community Empowerment Bioscientia Medicina : Journal of Biomedicine and Translational Research As-Sidanah : Jurnal Pengabdian Masyarakat Conferences of Medical Sciences Dies Natalis
Krisna Murti
Departemen Patologi Anatomi, Fakultas Kedokteran, Universitas Sriwijaya
Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Efek Pemberian Ekstrak Daun Kelor (Moringaoleifera) dalam Proses Menyusui Indri Seta Septadina; Krisna Murti; Neliza Utari
Sriwijaya Journal of Medicine Vol. 1 No. 1 (2018): Vol 1, No 1, 2018
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v1i1.8

Abstract

Pemberian ASI ekslusif selama 6 bulan merupakan salah satu strategi global untuk meningkatkan pertumbuhan, perkembangan, kesehatan dan kelangsungan hidup bayi. Meskipun banyak manfaat pemberian ASI ekslusif bagi bayi, ibu, keluarga, dan masyarakat namun cakupannya masih rendah diberbagai negara termasuk Indonesia.Air Susu Ibudiproduksi dari hasil kerjasama antara rangsangan mekanik faktor hormonal dan saraf. Salah satu hormon yangmempengaruhi adalah hormon estrogen. Hormon estrogen adalah hormon seks yang diproduksi oleh rahim untukmerangsang pertumbuhan organ seks seperti payudara dan rambut pubik serta mengatur siklus menstruasi. Hormonestrogen juga berperan menjaga tekstur dan fungsi payudara. Kehamilan pada seorang perempuan, membuat kelenjarpayudara akan makin berkembang oleh pengaruh hormon estrogen, somatomamotropin dan prolaktin. Proses tersebutdipengaruhi oleh hormon estrogen dan progesteron.Estrogen secara signifikan memacu sintesis dan pelepasan prolaktinoleh hipofisa, efek ini tergantung pada durasi dan dosis pemberian.Di Indonesia tanaman kelor merupakan bahanmakanan lokal yang memiliki potensi untuk dikembangkan dalam kuliner ibu menyusui karena mengandung senyawafitosterol yang berfungsi meningkatkan dan memperlancar produksi ASI (efek laktogogum).Pada tulisan ini akandibahas mengenai beberapa fakta mengenai pengaruh pemberian ekstrak daun kelor (Moringa oleifera) peningkatankuantitas dan kualitas ASI pada proses menyusui. Banyaknya kandungan nutrisi di dalam daun kelor (Moringa oleifera)salah satunya seperti senyawa fitosterol (efek laktogogum) dalam meningkatkan kadar hormon menyusui dan zat besidapat memberikan dampak positif bagi kesehatan bayi karena ASI merupakan makanan alamiah bayi paling utama danterbaik.
Product photography assistance for micro, small, and medium enterprises in Banyuasin, South Sumatra Farisha Sestri Musdalifah; Krisna Murti; Annisa Rahmawati; Januar Eko Aryansah; Harry Yogsunandar
Community Empowerment Vol 7 No 10 (2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/ce.7586

Abstract

In this digital era, online trade transactions have become a new culture. Small business owners in Sungai Pinang Village are familiar with technology and have been assisted in expanding the market to the online realm via smartphones. However, the challenge experienced by small business actors is that there are not proper and not attractive product photos to upload to social media and online stores, so they cannot attract the attention of potential consumers. This community empowerment activity aims to assist small business actors in being able to take photos of their business products in marketing and promoting their products digitally. There are 30 business owners attended the workshop with various types of business products. Small business participants were given materials about marketing, promotion, and basic knowledge of product photography. They also participated in workshops and mentoring on making attractive product photos so the photos could be promoted online. In addition, there are follow-up activities by monitoring the social media of small business owners to see the implementation of uploaded product photos in promoting their products. The result of this event is an increase in the general knowledge of small business owners about the basics of product photography so that it can be applied when marketing and promoting their business products online.
LANGERHANS CELLS HISTIOCYTOSIS Krisna Murti; Maria Ulfa
JURNAL KEDOKTERAN DAN KESEHATAN Vol 10, No 1 (2023)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V10I1.20142

