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All Journal Jurnal Kesehatan Andalas Paediatrica Indonesiana Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Health and Medical Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI)
Rismawati Yaswir
Bagian Patologi Klinik Dan Kedokteran Laboratorium, Fakultas Kedokteran, Universitas Andalas, Padang
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : Jurnal Kesehatan Andalas

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Gambaran Laboratorium Leukemia Kronik di Bagian Penyakit Dalam RSUP Dr. M. Djamil Padang Muthia Rendra; Rismawati Yaswir; Akmal M Hanif
Jurnal Kesehatan Andalas Vol 2, No 3 (2013)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v2i3.153

Abstract

AbstrakLeukemia merupakan penyakit keganasan sel darah yang berasal dari sumsum tulang ditandai oleh proliferasi sel-sel darah putih, dengan manifestasi adanya sel-sel abnormal dalam darah tepi. Pada tahun 2006, leukemia berada pada urutan ke-5 dari keseluruhan penderita kanker di Indonesia. Leukemia kronik merupakan leukemia yang paling sering terjadi pada dewasa dan lanjut usia. Secara umum leukemia kronik diklasifikasikan atas Leukemia Granulositik Kronik (LGK) dan Leukemia Limfositik Kronik (LLK). Leukemia kronik yang perjalanannya lambat dan diiringi oleh gejala yang tidak khas, maka penelitian ini bertujuan untuk mengetahui gambaran laboratorium leukemia kronik di bagian Peyakit Dalam RSUP DR. M. Djamil Padang. Jenis penelitian ini adalah deskriptif retrospektif. Instrumen yang digunakan pada penelitian ini adalah data sekunder yang diperoleh dari Instalasi Rekam Medik RSUP Dr. M. Djamil Padang berupa data pasien leukemia kronik yang dirawat di Bagian Penyakit Dalam RSUP Dr. M. Djamil Padang sejak 1 Januari 2010 – 31 Desember 2012. Hasil penelitian ini menunjukkan bahwa dari 16 kasus leukemia granulositik kronik terdapat 37,5% pasien mengalami anemia sedang, 100% leukositosis, jumlah trombosit dapat menurun, normal, dan meningkat dengan presentase masing-masing 25%, 25%, dan 50%. Gambaran eritrosit sebagian besar normositik anisositosis. Separuh pemeriksaan darah tepi menunjukkan peningkatan persentasi mielosit, 31,25% menunjukkan peningkatan persentasi metamielosit dan eosinofil, serta sebagian besar menunjukkan presentasi blast. Sedangkan gambaran sumsum tulang hiperseluler, penekanan eritropoetik, mielopoetik hiperaktif, dan trombopoetik dalam batas normal. Leukemia limfositik kronik yang terdiri dari 1 kasus menunjukkan gambaran laboratorium berupa anemia sedang, leukositosis, trombositopenia, gambaran eritrosit nomokrom anisositosis, peningkatan jumlah leukosit, peningkatan jumlah limfosit, presentasi smudge cell, dan ditemukan presentasi blast pada darah tepi, tetapi selularitas tidak dapat dinilai.Kata kunci: leukemia kronik, darah tepi, BMPAbstractLeukemia is a malignant disease of blood cells derived from the bone marrow characterized by the proliferation of white blood cells, with the manifestation of the abnormal cells in the peripheral blood. In 2006, leukemia was ranked 5th of all cancer patients in Indonesia. Chronic leukemia is the most common leukemia in adult and the elderly. In general, chronic leukemia classified on chronic myelocytic leukemia (CML) and chronic lymphocytic leukemia (CLL). The onset of chronic leukemia is insidious and accompanied by symptoms that are not typical, this research aims to describe the laboratory findings of chronic leukemia patients treated at Internal Medicine Department of Dr. M. Djamil Hospital Padang.This research is a retrospective descriptive research. The instruments used in this research are the secondary data derived from the Medical Record Departement Dr. M. Djamil Hospital Padang in the form of leukemia chronic patients’ data who were treated in Internal Medicine Department of Dr. M. Djamil Hospital Padang since January 1st 2010 – December 31st 2012. The results of this research showed that of 16 cases of chronic myelocytic leukemia contained 37.5% of the patients had moderate anemia, leukocytosis 100%, platelet count can be decreased, normal, and increased the percentage of each 25%, 25%, and 50%. The morphology of erythrocytes mostly normocytic anisocytosis. Half of peripheral blood examination showed an increase in the percentage of myelocyte, 31.25% showed an increase in the percentage metamyelocyte and eosinophils, as well as most of the shows presentation blast. The bone marrow are hypercellular, compressing erythropoietic, myelopoietic hyperactivity and thrombopoietic mostly normal in number. Chronic lymphocytic leukemia consisting of 1 case shows the laboratory findings are moderate anemia, leukocytosis, thrombocytopenia, the morphology of erythrocyte is normochromic anisocytosis, leukocytes increase in number, increase in the number of lymphocytes, presentations smudge cells, and blast presentation is found in the peripheral blood, but the cellularity not be assessed.Keywords: chronic leukemia, peripheral blood, BMP
Korelasi Kadar Adiponektin dengan Indeks Aterogenik Plasma pada Penyandang Obes Sari, Kartika Aulia; Yaswir, Rismawati; Prihandani, Tuty; Efrida, Efrida
Jurnal Kesehatan Andalas Vol. 9 No. 3 (2020): Online September 2020
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v9i3.1335

