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All Journal JURNAL KIMIA SAINS DAN APLIKASI Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Kartika Kimia Jurnal Ilmu Kefarmasian Indonesia Pharmacoscript Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Aisyah : Jurnal Ilmu Kesehatan Riset Informasi Kesehatan Borneo Journal of Pharmacy Kartika : Jurnal Ilmiah Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kefarmasian Indonesia
Hartyana Sutarna, Titta
Fakultas Farmasi Universitas Jenderal Achmad Yani
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary

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Formulation and Physical Evaluation of Sleeping Mask Gel Preparation of Mahogany Leaf Extract (Swietenia Mahagoni (L.) Jacq) As Antioxidant Ratih, Hestiary; Sutarna, Titta Hartyana; Febrianti, Mia; Alatas, Fikri; Purnamasari, Nira
Jurnal Kartika Kimia Vol 7 No 1 (2024): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkk.v7i1.265

Abstract

Antioxidants are used to neutralize free radicals. Mahogany leaves (Swietenia mahagoni (L.) Jacq) contain flavonoid chemicals that exhibit antioxidant properties. The purpose of the study was to determine the physical characteristics and antioxidant activity of sleeping mask gel preparations with the addition of mahogany leaf extract. Mahogany leaf extract is made using the maceration process. Determination of antioxidant activity using the DPPH method. The formulation is made by varying the concentration of mahogany leaf extract into 4 formulas, F0 (bases, F1 (0.0195%, IC50), F2 (0.0975%, 5xIC50) and F3 (0.195%, 10xIC50). There were several tests used to evaluate formulas, including homogeneity, dispersion, viscosity, pH, and organoleptic (odor, color, and shape) testing. IC50 value of mahogany leaf extract was 19.48 μg / mL. Mahogany leaf extract antioxidant gel sleeping mask preparations F0, F1, F2 and F3 was evaluated such as organoleptic testing requirements, homogeneity and pH produced between 6.15-6.65 including the skin's normal pH range of 4.0-7.0 during 28-day storage. F2 exhibits the best antioxidant stability, with an inhibition value of 54.59%.
Efek Iritasi Sabun Mandi Batang Mengandung Susu Produk Usaha Kecil Menengah di Kota Cimahi Vikasari, Suci Nar; Hermanto, Faizal; Simatupang, Elivas; Sutjiatmo, Afifah Bambang; Sutarna, Titta Hartyana; Puspadewi, Ririn; Rachmawan, Lucky; Haq, Fahmy Ahsanul
Jurnal Kefarmasian Indonesia VOLUME 10, NOMOR 2, AGUSTUS 2020
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v10i2.2592

Abstract

One of the ways to increase profit in small and medium business (UKM) in Cimahi is by diversifying its products, through manufacturing of bar soap derived from cow's milk from UKM. The requirement of bath soap is proper acidity (pH) level, otherwise it will make the skin dry, itchy or even increase irritation. Therefore, this in vivo non-clinical irritation evaluation is conducted to evaluate the effects of bar soap produced by UKM in Cimahi according to the guidelines in rat test animals. The animals is divided into five groups and exposed to soap for four hours. Five soap samples is obtained from UKM in Cipageran area, Cimahi. Observations is made at the hours of 1, 4, 24, 48, and 72 hours after exposure and is continued for 14 days. The measured parameters is erythema and edema, and the primary irritation index. The results showed that bar soap containing cow milk produced by UKM in Cimahi did not cause erythema and edema. Primary irritation index of all bath soap samples was 0.0 . It can be concluded that soap bars containing cow's milk produced by Cimahi City UKM including into the category of very mild irritation (negligigle).
The Effect of Meloxicam Nanocrystal Formation with the Addition of PVP K-60 and Decyl Glucoside as Stabilizers on Its Solubility Sutarna, Titta Hartyana; Meilina, Tika; Al-Hakim, Nur Achsan
Jurnal Kimia Sains dan Aplikasi Vol 28, No 4 (2025): Volume 28 Issue 4 Year 2025
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.28.4.200-207

