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All Journal JPMS (Jurnal Pendidikan Matematika dan Sains) Jurnal Penelitian Fisika dan Aplikasinya (JPFA) Jurnal Matematika & Sains Jurnal Sumberdaya Alam dan Lingkungan Science and Technology Indonesia Emerging Science Journal ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry Jurnal Analis Kesehatan ALKIMIA : Jurnal Ilmu Kimia dan Terapan Jurnal Abdi Insani Sinar Sang Surya: Jurnal Pusat Pengabdian kepada Masyarakat Analit: Analytical and Environmental Chemistry
Sutopo Hadi
Department Of Chemistry, Faculty Of Mathematics And Natural Sciences, Universitas Lampung, Bandar Lampung, 35145, Indonesia
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Physics Social Sciences

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Journal : Science and Technology Indonesia

 1 
Synthesis of Cellulose–Polylactic Acid Microcapsule as a Delivery Agent of Rifampicin Suripto Dwi Yuwono; Ridho Nahrowi; Andi Setiawan; Ni Luh Gede Ratna Juliasih; Irza Sukmana; Wasinton Simanjuntak; Sutopo Hadi
Science and Technology Indonesia Vol. 7 No. 3 (2022): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (997.285 KB) | DOI: 10.26554/sti.2022.7.3.263-268

Abstract

In medicinal field, delivery agent is a very important substance to improve the efficiency of drug used by improving the stability and preventing the degradation of drug during the medical treatment. Due to these important roles of the drug delivery agent, the search of effective agent is continuously in progress. In this respect, this current research was carried out to synthesize cellulose–polylactic acid (cellulose-PLA), as a potential delivery agent of rifampicin for the curing of tuberculosis. Cellulose was isolated from cassava bagasse, while PLA was obtained from commercial supplier. The two raw materials were used to synthesize cellulose–PLA in 3.5% HCl as solvent under magnetic stirring. The product obtained was then characterized by Fourier-Transform Infrared spectroscopy (FTIR), Particle-Size Analysis (PSA), and Scanning Electron Microscopy (SEM). The FT-IR result showed the presence of hydroxy (3446 to 3429 cm−1) and carbonyl (1757 to 1759 cm−1), confirming the formation new bond between cellulose and PLA. The PSA characterization displays a particle-sizes of PLA are in the range of 960–92780 nm, while cellulose–PLA are in the range of 100–17730 nm demonstrating that cellulose-PLA combined to form more compact structures. The results of SEM analysis indicate the distinct feature of cellulose-PLA, and combination of the features in the cellulose and PLA image. The results of the dissolution test carried out two different concentrations of rifampicin revealed that the optimum dissolution (8.42%) was achieved with cellulose–PLA of 0.3%, dissolution time of 12 h, and pH of 7.4.
Activity of Mangrove-Derived Fusarium equiseti 20CB07RF Extract Against Clinical, Antibacterial-Resistant Pseudomonas aeruginosa Bahri, Syaiful; Setiawan, Wawan Abdullah; Setiawan, Fendi; Lutfiah, Rosyidatul; Juliasih, Ni Luh Gede Ratna; Ambarwati, Yuli; Ahmadi, Peni; Arai, Masayoshi; Hendri, John; Hadi, Sutopo; Setiawan, Andi
Science and Technology Indonesia Vol. 9 No. 3 (2024): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.3.594-604