Abstract

Kadar adiponektin dalam plasma secara signifikan menurun pada penyandang obes. Adiponektin telah dilaporkan memiliki efek langsung anti-aterosklerosis. Indeks Aterogenik Plasma (IAP) dihitung sebagai log10(TG/ HDL-C), merupakan biomarker aterosklerosis. IAP dapat menjadi biomarker baru untuk risiko dan prognosis penyakit kardiovaskular. Tujuan: Menentukan korelasi kadar adiponektin dengan indeks aterogenik plasma pada penyandang obes. Metode: Penelitian ini merupakan studi analitik dengan rancangan potong lintang. Subjek penelitian adalah 30 orang penyandang obes dengan Indeks Massa Tubuh (IMT) ≥25 kg/m2 yang memenuhi kriteria inklusi dan eksklusi. Subjek penelitian melakukan pemeriksaan darah di Instalasi Laboratorium Sentral RSUP. Dr. M. Djamil Padang pada bulan Januari 2019 sampai September 2019. Pemeriksaan kadar adiponektin dengan metode enzyme linked immunoassay (ELISA). Pemeriksaan kolesterol high density lipoprotein (HDL) dan trigliserida menggunakan alat kimia klinik otomatis. Data univariat diolah dan disajikan dalam bentuk distribusi frekuensi dan rerata (standar deviasi). Data bivariat dianalisis dengan uji korelasi Pearson, bermakna secara statistik jika p˂0,05. Hasil: Rerata umur adalah 34,5 (6,2) tahun. Rerata kadar adiponektin adalah 2,5 (1,1) μg/mL. Rerata indeks aterogenik plasma (IAP) adalah 0,29 (0,17), termasuk risiko tinggi untuk penyakit kardiovaskular. Uji korelasi Pearson menunjukkan korelasi negatif sangat lemah antara adiponektin dengan IAP dan tidak bermakna secara statistik (r=-0,114, p=0,550). Simpulan: Tidak terdapat korelasi antara kadar adiponektin dengan indeks aterogenik plasma pada penyandang obes.Kata kunci: adiponektin, indeks aterogenik plasma, obes
Korelasi Kadar Adiponektin dengan Kadar Glukosa Puasa pada Penyandang Obes Bakma, Isphandra; Yaswir, Rismawati; Desywar, Desywar; Efrida, Efrida
Jurnal Kesehatan Andalas Vol. 9 No. 3 (2020): Online September 2020
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v9i3.1340

