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All Journal Jurnal Sain Veteriner Jurnal Veteriner Berkala Ilmu Kesehatan Kulit dan Kelamin Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan JBN (Jurnal Bedah Nasional) Jurnal Plastik Rekonstruksi JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Psikiatri Surabaya (Surabaya Psychiatry Journal) Indian Journal of Forensic Medicine & Toxicology Jurnal Rekonstruksi dan Estetik MEDICINUS Medical Sains : Jurnal Ilmiah Kefarmasian Folia Medica Indonesiana
Iswinarno Doso Saputro
Departemen Bedah Plastik Rekonstruksi Dan Estetik, Fakultas Kedokteran, Universitas Airlangga/RSUD Dr. Soetomo, Surabaya
Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Veterinary Other

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PROFILE OF KELOID PATIENTS IN SURGICAL WOUNDS: A STUDY AT DEPARTMENT OF PLASTIC AND RECONSTRUCTIVE SURGERY, DR. SOETOMO GENERAL ACADEMIC HOSPITAL, SURABAYA, INDONESIA (2019-2022) Nurfaiza, Diandra Yasmin; Saputro, Iswinarno Doso; Indramaya, Diah Mira; Aruja Dhar; Saleh Ashafi; Milan Muhammed
Jurnal Rekonstruksi dan Estetik Vol. 10 No. 1 (2025): Jurnal Rekonstruksi dan Estetik, June 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jre.v10i1.66572

Abstract

Highlights: Previous keloid surgery mostly caused keloid recurrence. The most common symptom that accompanies keloids in surgical wounds was itching. Surgery and combination therapy were the most used therapy. Abstract: Introduction:   Keloid is an abnormal scar resulting from disruptions in the wound healing process. Clinically, keloids extend beyond the original wound margins and progressively enlarge into dense, firm nodules. They can develop following various forms of trauma, including surgical procedures. Several factors contribute to keloid formation in surgical wounds, such as age, gender, genetics, skin color, hormones, incision location, wound tension, and delayed healing. Methods: This retrospective descriptive study analyzes medical records of patients diagnosed with keloids due to surgical wounds at the Department of Plastic and Reconstructive Surgery, Dr. Soetomo General Academic Hospital, Surabaya, between 2019 and 2022. Results: Among 58 keloid patients, 23 developed keloids following surgery. The most common risk factor was a history of previous keloid surgery. The majority of patients were female, aged 17–25 years, students, and had no family history of keloids. The most frequent keloid location was the chest, with an onset of ≥1 year, a size of <20 cm², and associated itching. Surgical excision and combination therapy were the most commonly used treatment approaches. Conclusion: Previous keloid surgery is the primary risk factor for developing keloids in surgical wounds. Surgery and combination therapy remain the most frequently employed treatment strategies.
Patients’ Profile of Cleft Lip and Palate : 3 Years Evaluation at Surabaya CLP Center Foundation Widjaja, Febe Alodia; Saputro, Iswinarno Doso
Jurnal Plastik Rekonstruksi Vol. 11 No. 2 (2024): (2024) Jurnal Plastik Rekonstruksi
Publisher : The Lingkar Studi Bedah Plastik Foundation and is affiliated with the Department of Plastic Surgery, Faculty of Medicine, Universitas Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14228/jprjournal.v11i2.381

