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All Journal Jurnal Ilmiah Farmasi Indonesian Journal of Cancer Chemoprevention Majalah Obat Tradisional Majalah Farmaseutik Jurnal FARMAKU (Farmasi Muhammadiyah Kuningan) HERBAPHARMA : Journal of Herb Farmacological Community Empowerment Journal of Fundamental and Applied Pharmaceutical Science Jurnal Ilmu Kesehatan Bhakti Setya Medika JURNAL JAMU KUSUMA Indonesian Journal of Jamu
Iramie Duma Kencana Irianto
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Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Antibacterial activity of cream, ointment, and emulgel of Ocimum basilicum L. essential oil against Propionibacterium acnes Iramie Duma Kencana Irianto; Ismiyati Ismiyati; Enggar Witaningrum; Elly Nur Ayuningtyas; Meilana Maria Ulfah; Purwanto Purwanto
Majalah Obat Tradisional Vol 28, No 1 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.80909

Abstract

Propionibacterium acnes is bacteria that is commonly found on healthy human skin. However, unbalanced hormonal conditions can lead to excessive growth of P. acnes, a bacteria causing acne. Previous research reported that Ocimum basilicum L. essential oil (BEO) has activity against P. acnes. Therefore, this study aims to make BEO into cream, ointment, and emulgel forms to determine its properties and antibacterial activity on those topical drug delivery systems. The preparations consisted of variations in BEO concentrations of 5%; 10%; and 15%. The three preparations were evaluated based on organoleptic, homogeneity, pH value, adhesion, and spreadability. The antibacterial activity test of the three preparations against P. acnes was carried out by the good diffusion method with the observation of the diameter of the inhibition zone (in mm). The produced cream, ointment, and cream had a typical BEO aroma, yellowish white color, and homogeneous. Based on organoleptic consistency, the texture of the thicker and longer adhesion was ointment > emulgel > cream, respectively. The pH value of the topical preparation was 5-6 and easily leveled. Antibacterial activity against P. acnes from the strongest was ointment > cream > emulgel, with a value of 14,30 + 0,30 mm; 10,54 + 0,01 mm; 3,90 + 0,04 mm, respectively.
Optimizing apothecary through medicinal plant cultivation and education of elderly posyandu cadres in Tegalwaras Nur Ismiyati; Hendra Rohman; Purwanto Purwanto; Ronggo Nurcahyo; Iramie Duma Kencana Irianto
Community Empowerment Vol 8 No 8 (2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/ce.9025

Abstract

As people age, the prevalence of degenerative diseases increases. These diseases can reduce the quality of life and often cause fatal effects, and this happens a lot in Tegalwaras hamlet. Treatment with modern medicine sometimes causes problems such as relatively expensive prices and dangerous side effects so alternatives such as herbal medicines are needed. This community service aims to increase the knowledge of Posyandu Lansia cadres in Tegalwaras about herbs as a therapy for degenerative diseases through counseling and planting medicinal plants. The method of implementation is the preparation stage, counseling, planting medicinal plants, monitoring and evaluation. The results of the program showed an increase in knowledge of 50% after the counseling was carried out.
Formulation and Evaluation of Formalin Washer Fluid Preparation from Garlic Peel Waste (Allium sativum L.) Burhan, Amelia Handayani; Irianto, Iramie Duma Kencana; Azizah, Shyella; Puji, Rian
Journal of Fundamental and Applied Pharmaceutical Science Vol 4, No 2 (2024): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i2.20201