Abstract

Akumulasi lemak tubuh abnormal dan berlebih pada obesitas menyebabkan low grade inflammation sel adiposit yang berkontribusi terhadap penurunan kadar adiponektin. Adiponektin berperan dalam metabolisme glukosa, sehingga kondisi hipoadiponektinemia dapat menyebabkan gangguan metabolisme glukosa. Tujuan: menentukan korelasi kadar adiponektin dengan kadar glukosa puasa pada penyandang obes. Metode: Penelitian ini merupakan studi analitik dengan rancangan potong-lintang terhadap 25 orang penyandang obes yang bekerja di Instalasi Laboratorium Sentral RSUP Dr. M. Djamil Padang yang memenuhi kriteria inklusi dan eksklusi. Penelitian dilakukan mulai bulan September 2018 sampai September 2019. Kadar adiponektin diperiksa dengan metode Elisa two-step sandwich enzyme immunoassay dan kadar glukosa puasa diperiksa dengan metode heksokinase. Data dianalisis dengan uji korelasi Pearson, bermakna jika p<0,05. Hasil: Subjek penelitian terdiri dari laki-laki 8 orang (32,0%) dan perempuan 17 orang (68,0%). Rerata umur adalah 33,5 (6,0) tahun dengan rentang 23-52 tahun. Rerata indeks massa tubuh adalah 34,0 (3,6) kg/m2. Rerata kadar adiponektin adalah 2,8 (1,5) μg/mL dan rerata kadar glukosa puasa adalah 92,8 (11,4) mg/dL. Uji korelasi Pearson menunjukkan korelasi negatif lemah antara log-adiponektin dengan kadar glukosa puasa dan tidak bermakna secara statistik (r= -0,217, p= 0,298). Simpulan: Tidak terdapat korelasi kadar adiponektin dengan kadar glukosa puasa pada penyandang obes.Kata kunci: adiponektin, glukosa puasa, inflamasi adiposit, obesitas
Gambaran Castelli’s Risk Index-1 pada Pasien Sindrom Koroner Akut di RSUP Dr. M. Djamil Padang Sabebegen, Eka Musmita; Yaswir, Rismawati; Efrida, Efrida
Jurnal Kesehatan Andalas Vol. 10 No. 2 (2021): Online July 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i2.1719

Abstract

Atherogenic dyslipidemia is one of the risk factors for the acute coronary syndrome (ACS). Castelli's risk index-1 (CRI-1) is one of which risk markers for ACS. Castelli's risk index-1 is the ratio of total cholesterol and HDL cholesterol. The test is cheap and easy to do in the hospital setting. Objectives: To described CRI-1 in ACS patients in Dr. M. Djamil Padang Hospital. Methods: This descriptive study was carried out in the central laboratory and the CardioVascular Care Unit (CVCU) of Dr. M. Djamil Hospital Padang from September 2017 to September 2018. The population was all ACS patients who have been diagnosed by the clinician. The samples were part of the population that meet the inclusion and exclusion criteria. Colorimetric enzymatic method using automated clinical chemistry used to measure total cholesterol and HDL cholesterol. Results: This study used CRI-1> 4. Data were presented descriptively in a frequency distribution table. Seventy ACS patients were consisting of 50 (71.43%) males and 20 (28.57%) females, with a median age of 60.1 (8.93) years old. The median total cholesterol and HDL cholesterol levels were 178.66 (46.84) mg / dL respectively and 35.71 (10.86) mg / dL. CRI-1 mean is 5.43 (2.27). 81.43% CRI-1 subject results were more than four. Conclusion: The low levels of HDL cholesterol and within normal median total cholesterol level made CRI-1 value increased.Keywords: Acute coronary syndrome, Castelli’s risk index-1
Korelasi Glukosa Kapiler Metode Glucose Dehidrogenase-Nicotinamide Adenine Dinucleotide Dengan Glukosa Serum Metode Heksokinase Fitria, Syarifah Tridani; Yaswir, Rismawati; Efrida, Efrida
Jurnal Kesehatan Andalas Vol. 10 No. 3 (2021): Online November 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i3.1827

