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All Journal Medicina E-Jurnal Medika Udayana Berkala Ilmu Kesehatan Kulit dan Kelamin ISM (Intisari Sains Medis) : Jurnal Kedokteran Bali Dermatology and Venereology Journal

I Gusti Ayu Agung Dwi Karmila

Departemen Dermatologi Dan Venereologi FK Udayana / RSUP Prof. Dr. IGNG Ngoerah Denpasar, Bali, Indonesia

Author-ID : 2936181

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Profil dermatitis kontak akibat kerja pada pekerja garmen di Kota Denpasar Made Wardhana; Made Martina Windari; I Gusti Ayu Agung Dwi Karmila; Ni Luh Putu Ratih Vibriyanti Karna; Ni Made Dwi Puspawati; I Gusti Ayu Agung Praharsisni; Luh Made Mas Rusyati; Nyoman Suryawati
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Background: The development of the garment industry in Bali is increasing as a tourism supporting industry. As a consequence the number of garment and textile companies is growing in quantity and quality. According to data in the Denpasar City, there were around 125 large garment companies employing at least 100 workers. A small garment company as a home industry is almost five hundred. The impact of the development of the garment industry requires a lot of human resources by recruiting, opening jobs both for trained and untrained workers, most of whom are casual workers, without getting attention in terms of health. This research was conducted to collect data about the pattern of skin lesions (work-related contact dermatitis) in garment workers in Denpasar City because they do not have complete and accurate data.Methods: The method used in this study was a survey on three large garment companies in Denpasar with interviews and examinations of their skin disease patterns.Results: Total 288 workers included in this study consisted of 105 (36.5%) men and 183 (63.5%) women. From 288 respondents, 74 workers (25.7%) suffer from skin disorders related to their work. The occupational category that suffered the most was colouring workers of 30 people.Conclusion: The pattern of skin disease in garment workers by 25.7% suffering from DKAK. Disease categories are often workers who come into contact with colour materials.Â Latar Belakang: Perkembangan industri garment di Bali semakin meningkat sebagai salah satu industri penunjang pariwisata. Sebagai konsekuensi jumlah perusahan garmen dan tekstil semakin banyak secara kuantitas dan kualitas. Menurut data di kodya Denpasar, tercatat sekitar 125 perusahan garmen yang besar dengan memperkerjakan sedikitnya 100 orang pekerja. Perusahan garmen yang kecil sebagai industri rumah tangga hampir sebanyak lima rastusan. Dampak dari perkembangan industri garment membutuhkan banyak tenaga kerja dengan merekrut, membuka lapangan pekerjaan baik itu untuk pekerja yang terlatih maupun yang tidak terlatih, kebanyakan merupakan pekerja lepas, tanpa mendapat perhatian dari segi kesehatan. Penelitian ini dilakukan untuk mengumpulkan data tentang pola kelainaan kulit pada(DKAK) pekerja garmentÂ di Kodya Denpasar, karena belum memiliki data yang lengkap dan akurat.Metode: Metode yang digunakan pda penelitian ini adalah survelanse, pada 3 perusahan garment yang besar di Denpasar dengan wawancara dan pemeriksaan terhadap pola penyakit kulitnya.Hasil: Dari 288 pekerja yang di ikut sertakan dalam penelitian ini terdiri dari 105 (36,5%) laki-laki dan 183 (63,5%) perempuan. Dari 288 responden, sebanyak 74 pekerja (25,7%) yang menderita kelainan kulit yang berhubungan dengan pekerjaannya. Katagori pekerjaan yang paling banyak menderita adalah pada pekerja pencelupan (coloring) sebesar 30 orang.Simpulan: Pola penyakit kulit pada pekerja garment sebesar 25,7% menderita DKAK. Katagori penyakit sering adalah pekerja yang berhubungan kontak dengan bahan warna.

