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All Journal Journal of Food and Pharmaceutical Science JURNAL KIMIA SAINS DAN APLIKASI Farmaka Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Journal of Islamic Pharmacy JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Journal of Pharmacopolium Jurnal Mandala Pharmacon Indonesia Jurnal Hexagro Pharmacoscript Health Information : Jurnal Penelitian Jurnal Midpro Jurnal Insan Farmasi Indonesia Berkala Ilmiah Kimia Farmasi Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Prosiding Seminar Nasional Universitas Ma Chung Media Informasi Detector: Jurnal Inovasi Riset Ilmu Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Srie Rezeki Nur Endah
Universitas Perjuangan Tasikmalaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Veterinary Other

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Antidiarrhea Activity of Ethanol Extract of Rambutan Leaves (Nephelium lappaceum L.) in Capsule Form on Male Mice Nurul Fadilah, Nitya; Ali Nofriyaldi; Ayu Rahmawati; Srie Rezeki Nur Endah; Widya Nurul Aini; Vincent O. Imieje
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 3 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i32024.291-297

Abstract

Background: Diarrhea is characterized by changes in stool form to soft or liquid, with an intensity of bowel movements more than three times a day. One of the plants used as an alternative treatment for diarrhea is rambutan, particularly its leaves. Previous studies have shown that rambutan leaf extract can treat diarrhea. Objective: The purpose of this study was to determine the antidiarrhea activity of ethanol extracts of rambutan leaves containing tannins and flavonoids that inhibit intestinal motility. Methods: This study was conducted experimentally using the intestinal transit method, which measures the length of the intestine passed through a marker. The smaller the ratio between the length of the intestine and the marker, the greater the decrease in intestinal motility in the mice. Group 1: loperamide HCl at a dose of 4 mg/kg BW; Group 2:  placebo; Group 3: FI, FII, and FIII capsules at doses of 50 mg, 100 mg, and 150 mg. Results: The test results showed that Formulations 1, 2, and 3 had activities of 23.3%, 26.8%, and 32.3%, respectively. The capsule with the best results was formulation 3, at a dose of 150 mg. Compared with the positive control, the effectiveness of this capsule was 22% higher than that of loperamide. Conclusion: The results of this study showed that rambutan leaves extracted in capsule form effectively treats diarrhea. The one-way ANOVA test showed a significant difference between the FI, FII, and FIII groups (p <0.05).
Pengujian Aktivitas Antioksidan Sediaan Stick Mask Ekstrak Etanol Daun Binahong (Anredera cordifolia (Ten.) Steenis): Aktivitas Antioksidan Sediaan Stick Mask Ekstrak Etanol Daun Binahong (Anredera cordifolia (Ten.) Steenis) Selvia Maslamah Aan; Lina Rahmawati Rizkuloh; Srie Rezeki Nur Endah
Berkala Ilmiah Kimia Farmasi Vol. 12 No. 1 (2025): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v12i1.62836

Abstract

The development of the cosmetic industry created many new variations of cosmetic products. One of the beauty products that was developing was a stick mask with the benefit of preventing premature aging. Binahong (A. cordifolia) leaf was one of the plants that had antioxidant activity because of flavonoids that prevent premature aging of the skin. The study aimed to make a stick mask of ethanol extract of binahong (A. cordifolia) leaf and evaluation and test the antioxidant activity using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method of the stick mask preparation. The preparation formulation was performed with variations in extract concentration at F0 0%, F1 25%, F2 30%, and F3 35%. Evaluation of the preparation includes organoleptic test, homogeneity, pH, spreadability, adhesives, dry time, and melting point test showed that the preparations met the standard requirements. The antioxidant activity of binahong (A. cordifolia) leaf ethanol extract stick mask in F3 with 35% extract concentration resulted in very strong antioxidant category with IC₅₀ 1,500 μg/mL.   Keywords:  Antioxidant, Binahong leaf (Anredera cordifolia (Ten.) Steenis), DPPH (2,2-diphenyl-1-picrylhydrazyl), Mask
In Silico Study of Corn Silk Luteolin (Zea mays L.) Derivatives as Potential Antihypertensive Agents Mardianingrum, Richa; Firiani, Yuli; Endah, Srie Rezeki Nur; Ruswanto, Ruswanto
Jurnal Kimia Sains dan Aplikasi Vol 28, No 3 (2025): Volume 28 Issue 3 Year 2025
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.28.3.155-167

