Anggoro Budi Hartopo
Department Of Cardiology And Vascular Medicine, Faculty Of Medicine, Public Health And Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, Working Group On Pulmonary Hypertension, Indonesian Heart Association

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Correlation between Apolipoprotein B/Apolipoprotein A-I Ratio with Atherogenic Index of Plasma among Acute Myocardial Infarction Patients Winardi Emmanuel Setiawan; Anggoro Budi Hartopo; Royhan Rozqie
The Indonesian Biomedical Journal Vol 10, No 2 (2018)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v10i2.400

Abstract

BACKGROUND: Acute myocardial infarction (AMI) is the most common cause of death in the world. One preventive attempt to reduce AMI is early detection of blood lipid profile. A simple method of lipid profile assessment is the measurement of atherogenic index of plasma (AIP), meanwhile more accurate method of lipid profile assessment is the measurement of apolipoprotein B/apolipoprotien A-I (ApoB/ApoAI) ratio. However, whether both measurements are interchangeable is need to be investigated. This study aims to investigate the correlation between AIP value and ApoB/ApoAI ratio in patients with AMI.METHODS: The study design was cross-sectional study. The blood samples of consecutively enrolled AMI patients had been selected after inclusion and exclusion criteria. The blood samples were taken within 24 hours of patient admission to the hospital. The blood concentration of high-density lipoprotein (HDL) and triglycerides (TG) were measured using turbidimetric method. The AIP was calculated as logarithmic of TG/HDL ratio (log10.[TG:HDL]) The concentration of ApoB and ApoAI were measured using immunoturbidimetric method. The correlation between these measurements was analyzed with Pearson correlation test.RESULTS: The blood samples of 76 subjects were collected and analyzed. The subjects were dominated by male (n=67, 88%) and those whose age ≥55 years old (n=54, 71%). The mean ApoB value was 88.66 mg/dL and ApoAI was 97.39 mg/dL. The AIP value was 0.05. The Pearson correlation test between AIP and ApoB/ApoAI ratio showed a significant positive correlation with the strength of correlation was moderate (r=0.51, p-value<0.01).CONCLUSION: There was a significantly positive and moderate correlation between AIP value and ApoB/ApoAI ratio in acute myocardial infarction patients.KEYWORDS: atherogenic index of plasma, acute myocardial infarction, apolipoprotein B/apolipoprotein A-I ratio
Wire Crossing Time Correlate with Left Ventricular End-Diastolic Pressure in Patients with ST Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention Indra Widya Nugraha; Anggoro Budi Hartopo; Nahar Taufiq
Jurnal Kardiologi Indonesia Vol 41 No 3 (2020): Indonesian Journal of Cardiology: July - September 2020
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.936

Abstract

Backgrounds: Mortality and morbidity in acute myocardial infarction depend on the extent of the infarct area. Rapid recovery of coronary artery blood flow with primary percutaneous coronary intervention (pPCI) can limit the extent of infarction and improve left ventricular function. Acute myocardial infarction reduce diastolic function, which in the early stage of diastolic dysfunction, there is an increase in left ventricular end-diastolic pressure (LVEDP). The non-invasive marker of E/e’ ratio is an accurate parameter of increased LVEDP.Methods: This was a cross-sectional study enrolled consecutive patients with ST Segment Elevation Myocardial Infarction (STEMI) who underwent pPCI at Dr. Sardjito Hospital. The wire crossing time was calculated from the onset of chest pain until the guidewire crossed the infarct-related artery during the pPCI procedure. The E/e’ ratio was determined by transthoracic echocardiography which performed within 48 hours after the primary PCI. Correlation between the wire crossing time and the E/e’ ratio was assessed by the Pearson correlation test. The value of p <0.05 was considered statistically significant.Results: A total of 40 patients were enrolled in this study. The mean wire crossing time was 12.73±5.22 hours. The median value of the E/e’ ratio was 8.36 (range: 4.71-22.00). There was a moderate strength and significant correlation between the wire crossing time and the E/e’ ratio (r = 0.572; p <0.001). Patients with E/e’ ratio >15 had significantly longer wire crossing time than in patient with E/e’ ratio ≤15 (20.21±2.5 hours vs. 11.41±4.39 hours; p <0.001; respectively). The wire crossing time was independently associated the E/e’ ratio (r = 0.463; p = 0.003).Conclusion: There was a moderate strength and significant positive correlation between the wire crossing time and increased LVEDP, an earlier marker of diastolic dysfunction, measured by E/e’ ratio using TTE in patients with STEMI underwent pPCI.
The Prevalence and Impact of Body Mass Index Category in Patients with Acute Myocardial Infarction Anggoro Budi Hartopo; Vina Yanti Susanti; Budi Yuli Setianto
ACI (Acta Cardiologia Indonesiana) Vol 2, No 2 (2016)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.22604