Abstract

Until 2022, there will still be many salted anchovies that contain formalin. This potential danger can be reduced by reducing the levels of formalin that may be contained in salted anchovies before consumption, one of which is by utilizing the saponin content in garlic peel waste. Garlic peel waste powder is proven to be able to reduce formalin levels in salted anchovies by up to 89.12%. However, the use of powder is less practical, and in a certain period, the powder can rot and emit an unpleasant odor. Therefore, an innovation is needed to transform the powder form into a formalin washer fluid. This study aims to determine the effect of garlic peel extract variation on several parameters evaluating the physical properties of formalin washing liquid. The extraction of garlic peel was done using the maceration method and a 70% ethanol solvent. Washing liquids were prepared using glycerin, PEG400, EDTA, and distilled water with varying extract concentrations. Evaluation of physical properties included organoleptic, pH value, specific gravity, viscosity, clarity, and physical stability of formalin washer fluid. The stability test of the physical properties of the sample liquid was carried out using the cycling test method. The samples were kept in storage conditions with extreme temperatures for 3 cycles. In each cycle, the test preparation was stored for 24 hours at 4±2oC and 24 hours at 40±2oC. The formalin washer fluid produced was in the form of a liquid with a weak to pungent garlic aroma, yellow to dark brown in color, homogeneous, clear, and had a pH value of 4. The more extract is used in the formalin washer fluid, the darker the color and the more pungent the garlic aroma will be. Increasing the concentration of garlic peel extract does not affect the pH and clarity of the preparation. The higher the concentration of extract is, the higher the specific gravity and viscosity will be. The selected formula is the formula with a 1% concentration of garlic peel extract.
Aktivitas antibakteri eco-enzyme limbah Citrus sinensis, Musa paradisiaca L. var bluggoe, dan kombinasinya terhadap Staphylococcus aureus Irianto, Iramie Duma Kencana; Purnomo, Krestanto; Amanati, Arfiana; Savila, Dhea; Mardiyaningsih, Ana
Majalah Farmaseutik Vol 19, No 4 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v19i4.79019

Abstract

Pengendalian penularan COVID-19 pada fase transmisi lokal dapat dilakukan dengan penyemprotan cairan disinfektan. Eco-enzyme memiliki banyak manfaat, salah satunya adalah sebagai disinfektan sehingga dapat menangani masalah pengolahan limbah. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri dari eco-enzyme limbah Citrus sinensis, Musa paradisiaca L. var bluggoe, dan kombinasinya terhadap Staphylococcus aureus. Preparasi eco-enzyme dilakukan dengan mencampur limbah, molase dan air pada perbandingan 3:1:10. Fermentasi dilakukan selama 90 hari. Evaluasi berupa organoleptik, nilai pH, skrining fitokimia, dan uji aktivitas antibakteri. Eco-enzyme yang dihasilkan berwarna coklat tua beraroma khas menyengat dan lebih asam dibanding bahan segarnya. Eco-enzyme C.sinensis mengandung alkaloid, polifenol, flavonoid dan saponin. Eco-enzyme M.paradisiaca var. bluggoe mengandung tanin, polifenol, flavonoid dan saponin. Ketiga eco-enzyme yang dihasilkan mampu menghambat pertumbuhan bakteri S.aureus. Urutan aktivitas antibakteri terhadap S.aureus dari yang lebih kuat adalah (1) eco-enzyme M.paradisiaca; (2) eco-enzyme C.sinensis; (3) eco-enzyme kombinasi C.sinensis dan M.paradisiaca var. bluggoe.
Aktivitas Antibakteri Daun Polyscias scutellaria, Carica papaya, dan Kombinasinya terhadap Propionibacterium acnes Mardiyaningsih, Ana; Ismiyati, Nur; Hariyanti, Laras; Irianto, Iramie Duma Kencana; Zaenirohmah, Rizqi Rochim
Majalah Farmaseutik Vol 20, No 1 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v20i1.79184

