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All Journal Indonesian Journal of Pharmaceutical Science and Technology JURNAL FARMASIMED (JFM) Journal of Pharmaceutical and Health Research Mejuajua Jurnal Pengabdian Masyarakat Tjut Nyak Dhien Jurnal Abdi Masyarakat Multidisiplin Journal of Pharmaceutical and Sciences. Journal of Innovative and Creativity Servitia: Journal of Community Service and Engagement Journal of Pharmascience
Yessi Febriani
Fakultas Farmasi, Universitas Tjut Nyak Dhien, Medan, Sumatera Utara, Indonesia.
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Transportation Other

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Antibacterial and Antifungal Activity Test of N-Hexane, Ethyl Acetate, and Ethanol Extracts of Menteng Leaves (Baccaurea racemosa (Reinw.) Mull.Arg.) Against Candida albicans, Staphylococcus aureus, and Escherichia coli Ika Julianti Tambunan; Yessi Febriani; Yufida Laia; Peronika Tampubolon; Sudewi
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/d6fm3g18

Abstract

Background: Infectious diseases caused by Staphylococcus aureus, Escherichia coli, and Candida albicans remain a global health problem. Since prolonged use of synthetic drugs can cause side effects and resistance, natural alternatives are needed. Menteng leaves (Baccaurea racemosa) contain alkaloids, flavonoids, saponins, steroids/terpenoids, and tannins, which have potential antimicrobial properties. Objective: This study aimed to determine the antibacterial and antifungal activities of n-hexane, ethyl acetate, and ethanol extracts of menteng leaves against S. aureus, E. coli, and C. albicans. Method: The research was conducted experimentally through sample collection, simplicia preparation, successive maceration extraction, phytochemical screening, and antimicrobial testing using the agar well diffusion method. Results: From 500 g of simplicia, 10.5 g of n-hexane extract, 11.4 g of ethyl acetate extract, and 18 g of ethanol extract were obtained. Phytochemical screening showed that all three extracts contained different secondary metabolites, with the ethanol extract having the most complete profile. The highest antimicrobial activity was observed in the ethanol extract, with inhibition zones of 18.92 mm against S. aureus, 18.35 mm against E. coli, and 19.58 mm against C. albicans at a concentration of 200 mg/mL. Conclusion: These results indicate that the ethanol extract of menteng leaves has strong potential as a natural antibacterial and antifungal agent.
Studi Aktivitas Antioksidan Hasil Fermentasi Kopi Arabika (Coffea arabica L.) Dan Andaliman (Zanthoxylum acanthopodium DC.) Yessi Febriani; Salman Salman; Dewi Lestari
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1634

Abstract

Introduction: Arabica coffee (Coffea arabica L.) and andaliman (Zanthoxylum acanthopodium DC.) are recognized as sources of bioactive compounds, particularly phenolic and flavonoid compounds, which have potential antioxidant activity. Fermentation processes may improve the bioactive components of coffee, while the addition of andaliman may enhance its antioxidant potential. However, information regarding the antioxidant activity of fermented Arabica coffee combined with andaliman in various formulations remains limited. Objective: This study aimed to analyze the phytochemical characteristics and antioxidant activity of fermented Arabica coffee with the addition of andaliman in various formulations using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. Methods: An experimental study was conducted using six formulations consisting of F0 (control), F1, F2, F3, F4, and F5 with different amounts of andaliman addition. Phytochemical screening was performed to identify secondary metabolites. Antioxidant activity was evaluated using the DPPH method at sample concentrations ranging from 5 to 25 ppm, while vitamin C was used as a positive control at concentrations of 0.3–0.7 ppm. The sample and DPPH solution were incubated for 30 minutes in a dark condition, and absorbance was measured using a UV-Vis spectrophotometer. The percentage of inhibition and IC₅₀ values were calculated using linear regression analysis. Results: Phytochemical screening showed the presence of alkaloids, flavonoids, tannins, saponins, and phenolic compounds in fermented Arabica coffee with andaliman addition. Antioxidant evaluation demonstrated that all formulations exhibited very strong antioxidant activity. The IC₅₀ values obtained were 28.09 µg/mL for F0, 26.90 µg/mL for F1, 22.10 µg/mL for F2, 17.49 µg/mL for F3, 21.79 µg/mL for F4, and 23.71 µg/mL for F5, while vitamin C showed an IC₅₀ value of 0.08 µg/mL. Formula F3 exhibited the highest antioxidant activity, indicated by the lowest IC₅₀ value among all formulations. Conclusion: Fermentation of Arabica coffee with the addition of andaliman produced very strong antioxidant activity. Formula F3 was identified as the optimal formulation and has potential to be developed as a functional beverage based on local ingredients. Further studies regarding product stability and in vivo antioxidant activity are recommended.
Penguatan Pembelajaran Kimia Industri Melalui Dukungan Modul Ajar Berbasis Kebutuhan Industri di SMK Negeri 1 Air Putih Pravil Mistryanto Tambunan; Aldella Makhfiza; Masdi Masdi; Rara Pramudhita; Yessi Febriani; Desi Natalia Siahaan; Syarifah Nadia
Journal of Community Service and Engagement Vol 2 No 1 (2026): August: Servitia: Journal of Community Service and Engagement
Publisher : CV SCRIPTA INTELEKTUAL MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.65310/r57g3c39