Abstract

Langerhans cell histiocytosis (LCH) merupakan salah satu penyakit terbanyak dari histiositosis dengan 2,0–5,4 kasus/100 juta populasi diseluruh dunia usia<15 tahun dan jarang terjadi pada dewasa. Penyakit ini bermanifestasi sebagai spektrum klinik dengan gejala bervariasi mulai dari ringan, tersebar diseluruh tubuh, bahkan bisa mengancam nyawa penderitanya. Klinisi dan ahli patologi dapat mengenali manifestasi klinis dan gambaran mikroskopik LCH, sehingga dapat menegakkan diagnosis LCH secara akurat. Diagnosis akurat bermanfaat untuk penatalaksaan yang adekuat bagi pasien. Metode yang digunakan adalah literature review. Data diperoleh dari buku dan artikel internasional hasil penelitian dan pemikiran para peneliti dan praktisi. Pasien LCH distratifikasi dalam kategori resiko berdasarkan keberlanjutan penyakit dan berat ringannya disfungsi organ; yaitu pasien dengan single-system disease, biasanya hanya memerlukan terapi lokal atau observasi saja. Pasien dengan multy-system disease yaitu penyakit yang lebih berat yang juga melibatkan multi organ membutuhkan terapi sistemik. Efek jangka panjang banyak terjadi pada pasien dengan keterlibatan multy-system disease dan pasien dengan reaktivasi penyakit beberapa kali. Efek jangka panjang yang dilaporkan yang tersering adalah diabetes insipidus dan orthopedic abnormalities (20%). Gambaran  mikroskopik sel-sel tumor LCH berupa sel-sel bentuk oval, berinti satu dengan bentuk inti berlobus seperti biji kopi atau bentuk ginjal atau groove dan sitoplasma eosinofilik mengandung Birbeck granules yang dapat dideteksi dengan marker anti- CD1a dan Langerin (CD207). LCH dapat di diagnosis secara akurat dengan mengenali gambaran klinis dan gambaran mikroskopik. Penderita  dapat ditangani secara tepat dan adekuat, sehingga mengurangi morbiditas, mortalitas dan komplikasi.
Effects of Fluoride Exposure During Pregnancy in Mice Brain Neurogenesis (Mus musculus) Siti Sarahdeaz Fazzaura Putri; Irfannuddin Irfannuddin; Krisna Murti; Yudianita Kesuma; Hardi Darmawan; Noriyuki Koibuchi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 17 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i17.720

Abstract

Background: Fluoride is a type of micromineral found in teeth and bones. This mineral is also found in nature, such as in soil, water, plants, rocks, and even air. Fluoride can cross the placental barrier and diffuse into the cord blood, with a range from 60% to 91% of maternal fluoride. Maternal fluoride exposure during pregnancy and lactation can affect learning ability, memory, and expression of glutamate receptors. This study aimed to determine the effect of fluoride exposure during pregnancy and lactation on brain neurogenesis in vivo. Methods: In vivo, experimental study using mice (Mus musculus) C57BL/6 as many as 60 brood mice (20 males and 40 females) and as many as 30 offspring mice. Mice broodstock were first mated to produce offspring. During pregnancy, the female mice were exposed to fluoride (NaF). Exposure of broodstock mice to NaF was divided into 0 mg/L, 50 mg/L, 100 mg/L, and 150 mg/L exposure groups. Expression of PSD-95 protein was carried out by immunohistochemical examination of mouse brain tissue. Data analysis was carried out with the help of SPSS using univariate and bivariate methods. Results: There was a decrease in the expression of PSD-95 with increasing exposure to NaF doses during pregnancy and lactation. Giving NaF at a dose of 50 mg/L did not decrease PSD-95 expression because the results were not different from the control. In contrast, the administration of NaF doses that can reduce the expression of PSD-95 are doses of 100 and 150 mg/L. Conclusion: Fluoride exposure during pregnancy contributed to a decrease in mice brain neurogenesis, as indicated by the expression of the PSD-95 protein in the hippocampus area.
Perempuan dan perilaku berkelanjutan dalam komunitas online pecinta barang lokal Krisna Murti; Raden Ayu Wulantari; Nurly Meilinda; Anang Dwi Santoso
Bricolage : Jurnal Magister Ilmu Komunikasi Vol 8, No 2 (2022): Accredited by Kemenristekdikti RI SK No. 36/E/KPT/2019
Publisher : Universitas Bunda Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30813/bricolage.v8i2.3248