Abstract

Meloxicam (MLX) is a non-steroidal anti-inflammatory drug that has low bioavailability when administered orally due to its low solubility, and efforts have been made to improve drug delivery to improve solubility. The aim of this study was to prepare and characterize Meloxicam nanocrystals (MLX-NC) and evaluate them with the addition of polyvinylpyrrolidone K-60 (PVP K-60) and decyl glucoside (DG) to prevent nanoparticle aggregation. MLX-NC preparation by a combination of ultrasonic homogenization and the freeze-drying method. The particle size analysis results ranged from 9.76 to 12.73 nm with a polydispersity index <0.5, indicating a homogeneous and stable size distribution. PXRD and DSC characterization revealed the disappearance of the characteristic crystalline peaks of MLX, indicating a transformation to an amorphous form. Additionally, based on saturated solubility studies, the solubility of MLX-NC increased by up to 173 times compared to pure MLX. This study shows that the formulation, initially intended as nanocrystals, resulted in an amorphous solid dispersion due to the influence of stabilizer concentration. This transformation, along with reduced particle size, contributed synergistically to the enhanced solubility of MLX.
FORMULASI DAN EVALUASI MIKROEMULSI KALIUM DIKLOFENAK Sari, Suci Wulan; Sutarna, Titta Hartyana; Ngadeni, Achmad
Kartika : Jurnal Ilmiah Farmasi Vol 9 No 3 (2024)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v9i3.870

Abstract

Diclofenac potassium is a anti-inflammatory drug that can treat mild to severe pain. Diclofenac potassium is often used but has low water solubility and high permeability. This research aimed to evaluate the microemulsion formulation containing diclofenac potassium in vitro. The microemulsion was made by mixing Tween 80: Span 80 (9: 1) as a surfactant, oleic acid as the oil phase, and propylene glycol as a co-surfactant. Evaluation of the diclofenac potassium microemulsion formulation included determining diclofenac potassium levels and in vitro release studies carried out using a modified flow-through method from a Franz diffusion cell and samples were measured by UV-visible spectrophotometry. The results showed that the levels of potassium diclofenac in the microemulsion preparation were respectively 1: 102.57%, formula 2: 101.38%, formula 3: 102.15, and the average diffusion rate test of the microemulsion preparation at F1 0.1147mg/cm2 F2 0.1552 mg/cm2 F3 0.1633 mg/cm2 with a permeation percentage of F1 6.5%, F2 8.8%, F3 9.2% for 180 minutes.
Perbaikan Kelarutan Albendazol Melalui Pembentukan Kristal Multikomponen dengan Asam Malat: Improvement of Albendazole Solubility Through Multicomponent Crystal Formation with Malic Acid Alatas, Fikri; Abdul Azizsidiq, Fahmi; Hartyana Sutarna, Titta; Ratih, Hestyari; Nurono Soewandhi, Sundani
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 1 (2020): (March 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (492.571 KB) | DOI: 10.22487/j24428744.2020.v6.i1.14998

Abstract

An effort to improve the solubility of albendazole (ABZ), an anthelmintic drug has been successfully carried out through the formation of multicomponent crystal with dl-malic acid (MAL). Construction of phase solubility curve of ABZ in MAL solution and crystal morphological observations after recrystallization in the acetone-ethanol (9:1) mixture were performed for initial prediction of multicomponent crystal formation. ABZ-MAL multicomponent crystal was prepared by wet grinding or also known as solvent-drop grinding (SDG) with acetone-ethanol (9:1) mixture as a solvent followed by characterization of the multicomponent crystal formation by powder X-ray diffraction and Fourier transform infrared (FTIR) methods. The solubility of ABZ-MAL multicomponent crystal was tested in water at ambient temperature and in pH 1.2, 4.5 and 6.8 of buffered solutions at 37°C. The phase solubility curve of the ABZ in the MAL solution showed type Bs. The ABZ-MAL mixture has a different crystalline morphology than pure ABZ and MAL after recrystallization in the acetone-ethanol mixture (9:1). The powder X-ray diffraction pattern and the FTIR spectrum of ABZ-MAL from SDG different from intact ABZ and MAL powder X-ray diffraction patterns and these results can indicate the ABZ-MAL multicomponent crystal formation. The ABZ-MAL multicomponent crystal has better solubility than pure ABZ in all media used. These results can be concluded that ABZ-MAL multicomponent crystal can be prepared by solvent-drop grinding method with acetone-ethanol (9:1) mixture as a solvent and can increase the solubility of albendazole.
Utilization rhizome of jahe merah (Zingiber officinale Roscoe) as a bioreductant in the manufacture of gold nanoparticles with addition of polyvinylpyrrolidone 90 (PVP K90) as a stabilizer Sutarna, Titta Hartyana; Alatas, Fikri; Purnamasari, Nira; Rachmah, Mutia Alifah
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 3: September 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v8i3.1964