Abstract

The misalignment between vocational education curricula and dynamic industrial requirements contributes significantly to graduate unemployment in the chemical manufacturing sector. This study evaluates a community engagement program designed to strengthen industrial chemistry instruction through the collaborative development and handover of industry integrated teaching modules at SMK Negeri 1 Air Putih in partnership with PT Bakrie Renewable Chemicals. Utilizing a non-empirical, participatory implementation framework, the intervention focused on upstream instructional enhancement without experimental sampling. The program generated a standardized annual teaching module encompassing effective lesson planning, industrial case studies, and safety protocols, thereby shifting instructional approaches toward case based and project based learning. Strategic institutional synergy established clear roles, placing pedagogical design under teacher ownership while the corporate partner provided technical context and document production support. A sustainable roadmap incorporating expert validation, periodic content updates, and digital media integration was established to maintain curriculum relevance. The findings demonstrate that upstream instructional support effectively bridges the school to work transition and reinforces vocational learning quality.  
Formulasi dan Evaluasi Gel Pengharum Serai Wangi dengan Kombinasi Basis Karagenan, Xanthan Gum, dan HPMC Windi Anggraini; Salman Salman; Yessi Febriani; Meutia Indriana; Muzakkir Muzakkir
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1459

Abstract

Background: Unpleasant odors in bathroom areas are a common hygiene problem that requires practical and environmentally friendly solutions. Citronella oil (Cymbopogon nardus L. Randle) is known to contain active compounds with a distinctive aroma that has potential as a natural fragrance agent. However, an appropriate gel base is needed to maintain the stability and aroma retention of the preparation. Objective: This study aims to formulate and evaluate a bathroom fragrance gel from citronella oil with a combination of carrageenan, xanthan gum, and hydroxypropyl methylcellulose (HPMC) bases and to determine the concentration of citronella oil that produces the preparation with the best physical stability and aroma retention. Methods: This research was an experimental laboratory study. Citronella oil was formulated into gel preparations with four concentration variations (2.5%; 5%; 7.5%; and 10%) using a combination of carrageenan, xanthan gum, and HPMC bases. Evaluation of the preparations included organoleptic test, syneresis, liquid evaporation, preference test (hedonic), and aroma retention test for 15 days of storage. Data were analyzed statistically with a 95% confidence level. Results: The results showed that all formulas produced gels with good organoleptic characteristics (cloudy white color, characteristic citronella aroma, and semi-solid texture). The formula with 10% citronella oil concentration (F4) showed the best results with the lowest syneresis value (0.62%), the lowest liquid evaporation percentage (21.69%), and the highest remaining gel weight (92.03%). The preference test showed that F4 had the highest average value (4.25) in the like category, and the best aroma retention with a score range of 4.19-4.70 until day 15. Conclusion: The combination of carrageenan, xanthan gum, and HPMC bases can produce physically stable bathroom fragrance gel preparations. The formula with 10% citronella oil concentration (F4) is the best formulation and has the most potential to be developed as a natural bathroom fragrance product.
Peningkatan Literasi Kesehatan Diabetes Melitus melalui Edukasi Penggunaan Obat Rasional dan Gaya Hidup Sehat di Puskesmas Langkat Yettrie Simarmata; Salman Salman; Meutia Indriana; Ika Julianti Tambunan; Fenny Hasanah; Sudewi Sudewi; Yessi Febriani
 Jurnal Abdi Masyarakat Multidisiplin Vol. 5 No. 2 (2026): Agustus: JURNAL ABDI MASYARAKAT MULTIDISIPLIN
Publisher : Asosiasi Dosen Muda Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56127/jammu.v5i2.3031