Profil onikomikosis pada pasien lanjut usia di Rumah Sakit Umum Pusat Sanglah, Bali, Indonesia: studi retrospektif I Gusti Ayu Agung Dwi Karmila; Made Swastika Adiguna; Luh Made Mas Rusyati
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Background: Fungal infections are one of the most common dermatologic conditions affecting elderly population. Elderly population is susceptible to all of the superï¬cial mycoses such as tinea pedis, candidiasis, and onychomycosis in geriatric populations compared to other age groups.Objective:Â To determine the profile of onychomycosis among elderly patients over a period of 1 years (January 2018â€“August 2019) at Dermatology and Venereology outpatient clinic, Sanglah General HospitalMethods:Â Retrospective study was performed at Department of Dermatology and Venereology, Sanglah General Hospital, Denpasar, Bali. The data collected from patientâ€™s register data of outpatient clinic.Result:Â A total of 11 patients were diagnosed with onychomycosis, consist of 5 women and 6 men. From these, 4 (36,3%) was reported with chronic systemic diseases and 7 (63,6%) reported with no concomitant diseases. The most common clinical sign were onychodystrophy, hyperkeratotic subungual and dyschromia (6 patients, 54,54%). Potassium hydroxide examination reveal positive results in all patient. From 5 patients, on culture examination, Candida (2 patients, 40%), Trichophyton rubrum (2 patients, 40%), and Trychophyton mentagrophytes (1 patient, 20%) were found. For therapy, there were 7 patients got combination therapy (fluconazole 150 mg and ciclopirox lacquer 8%) and 4 patients with single therapy (ciclopirox lacquer 8%).Conclusion: Onychomycosis is more common in the elderly or geriatric patients, this occurs because old age can change the body's immune function, including decreased immune response to fight infections against viruses, bacteria, and fungi. Â Pendahuluan: Infeksi jamur adalah salah satu kondisi dermatologis paling umum yang mempengaruhi populasi lansia. Populasi lansia rentan terhadap semua mikosis superfisial seperti tinea pedis, kandidiasis, dan onikomikosis pada populasi geriatri dibandingkan dengan kelompok usia lainnya.Tujuan:Â Untuk menentukan profil onikomikosis pada pasien usia lanjut selama 1 tahun (Januari 2018 - Agustus 2019) di poliklinik rawat jalan Dermatologi dan Venereologi, Rumah Sakit Umum Pusat Sanglah.Metode:Â Studi retrospektif dilakukan di Departemen Dermatologi dan Venereologi, Rumah Sakit Umum Pusat Sanglah, Denpasar, Bali. Data dikumpulkan dari data pendaftaran pasien di klinik rawat jalan.Hasil:Â Sebanyak 11 pasien didiagnosis menderita onikomikosis, terdiri dari 5 wanita dan 6 pria. Dari hasil ini, sebanyak 4 orang (36,3%) dilaporkan dengan penyakit sistemik kronis dan 7 orang (63,6%) dilaporkan tanpa penyakit bersamaan. Tanda klinis yang paling umum adalah onikodistrofi, hiperkeratotik subungual dan dischromia (6 pasien, 54,54%). Pemeriksaan kalium hidroksida mengungkapkan hasil positif pada semua pasien. Dari 5 pasien pada hasil pemeriksaan kultur ditemukan adanya infeksi Candida (2 pasien, 40%), Trichophyton rubrum (2 pasien, 40%), dan Trychophyton mentagrophytes (1 pasien, 20%). Untuk penatalaksanaan, terdapat sejumlah 7 orang pasien mendapatkan terapi kombinasi (fluconazol 150 mg dan ciclopirox lacquer 8%) dan 4 orang pasien dengan terapi tunggal (ciclopirox lacquer 8%).Simpulan: Onikomikosis lebih sering terjadi pada pasien usia lanjut atau usia lanjut dimana hal ini terjadi karena usia tua dapat mengubah fungsi kekebalan tubuh, termasuk penurunan respons imun untuk melawan infeksi terhadap virus, bakteri, dan jamur.