Abstract

Introduction: Cleft lip and cleft palate are the most common birth defects affecting newborns, yet their variability across each geographic origin is not clearly understood. This study aims to investigate the CL/P prevalence, profile, and corrective surgery timing in Surabaya, Indonesia.Method: This retrospective research used a descriptive method by collecting medical data records from the Surabaya CLP Center Foundation from January 2021 to December 2023, which related to sociodemographic problems, clinical features, and management timing were then statistically analyzed.Results: A total of 495 patients underwent cleft surgery, of which 59.4% were male and 40.6% were female. The most common type of Craniofacial Cleft observed is Combination Cleft Lip and Palate “CLP” (71.1%). CLP is more common in male patients than in female patients (43.4% vs. 27.7%); while CL is more common among males (14.1% vs. 9.7%) and CP is more common in females (3.2% vs. 1.8%). Significantly, complete clefts (72.9%) were more common than the incomplete clefts (27.1%). Unilateral clefts were more common than bilateral clefts (76.2% vs 18.8%). It was observed that only 22% of patients had a family history of CL/P. Overall, 74,9% of patients underwent corrective surgery within the right period.Conclusions: The data shows that most patients tended to seek medical advice and treatment at appropriate times, suggesting a high awareness of CLP as the result of proactive education and social outreach by the charity institution. Further investigations using data from other institutions are suggested to conclude the CLP management in Surabaya entirely.
THERAPEUTIC POTENTIAL OF SNAIL MUCUS IN WOUND HEALING : A SYSTEMATIC REVIEW AND META-ANALYSIS Widjaja, Febe Alodia; Saputro, Iswinarno Doso; Asmaradianti, Aryunidya; Sindhu, Florencia Christina; Fabian, Pascalis; Irsyan Baginda Maulana
Jurnal Rekonstruksi dan Estetik Vol. 10 No. 2 (2025): Jurnal Rekonstruksi dan Estetik, December 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jre.v10i2.72008

Abstract

Highlights: Snail mucus extract significantly improves wound healing rates compared to standard treatments. A meta-analysis of randomized controlled trials (RCTs) showed a statistically significant effect (MD = -3.21%, P < 0.00001). The bioactive compounds in snail mucus promote collagen production and reduce inflammation. Abstract Introduction: Wound healing is a fundamental biological process comprising four sequential and overlapping phases: hemostasis, inflammation, proliferation, and remodeling. The successful restoration of tissue integrity requires that these phases proceed in the correct order and within an appropriate temporal framework. Proteins are indispensable to this process, as they mediate tissue growth, cellular renewal, and reparative mechanisms. Snail mucins, a class of large glycosylated proteins, have been reported to facilitate wound healing by stabilizing protein structures, modulating solubility and viscosity, and enhancing cell–cell recognition. In light of these properties, we conducted a meta-analysis of randomized controlled trials (RCTs) to assess the therapeutic efficacy of snail mucus extract in promoting wound repair. Method: RCTs on snail mucus extract for wound healing were identified through searches of PubMed, ProQuest, Web of Science, ScienceDirect, Scopus, EBSCOHost, and ClinicalTrials.gov. The review adhered to PRISMA guidelines, applied the PICO framework, and assessed study quality using the JADAD scale. Result: A total of 60 rats from three RCTs conducted between 2021 and 2023 were included in the meta-analysis. The findings demonstrated that the snail mucus group exhibited a significantly improved wound healing rate compared to the control group (MD = -3.21%, 95% CI: -3.72 to -2.69%, P < 0.00001). Conclusion: Snail mucus extract has been shown to significantly accelerate wound healing in animal models; however, further clinical studies are required to confirm its therapeutic efficacy in humans.
Elevated Serum Transaminase (SGOT/SGPT) and Sepsis in Burn Patients in a Tertiary Hospital, Surabaya, Indonesia Saputro, Iswinarno Doso; Zarasade, Lobredia; Kurniawan, Rifqi
Folia Medica Indonesiana Vol. 58, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: • There is no correlation between the increase of SGOT and sepsis. • Correlation between the increase of SGPT and sepsis was significant founded. Abstract: Burns trigger hypermetabolic stress reactions that cause inflammatory responses. When there is a sustained or increased hypermetabolic reaction, the inflammatory response can be life-threatening, such as sepsis, and significantly impact hepatic metabolic function. After burns, varying degrees of liver injury are usually associated with burn severity. This study determined the correlation between elevated serum transaminases (SGOT/ SGPT) and sepsis in burn patients at a tertiary hospital of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, from January 1, 2018, to December 31, 2020. This was a descriptive-analytic study with a retrospective cohort design. The data in this study included the demography of burn patients, causes of burns, inhalation trauma, burn severity, increased serum transaminase (SGOT/SGPT), mortality, and sepsis. This study found that the correlation between elevated serum transaminases (SGOT/SGPT) and sepsis was determined using the Spearman-Rho Rank statistical test. Burn patients with sepsis in the hospital were dominated by males (65.2%) and mostly aged 26-55 years (69.6%). The flame was found to be the highest cause of burns (80.4%), burn area above 20% (91.3%), the highest level of severity was major burn (91.3%), and no inhalation trauma (54.3%). In this study, there was an increase in SGOT of 69.6% and SGPT of 78.3%, with a mortality rate of 39.1%, with average inpatient days of 24 days. The correlation test between elevated serum transaminase (SGOT) and sepsis showed an insignificant relationship (p = 0.065, p> 0.05) with a correlation coefficient of 0.200. In contrast, the correlation between elevated serum transaminase (SGPT) and sepsis was significant (p=0.006, p<0.05) with a correlation coefficient of 0.296.
Effect of platelet rich plasma (prp) to autogenous bone graft Saputro, Iswinarno Doso; Hutagalung, Magda Rosalina; Wahdini, Siti Isya
Folia Medica Indonesiana Vol. 53, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