Abstract

Endophytic fungi originating from mangroves are potential sources of secondary metabolites with varying bioactivities. This research explores the bioactive metabolites produced by endophytes derived from mangrove plants. Endophytic fungi were collected from various parts of several mangrove plants (roots, stems, and leaves, as well as the surrounding mud). A total of 17 endophytics fungi were obtained. The isolates were derived from the leaves (1 isolate), stems (8 isolates), roots (5 isolates), and surrounding mud (3 isolates). A single fungal colony was cultured using solid-state fermentation for 14 days. The fermented fungal biomass was extracted using ethyl acetate (EtOAc) and evaluated for its antibacterial activity against clinical pathogenic bacteria. In the preliminary screening, the EtOAc extract of the CB07RF1 isolate exhibited notable growth-inhibitory effects against Pseudomonas aeruginosa. The isolate was verified by molecular identification using a study of the rDNA internal transcribed spacer (ITS) sequence, revealed that isolate CB07RF1 was very similar to Fusarium equiseti (99% similarity). Isolate 20CB07RF1, obtained by solid-state fermentation using a rice medium indicated as peptide compound group, and featured active components that exhibited potent growth inhibitory activity against Pseudomonas aeruginosa at a concentration of 12.5 mg/mL. This study demonstrates, for the first time, that Fusarium equiseti extracts grown in a rice medium contain antimicrobial compounds that can inhibit the growth of P. aeruginosa, an important clinical pathogen known for its antibacterial resistance. These findings accent mangrove endophytic fungi as important sources of bioactive compounds and will advance related research in the fields of biotechnology, pharmacology, and life sciences.
Synthesis of Silver Nitrate by Evaporation Chemical Reduction Process as Potential Materials for Silver Nanowires Application Junaidi; Malik, Daffa Abdul; Rizki, Muhammad; Pratiwi, Indah; Karo-Karo, Pulung; Marjunus, Roniyus; Asmi, Dwi; Hadi, Sutopo
Science and Technology Indonesia Vol. 9 No. 3 (2024): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.3.642-650

Abstract

In this study, we conducted the extraction of silver nitrate (AgNO3) using the chemical reduction evaporation method, involving silver metal (Ag) with a molarity of 7.716 M and nitric acid (HNO3). The heating process via evaporation was carried out at 85oC for 2 hours. Subsequently, the synthesis of silver nanowires (AgNWs) was performed using a 0.3 M of AgNO3 solution in ethylene glycol (EG), polyvinyl pyrrolidone (PVP), and Iron (III) Chloride hexahydrate (FeCl36H2O). XRD analysis of the AgNO3 sample revealed an orthorhombic crystal structure with a single AgNO3 phase peak. In AgNWs, three crystalline phases were observed, with the Ag phase being the most dominant. The average crystal size of AgNO3 and AgNWs was 109.42 nm and 22.06 nm, respectively. The average crystal size of the AgNO3 sample may be influenced by the aggregation between crystal nuclei during the heating process. XRF analysis indicated a 98.84% Ag concentration in AgNO3. SEM-EDS analysis showed that the AgNO3 sample had a non-aggregated morphological structure, with particle size measuring 49.46 μm and an overall AgNO3 purity of 92.68%. The SEM image of the AgNWs sample displayed a very homogeneous diameter of ∼200 nm with a length of around 10-20 μm. Meanwhile, AgNWs exhibited a morphology resembling rod-shaped wires with a purity of 68% for Ag.
Co-Authors Afriyani, Hapin Ahmadi, Peni Ambarwati, Yuli Ambarwati, Yuli Andi Setiawan Andi Setiawan Arai, Masayoshi Aspita Laila Bambang Irawan Bambang Irawan C. N. Ekowati Dwi Asmi Ezra Rheinsky Tiarsa Hardoko Insan Qudus Hardoko Insan Qudus Hendri Ropingi Heri Satria Humairoh Ratu Ayu Indah Pratiwi Irvana, Raihan Irza Sukmana John Hendri John Hendri John Hendri Juliasih, Ni Luh Gede Ratna Junaidi Junaidi Karo , Pulung Karo Khalimatus Sa’diah Lailatul Farihah Lina Marlina Lutfiah, Rosyidatul Malik, Daffa Abdul Marjunus, Roniyus Mita Rilyanti Muhammad Rizki NANIK SUWARSO Ni Luh Gede Ratna Juliasih NOPIANI NOPIANI Nova Tri Irianti Noviany Noviany Nurul Nadila Pulung Karo-Karo Qudus, Hardoko Insan Ridho Nahrowi Setiawan, Fendi Suharso Suharso Sumardi Sumardi Supriyanto Supriyanto Suripto Dwi Yuwono Suripto Dwi Yuwono Suripto Dwi Yuwono Suripto Dwi Yuwono, Suripto Dwi Surtono, Arif Syaiful Bahri SYAIFUL BAHRI Tati Suhartati Tati Suhartati Tati Suhartati Tati Suhartati Tati Suhartati Tati Suhartati Trevor G Appleton Valennisa Qunifah Wasinton Simanjuntak Wasinton Simanjuntak WAWAN ABDULLAH SETIAWAN, WAWAN ABDULLAH YANDRI AS Yandri Yandri Yandri Yandri Yandri Yandri Yandri Yandri Yandri Yandri Yandri Yandri