Korelasi jumlah sel CD4 dengan skor nugent pada wanita dengan infeksi human immunodeficiency virus Ni Made Dwi Puspawati; Anak Agung Gde Putra Wiraguna; I Gusti Ayu Agung Dwi Karmila; I Ketut Agus Somia
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Introduction: CD4 cell counts are still used to assess disease progression due to infection with Human Immunodeficiency Virus (HIV). The lower the number of CD4 cells, the more susceptible patients are to various kinds of opportunistic infections. Nugent Score is a rating system to determine the presence of Lactobacillus which is a normal microbiota in the vaginal ecosystem. The purpose of this study was to determine the relationship of CD4 cell counts with Nugent scores in HIV-infected women.Method: This study is an analytic study with a cross-sectional approach in women with HIV infection in Sanglah Hospital Denpasar. Sampling with consecutive sampling technique. For each sample, venous blood was taken to measure CD4 cell counts and gram stains were examined from a vaginal swab to measure Nugent's score.Results: The study found the average age of the study sample was 36.42 years. Most of the samples had a normal Nugent score (0-3) with a CD4 count> 500 or were not immunodeficient (34%). There was a significant difference in the Nugent score based on the number of partners owned (p<0.05). There was no significant difference in Nugent's score based on condom use, vaginal wash and smoking history (p>0.05). The majority of patients who experienced immunodeficiency, mild immunodeficiency, and moderate immunodeficiency had normal Nugent scores (47.1%, 80%, 54.5%, respectively). Only the group with the most severe immunodeficiency had bacterial vaginosis (57.1%).Conclusions: No significant differences were found between CD4 cell counts and Nugent scores. This can be caused because there is no relationship between the two or because of confounding factors that have not been controlled. Further research needs to be done by correcting confounding factors so that subsequent research can improve precision.Â Pendahuluan: Jumlah sel CD4 sampai saat ini masih digunakan untuk menilai perkembangan penyakit akibat infeksi Human Immunodeficiency Virus (HIV). Semakin rendah jumlah sel CD4 semakin rentan penderita terhadap berbagai macam infeksi oportunistik. Skor Nugent adalah sistem penilaian untuk mengetahui keberadaan Lactobacillus yang merupakan mikrobiota normal pada ekosistem vagina. Tujuan penelitian ini untuk mengetahui hubungan jumlah sel CD4 dengan skor Nugent pada wanita terinfeksi HIV.Metode: penelitian ini merupakan penilitian analitik dengan pendekatan cross-sectional pada wanita dengan infeksi HIV di RSUP Sanglah Denpasar. Pengambilan sampel dengan teknik consecutive sampling. Pada setiap sampel dilakukan pengambilan darah vena untuk pengukuran jumlah sel CD4 dan pemeriksaan pengecatan gram dari swab vagina untuk mengukur skor Nugent.Hasil: penelitian didapatkan rerata usia sampel penelitian adalah 36,42 tahun. Sebagian besar sampel memiliki skor Nugent normal (0-3) dengan jumlah CD4 >500 atau tidak imunodefisiensi (34%).Terdapat perbedaan signifikan pada skor Nugent berdasarkan jumlah pasangan yang dimiliki (p<0,05). Tidak ada perbedaan signifikan pada skor Nugent berdasarkan penggunaan kondom, pencuci vagina dan riwayat merokok (p>0,05). Mayoritas pasien yang mengalami imunodefisiensi, imunodefisiensi ringan, dan imunodefisiensi sedang memiliki skor Nugent yang normal (47,1%, 80%, 54,5%, secara berurutan). Hanya kelompok dengan imunodefisiensi berat yang mayoritas memiliki bakterial vaginosis (57,1%).Simpulan: tidak ditemukan perbedaan yang bermakna antara kadar CD4 dengan skor Nugent. Hal ini bisa disebabkan karena memang tidak ada hubungan antara keduanya atau karena faktor perancu yang belum dikontrol. Perlu dilakukan penelitian lanjutan dengan mengkoreksi faktor perancu sehingga penelitian berikutnya dapat meningkatkan presisi.

Immunopathogenesis of erythema nodosum leprosum Made Sanitca Indah; I Gusti Agung Ayu Dwi Karmila
Intisari Sains Medis Vol. 12 No. 3 (2021): (Available online: 1 December 2021)
Publisher : DiscoverSys Inc.

Leprosy is a chronic granulomatous disease. Its etiology is caused by Mycobacterium leprae (M. leprae). This disease may affect the skin, however it also may affect peripheral nervous system and other organs. The immunologic mechanism of erythema nodosum leprosum (ENL) has not been fully understood. The ENL reaction is the reaction of deposition in immune complex in the blood vessels. Recent studies have reported the association of several immunological markers with leprosy reactions, but inconsistent results have been obtained. Neutrophils are considered a histologic feature of ENL, histologic examination of ENL skin lesions revealed a strong perivascular neutrophil infiltrate throughout the dermis and subcutis. Another thing to note is T lymphocytes. It has been showed that the T-cell counts in peripheral blood of ENL patients is higher. Other immunological processes that play a role in EL immunopathogenesis involve T-helper (Th) cells, T regulatory cells, B cells, and other cytokines.

