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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Pertanian Indonesia Jurnal Pengolahan Hasil Perikanan Indonesia Jurnal Veteriner ILMU KELAUTAN: Indonesian Journal of Marine Sciences Indonesian Journal of Chemistry Narra J Makara Journal of Science Borneo Journal of Pharmacy

Novriyandi Hanif

Departemen Kimia, Fakultas Matematika Dan Ilmu Pengetahuan Alam, IPB University, Kampus IPB Darmaga, Bogor 16680

Author-ID : 274611

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

Published : 10 Documents Claim Missing Document

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Articles

In Vitro Pancreatic Lipase Inhibition by Marine Fungi Purpureocillium lilacinum Associated with Stylissa sp. Sponge as Anti-obesity Agent Wendi Nurul Fadillah; Nampiah Sukarno; Dyah Iswantini; Min Rahminiwati; Novriyandi Hanif; Mashuri Waite
HAYATI Journal of Biosciences Vol. 29 No. 1 (2022): January 2022
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.29.1.76-86

This study aimed to evaluate the potential of marine fungus Purpureocillium lilacinum isolated from an Indonesian marine sponge Stylissa sp. as an anti-obesity agent through pancreatic lipase inhibition assay. The fungus was identified as P. lilacinum through morphological and molecular characteristics. The fungal extract’s inhibition activity and kinetics were evaluated using spectrophotometry and Lineweaver-Burk plots. Ethyl acetate and butanol were used for extraction. Both extracts showed pancreatic lipase inhibition in a concentration-dependent manner. Both crude extracts were then fractionated once. All fractionated extracts showed inhibitory activity above 50%, with the highest activity found in fraction 5 of ethyl acetate at 93.41% inhibition. The best fractionated extract had an IC50value of 220.60 µg.mL-1. The most active fraction of P. lilacinum had a competitive-type inhibitor behavior as shown by the value of Vmax not significantly changing from 388.80 to 382.62 mM pNP.min-1, and the Michaelis-Menten constant (KM) increased from 2.02 to 5.47 mM in the presence of 500 µg.mL-1 fractionated extract. Metabolite identification with LC-MS/MS QTOF suggested that galangin, kaempferol, and quercetin were responsible for the observed lipase inhibition.

Characterization and Photoprotector Activity of Endophytic Fungal Pigments from Coastal Plant Sarang Semut (Hydnophytum formicarum) Mada Triandala Sibero; Kustiariyah Tarman; Novriyandi Hanif
Jurnal Pengolahan Hasil Perikanan Indonesia Vol 19 No 1 (2016): Jurnal Pengolahan Hasil Perikanan Indonesia
Publisher : Masyarakat Pengolahan Hasil Perikanan Indonesia (MPHPI)

Endophytic fungus RS3 isolated from coastal plant sarang semut (Hydnophytum formicarum) produced extracellular black pigment. The aims of this research were to obtain the pigment, to characterize and to determine the photoprotector activity. This research was conducted into several steps, that were determination of the best precipitating agent, characterization using instrument and solubility analysis, and analysis of Sun Protection Factor (SPF). Results showed the pigment was precipitated using acid solvent with pH ≤ 2.5. Functional groups of pigment were hydroxyl, aromatic ring, phenol and amine. According to its characteristics, black pigment produced by RS3 isolate was proposed as melanin. The photoprotector analysis showed the SPF value was 11.33.

Pengimbuhan Fraksi Heksana Daun Katuk Varietas Zanzibar dalam Pakan Meningkatkan Produksi Susu, Tampilan Induk dan Anak Tikus Fachruddin Fachruddin; Agik Suprayogi; Novriyandi Hanif
Jurnal Veteriner Vol 18 No 2 (2017)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