Abstract

Propionibacterium acnes merupakan salah satu jenis bakteri penyebab jerawat. Bakteri initumbuh pada kondisi anaerob dan lipofilik di daerah pori-pori kulit yang tertutup oleh sel kulit mati dan asam lemak. Kondisi tersebut dipicu oleh ketidakseimbangan hormon yang menyebabkan peningkatan produksi sebum yang disertai hiperkeratinisasi. Klindamisin merupakan antibiotik yang dapat digunakan untuk mengatasi infeksi bakteri P.acnes, namun penggunaannya dalam jangka waktu lama dapat memicu resistensi dan membunuh mikroba baik pada kulit. Alternatif pengobatan jerawat yang aman dan efektif dapat dilakukan melalui pengembangan ekstrak dari P. scutellaria maupun C.papaya, yang berdasar penelitian sebelumnya menunjukkan potensi antimikroba. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri ekstrak heksan daun P.scutellaria, C.papaya serta kombinasinya terhadap P.acnes. Bahan yang diteliti adalah daun P.scutellaria dan C.papaya. Preparasi ekstrak dilakukan dengan metode maserasi menggunakan pelarut heksan. Evaluasi ekstrak meliputi organoleptik, rendemen, susut pengeringan dan analisis kualitatif dengan KLT. Uji aktivitas antibakteri terhadap P.acnes ATCC6919 menggunakan metode difusi cakram dengan kontrol negatif DMSO, dan kontrol positif klindamisin. Ekstrak yang diperoleh memiliki karakteristik spesifik sesuai dengan bahan baku. Rendemen kedua ekstrak yang diperoleh ¼ dari bobot serbuk awal. Susut pengeringan kedua ekstrak sangat kecil (<1%). Baik P.scutellaria maupun C.papaya mengandung banyak senyawa golongan terpenoid. Aktivitas antibakteri ekstrak heksan daun C.papaya lebih kuat dibandingkan P.scutellaria. Kombinasi kedua ekstrak dengan perbandingan 1:1 menunjukkan aktivitas antibakteri yang tertinggi dibandingkan dengan perlakuan yang lain. Kombinasi kedua ekstrak tergolong dalam antibakteri kuat
Analisis Penangkapan Radikal Bebas Jamu Rosella dan Fenolik Totalnya Nurhaeni, Farisya; Purwanto, Purwanto; Irianto, Iramie Duma Kencana; Fiqoh, Latifah Nisa; Ardiyanti, Febriana
Majalah Farmaseutik Vol 20, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v20i2.92578

Abstract

Dengan semakin berkembangnya tingkat aktivitas manusia, semakin tinggi pula prevalensi penyakit-penyakit yang diakibatkan oleh radikal bebas, yang salah satunya disebabkan oleh pola hidup dan polusi yang ada. Untuk menanggulangi radikal bebas tersebut diperlukan antioksidan, yang mana salah satu sumber utamanya adalah dari tanaman herbal. Guna meningkatkan pemanfaatan herbal tersebut, pembuatan sediaan seperti jamu adalah diperlukan karena sediaan ini yang banyak diminati masyarakat. Dalam penelitian ini, herbal seperti bunga rosella, rimpang kunyit, rimpang jahe, sereh, dan jeruk nipis dipilih sebagai bahan jamu godhog yang kaya akan antioksidan. Dalam hal sebagai sediaan jamu, produk ini terbukti cukup aktif dapat menangkap radikal bebas dengan reagen DPPH. Kandungan fenolik dan flavonoid dalam sediaan jamu tersebut adalah komponen utama yang bertanggung jawab terhadap aktivitas penangkapan radikal bebasnya.
EVALUASI KESESUAIAN PERESEPAN OBAT PADA PASIEN RAWAT JALAN POLI PENYAKIT DALAM DENGAN FORMULARIUM NASIONAL DI RSUD PRAMBANAN Khasanah, Uswatun; Mayasari, Gita; Irianto, Iramie Duma Kencana
Jurnal Farmaku (Farmasi Muhammadiyah Kuningan) Vol. 7 No. 1 (2022): Volume 7 Nomor 1 Maret 2022
Publisher : STIKes Muhammadiyah Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55093/jurnalfarmaku.v7i1.283