Incontinentia pigmenti in neonate: a case report Putu Gde Hari Wangsa; Luh Made Mas Rusyati; I Gusti Ayu Agung Dwi Karmila; Ni Luh Putu Ratih Vibriyanti Karna; Ketut Wida Komalasari; Made Hermina Laksmi
Intisari Sains Medis Vol. 13 No. 1 (2022): (Available Online : 1 April 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/ism.v13i1.1227

Background: Incontinentia pigmenti (IP) is a rare X-linked dominant inherited genodermatosis that occurs almost in females and is usually accompanied by other ectodermal tissue diseases such as the central nervous system, eyes, hair, nails, teeth and skeletal system. This case report aims to enhance understanding of incontinentia pigmenti and provide appropriate treatment to patients and proper education to families. Case report: A 3-days-od baby girl was consulted by the Pediatric department with complaints of blisters and erythematous rashes on almost her entire body with the Blaschko line distribution. The nails on the right and left big toes appeared inward. No history of fever and seizure. No family had similar complaints. There were no eye and nerve abnormalities involved. She treated with hydrocortisone 1% cream every 12 hours on erythematous papules and vesicles, open compresses with 0.9% NaCl every 8 hours for 10-15 minutes on lesions with yellowish crusts. Thus, the patient diagnosed with incontinentia pigmenti. Conclusion: The diagnosis of incontinentia pigmenti is based on history and physical examination. This case is very rare, so the family needs to understand the course of this disease. Appropriate management and education can prevent secondary infection.

Kadar feritin yang rendah merupakan faktor risiko melasma pada wanita Aurelia Stephanie; Luh Made Mas Rusyati; Ni Luh Putu Ratih Vibriyanti Karna; Ketut Kwartantaya Winaya; Nyoman Suryawati; I Gusti Ayu Agung Dwi Karmila
Intisari Sains Medis Vol. 13 No. 2 (2022): (In Press : 1 August 2022)
Publisher : DiscoverSys Inc.

Introduction: Melasma is an acquired pigmentation disorder characterized by symmetrical hyperpigmented patches, most commonly seen on the face. Melasma and iron deficiency are most common in women of reproductive age. Iron deficiency causes a decrease in ferritin levels, which are iron stores in the body. The mechanism of iron deficiency causing melasma is thought to be due to cell hypoxia in the tissue involving mediators that increase melanogenesis. This study aims to prove that the mean ferritin level is lower in melasma than without melasma and that low ferritin levels are a risk factor for melasma in women. Methods: A case-control research included 28 participants with melasma and 28 without melasma who visited the dermatovenereology department of Prof. Dr. I.G.N.G Ngoerah Hospital, medical cosmetic division, in May-July 2022. The two groups will compare ferritin mean and ferritin risk factor analysis on the incidence of melasma. Data were tabulated and analyzed using SPSS 26. Results: The mean age in the melasma group was 40.64±3.39 years old, and the group without melasma was 37.64±3.50 years old (p=0.75). Of the 28 melasma subjects, there were more subjects with low ferritin levels (60.7%) than the group without melasma (32.1%). From the results of the Mann-Whitney test, the mean ferritin level in the melasma group (36.32±31.05) was significantly lower than in the non-melasma group (58.26±5.39); p=0.006. From the results of the Chi-Square test, it was found that low ferritin levels had a risk of 3.2 times the occurrence of melasma [OR (95% CI) = 3.2 (1.098-9.776), p=0.032]. Conclusion: The mean ferritin level in women with melasma is lower than in women without melasma, and low ferritin levels are a risk factor for melasma. Latar Belakang: Melasma merupakan kelainan pigmentasi didapat yang ditandai dengan adanya bercak hiperpigmentasi simetris, paling sering terlihat pada wajah. Melasma dan defisiensi besi paling sering dijumpai pada wanita usia reproduktif. Defisiensi besi menyebabkan turunnya kadar feritin yang merupakan cadangan besi dalam tubuh. Mekanisme defisiensi zat besi menyebabkan melasma diduga akibat hipoksia sel di dalam jaringan melibatkan mediator yang meningkatkan melanogenesis. Studi ini bertujuan untuk membuktikan rerata kadar feritin lebih rendah pada melasma dibandingkan tanpa melasma serta membuktikan kadar feritin yang rendah merupakan faktor risiko melasma pada wanita. Metode: Studi case-control yang melibatkan 28 subjek dengan melasma dan 28 subjek tanpa melasma yang berobat ke poliklinik kulit dan kelamin RSUP Prof. Dr. I.G.N.G Ngoerah divisi kosmetik medik periode Mei-Juli 2022. Kedua kelompok akan dibandingkan rerata feritin dan analisis faktor risiko feritin terhadap kejadian melasma. Data ditabulasi dan dianalisis dengan menggunakan SPSS 26. Hasil: Rerata usia pada kelompok melasma 40.64±3,39 tahun dan kelompok tanpa melasma 37,64±3,50 tahun (p=0,75). Dari 28 subjek melasma, didapatkan lebih banyak subjek dengan kadar feritin rendah (60,7%) dibandingkan kelompok tanpa melasma (32,1%). Dari hasil uji Mann-Whitney didapatkan rerata kadar feritin pada kelompok melasma (36,32±31,05) lebih rendah secara signifikan dibandingkan pada kelompok bukan melasma (58,26±5,39); p=0,006. Dari hasil uji Chi-Square didapatkan kadar feritin yang rendah memiliki risiko sebesar 3,2 kali terjadinya melasma [OR (IK 95%) =3,2 (1,098-9,776), p=0,032]. Simpulan: rerata kadar feritin pada wanita dengan melasma lebih rendah dibandingkan wanita tanpa melasma dan kadar feritin yang rendah merupakan faktor risiko melasma.