Abstract

Scholars discovered that the majority of studies studying why women engage in sustainable fashion practices focused on environmental incentive, personal drive, or hedonistic motivation. In fact, women may anticipate the social value of fashion to be associated with the concept of self-improvement rather than the dimension of conservatism. This study aims to determine whether women's fashion consumption serves as a signifier of social identity, class, or position, as well as the degree to which the social value of fashion is embedded inside the product itself. The thesis to be demonstrated in this study is that women are agents of sustainable behavior to transmit sustainable habits because women are grassroots agents with the most influence in daily life. This research is based on a constructivist paradigm with a qualitative method that enables researchers to comprehend how behavior from the perspective of research subjects (women) with their subjective understanding underpins the sustainable behavior that they practice. Seven female agents were interviewed via Zoom meetings or WhatsApp video calls to collect the primary data. This study finds that sustainable fashion consumption has a social value. The social value of sustainable fashion consumption is inherent in the purchase or consumption of these products, as well as in the location where these items are purchased. The implication of this study is that a campaign to promote sustainable fashion consumption may incorporate social values.
DIFFUSE LARGE B CELL LYMPHOMA Krisna Murti
Majalah Kedokteran Sriwijaya Vol 53, No 3 (2021): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/mks.v53i3.20435

Abstract

Diffuse large B cell lymphoma is a neoplasm arising from B lymphocytes and having a diffuse growth pattern. The nuclei cells showed a medium or similar or larger than the sizes of normal macrophages. This entity is the most common type of non-Hodgkin lymphoma (NHL) with incidence 30-40% from all NHL types. In Indonesia DLBCL cases was 68.2%, much higher than that in western countries (37%) and slightly higher than in other Asian countries (30-60%). Another data showed that in Indonesia there was 16.125 new NHL cases in 2020. This entity has diversity of molecular pathogenesis causes DLBCL showed some heterogeneity and similarities of clinical sign and symptoms, morphology and immunopheno types with other non-Hodgkin lymphomas. Therefore, some other molecular analysis such mutation events should be performed to achieve a correct diagnosis. All clinical data, morphologic immunhistochemical foundings have to be collected and analyzed and some additional molecular examination should be also conducted such as FISH analysis, PCR-based assay to exclude differential diagnosis. Some patients can be cured with a standard regimen Rituximab-Cyclophosphamide, Doxorubicin, Vincristine, and Prednisolone (R-CHOP). However, 40% of patients is refractory or relapse.
ADVANCE STAGE OF HODGKIN LYMPHOMA SHOWS HIGH DENSITY OF PLASMA CELLS BUT LOW ANGIOGENESIS Krisna Murti; Neti Neti; Iche Andriyani Liberty
Majalah Kedokteran Sriwijaya Vol 55, No 1 (2023): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/mks.v55i1.21035