The research purpose was to examine the potential of hexane fraction from Sauropus androgynus (SA) leaves of Zanzibar variety as a substance for increasing milk yield and performance of female and rat pups. The experiment was conducted on the fifteen pregnant-lactating rats that divided into five groups, such as control, hexane fraction (HF) of Zanzibar, Bastar, Paris, and Kebo. The administration of hexane fraction was executed by feeding and it was consumed after the state of rat pregnancy on three days up to ten days after parturition. The average consumed dose by pregnant rat was 69.07 mg/day/rat. The treatment for 16 days showed no significant effect on the average daily feed consumption, body weight gain of female rats, pups number, and birth weight of pups between treatment groups. The administration of hexane fraction from SA leaves of Zanzibar veriety showed significant effect on the milk yield and body weight gain of pup compared with control group (P<0.05). The results suggested that SA leaves from Zanzibar variety had a better potential to be developed as a substance for increasing milk yield and performance of female and rat pups compared to SA leaves from the other varieties. ABSTRAK Penelitian ini bertujuan untuk menguji potensi fraksi heksana daun katuk (Sauropus androgynus) varietas Zanzibar sebagai substansi yang dapat meningkatkan produksi susu dan tampilan induk dan anak tikus. Penelitian dilakukan pada 15 ekor tikus bunting-laktasi yang dibagi dalam lima kelompok perlakuan, yaitu kelompok kontrol, fraksi heksana (FH) daun katuk varietas Zanzibar, Bastar, Paris, dan Kebo. Pemberian fraksi heksana dilakukan melalui pakan setelah umur kebuntingan tiga hari dan diteruskan sampai sepuluh hari setelah beranak. Rataan dosis konsumsi fraksi heksana sebesar 69,07 mg/hari/ekor. Pemberian perlakuan selama 16 hari tidak menunjukkan adanya perbedaan nilai rataan konsumsi pakan, pertambahan bobot badan (PBB) induk tikus bunting, jumlah anak, dan bobot lahir anak tikus antar kelompok perlakuan. Pemberian fraksi heksana daun katuk varietas Zanzibar memberikan pengaruh nyata terhadap produksi susu dan PBB anak tikus dibandingkan dengan kelompok Kontrol (P<0,05). Hasil ini menunjukkan bahwa daun katuk varietas Zanzibar memiliki potensi yang lebih baik dalam meningkatkan produksi susu dan tampilan induk dan anak tikus dibandingkan dengan varietas lainnya.

A NEW CYTOTOXIC DOLABELLANE FROM THE INDONESIAN SOFT CORAL Anthelia sp. Anggia Murni; Novriyandi Hanif; Junichi Tanaka
Indonesian Journal of Chemistry Vol 13, No 3 (2013)
Publisher : Universitas Gadjah Mada

One new dolabellane (1) and two known diterpenoids stolonidiol (2) and clavinflol B (3) have been isolated from the ethyl acetate extract of the Indonesian soft coral Anthelia sp. A new compound 1 exhibited a moderate cytotoxicity against NBT-T2 cells at 10 µg/mL, while known compounds 2 and 3 showed cytotoxicity at 1 and 0.5 µg/mL, respectively. Structure of the new compound 1 was elucidated by interpretation of NMR spectroscopic data (1D and 2D NMR data) and mass spectrometry (ESIMS data) as well as comparison with those of related ones. This finding should be useful for anti cancer drug development of the promising dolabellane-types compound.

Identification of Drought-tolerant Local Cowpea Varieties of Southwest Maluku (Indonesia) Karuwal, Ritha Lusian; Suharsono, Suharsono; Tjahjoleksono, Aris; Hanif, Novriyandi
Makara Journal of Science Vol. 22, No. 4
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Cowpeas grown in Southwest Maluku have local potential due to their diversity and ability to adapt to drought stress conditions that otherwise cause low productivity. The purpose of this study was to identify of local cowpea varieties of Southwest Maluku that show tolerance to drought. The experimental samples were seven local varieties and threereference cultivars. The drought stress treatment was altered watering periods, i.e., every two (P0) and ten days (P1) from growth to harvest. The results of this research showed that a ten-day watering period significantly decreased plant height, number of leaves, number of root nodules, root and shoot dry weight, photosynthesis rate, stomatal conductance, transpiration rate, relative water content, media water content, chlorophyll content, and number and weight of seeds perplant. Drought stress treatment increased proline content and root length. Correlation analysis showed a significant correlation between plant height with all variables, except for root length, proline content, and weight of seedsper plant. The correlation and cluster analyses showed that the KM7 variety is a drought tolerant genotype among the local cowpea varieties from Southwest Maluku. Therefore, the KM7 variety can be used as plant material in future breeding programs.

Nilai Nutrisi dan Rendemen Ekstrak Metanol Pelet Katuk Depolarisasi sebagai Parameter Standar Mutu Produksi Agik Suprayogi; Fadjar Satrija; Muladno Muladno; Ronald Tarigan; Afton Atabany; Novriyandi Hanif; Welly Sugiono; Yuliantoni Yuliantoni
Jurnal Ilmu Pertanian Indonesia Vol. 28 No. 4 (2023): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18343/jipi.28.4.607