Alopesia universalis pada anak yang berespon baik dengan terapi kombinasi: sebuah laporan kasus I Gusti Ayu Agung Praharsini; I Gusti Ayu Agung Dwi Karmila; Ratih Purnamasari Nukana; Henny Wijaya
Intisari Sains Medis Vol. 13 No. 3 (2022): (In Press 1 December 2022)
Publisher : DiscoverSys Inc.

Background: Alopecia universalis is an autoimmune disease of the hair follicles, which results in complete loss of head and body hair. Until now there is no proven effective therapy in dealing with this disease. We report a case of alopecia universalis that responded well to combination therapy. Case: Female, 22 months old, complained by her parents due to hair loss on her head, eyebrows and eyelashes that had not grown back since the age of 8 months. On the fingernails and toenails found pitting nails, trachonycia. On scalp dermoscopy examination, multiple yellow dots were found. Severity of Alopecia Tool Score (SALT) was 100%. The patient was treated with minoxidil 5%, mometasone 0.1%, triamcinolone 12 mg and excimer laser. Administration of minoxidil increases prostaglandin production and maintains the anagen phase. Corticosteroids are immunosuppressive which suppress the immune attack of T cells on hair follicles. UV light on the excimer laser can reduce the proliferation of T lymphocytes, thereby reducing perifollicular inflammation and hair follicle damage. In this case, after 4 months of observation, the growth of terminal hair and vellus hair on the scalp, eyebrows and eyelashes was seen. On the patient's nails, the trachonycia was improved, with pitting nails remaining. SALT decreased to 58%. Conclusion: The combination therapy of minoxidil, corticosteroid and excimer laser gave good results in this case. During treatment, there were no side effects or recurrences. Latar belakang : Alopesia universalis adalah penyakit autoimun pada folikel rambut, yang mengakibatkan kerontokan seluruh rambut kepala dan tubuh. Hingga saat ini belum ada terapi yang terbukti efektif dalam menangani penyakit ini. Berikut dilaporkan kasus alopesia universalis yang memberikan respon baik dengan terapi kombinasi. Kasus: Pasien perempuan, 22 bulan, dikeluhkan orang tuanya mengalami rambut kepala, alis dan bulu mata yang rontok dan tidak tumbuh kembali sejak usia 8 bulan. Pada kuku tangan dan kaki didapatkan adanya pitting nails, trachonycia. Pada pemeriksaan dermoskopi kulit kepala didapatkan adanya multiple yellow dots. Severity of Alopecia Tool Score (SALT) 100%. Pasien diberikan terapi minoksidil 5%, mometason 0.1%, triamsinolone 12 mg dan laser excimer. Pemberian minoksidil meningkatkan produksi prostaglandin dan mempertahankan fase anagen. Kortikosteroid bersifat imunosupresif yang menekan serangan imunitas sel T pada folikel rambut. Sinar UV pada laser excimer dapat menurunkan proliferasi sel T limfosit sehingga mengurangi peradangan perifolikular dan kerusakan folikel rambut. Pada kasus, setelah pengamatan selama 4 bulan nampak adanya pertumbuhan rambut terminal dan rambut vellus pada kulit kepala, alis dan bulu mata. Pada kuku pasien nampak trachonycia membaik, tersisa pitting nails. SALT menurun menjadi 58%. Simpulan: Terapi kombinasi minoksidil, kortikosteroid dan laser excimer memberikan hasil yang baik pada kasus ini. Selama pengobatan tidak didapatkan adanya efek samping dan rekurensi.