Abstract

Rapid and accurate measurement of capillary glucose level using point-of-care testing (POCT) is needed to maintain the patient’s normoglycemic status in obtaining adequate management. The glucose POCT method should be evaluated to determine analytical performance by comparing with the hexokinase method as a reference method to provide accurate and reliable results. Objectives: To determined the correlation between capillary glucose using glucose dehydrogenase-nicotinamide adenine dinucleotide (GDH-NAD)  and serum glucose hexokinase methods. Methods:  This analytic cross-sectional study on 42 outpatients who underwent fasting blood glucose examination at Dr. M Djamil Padang General Hospital. This study was conducted from February until September 2020. Capillary fasting blood glucose was measured using glucose POCT GDH-NAD method and serum glucose with hexokinase method. The Spearman correlation test was used to analyze data, significant if p<0.05. Results: The subjects were 28 male (66.7%),14 female (33.3%) with mean age and hematocrit level was 56.12±12.97 years and 40.90±2.42%, respectively. The median capillary glucose GDH-NAD method and serum glucose hexokinase method were 100.00 mg/dL each, with a median difference was 3.00 mg/dL. Spearman correlation test showed very strong positive correlation and statistically significant (r=0,961;p=<0,001). Conclusion: Capillary glucose GDH-NAD method had a very strong positive correlation with serum glucose hexokinase method.Keywords:  hexokinase, fasting glucose level, GDH-NAD, glucose POCT
Co-Authors Adelin, Prima Afrida Maiyesi Akmal M Hanif Amirah Zatil Izzah Ardho Mahamada Arina Widya Murni Aulia Rahman Aulia Rahman Bahana Sasmita Bakma, Isphandra Bayu Rahmadin Cici Julia Sri Dewi Debie Anggraini Deswita Sari Desywar Desywar Desywar Desywar Desywar Desywar Desywar Desywar Desywar Desywar Desywar, Desywar Dewi Oktavia Dia Rofinda, Zelly Dia Dian Eka Putri Didik Hariyanto Didik Hariyanto Donaliazarti Donaliazarti Dwi Yulia Dwitya Elvira, Dwitya Efrida Efrida Efrida Efrida Efrida, Efrida Eka Agustia Rini Eka Musmita Sabebegen Ellyza Nasrul Elsi Kelana Eugeny Alia Fadhillah Al Hijjah Farida Isroani Fitria, Syarifah Tridani Gunawan, Syahri Hanifah Maani Helma Helma Huriyah Fauzani Husna Yetti Husni Husni Husni Husni Ilhamifithri Ilhamifithri Ima Septia Indra Ihsan Ira Ferawati Irza Wahid Isphandra Bakma Kartika Aulia Sari Kurniawan Lillah Lillah Lillah Lillah Lillah Lillah Lillah Lillah M. Ikhlasul Amal Eel Taslim Meiti Frida Mira Purwinanty Muthia Rendra Nafiandi Nafiandi Nora Harminarti Novialdi . Nur Afrianin Syah Prihandani, Tuty Putri Mira Magistri Raisa Putri Secioria Reni Lenggogeni Ridha Amaliah Rizanda Machmud Rosfita Rasyid Rudy Afriant Sabebegen, Eka Musmita Sari, Kartika Aulia Sri Vanny Suhirman Syahri Gunawan Syarifah Tridani Fitria Syofiati Syofiati Syofiati Tuti Asryani Tuty Prihandani Tuty Prihandani Tuty Prihandani Wardhy Arief Hidayat Yashinta Octavian Gita Setyanda Yayie Dwina Putri Yerizal Karani Yessi Yestiani Yoshie Anto Chicamy Yustini Alioes zahra salsabila Zelly Dia Rofinda