Abstract

Thel making of gold nanoparticlels (AuNPs) by thel biosyntheltic melthod using plants as biorelductors is onel of thel nanoparticlel synthelsis melthods that is beling carrield out belcausel it is elnvironmelntally frielndly and non-toxic to thel body. Elxtract rhizomel of Reld Gingelr ( Zingibelr officinalel Roscoel ) contains selcondary meltabolitels that function as antioxidants that can bel useld as biorelductor in thel making of gold nanoparticlels. Thel relselarch belgan with thel elxamination of IC50, thel manufacturel of gold nanoparticlels and thel addition of PVP K90 stabilizelr. Thel formation of gold nanoparticlels was madel in selvelral concelntrations, namelly 600 g/mL, 900 g/mL and 1200 g/mL. Theln thel relsults of thel synthelsis of gold nanoparticlels welrel charactelrizeld by visual obselrvation solution color, UV-Vis spelctrophotomeltry, particlel sizel analyzelr and polarization microscopel. Thel relsults obtaineld arel all variations in concelntration can form gold nanoparticlels, but 600 g/mL was choseln belcausel it has thel smallelst particlel sizel compareld to othelr concelntrations. Howelvelr, belcausel gold nanoparticlels elasily and quickly aggrelgatel to form largelr particlel sizels, in this study a stabilizelr in thel form of Polyvinylpyrrolidonel 90 (PVP K90) was addeld. PVP K90 was useld with various concelntrations of 0.5%, 1%, 2% and 5%. Gold nanoparticlels that havel beleln addeld to PVP K90 arel charactelrizeld by visual obselrvation thel color changel of thel solution, thel maximum wavellelngth with spelctrophotomeltry UV-Vis and particlel sizel distribution with a particlel sizel analyzelr, thel relsults obtaineld arel thel addition of 1% concelntration of PVP K90 melt all standards as a stabilizelr of gold nanoparticlels with elxtract rhizomel of reld gingelr.
PENGARUH PENGGUNAAN DUA TIPE ENKAPSULAT PHARMACOAT TERHADAP KARAKTERISTIK MIKROKAPSUL ASAM ASKORBAT Pratiwi, Gladdis Kamilah; Alatas, Fikri; Ratih, Hestiary; Sutarna, Titta Hartyana; Bintary, Dyan; Prianto, Ulla L. F.
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 7 No 4 (2024): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Asam askorbat, suatu vitamin yang larut dalam air, dapat teroksidasi oleh faktor lingkungan dan pembuatan mikrokapsul dengan enkpasulat yang tepat menjadi sangat penting untuk meningkatkan karakteristiknya. Tujuan penelitian ini adalah untuk mengetahui pengaruh penggunaan dua tipe enkapsulat Pharmacoat terhadap karakteristik mikrokapsul asam askorbat. Mikrokapsul asam askorbat dibuat dengan metode penguapan pelarut dengan menggunakan variasi konsentrasi dua tipe Pharmacoat sebagai enkapsulat, yaitu F1 dan F2 menggunakan Pharmacoat 606 dengan rasio asam askorbat-Pharmacoat 606 berturut-turut 1 : 1 dan 2 : 3, sementara F3 dan F4 menggunakan Pharmacoat 615 dengan rasio asam askorbat : Pharmacoat 615 berturut-turut 1 : 1 dan 2 : 3. Etanol digunakan sebagai pelarut polimer dan asam askorbat, parafin cair sebagai fase minyak, dan Span 80 sebagai emulgator. Karakteristik mikrokapsul yang dievaluasi, meliputi penetapan kadar air, uji perolehan kembali, distribusi ukuran partikel mikrokapsul, uji stabilitas terhadap paparan cahaya, dan morfologi mikrokapsul menggunakan Scanning Electron Microscopy (SEM). Hasil evaluasi menunjukkan seluruh formula mikrokapsul memiliki kadar air adalah sekitar 1-3 %, dan distribusi ukuran partikel mikrokapsul pada rentang 250-500 μm. Efisiensi penjeratan mikrokapsul F1, F2, F3, dan F4 berturut-turut adalah 75,67, 86,88, 82,02, dan, 93,72%. F4 memiliki efektivitas paling naik dalam mengurangi oksidasi asam askorbat dari pararan cahaya. Fotomikrograf SEM menunjukkan F4 memiliki morfologi paling baik. Kesimpulannya, mikrokapsul yang dibuat dengan rasio asam askorbat: Pharmacoat 615 (2 : 3) menunjukkan stabilitas terhadap paparan cahaya dan morfologi paling baik. Kata kunci : asam askorbat, mikrokapsul, Pharmacoat® 606, Pharmacoat® 615 DOI : 10.35990/mk.v7n4.p331-340
Evaluation of The Rationality of Hypertension Medication Use in Puskesmas Central Cimahi Hermanto, Faizal; Choirunissa, Anna; Sutarna, Titta Hartyana; Amelia, Riza; Rizwan, Akmal
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.8673