Borderline Lepromatous Leprosy with Severe Erythema Nodosum Leprosum: A Case Report Nevristia Pratama; Luh Made Mas Rusyati; Prima Sanjiwani Saraswati Sudarsa; IGAA Dwi Karmila; NLP Ratih Vibriyanti Karna
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 3 (2022): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.3.2022.210-216

Background: Leprosy is a chronic granulomatous infectious disease caused by Mycobacterium leprae (M. leprae) that primarily infects Schwann cells in the peripheral nerves, leading to nerve damage and the development of disabilities. In 2018, Indonesia was the third country with the most leprosy cases in the world. Erythema nodosum leprosum (ENL), also known as type II leprosy reaction, is a severe immune-mediated complication of multibacillary leprosy. Purpose: To report a case of borderline lepromatous leprosy with severe ENL. Case: A 49-year-old Balinese man presented with multiple tender erythematous skin nodules all over his body, fever, arthralgia, bilateral cervical lymphadenopathy, and sensory loss for the past week. The acid-fast bacilli bacteriological examination showed a positive result. The patient was diagnosed with borderline lepromatous (BL) leprosy with severe ENL and was treated with multibacillary multidrug therapy (MB MDT), methylprednisolone, and other symptomatic medications. After 1 month of treatment, there was an improvement in skin lesions. The MB-MDT treatment was continued and methylprednisolone was planned to be tapered down gradually. Discussion: Approximately 20-50% of all leprosy patients show leprosy reactions in the course of the disease. The goals of treatment for severe ENL are to control inflammation, reduce pain, treat neuritis to prevent nerve dysfunction and contractures, and prevent recurring ENL. The prognosis of leprosy with ENL reactions depends on the severity of the occurring leprosy reaction; early diagnosis and prompt treatment; and patient compliance with treatment. Conclusion: Early diagnosis and treatment are essential to avoid deformities in leprosy patients.

TINGKAT EFEKTIVITAS DAN KEAMANAN PROSEDUR DESENSITISASI PENISILIN PADA PASIEN SIFILIS : A SYSTEMATIC REVIEW ajisma, Seva; Indira, I Gusti Ayu Agung Elis; Karmila, IGAA Dwi; Wiraguna, A.A.G.P
E-Jurnal Medika Udayana Vol 11 No 2 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i02.P13

Penisilin masih menjadi pilihan utama untuk terapi sifilis. Namun mulai didapatkan kasus alergi terhadap penisilin, sehingga CDC membuat rekomendasi untuk melaksanakan prosedur desensitisasi penisilin. Belum ada studi yang meninjau tingkat efektivitas dan keamanan dari prosedur ini dalam bentuk systematic review. Dalam tinjauan ini akan dibahas lebih jauh mengenai efektivitas dan keamanan prosedur desensitisasi penisilin pada pasien sifilis. Pencarian dilakukan pada database Wiley Online Librabry, Sciencedirect dan Pubmed dengan mengidentifikasi jurnal yang diterbitkan pada Januari tahun 2015 hingga Januari tahun 2020 yang berfokus pada evaluasi tingkat efektivitas dan keamanan prosedur desensitisasi penisilin pada pasien sifilis. Penyusunan systematic review ini didasarkan pada guideline penulisan systematic review oleh Cochrane Textbook of Systematic Review. Terdapat 6 studi yang digunakan dalam penyusunan tinjauan ini. Partisipan yang terlibat adalah ibu hamil dengan sifilis, ibu hamil dengan sifilis laten, ibu hamil dengan sifilis latent dan sekunder, neuro sifilis dan okular sifilis serta sifilis kardiovaskuler. Seluruh pasien dilaporkan mengalami reaksi alergi terhadap penisilin dan mendapatkan intervensi prosedur desensitisasi. Penelitian dilakukan pada beberapa lokasi yaitu Brazil, Chile, Inggris dan 3 studi dari Amerika Serikat. Terdapat 16 partisipan yang terlibat dengan rentang usia 21-50 tahun. Seluruh studi melaporkan respon yang baik dan tidak menimbulkan komplikasi yang fatal terhadap prosedur desensitisasi. Prosedur desensitisasi terbukti efektif dan cukup aman tanpa menghasilkan efek samping maupun komplikasi yang merugikan. Meskipun demikian prosedur ini memiliki risiko berupa reaksi anafilaksis saat menjalankan prosedur desensitisasi namun hal ini dapat ditangani dan tidak sampai menyebabkan kematian. Kata Kunci : Sifilis, Alergi Penisilin, Desensitisasi