Abstract

Background: Body mass index is widely recognized as a tool to classify obesity and adiposity. In Asian population, body mass index category can be divided as underweight, normal, overweight and obese. The prevalence of this categorisation is varied among patients with acute myocardial infarction. Furthermore, there is a J and U curve relationship between body mass index category with outcome in acute myocardial infarction. This research aims to investigate the prevalence of body mass index category and its impact on patients with acute myocardial infarction.Methods: The research design is a cross sectional study. The subjects of this research are patients hospitalised with acute myocardial infarction. Subjects are categorised as underweight, normal, overweight and obese, based on Asian body mass index categorisation. The demography, clinical and laboratory data is compared among categories and statistically analysed. The major adverse cardiac events occuring during hospitalisation are recorded and its incidence is compared among group. A p value < 0.05 is statistics limit for significance.Results: We analyse 375 subjects hospitalised with acute myocardial infarction. The most prevalence BMI category is overweight (47.7 %), the second most common category is normal (33.1 %), followed by obese (15.5 %) and the least common category is underweight (3.7 %). No significant difference is observed in respect of gender and cardiovascular risk factors. The underweight subject is significantly older as compared to other categories. The glucose level and atherogenic lipid tend to be higher in underweight subject as compared with normal subject. There is no difference in the incidence of major adverse cardiac events among body mass index categorisation.Conclusion: The overweight is the most common body mass index category in acute myocardial infarction. The underweight subject is significantly older and tend to have worse biochemical parameters as compared to other categories. The incidence of MACE is not associated with the body mass index category.Keywords: body mass index; overweight; underweight; acute myocardial infarction 
The Dynamic Electrocardiogram Pattern of T Wave Inversion Following ST Segment Elevation in Acute Coronary Syndrome with Non Significant Coronary Artery Disease Anggoro Budi Hartopo; Hariadi Hariawan; Nahar Taufiq
ACI (Acta Cardiologia Indonesiana) Vol 2, No 2 (2016)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.22608

Abstract

ST segment elevation acute myocardial infarction (STEMI) is sometime indicated by typical electrocardiogram pattern, and rarely by atypical pattern. The definite diagnosis of STEMI is important to be determined rapidly and timely and becoming the key management success. The 12 lead electrocardiogram is the main diagnostic tool which should be completed and interpreted as soon as possible on patient admission. In the case, a female patient with anginal chest pain and initial ST segment elevation in electrocardiogram with non significant coronary artery disease. The subsequent electrocardiogram shows T wave inversion evolution pattern.Keywords: STEMI; T wave inversion; variant angina; evolution
Prognostic Factor of Soluble ST2 Serum on 90 Days-Major Cardiovascular Events in ST-Elevation Acute Myocardial Infarction Patients with Reperfusion Therapy Pamrayogi Hutomo; Anggoro Budi Hartopo; Indah Sukmasari; Ira Puspitawati; Putrika Prastuti Ratna Gharini; Budi Yuli Setianto
ACI (Acta Cardiologia Indonesiana) Vol 3, No 1 (2017)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.29680