Abstract

Hypertension is a condition where the systolic blood pressure is > 140 mmHg and the diastolic pressure is > 90 mmHg. Hypertension is caused by the formation of Angiotensin II from Angiotensin I by Angiotensin Converting Enzyme (ACE). Lisinopril is one of the drugs commonly used to treat hypertension; however, long-term use may be associated with carcinogenic effects. This study aims to find candidates for new medicinal ingredients from luteolin derivative compounds contained in corn silk (Zea mays L.) as antihypertensives that have the activity of inhibiting ACE enzymes. Molecular docking and molecular dynamics simulations were employed in this study. The results showed that the TL59 compound exhibited lower predicted toxicity than lisinopril. Based on molecular dynamics analysis, TL59 demonstrated an RMSD value of 1 Å and a ΔGTOTAL of –44.65 kcal/mol, whereas lisinopril showed an RMSD value of 1.3 Å and a ΔGTOTAL of –29.25 kcal/mol. These findings suggest TL59 has a higher binding affinity and greater stability toward the 1O86 receptor than lisinopril. Therefore, TL59 is predicted to be a promising candidate for a new antihypertensive drug that inhibits the conversion of Angiotensin I to Angiotensin II. In conclusion, TL59 demonstrates strong binding affinity and pharmacokinetic properties, indicating its potential as a promising antihypertensive candidate. However, this study is limited to in silico analysis and requires further in vitro and in vivo validation to confirm its efficacy and safety.
Stability Formulation Of Mouthwash From Sapodilla Fruit Extract (Manilkara Zapota) As Antibacterial Preventing Dental Caries Nur Endah, Srie Rezeki; Suhardiana, Eddy; Roesman, Kamiel
Jurnal Midpro Vol. 12 No. 1 (2020): JURNAL MIDPRO
Publisher : Universitas Islam Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30736/md.v12i1.152

Abstract

Sapodilla fruit (Manilkara zapota) which is often used by the community as an antibacterial drug is part of the sapodilla plant. Sapodilla contains saponin, tannin, and flavonoid compounds which can be as antibacterial so it is suspected to be able to inhibit the growth of bacteria that cause dental caries. The purpose of this study was the Evaluation of Sawo Extract Mouthwash Formulation as an Antibacterial. The sample used was sapodilla fruit which had been extracted using the infusion method. The formulation of sapodilla fruit extract mouthwash was evaluated with the extract concentration of sapodilla fruit (Manilkara zapota) 1%, 5% and 10%. The results of this study obtained the most stable formulation with a concentration of extract of sapodilla fruit (Manilkara zapota) 1%.  
A Activity Test Of Antidiarrheal Granule Ethanol Extract Of Rambutan Leaf (Nephelium lappaceum L.) In Mice (Mus musculus) Fadilah, Nitya Nurul; Nurul Aini, Widya; Nur Endah, Srie Rezeki; Nofriyaldi, Ali; Rahmawati, Ayu
Health Information : Jurnal Penelitian Vol 17 No 1 (2025): Januari-April
Publisher : Poltekkes Kemenkes Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36990/hijp.v17i1.1610

Abstract

Ringkasan: Latar belakang: Diare adalah perubahan konsistensi tinja menjadi lunak dan peningkatan frekuensi buang air besar yang dapat menyebabkan dehidrasi hingga kematian. Daun rambutan mengandung tanin dan flavonoid sebagai adstringen yang menghambat motilitas usus untuk terapi antidiare. Tujuan: Menganalisis efektivitas antidiare granul ekstrak etanol daun rambutan dengan metode transit intestinal pada mencit. Metode: Penelitian eksperimental menggunakan 25 mencit Swiss Webster jantan, dibagi 5 kelompok: kontrol positif (loperamide HCl 4 mg/kg), kontrol negatif (granul tanpa ekstrak), dan tiga kelompok uji dengan granul ekstrak daun rambutan dosis 50 mg, 100 mg, 150 mg. Analisis One Way ANOVA dengan signifikansi p<0,05. Hasil: Efektivitas antidiare berturut-turut 23,3%, 26,8%, dan 32,3%, dengan efektivitas tertinggi pada dosis 150 mg. Uji ANOVA menunjukkan perbedaan signifikan antar kelompok (p<0,05). Simpulan: Granul ekstrak etanol daun rambutan memiliki aktivitas antidiare berbanding terbalik dengan rasio transit intestinal. Saran: Penelitian lanjutan diperlukan untuk uji pra-klinis seperti kadar etanol, farmakokinetik, dan toksisitas.
Efektivitas Larvasida Ekstrak Etanol Bunga Kecombrang (Etlingera elaitor) dan Daun Jambu Biji (Psidium guajava) terhadap Mortalitas Larva Aedes aegypti Bachtiar, Kamiel Roesman; Rizkuloh, Lina Rahmawati; Susanti, Susanti; Nur Endah, Srie Rezeki
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 9 No. 2 (2022): October
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v9i2.3421