CHARACTERISTICS OF DERMATOPHYTOSIS PATIENTS AT DERMATOVENEROLOGY CLINIC OF RSUP SANGLAH DENPASAR DURING THE PERIOD OF 2017-2019 Natih, Sintha Aprillia Gita; Wardhana, Made; Puspawati, Ni Made Dwi; Karmila, IGAA Dwi
E-Jurnal Medika Udayana Vol 11 No 2 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i02.P04

Dermatophytosis is a desases that caused by dermatofita from the family of arthrodermatacecae. There are six types of dermatofitosis based on the lesi location ; which are tinea korporis, tinea kruris, tinea pedis, tinea kaptisis, tinea unguium, tinea barbae and tinea kapitis. tinea korporis and tinea kruris are the most common happens in the dermatifita deases. This research conduct with a descriptive retrospektif method using secondary data from the patient book registration at dermatovenerology clinic of RSUP Sanglah Denpasar during the period of 2017-2019. the data collection base on the criteria of age, sex, old or new patient, type of dermatophytosis and the type of theraphy. during the researc, 123 data were meet the criteria of age, sex,old or new patient, type of dermatophytosis and the type of therapy. Thus, the data analyzed deskriptifly. the highest percentage obtained are tines corporis (33,6%) age group range 1-14 years old (25,4%) 15-24 years old (25,4%), male (55,0%), old patient (51,6%), combination theraphy (54,1%) Keywords : Dermatophytosis, Tinea, Descriptive

Co-Authors Adeline Santoso ajisma, Seva Anak Agung Gde Putra Wiraguna Aurelia Stephanie Henny Wijaya I Gde Nengah Adhilaksman I Gde Nengah Adhilaksman Sunyamurti Wirawan I Gusti Ayu Agung Elis Indira I Gusti Ayu Agung Praharsini I Gusti Ayu Agung Praharsisni I Gusti Nyoman Darmaputra I Ketut Agus Somia Indira, I Gusti Ayu Agung Elis Joanne Roxanne Ketut Kwartantaya Winaya Ketut Wida Komalasari Laksmi, Hermina Laksmi, I Gusti Ayu Agung Mini Luh Made Mas Rusyati Made Hermina Laksmi Made Martina Windari Made Sanitca Indah Made Swastika Adiguna Made Wardhana Marrietta Sugiarti Sadeli Natih, Sintha Aprillia Gita Nevristia Pratama Ni Luh Putu Ratih Vibriyanti Karna Ni Made Dwi Puspawati Nyoman Suryawati Nyoman Yoga Maya Pramita Nyoman Yoga Maya Pramita Prima Saraswati Sanjiwani Sudarsa Putu Ayu Saraswati Putu Dyah Sawitri Putu Gde Hari Wangsa Rania Ayu Permata Putri Kornia Ratih Purnamasari Nukana Ricky Fernando Maharis Rikcy Fernando Maharis Sadeli, Marrietta Sugiarti Santoso, Adeline Sawitri, Putu Dyah Sayu Widiawati, Sayu Stella, Aurelia Stephanie, Aurelia Vibriyanti Karna, NLP Ratih Winaya, Ketut Kwartantaya Wiraguna, A.A.G.P

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