Abstract

BackgroundTumor microenvironmental of classical Hodgkin lymphoma (cHL) containing plasma cells and angiogenesis, however their exact roles remained indeterminate. Plasma cells are important prognostic factors of various malignancies. Angiogenesis can be assessed by evaluating of micro vessel density (MVD). Higher MVD is associated with a poor prognosis in various type of malignancies. The objectives of this study were to investigate the density of plasma cells and MVD in the microenvironment of cHL and to determine the association of both components with the stage of cHL.Materials and methodsThe selected 37 paraffin blocks of cHL cases were sectioned. The clinical staging was performed using modification of Ann Arbor staging system. To assess the density of plasma and endothelial cells, anti-CD138 and anti-CD34 antibodies were employed by immunohistochemistry. The association of plasma cells’densities and MVD with cHL stages was measured by statistical analysis using t-test by STATA version 15 with significant consideration if p <0.05.ResultsIn our cohort cHL was occurred in slightly older patients (?40 years; 53.33%), more in male (60%), and majority with nodal location (86.67%). The subtypes was dominated by lymphocyte rich (43.33%); followed by nodular sclerosing (30%) and mixed cellularity (26.67%), while lymphocyte depleted was not found. Statistical analysis revealed that higher density of plasma cells was significantly correlated to the patient higher stages (p=0.0003). While density of micro vessels is not significant correlation (p=0.5564) to the stages of cHLConclusionHigh densities of plasma cells but not angiogenesis correlate to advance stage of Hodgkin lymphoma.
STATUS ANEMIA TIDAK BERHUBUNGAN DENGAN SUBTIPE DIFFUSE LARGE B-CELL LYMPHOMA Angga Febriyanto; Krisna Murti; Soilia Fertilita
JURNAL KEDOKTERAN DAN KESEHATAN Vol 10, No 3 (2023)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V10I3.22336

Abstract

AbstrakDiffuse large B-cell lymphoma (DLBCL) merupakan neoplasma sel-B sedang atau besar yang pola pertumbuhanya secara difus dengan inti besar. Sekitar 30-40 % kasus limfoma merupakan DLBCL. Berdasarkan fiturmolekuler dan cell of origin (COO), DLBCL dibagi menjadi subtipegerminal center B-cell (GCB) dan activated B-cell (ABC) / non-germinal center B-cell (non-GCB). Anemia menjadi salah satu kondisi klinis yang seringmenyertai limfoma. Anemia pada limfoma dikaitkan dengan prognostik yang lebihburuk. Tujuan penelitian ini untuk mengetahui hubungan subtipe molekular DLBCL dengan anemia. Penelitian ini adalah jenis penelitian cross-sectional, dengan sampel adalah semua pasien yang terdiagnosis DLBCL di RSUP Dr. Mohammad Hoesin Palembang tahun 2017-2021 sesuai kriteria yang ditentukan. Data Hb yang diambil adalah hasil pemeriksaan Hb paling awal pasien sebelum dilakukan biopsi. Dari 93 sampel, kasus DLBCL tinggi pada kelompokusia<60 tahun (64,5%), jenis kelaminlaki-laki (58,1%), lokasi ekstranodal (72%), varian sentroblastik (75,3%), dan subtipe non-GCB (75,3%). Anemia terjadi pada 76,3% kasus. Derajat mild (69%) memiliki proporsi yang paling tinggi. Tidak terdapat hubungan yang signifikan antara subtipe molekular DLBCL baik dengan status anemia (p= 0,97) maupun dengan derajat anemia (p= 0,97). Berdasarkan hasil penelitian, tidak terdapat hubungan yang bermakna subtipe molekular DLBCL dengan status anemia dan derajat anemia.Kata Kunci: DLBCL, SubtipeMolekular, GCB, Non-GCB, Anemia.
Burkitt Lymphoma Krisna Murti
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 2 No. 2 (2015): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universi
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v2i2.35