Abstract

Background: Soluble ST2 (sST2) is released by strained myocardial. High baseline sST2 levels have been shown to be a predictor of mortality and heart failure in STEMI patients within 30 days and within 1 year, but its effect on medium-term events has not been widely investigated. Aims: To assess the prognostic factor of sST2 levels during admission with major cardiovascular events in the form of cardiovascular death and heart failure due to left ventricular dysfunction within 90 days of observation. Methods: A retrospective cohort study was conducted on STEMI patients with an onset of ≤ 24 hours undergoing reperfusion therapy from April 2014 - June 2015 in Dr. Sardjito General Hospital, Yogyakarta, Indonesia. The sST2 sample of venous blood was performed at admission. Primary outcomes for this analysis included cardiovascular death and congestive heart failure (CHF) through 90 days of follow-up. Assessment of major cardiovascular events was based on medical record data. Bivariate analysis were conducted on demographic and clinical factors related to sST2 and major cardiovascular events. A multivariate analysis was then conducted to determine the independent factors that influenced the emergence of major cardiovascular events. Results: Of the 107 patients who met the subject criteria, there were 33 (30.8%) subjects withmajor cardiovascular events and 74 subjects (69.2%) without major cardiovascular events in 90 days of observation. Of the 33 subjects with major cardiovascular events, there were 10 subjects (9.3%) died and 23 subjects (21.5%) with heart failure. The sST2 levels did not have a significant relationship with the incidence of mortality (p=0.617), heart failure (p=1.000), orboth combined (p = 1.000) in 90 days of observation. Conclusion: High serum sST2 levels during admission in STEMI patients who had undergonereperfusion therapy were not associated with increased incidence of major cardiovascular events (either the incidence of mortality or heart failure alone or both combined) in 90 days observation. 
Correlation between Left Ventricular Eccentricity Index and Mean Pulmonary Arterial Pressure in Secundum Type Atrial Septal Defect Adult Patients Citra Dewi Wahyu Fitria; Azhafid Nashar; Dyah Wulan Anggrahini; Anggoro Budi Hartopo; Hasanah Mumpuni; Lucia Kris Dinarti
ACI (Acta Cardiologia Indonesiana) Vol 4, No 1 (2018)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.36634

Abstract

Background: Secundum type atrial septal defect (ASD) is the most common adult congenital heart disease. Hemodynamically, ASD result in a left-to-right shunt that causes right heart volume overload. This condition affects interventricular septal position and shape. Left ventricular (LV) eccentricity index (EI) suggests right ventricle (RV) overload when this ratio is >1.0. The aim of this study was to assess correlation between LV EI and mean pulmonary arterial pressure (mPAP) in secundum type ASD patients. Methods: We conducted a cross sectional study from ASD patients registry data. We enrolled subjects with secundum type ASD from the complete registry data. The LV EI was calculated from transthoracal echocardiography. The mPAP was measured by right heart catheterization as a gold standart. The correlation was performed by Spearman correlation test. Results: There were 40 adult secundum type ASD patients participated. The mean LV EI in enddiastolic was 1.55±0.39 and LV EI in end-systolic was 1.75±0.58. The median value of mPAP was 29 (12-99) mmHg. There was a moderate strength, positive and significant correlation between LV EI in end-diastolic and mPAP (r=0.37, p=0.018). The correlation was more significant and stronger between LV EI in end-systolic and mPAP (r=0.52, p=0.001). Conclusion: There was sufficiently strong and significant correlation between LV EI in both end-diastolic and end-systolic phase with mPAP in adult secundum type ASD.
The Shared Pathogenesis of Pulmonary Artery Hypertension Anggoro Budi Hartopo; Lucia Kris Dinarti
ACI (Acta Cardiologia Indonesiana) Vol 4, No 1 (2018)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.36635