Abstract

Pelayanan obat untuk peserta Jaminan Kesehatan Nasional (JKN) yang diselenggarakan oleh BPJS Kesehatan mengacu pada daftar obat Formularium Nasional. Formularium Nasional adalah daftar obat terpilih yang disusun oleh Komite Nasional yang penyusunannya didasarkan bukti ilmiah terkini, berkhasiat, aman, dan bermutu, yang digunakan sebagai acuan penulisan resep, sehingga dapat meningkatkan mutu pelayanan kesehatan, melalui peningkatan efektifitas dan efisiensi pengobatan sehingga tercapai penggunaan obat rasional. Penelitian ini bertujuan untuk mengetahui persentase kesesuaian peresepan obat pada pasien rawat jalan peserta JKN poli penyakit dalam dengan Formularium Nasional di RSUD Prambanan Desember 2019. Penelitian ini berjenis deskriptif dengan metode pengumpulan data secara retrospektif berdasarkan dokumen resep pada bulan Desember 2019. Pengambilan sampel menggunakan systematic random sampling. Jumlah resep pasien peserta JKN di poli penyakit dalam sebanyak 1403 lembar resep dengan kriteria inklusi sebanyak 1279 lembar resep. Sampel yang digunakan sebanyak 214 lembar resep dengan 1038 obat yang ditulis oleh dokter spesialis penyakit dalam yang kemudian data tersebut diolah dan dihitung persentase kesesuaian jenis obatnya dengan Formularium Nasional. Persentase kesesuaian peresepan obat pada pasien rawat jalan peserta JKN poli penyakit dalam dengan Formularium Nasional di RSUD Prambanan sebesar 98,84%. Persentase obat generik yang sesuai Formularium Nasional sebesar 99,58%. Persentase obat bermerk (brand) yang sesuai Formularium Nasional sebesar 97,21%. Obat yang paling banyak diresepkan dan sesuai dengan Formularium Nasional antara lain amlodipine 5 mg, asam asetilsalisilat 80 mg, kandesartan 8 mg, natrium bikarbonat serta metformin 500 mg. Obat yang paling banyak diresepkan dan tidak terdapat dalam Formularium Nasional adalah Intifen® 1 mg.
Formulation of Fermented Earthworm (Lumbricus rubellus) Lotion as a Therapy for Atopic Dermatitis Irianto, Iramie Duma Kencana; Kurniadi, Muslih; Ismiyati, Ismiyati; Trilestari, Trilestari
Jurnal Jamu Indonesia Vol. 10 No. 2 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i2.358

Abstract

The prevalence of atopic dermatitis in industrialised countries has increased two- to threefold over the past 30 years. Fermented earthworm (Lumbricus rubellus) extract has been shown to effectively reduce atopic dermatitis by increasing interleukin-10 (IL-10) and FOXP3, and decreasing interleukin-5 (IL-5), interleukin-31 (IL-31), immunoglobulin E (IgE), and eosinophils. The extract has also been reported to inhibit the growth of skin surface bacteria, particularly Streptococcus aureus, at a minimum inhibitory concentration (MIC) of 0.625%. L. rubellus contains lumbricin-I, proline-rich antimicrobial peptides (AMPs), lumbrokinase, lysenin, and coelomic cytolytic factor-1 (CCF-1), which play important roles in anti-inflammatory and antibacterial responses. Cetyl alcohol influences the viscosity of semi-solid preparations, thereby affecting the lotion's quality and stability. This study aimed to determine the optimum concentration of cetyl alcohol in the formulation of fermented L. rubellus lotion with good physical characteristics. The lotion was formulated by varying the concentration of cetyl alcohol and comparing it with commercial lotion based on organoleptic properties, pH, adhesion, spreadability, and physical stability using a cycling test. Lotion formulas F2 (0.5% cetyl alcohol) and F3 (1% cetyl alcohol) exhibited physical properties similar to the positive control, remained semi-solid, and were comfortable to use. A 1% concentration of cetyl alcohol was found to be optimal for maintaining pH stability and spreadability of the fermented L. rubellus lotion.
Identifikasi Prednison dan Piroxicam dalam Jamu Pegel Linu di Yogyakarta dengan Metode Kromatografi Lapis Tipis Burhan, Amelia Handayani; Irianto, Iramie Duma Kencana; Indraswari, Laksita Putri; Saputri, Lintang Handoyo
Jurnal Ilmu Kesehatan Bhakti Setya Medika Vol 9 No 2 (2024): Jurnal Ilmu Kesehatan Bhakti Setya Medika
Publisher : Politeknik Kesehatan Bhakti Setya Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56727/bsm.v9i2.141