Standardization of the quality of the depolarized katuk pellet production process as a feed additive is very important to maintain product quality. The production process requires dry katuk leaves (DKK) as raw materials which are then processed into depolarized katuk leaves (DKD), and continues in the pelleting process to become depolarized katuk pellets (PKD). Quality standard can be done by measuring the parameters of nutritional value and also the yield of methanol extract. Nutritional values were obtained from the results of proximate analysis, namely the percentage of dry matter, ash content, crude protein, crude fiber, crude fat, beta-N, calcium, phosphorus, and gross energy (Cal/g). Mean while, the yield of methanol extract was obtained by maceration using methanol solvent. This study aims to evaluate the nutritional value and yield of crude methanol extract of katuk leaves (DKK, DKD, PKD) which can be used as a quality assurance standard for the depolarized katuk pellet production process. In general, the nutritional value of DKD and PKD had the same value as that of DKK, except for calcium which was quite high (P<0.05) in DKD and PKD, and the percentage of crude fiber was lower (P<0.05) in PKD compared to DKK and DKD. The percentage of crude fat in pellets (PKD) was higher (P<0.05) when compared to DKK and DKD. The yield of methanol extract was very high (P<0.05) in DKK, compared to DKD and PKD. The nutritional parameters and the yield of the katuk leaf extract can be used as quality assurance standards for the depolarized katuk pellet production process. Keywords: depolarization, katuk, methanol, nutrition, pellet

Exploring Indonesian Sponge-Associated Marine Aspergillus hortai: Characterization of Bioactive Compounds with Potential Anti-Escherichia coli Properties Fadillah, Wendi Nurul; Sukarno, Nampiah; Iswantini, Dyah; Rahminiwati, Min; Franco, Christopher MM; Zhang, Wei; Hanif, Novriyandi; Waite, Mashuri
HAYATI Journal of Biosciences Vol. 31 No. 4 (2024): July 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.4.712-724

Sponge-associated marine fungi are potential source for secondary metabolite compounds. The aim of this research was to investigate sponge-associated marine fungus as secondary metabolite producers against Escherichia coli. The fungus was isolated from Indonesian marine sponge Stylissa sp. and identified as Aspergillus hortai through a combination of morphological and molecular characteristics of ITS DNA and β-tubulin genes. The fungus was tested against E. coli using fungal broth and mycelial extracts. The optimized condition was achieved by fungal broth grown in corn meal broth at 6-days of shaking incubation. Fungal extract was produced using three liters of filtered fungal broth and extracted in ethyl acetate. The antibiotic activity of the extract is vulnerable to 45°C heat and basic or acidic conditions. Therefore, the extraction was done at pH 7 with evaporation at 40°C. The extract shows 7 major bands on TLC with 1 band shows activity against E. coli (Rf 0.81) on bioautogram. The band was observed as a yellow color and turned black in short-wave UV and did not show any fluorescence in long-wave UV. This research shows that sponge-associated marine fungi obtained from Indonesia has the potential as anti E. coli worth to be explored for searching new antibiotics.

Analysis of Amino Acid Profiles in Bone, Oil, and Muscle Tissue and Wound Healing Activity of Pangasius hypophthalmus Oil in Rattus norvegicus Hidayaturrahmah, Hidayaturrahmah; Suprayogi, Agik; Hanif, Novriyandi; Roosita, Katrin; Darusman, Huda Shalahudin; Aprilyana, Lia
Borneo Journal of Pharmacy Vol. 8 No. 1 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i1.8182

Patin (Pangasius hypophthalmus), a commercially important freshwater fish, is a rich source of protein containing both essential and non-essential amino acids, crucial for various biological functions. This study aimed to determine the amino acid composition of muscle tissue, oil, and bones of P. hypophthalmus and evaluate the wound healing potential of its oil extract in Rattus norvegicus. High-Performance Liquid Chromatography was employed to quantify the levels of essential and non-essential amino acids in each tissue. Results revealed that P. hypophthalmus oil exhibited the highest total amino acid content, particularly rich in histidine, arginine, and lysine. The wound healing activity of P. hypophthalmus oil extract was assessed in a rodent model, demonstrating a significant reduction in wound area (0.62-0.84 mm) and an impressive wound healing percentage (79-84.45%). These findings suggest that different parts of P. hypophthalmus possess valuable nutritional and therapeutic properties. Notably, the high amino acid content of P. hypophthalmus oil, particularly essential amino acids, highlights its potential as a promising source for developing pharmaceutical products, including amino acid supplements, wound healing agents, and formulations for metabolic support. Further research is warranted to fully explore the therapeutic potential of P. hypophthalmus oil and its bioactive components.