Abstract

Pulmonary artery hypertension is defined as an increased in pulmonary artery pressureexceeding 25 mmHg with normal pulmonary wedge pressure. The pathogenesis of pulmonaryartery hypertension involves interaction among vascular, cellular and biomarker componentsin the pulmonary tissue; with eventual result is elevated pulmonary artery pressure. Vascularcomponents are remodeling of intimal, medial and adventitial layers. Cellular components areplayed by apoptosis-resistant endothelial cells, proliferative-prone pulmonary artery smoothmuscle cells, fibroblasts and inflammatory cells. The functional biomarkers are produced andmediated by these cellular changes, mainly endothelin-1, thromboxane, serotonin, nitric oxide,and prostacyclin. The pulmonary vascular remodeling in pulmonary artery hypertension arediverse and may present in various severity based on underlying etiology. Understanding theshared pathogenesis in pulmonary artery hypertension is of paramount importance in order toimprove the disease management and treatment approach.
Pericardial and Pleural Effusion in Patient with Relapse Stage IV Breast Cancer: Same Pathology, Different Etiology? Vienna Rosalinda; Anggoro Budi Hartopo; Dyah Wulan Anggrahini; Bambang Irawan
ACI (Acta Cardiologia Indonesiana) Vol 4, No 2 (2018)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/aci.40856

Abstract

Pericardial effusion associated with malignacy has poor prognosis. The prompt identification of etiology is mandatory, such that timely management can be performed and survival can be increased. However, difficulty in etiology determination is commonly encountered. In this case, we report female patient with relapse stage IV breast cancer who develop massive pericardial and bilateral pleural effusion. The similar characteristics were found in both effusion fluids, however the identification of etiology was not similar. Metastatic cells were found in pleural effusion, whereas they were absent in pericardial effusion.
Functional Capacity Improvement on Patent Ductus Arteriosus with Pulmonary Arterial Hypertension: A Case Report and Literature Review Annis Rakhmawati; Irsad Andi Arso; Anggoro Budi Hartopo; Lucia Kris Dinarti
ACI (Acta Cardiologia Indonesiana) Vol 5, No 1 (2019)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (627.282 KB) | DOI: 10.22146/aci.44554

Abstract

Pulmonary artery hypertension (PAH) is a pathophysiological disorder involving a wide range of clinical conditions. This can be a condition of complications from heart disease and respiratory system. Pulmonary arterial hypertension is defined as an increase in mean pulmonary arterial pressure (mPAP) ≥ 25 mmHg at rest assessed by right heart catheterization. The cardiovascular rehabilitation program is a set of efforts to improve the underlying cause of cardiovascular disease such that it can maintain or restore the best conditions and secondary prevention. Cardiac rehabilitation and physical exercise programs have the benefit of improving pulmonary vascular endothelial function, physical activity capacity and quality of life parameters for PAH patients. A 6-minute walk test can be used to assess the functional capacity of PAH patients.
The BMPR2, ALK1 and ENG Genes Mutation in Congenital Heart DiseaseAssociated Pulmonary Artery Hypertension Anggoro Budi Hartopo; Dyah Wulan Anggrahini; Noriaki Emoto; Lucia Kris Dinarti
ACI (Acta Cardiologia Indonesiana) Vol 5, No 2 (2019)
Publisher : Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (750.759 KB) | DOI: 10.22146/aci.50222