Abstract

Berbagai jenis tanaman di Indonesia telah diketahui mengandung senyawa bioaktif yang dapat dimanfaatkan sebagai biopestisida. DIantaranya adalah bunga kecombrang dan daun jambu biji yang dapat berfungsi sebagai larvasida. Tujuan dari penelitian ini adalah mengetahui efektivitas campuran ekstrak etanol bunga kecombrang (Etlingera elaitor) dan daun jambu biji (Psidium guajava) terhadap mortalitas larva Aedes aegypti. Objek dalam penelitian ini adalah semua larva Aedes aegypti instar III yang berumur 3-4 hari Sampel total yang digunakan pada penelitian ini sebanyak 280 larva, yang di tentukan dengan teknik Purposive Sampling. Hasil penelitian menunjukkan ada pengaruh campuran ekstrak etanol bunga kecombrang (Etlingera elaitor) dan daun jambu biji (Psidium guajava) terhadap kematian larva nyamuk Aedes aegypti. Semakin tinggi konsentrasi ekstrak bunga kecombrang dan daun jambu biji yang diberikan, semakin banyak pula terjadinya kematian pada larva Aedes aegypti. Angka kematian tertinggi sebesar 90% dengan label konsentrasi uji 5 pada konsentrasi 5000 ppm (komposisi 1250 ppm ekstrak bunga kecombrang dan 3.750 ppm ekstrak daun jambu biji). Hasil analisis probit menunjukkan nilai LC50 pada larva Aedes aegypti untuk formula campuran ekstrak bunga kecombrang (Etlingera elaitor) dan daun jambu biji (Psidi guajava L.) adalah pada konsentrasi 2567,83 ppm
Karakterisasi Sediaan Gel Face Scrub Yang Mengandung Variasi Ampas Kelapa (Cocos nucifera L.) Sebagai Exfoliating Nofriyaldi, Ali; Endah, Srie Rezeki Nur; Aida, Yopi
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 11 No. 1 (2024): February
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v11i1.4926

Abstract

Ampas Kelapa (Cocos  nucifera L.) merupakan sumber protein rendah lemak bebas gluten yang membantu menjaga kulit tetap terhidrasi. Tujuan penelitian ini yaitu untuk memformulasikan ampas kelapa kedalam bentuk sediaan gel face scrub dan mengetahui stabilitas sediaan gel face scrub ampas kelapa. Metode yang digunakkan dalam penelitian ini yaitu metode eksperimental dengan membuat sediaan gel face scrub dengan variasi konsentrasi dari ampas kelapa (Cocos  nucifera L.) sebagai exfoliating. Hasil pengujian sediaan gel face scrub ampas kelapa variasi konsentrasi 3%, 6% dan 9% pada pengujian organoleptis sediaan berbentuk gel, bau ampas kelapa dan berwarna putih, dan putih kecoklatan, sediaan homogen, nilai pH memenuhi syarat yang ditentukan 4,5-6,5, daya sebar berkisar antara 5-7 cm, daya lekat berkisar lebih dari 1 detik, dan untuk viskositas masuk kedalam rentang standar yaitu antara 2000-4000 Cp.
Formulasi Mucoadhesive Edible Film Ekstrak Etanol Buah Kapulaga (Amomum compactum Sol. Ex Maton) Sebagai Antihalitosis Susanti, Susanti; Endah, Srie Rezeki Nur; Nofriyaldi, Ali; Indri, Eneng; Adlina, Salsabila
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 2 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i2.625