Abstract

Burkitt lymphoma merupakan keganasan limfosit B yang agresif. Diagnosa tepat BL memerlukan kelengkapan sarana laboratorium yang lengkap, karena morfologi BL dapat menyerupai limfoma afresif lainnya. Dijumpai tiga varian BL yang tersebar sesuai dengan kondisi geografi. Sel-sel BL membelah dengan cepat sehingga memerlukan pengobatan segera. Regimen intensif dapat membantu remisi pasien BL namun cara ini sering menimbulkan efek toksik yang sulit di toleransi oleh pasien.
The Expression of NFATc1 is more Predominant in Triple Negative Breast Carcinoma Patients Riana Sari Puspita Rasyid; Krisna Murti; Zen Hafy
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 9 No. 1 (2022): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universi
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v9i1.193

Abstract

Karsinoma payudara adalah keganasan paling umum pada wanita di negara maju dan berkembang. Karsinoma payudara invasif diklasifikasikan menjadi 4 subtipe yaitu luminal A dan B, human epidermal growth factor receptor 2 (HER2) dan triple negative yang memiliki prognosis terburuk. Nuclear factor of activated T cell (NFATc) 1 merupakan faktor transkripsi penting dalam proses transformasi dan perkembangan keganasan. Oleh karena itu, ekspresi NFATc1 dapat menentukan prognosis karsinoma payudara. Penelitian ini bertujuan untuk mengetahui peran NFATc1 pada progresivitas karsinoma payudara. Bahan dan metode, 52 blok parafin dipilih dan disiapkan untuk menilai ekspresi NFATc1 dengan imunohistokimia. Data ini diambil dari rekam medis: yaitu klasifikasi molekuler, usia pasien, ukuran tumor, invasi limfovaskular dan grade tumor. Ekspresi NFATc1 positif diamati pada 4 sampel yaitu pada inti luminal A (1 dari 12; 8,8%), luminal B (1 dari 15; 6,7%), dan triple negative (2 dari 12; 16,7%), tetapi tidak ada ekspresi NFATc1 yang terdeteksi dalam sampel HER2. Secara klinis, pasien ini lebih banyak pada usia dekade kelima (38,5%), dengan ukuran tumor lebih besar (≥2 cm; 90%), invasi limfovaskular positif (80,8%), dan derajat tinggi (3; 59,6%). Ekspresi NFATc1 lebih dominan pada karsinoma payudara triple negative.
Co-Authors Adrina Esther Liaw Aida Farida Anang Dwi Santoso Anang Dwi Santoso Angga Febriyanto Annisa Rahmawati Aspitriani Aspitriani Budi Santoso Debby Handayati Dwi Mirani Dwi Tantri Marylin Ella Amalia, Ella Erial Bahar Farisha Sestri Musdalifah Hardi Darmawan Harry Yogsunandar Iche Andriyani Liberty Iche Andriyani Liberty Iche Andriyani Liberty, Iche Andriyani Ika Kartika Ika Kartika Indah Yunalda Indri Seta Septadina Irfannuddin Irfannuddin Irfannuddin Irfannuddin Januar Eko Aryansah Jayawarsa, A.A. Ketut M. Yogi Riyantama Isjoni Maria Ulfa Maria Ulfa Mariana Mariana Mudinillah, Adam Muhammad Irsan Saleh Muhammad Totong Kamaluddin Muhammad Yusuf Abror Neliza Utari Neti Neti Neti Neti Nora Ramkita Noriyuki Koibuchi Noriyuki Koibuchi Novaria Maulina Nurly Meilinda Nurly Meilinda Nurly Meilinda Nurly Meilinda Nurly Meilinda Nyimas Chodijah Oemar Madri Bafadhal Oemar Madri Bafadhal Pariyana Pariyana Pariyana Pariyana Phey Liana Prabujaya, Sena Putra Putri Mahirah Afladhanti RACHMAT HIDAYAT Raden Ayu Wulantari Rasyid, Riana Sari Puspita Riana Sari Puspita Rasyid Riana Sari Puspita Rasyid Siti Sarahdeaz Fazzaura Putri Soilia Fertilita Sri Nita Tungki Pratama Umar Wresnindyatsih Wresnindyatsih Yudianita Kesuma Yudianita Kesuma, Yudianita Zen Hafy