Abstract

The gene mutation is one of the background underlie the pathogenesis of pulmonary artery hypertension (PAH). Several genes have been recognized to be responsible for the development of PAH. The mutation in transforming growth factor-β (TGF-β) pathway is considered to be major genotype background in heritable PAH. The genetic mutation in bone morphogenetic protein receptor-2 (BMPR2), activin receptor-like kinase 1 (ALK-1) and endoglin (ENG) are known to cause heritable PAH. In congenital heart disease–associated PAH (CHDAPAH), their mutation are also presence.
Co-Authors Abdul Majid Halim Wiradhika Abdul Majid Halim Wiradhika Abdul S Wahab, Abdul S Abdus Samik Wahab Ade Meidian Ambari Ahmad Hamim Sadewa Alifia Salsabila Ambari, Ade Meidian Anandini, Hesti Andreasta Meliala Anggraeni, Vita Yanti Anggrahini, Dyah Wulan Annis Rakhmawati Anwar Santoso Anwar Santoso Arityanti, Dean Armalya Pritazahra Armalya Pritazahra Azhafid Nashar Badai Bhatara Tiksnadi Baiq Gerisa Rahmi Faharani Baiq Gerisa Rahmi Faharani Bambang Budi Siswanto Bambang Dwiputra Bambang Irawan Bambang Irawan Basuni Radi Budi Yuli Setianto Cholid Tri Tjahjono Citra Dewi Wahyu Fitria Desandri, Dwita Rian Detty Siti Nurdiati Deva Bachtiar Deva Bachtiar Dwiputra, Bambang Dyah Samti Mayasari Dyah Wulan Anggrahini Eko Budiono Erna Ashlihah Rochmat Erwan, Nabila Erina Evita Devi Noor Rahmawati Fajarwati, Prahesti Febrianora, Mega Fika Humaeda Assilmi Firandi Saputra Fitra, Maha Gharini, Putrika Prastuti Ratna Gumilang, Rizki Amalia Hariadi Hariawan Hariadi Hariawan Hasan, Harris Hasanah Mumpuni Hendry Purnasidha Bagaswoto Hergaf, Indah Widyasari I Dewa Putu Pramantara Ika Trisnawati Indah Sukmasari Indra Widya Nugraha Ira Puspitawati Iri Kuswadi Irsad Andi Arso Irsad Andi Arso Irsad Andi Arso Irsad Andi Arso, Irsad Andi Iswandi Darwis Jarir At Thobari Jarir At Thobari Jati, Lintang Daru Julia Sari Kathrine, Anita Septiana Maria Kelvin Supriami Krevani, Citra Kiki Krisdinarti, Lucia Likke Prawidya Putri Lucia Kris Dinarti Lucia Kris Dinarti Lucia Kris Dinarti Lucia Kris Dinarti Lucia Kris Dinarti Lucia Kris Dinarti Lucia Krisdinarti Lucida Kris Dinarti, Lucida Kris Luhur Pribadi Luhur Pribadi Lukman Ade Chandra Lukman Ade Chandra M. Taufik Ismail M. Yogi Riyantama Isjoni Makes, Indira Kalyana Mardiah Suci Hardianti Megawati Abubakar Megawati Abubakar Metalia Puspitasari Muhammad Gahan Sarwiko Muhammad Gahan Satwiko Muhammad Gahan Satwiko Muhammad Reyhan Hadwiono Muhammad Reyhan Hadwiono Muhammad Reyhan Hadwiono Muhammad Reyhan Hadwiono Muhammad Ridwan Nahar Taufiq Nahar Taufiq Nahar Taufiq, Nahar Noriaki Emoto Nu Pravitasari Pamrayogi Hutomo Pompini Agustina Sitompul Pompini Agustina Sitompul Prasetia, Arif Eka Prasetya, Arif Eka Putri Ayudhia Trisnasari Putrika Prastuti Ra Gharini Putrika Prastuti Ra Gharini Qhabibi, Faqrizal Ria Raden Heru Prasanto Rahadiyani, IDA Swasty Rahayu, Dian Herlusiatri Raynaldo, Abdul Halim Real Kusumanjaya Marsam Rita Hamdani Rizki Amalia Gumilang Rochmat, Muflihatul Baroroh Royhan Rozqie setiaji, dimas Shiddiq, Achmad Sjughiarto, M.Afies Susanti, Vina Yanti Susilowati, Eliana Syaoqi, Muhammad Tarsidin, Najmi Fauzan Togi Junice Hutadjulu Togi Junice Hutadjulu Tri Asti Isnariani Tri Asti Isnariani Umi Sa'adatun Nikmah Umi Sa'adatun Nikmah Vera Dewanto Vera Dewanto Vienna Rosalinda Vina Yanti Susanti Vita Yanti Anggraeni Vita Yanti Anggraeni Winardi Emmanuel Setiawan Wiradhika, Abdul Majid Halim Yasmine Fitrina Siregar Yulia Wardhani