Abstract

A persistent and abnormal increase in blood pressure in the arteries is known as hypertension (HT. This research aims to assess the consumption of antihypertension at the Puskesmas Central Cimahi. Non-analytical descriptive methods were used in this investigation. Retrospective data was collected by accessing patient prescriptions and medical record data. Fifty-six patient samples in this study met the inclusion requirements. Quantitative and qualitative methods are used to evaluate rationality. Quantitative data analysis is processed to determine the number of patients, gender, age, and type of drug classification. Qualitative data analysis is processed to evaluate the appropiate of the indication, drug, patient and dose. Based on the research results, 52 people suffered from stage 1 hypertension, and four patients suffered from stage 2 hypertension. Amlodipine monotherapy was the most frequently prescribed drug, namely 92%. While the combination of amlodipine, captropil, amlodipine, and hydrochlorothiazide amounted to 4%. The rationality of treating hypertensive patients who meet the right indications, the right drug, the right patient and the right dose is 100%. It can be concluded that the evaluation and use of hypertension medication at the Puskesmas Central Cimahi as a whole meets the criteria for rational treatment.
Co-Authors Abdul Azizsidiq, Fahmi Afifah Bambang Sutjiatmo Afifah Bambang Sutjiatmo, Afifah Bambang Ahmad Ngadeni Alya Nur Asilla Amalia Hasna Ambarsundari Ambarsundari Ambarsundari, Ambarsundari Angraeni, Wulan Bintary, Dyan Choirunissa, Anna Dini Tereslina Elivas Simatupang Elivas Simatupang Erina Sifa Mutmainah Euis Reni Yuslianti, Euis Faizal Hermanto Febrianti, Mia Fikri Alatas Frita Ferlita Shafri Djohan Gayatri Simanullang Haq, Fahmy Ahsanul Hestiary Ratih Karin, Amada Lucky Rachmawan Lucky Rachmawan Meilina, Tika Moch. Reza Pratama Ngadeni, Achmad Nira Purnamasari, Nira Nur Achsan Al-Hakim Nurono Soewandhi, Sundani Oskar Skarayadi, Oskar Pratama, Moch. Reza Pratiwi, Gladdis Kamilah Prianto, Ulla L. F. Purwoko, Agus Qotrunnada, Daffa Rachmah, Mutia Alifah Rachmawan, Lucky Ratih, Hestyari Regita Ayu Lestari Ririn Puspadewi Ririn Puspadewi, Ririn Riza Amelia Rizwan, Akmal Sari, Suci Wulan Simatupang, Elivas Sintia Resni Pratiwi Suci Nar Vikasari, Suci Nar Sundani Nurono Soewandhi Sundani Nurono Soewandhi Tresna Lestari, Tresna Wulan Anggraeni Yoga Windu Wardhana