Abstract

Ekstrak etanol buah kapulaga diketahui mempunyai aktivitas antibakteri yang baik terhadap Streptococcus mutans penyebab halitosis, sehingga cocok diformulasikan ke dalam sediaan oral, salah satunya sediaan Mucoadhesive edible film. Tujuan dari penelitian ini untuk membuat formulasi sediaan Mucoadhesive edible film ekstrak etanol buah kapulaga dan untuk mengetahui aktivitasnya terhadap bakteri Streptococcus mutans. Sediaan Mucoadhesive edible film dibuat menjadi 4 formula yaitu F0 (basis), F1 (ekstrak etanol buah kapulaga 2%), F2 (ekstrak etanol buah kapulaga 4%), dan F3 (ekstrak etanol buah kapulaga 6%). Evaluasi sediaan Mucoadhesive edible film meliputi uji organoleptis, uji ketebalan, uji keseragaman bobot, uji pH dan uji waktu hancur. Uji aktivitas antibakteri sediaan mucoadhesive edible film menggunakan sediaan klorheksidin 0,2% sebagai pembanding, dengan metode difusi cakram. Hasil penelitian menunjukan bahwa ekstrak etanol buah kapulaga dengan konsentrasi 2%, 4% dan 6% dapat diformulasikan menjadi sediaan mucoadhesive edible film yang memenuhi syarat evaluasi fisik sediaan. Hasil uji aktivitas antibakteri sediaan Mucoadhesive edible film memberikan diameter rata-rata daya hambat sebesar F1 (9,03 mm), F2 (7,10 mm), dan F3 (6,30 mm) terhadap bakteri Streptococcus mutans. Berdasarkan analisis varian satu arah (ANOVA) menunjukan hasil p-value 0,00< 0,05) yang menunjukan adanya perbedaan yang signifikan.
Potensi Ekstrak Daun Kersen (Mutingia calabura L.) sebagai Sumber Antioksidan Alami Dalam Sediaan Eye Gel Adlina, Salsabila; Vikandari, Sonya Nurizki; Fauziah, Nurma Sari; Endah, Srie Rezeki Nur
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 2 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i2.692

Abstract

Kulit bawah mata merupakan bagian paling rapuh dan lebih rentan terlihat tanda kelelahan dan penuaan akibat meningkatnya radikal bebas. Untuk mengurangi tanda penuaan dibagian bawah mata dapat diatasi dengan menggunakan kosmetik yang mengandung antioksidan. Tujuan penelitian yang dilakukan ialah untuk membuat sediaan dengan bentuk eye gel menggunakan ekstrak daun ceri dan mengevaluasi sifat antioksidannya. Pada sediaan gel mata, ekstrak daun kersen dibuat dengan kekuatan formula I (1%), formula II (3%), dan formula III (5%). Hasil pengujiaan menunjukkan sediaan eye gel ekstrak daun kersen memenuhi parameter uji evaluasi fisik. Nilai antioksidan menunjukkan bahwa formula I memiliki nilai IC50 sebesar 83,742 ppm, formula II 73,936 ppm, dan formula III sebesar 66,154 ppm termasuk kedalam kategori aktivitas antioksidan yang kuat.
Co-Authors Ai Parida Mutiara Aida, Yopi Amelia Aprini Ayu Rahmawati AYU RAHMAWATI Ayu Rahmawati Bachtiar, Kamiel Roesman C Shintia Cheryl Alodya Citra Shintia Eddy Suhardiana Eddy Suhardiana Elin Elsa Fauziah Fauziah, Nurma Sari Firiani, Yuli Hisyam Arief Indah Pitaloka Sari Indri, Eneng Kamiel Roesman Bachtiar Kamiel Roesman Bachtiar Lina Rahmawati Rizkuloh Nitya Nurul Fadilah Nofriyaldi, Ali Nurfadilah Yusuf Nurul Aini, Widya Resti Hastuti Richa Mardianingrum Rizky Farhan Pratama Roesman, Kamiel Ruswanto, Ruswanto Sa'banah, Nonah Salsabila Adlina Selvia Maslamah Aan Septiani, Gina Shofuro Sholihah Suhardiana, Eddy Susanti Susanti Susanti Susanti Vikandari, Sonya Nurizki Vincent O. Imieje Widya Nurul Aini