Abstract

Diabetes melitus merupakan penyakit kronis yang memerlukan literasi kesehatan yang memadai untuk mendukung penggunaan obat yang tepat, penerapan gaya hidup sehat, dan pencegahan komplikasi. Kegiatan pengabdian kepada masyarakat ini bertujuan meningkatkan literasi kesehatan peserta mengenai diabetes melitus melalui edukasi penggunaan obat yang rasional dan gaya hidup sehat di Puskesmas Langkat. Kegiatan menggunakan desain evaluasi one-group pre-test–post-test dengan melibatkan 30 peserta yang terdiri atas pasien diabetes melitus, keluarga pasien, dan masyarakat berisiko diabetes. Intervensi dilakukan melalui penyuluhan interaktif, pembagian leaflet, diskusi, dan simulasi membaca etiket obat. Pengetahuan dievaluasi menggunakan 10 pertanyaan sebelum dan sesudah intervensi. Hasil menunjukkan bahwa rata-rata skor pengetahuan meningkat dari 56,3 pada pre-test menjadi 84,7 pada post-test, dengan peningkatan sebesar 28,4 poin. Peserta dengan kategori pengetahuan baik meningkat dari 20,0% menjadi 80,0%, sedangkan kategori kurang menurun dari 50,0% menjadi 3,3%. Peningkatan terbesar ditemukan pada pengetahuan mengenai tanda hipoglikemia, kepatuhan penggunaan obat, larangan menghentikan obat tanpa konsultasi, serta komplikasi dan perawatan kaki. Uji Wilcoxon menunjukkan perbedaan yang signifikan antara skor pre-test dan post-test (p < 0,001). Hasil kegiatan menunjukkan bahwa edukasi interaktif yang dikombinasikan dengan informasi praktis mengenai penggunaan obat dapat meningkatkan pengetahuan peserta mengenai pengelolaan diabetes dan berpotensi mendukung kegiatan edukasi kesehatan di pelayanan kesehatan primer.
Co-Authors Aldella Makhfiza Aldy Fardiansyah alma Handayani Lubis Ariyanti Kesuma Wardani Desi Natalia Siahaan Dewi Lestari Ernawaty Ginting Eva Dasopang Eva Sartika Dasopang Fatia Zahra Ika Julianti Tambunan Ira Nofriani Kanne Dachi Kurniawan Sinaga Mariani Razali Mariany Razali Masdi Masdi Meutia Indriana Muhammad Taufik Muharni Saputri Muzakkir Muzakkir Nilsya Febrika Zebua, Nilsya Febrika Nurisma Kemalasari Nurmala Sari Olyvia putri Olyvia putri Peronika Tampubolon Pravil Mistriyanto Tambunan Pravil Mistryanto Tambunan Rara Pramudhita Rika Silvany Rosanna Sembiring Rowina Trinida Sitompul Salman Salman siti muliani julianty Siti Raudah Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sudewi Sumardi Supran Hidayat Sihotang Syarifah Nadia Tri Putri Ananda Vriezka Mierza Windi Anggraini Yettrie Simarmata Yufida Laia Zulfikar Zulfikar