Abstract

 Herbal medicine (Jamu) is a part of Indonesian cultural heritage passed down through generation. One of the commonly consumed “Jamu” in Yogyakarta is “Jamu Pegal Linu” (herbal medicine for aches and pains). Competition among “Jamu” producers often leads to the addition of chemicals subtances to enhance the drug’s effectiveness. This practice is strictly prohibited due to its potential adverse health effects. Prednisone and piroxicam, which are pharmaceutical compounds, are suspected to be frequently added to “Jamu Pegal Linu”. Therefore, this study aims to identify the presence of prednisone and piroxicam in “Jamu Pegal Linu” available in Yogyakarta. Sampel of “Jamu Pegel Linu” were collected using a purposive sampling method from herbal  shops in the Yogyakarta area. The samples were extracted using 96% ethanol. The extracted samples were then spotted onto a TLC plate, which was placed in a saturated chamber. The mobile phase used to identify prednisone were ethyl acetate: chloroform in  ratios of 9:1, 6:4, and 8:2; whereas for piroxicam, three mobile phases were used: chloroform : acetone (80: 20), ethyl acetate : methanol : ammonia (60: 30: 10), and chloroform : methanol (100: 5). The stationary phase used was a silica gel GF254 plate. A sample was considered positive if the Rf value and the color of the spot of the spot matched those of the reference standard. The results of the study, using the thin-layer chromatography (TLC) method, showed that none of herbal medicine samples for aches and pains circulating in the Special Region of Yogyakarta contained prednisone or piroxicam. Therefore, the analyzed herbal medicine samples are considered safe for public consumption.
Formulation and Organoleptic Evaluation of Roselle (Hibiscus sabdariffa) Jamu Godog with Stability and Microbial Quality Assessment Irianto, Iramie Duma Kencana; Purwanto; Nurhaeni, Farisya; Ana Mardiyaningsih; Bangkit Ary Pratama; Fiqoh, Latifah Nisa; Febriana Ardiyanti
Journal of Fundamental and Applied Pharmaceutical Science Vol. 6 No. 1 (2025): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v6i1.22102

Abstract

Jamu is a traditional medicinal preparation proven to have many pharmacological properties and is widely used in Indonesian society. Unfortunately, many people do not like herbal medicine because of its unpleasant taste and odor. This phenomenon has driven much research in modifying the organoleptic parameters of jamu to make it more acceptable to the tongues and noses of consumers while still having a potent effect on health. This study, thus, aimed to formulate a roselle (Hibiscus sabdariffa)-enhanced jamu godog (traditional Indonesian herbal decoction) and evaluate its organoleptic properties, physical stability, and microbial quality. Jamu godog was prepared by sequentially boiling and mixing ground ginger, turmeric, lemongrass, roselle, rock sugar, and lime, with roselle concentrations set at 0%, 0.3%, and 0.6%. Organoleptic attributes and pH stability were assessed before and after storage at 4°C and 25°C for seven days. Microbial contamination was measured via total plate count (TPC) after storage at 4°C for three and seven days. A hedonic test with 40 participants across two age groups evaluated sensory acceptance. Results indicate that the addition of roselle at 0.3% concentration optimized taste and overall acceptability while maintaining pH stability and microbial safety within BPOM standards throughout the storage period. This formulation demonstrates potential as a palatable and microbiologically safe herbal preparation with enhanced consumer acceptance.  
Co-Authors Adhyatmika Adhyatmika Aini Febriana Aini Febriana  Aini, Rahma Nur Alwhan Nurrochman Amanati, Arfiana Ana Mardiyaningsih Ana Mardiyaningsih Ardiyanti, Febriana Azizah, Shyella Bangkit Ary Pratama burhan, Amelia handayani Dian Purwita Sari Elly Nur Ayuningtyas Enggar Witaningrum Farisya Nurhaeni Febriana Ardiyanti Fiqoh, Latifah Nisa Gita Mayasari Hariyanti, Laras Hendra Rohman Indraswari, Laksita Putri Ismiyati Ismiyati Ismiyati, Ismiyati Karinda Paramastri Dewi Kurniadi, Muslih Marwan Triafrian Mardan Mayasari, Gita Meilana Maria Ulfah Munawaroh, Umu Azizah Nur Ismiyati Nur Ismiyati Nur Ismiyati Puji, Rian Purnomo, Krestanto Purwanto Purwanto Purwanto Purwanto Purwanto Purwanto Purwanto Purwanto Purwanto Rangga Pramudya Saputra Ronggo Nurcahyo Ronny Martien Rony, Zahara Tussoleha Saputri, Lintang Handoyo Savila, Dhea Sembiring, Rinawati Sylvia Utami Tunjung Pratiwi Tri Sumarlini Triana Hertiani trilestari, trilestari Uswatun Khasanah Vertika Susandy Zaenirohmah, Rizqi Rochim