Challenges in Molecular and Morphological Identification of Sponge Species in Raja Ampat Aisyah, Siti Zanuba; Zamani, Neviaty Putri; Cahyani, Ni Kadek Dita; Elfahmi, Elfahmi; Syafrizayanti, Syafrizayanti; Andriani, Yosie; Arafat, Dondy; Bashari, Muhammad Hasan; Hanif, Novriyandi; Sani, Lalu M. Iqbal; Ayu, Inna Puspa; Akbar, Nebuchadnezzar; Subhan, Beginer
ILMU KELAUTAN: Indonesian Journal of Marine Sciences Vol 30, No 1 (2025): Ilmu Kelautan
Publisher : Marine Science Department Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/ik.ijms.30.1.115-125

Sponges (Phylum Porifera) are a group of highly diverse, sessile, and filter-feeding basal metazoans, except spongillids. The majority of sponges are marine species that play an important role in benthic habitat by maintaining the stability of marine ecosystems through nutrient cycling, habitat provision, and bioerosion. However, marine sponges are not easily identifiable because of their lack of species-level distinctive morphological features, which limits efforts to monitor actual species biodiversity. Indonesia is home to approximately 850 identified species of marine sponges, and Raja Ampat archipelago of West Papua province is known for its exceptional marine biodiversity. Despite the species abundance, the exact number of sponges in the region is not well-documented due to the lack of specific studies providing comprehensive data on their diversity. Therefore, this study aimed to conduct a DNA barcoding analysis using the mitochondrial cytochrome oxidase I (COI) gene as a marker, combined with morphological analyses of 22 individuals collected in the waters of Waigeo, Mansuar, and Gam Islands in Raja Ampat. The results showed that 3 samples were identified at the species level (Halichondria sp. and Stylissa carteri) with good query cover and percent identity. This showed the possible presence of undescribed or cryptic species, suggesting a severe lack of reference data for both morphology and molecular analyses of marine sponges in the region. Consequently, the analysis showed the presence of a significant gap in the understanding of sponge biodiversity in Raja Ampat's waters.

Effects of patin fish-based nutritional intervention on biochemical and physiological recovery in malnourished rats: An in vivo study and its implications for clinical nutrition Hidayaturrahmah, Hidayaturrahmah; Suprayogi, Agik; Darusman, Huda S.; Roosita, Katrin; Hanif, Novriyandi
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1811

Malnutrition is a major global health concern, especially in developing countries. Although patin fish oil and protein offer benefits, their individual and combined effects on maternal physiology remain unclear, particularly during early pregnancy. The aim of this study was to assess the effect of patin-based nutritional intervention on total serum protein, albumin, hemoglobin levels, body weight during pregnancy, body weight during lactation, heart rate, respiratory rate, body temperature, external appearance, behavioral activity, and milk production in malnourished rats. An in vivo study was conducted using Rattus norvegicus rats. The rats were divided into six groups: (1) healthy control, receiving standard feed; (2) malnourished control, receiving an 8% low-protein diet; (3) malnourished group, receiving standard feed; (4) malnourished treated with patin oil; (5) malnourished treated with patin meat; and (6) malnourished treated with a combination of patin oil and meat. The treatment consisted of 21 days during pregnancy and 23 days during lactation, for a total of 44 days. Our data indicated that patin-based intervention significantly increased total protein (p=0.044), albumin (p=0.001), and hemoglobin levels (p=0.034) compared to malnourished control group. The malnourished animals treated with patin oil showed the highest increases in total protein (1.67%), albumin (17.75%), and hemoglobin (24.26%). Body weight gain improved significantly in patin-treated group in both pregnancy (p=0.032) and lactation (p<0.001) compared to the malnourished control, with the highest gains observed in the patin oil group. Milk production also increased significantly (p<0.05), reaching its peak in the patin oil and meat combination group (6.97 g). Physiological parameters, including heart rate (p=0.021), respiratory rate (p=0.025), and body temperature (p=0.023), were significantly different among groups, of which patin oil and meat groups had the most optimal parameters compared to malnourished control group. In conclusion, patin-based nutritional intervention effectively enhances protein metabolism, hematological parameters, and physiological health in malnourished maternal rats, with patin oil demonstrating the most pronounced effects.

Co-Authors Afton Atabany Agik Suprayogi Aisyah, Siti Zanuba Anggia Murni Aprilyana, Lia Aris Tjahjoleksono Ayu, Inna Puspa Bashari, Muhammad Hasan Beginer Subhan Dondy Arafat Dyah Iswantini Elfahmi Elfahmi, Elfahmi Fachruddin Fachruddin Fadillah, Wendi Nurul Fadjar Satrija Franco, Christopher MM Hidayaturrahmah Hidayaturrahmah Huda Shalahudin Darusman Junichi Tanaka Karuwal, Ritha Lusian Katrin Roosita Kustiariyah Tarman Mada Triandala Sibero Mashuri Waite Muladno - Nampiah Sukarno Nebuchadnezzar Akbar NEVIATY PUTRI ZAMANI Ni Kadek Dita Cahyani, Ni Kadek Dita Rahminiwati, Min Ritha Lusian Karuwal Ronald Tarigan Sani, Lalu M. Iqbal Suharsono Suharsono Suharsono Suharsono Syafrizayanti, Syafrizayanti Waite, Mashuri Wei Zhang Welly Sugiono Wendi Nurul Fadillah Yosie Andriani Yuliantoni Yuliantoni

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