Bone graft use in maxillofacial surgery is currently developing, though some problems still persist. One of promising solutions to the problems is application of platelet rich plasma which may accelerate soft tissue healing and bone formation. This study aims to provide basic understanding to the development of PRP application in bone healing where bone graft is applied on human maxillae. Bone defects were made on maxillae of albino rabbits, with an application of bone graft in control group and bone graft plus PRP in treatment group. Histopathological analysis was performed in both groups to assess osteoblast density and collagen tissue area. On day 21st, more osteoblast density and collagen area in treatment group are significantly observed (p<0.05, 95% confidence interval). Observations were made on hard callus formation. In conclusions, platelet rich plasma may increase density of osteoblast in rabbit maxillary bone graft.
Co-Authors Agus Santoso Budi, Agus Santoso Amandita, Tiara Amatullah, Nida' Fahima Ardia Respati Hapsari Aruja Dhar Aryati Asmaradianti, Aryunidya Azzahra, Alya Mutiara Diah Mira Indramaya Dwi Murtiastutik Evy Evrianti Fabian, Pascalis Hamiseno, Gifta Marshanda Qanitah Hariani, Lynda Hasan, Helmia Hesty Aulia Palupi Hutagalung, Magda Rosalina Huvi, Indira I Made Suka Adnyana Irsyan Baginda Maulana Karimah, Azimatul Kurniawan, Rifqi Kusuma, Diana Murtiati Lilihata, Jilvientasia Godive Medisa Primasari Milan Muhammed Muhaimin Rifa’i N, Priscilla Valentin Nata’atmadja, Beta Subakti Ningrum, Laras Puspita Noverta, Dhitta Aliefia Nur Aida Nurfaiza, Diandra Yasmin Oki Nugraha Putra Perdanakusuma, Arda Rahmanisa Perdanakusuma, David Sontani Prasetyo, Arif Tri Putri, Nadia Tamara Rahel Yuana Sadikim Revita Widya Prasanti Rifqi Kurniawan Rizaliyana, Sitti Saleh Ashafi Salsabilla Gina Rania Samiyah Septin Mauludiyana Setya, Aldy Mulia Hati Sindhu, Florencia Christina Sintaningrum, Elisabeth Prajanti U H, Muhammad Aulia Vaniode Dyahayu Vitari Wahdini, Siti Isya Waode Fifin Ervina Wardhani, Rr. Indrayuni Lukitra Widjaja, Febe Alodia Willy Sandhika Wiwik Misaco Yuniarti Yoes Prijatna Dachlan Zakanito, Marelno Zarasade, Lobredia