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All Journal HAYATI Journal of Biosciences ACTA VETERINARIA INDONESIANA Hemera Zoa Jurnal Veteriner Padjadjaran Journal of Dentistry ARSHI Veterinary Letters FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Ilmu Kefarmasian Indonesia Indonesian Journal of Applied Research (IJAR) Jurnal Sylva Lestari Jurnal Kedokteran Hewan
Eva Harlina
Division Of Pathology, School Of Veterinary Medicine And Biomedical Sciences, IPB University, Bogor
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Veterinary

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Journal : Jurnal Kedokteran Hewan

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EFFECTIVENESS OF STEM CELL THERAPY IN MYOCARDIAL INFARCTION BASED ON ENZYME ACTIVITY AND LIVER HISTOPATOLOGY Rahmi, Riska Asria Sa'adatur; Gunanti, Gunanti; Noviana, Deni; Harlina, Eva
Jurnal Kedokteran Hewan Vol 18, No 4 (2024): December
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v18i4.30881

Abstract

This research aims to study the effectiveness of single placenta stem cell therapy (ST) or a combination of cardiomyocyte co-cultures in pigs with myocardial infarction based on enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity as well as liver histopathology. Nine pigs were divided into three treatment groups (K1, K2, and K3) consisting of three pigs per group. Blood sampling was performed one-hour pre-surgery, post-ST-elevation, and eight weeks post-therapy. The experimental animals were treated for eight weeks, then euthanized and necropsied for liver removal. ALT and AST values were analyzed using one-way analysis of variance (ANOVA) and followed by Tukey's test. Histopathological changes in liver tissue were analyzed using Image J 1.53 software, and the measured data were analyzed using oneway ANOVA. The results showed an increase in the ALT and AST values of the three treatment groups on post-ST-elevation blood sampling but were still within normal limits except for K1. ALT and AST values decreased significantly (P0.05) in the group treated with single placental stem cell (K2) or combined cardiomyocyte co-culture (K3). The ALT value of K3 decreased but not significantly (P0.05) compared to K2. The AST value of K3 decreased significantly (P0.05) but was not significantly different (P0.05) compared to K2. The liver tissue showed circulatory disturbances in the central venous congestion, portal vein, sinusoidal dilatation and congestion, and hepatocyte changes in the form of centrilobular necrosis and hydropic degeneration. Stem cell therapy alone (K2) or in combination with cardiomyocyte co-culture (K3) had similar percentage of centrilobular necrosis which was significantly lower than K1 (P0.05). Hepatocyte hydropic degeneration on K2 was classified as mild, whereas on K3 was classified as moderate. As conclusion, administration of placental stem cell therapy alone or in combination with cardiomyocyte co-culture can reduce ALT and AST values and could repair liver tissue.
THE EFFECTIVENESS OF STEM CELL THERAPY IN MYOCARDIAL INFARCTION REVIEWED FROM UREUM, CREATININE AND KIDNEY HISTOPATHOLOGY LEVELS Rahmi, Nur; Gunanti, Gunanti; Noviana, Deni; Harlina, Eva
Jurnal Kedokteran Hewan Vol 18, No 3 (2024): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v18i3.30831

Abstract

This study aims to study the effectiveness of single placental stem cell therapy or cardiomyocyte combination in pigs experiencing myocardial infarction in terms of urea, creatinine and kidney organ histopathology values. A total of 9 pigs were divided int o three groups: without therapy (K1), single placental stem cell therapy (K2), and cardiomyocyte coculture combination therapy (K3). All pigs underwent circumflex artery ligation of the proximal coronary artery branch to stimulate cardiac ischemia and therapy was given after myocardial infarction and ST-elevation were formed. The pigs were then treated for eight weeks, euthanized and necropsied for kidney organ removal. The re sults showed a significant decrease in urea and creatinine values (P0.05) in K2 and K3 as compared to K1. Histopathology results showed a decrease in glomerular atrophy values (K2: 10.260.93 and K3: 12.441.21), tubular necrosis (K2: 13.673.76 and K3: 17.230.55), and tubular dilation (K2: 16.361.26 and K3: 18.031.76) and these values were significantly different than those observed in K1. It was concluded that the administration of placental stem cell therapy or combined with cardiomyocyte coculture could reduce urea, creatinine values, and improve kidney tissue histopathologically.
Co-Authors . Jumari A.S. Satyaningtijas Abel Tasman Yuza, Abel Tasman Alvernita, Gita Andri Hardianto Ardi Sandriya Az Zahra, Shafiyyah Bambang Pontjo Priosoeryanto Bayu Febram Prasetyo Bernadi, Willy Deni Noviana DIMAS ANDRIANTO Dwi Utari Rahmiati Erni H Purwaningsih Erni H Purwaningsih Gita Alvernita Gunanti . Gunanti Gunanti Hamidi, Zikri HERA MAHESHWARI Heryudianto Vibowo Huda S Darusman IETJE WIENTARSIH Iis Ismawati Ikrar Trisnaning Hardi Utami Kiagus Dahlan KUSMARDI KUSMARDI Lanniari, Nafrina Lina Noviyanti Sutardi Madyastuti, Rini MUHAMMAD ADIB MUSTOFA MULYATI EFFENDI Nur Rahmi Okabayashi, Tamaki Prayogo, Yanico Hadi Putu Angga Wiradana Putu Eka Sudaryatma Rachmi Ridho Rahmi, Riska Asria Sa'adatur Retno Wulansari Riski Rostantinata Riski Rostantinata Rita Kartika Sari Rizki Rostantinata Rostantinata, Riski S Darusman, Huda SANTOSO CORNAIN Sa’diah, Siti Setyo Widodo Setyo Widodo Siti Subangkit, Mawar Surachmi Setiyaningsih TATI NURHAYATI Umi Cahyaningsih Vetnizah Juniantito Vici Eko Handayani Waras Nurcholis Wasrin Syafii Wilujeng, Retno Wiranti, Rahayu Woro YENI KEZIA BEKALANI