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All Journal HAYATI Journal of Biosciences ACTA VETERINARIA INDONESIANA Hemera Zoa Jurnal Veteriner Padjadjaran Journal of Dentistry Communications in Science and Technology ARSHI Veterinary Letters FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Ilmu Kefarmasian Indonesia Indonesian Journal of Applied Research (IJAR) Jurnal Sylva Lestari Jurnal Kedokteran Hewan

Eva Harlina

Division Of Pathology, School Of Veterinary Medicine And Biomedical Sciences, IPB University, Bogor

Author-ID : 2938555

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Veterinary

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Aktivitas Antitumor Ekstrak Etanol Daun Keladi Tikus (Typhonium flagelliforme) secara In Vivo pada Mencit Ardi Sandriya; Bambang Pontjo Priosoeryanto; Gunanti Gunanti; Eva Harlina; Riski Rostantinata; Lina Noviyanti Sutardi; Rachmi Ridho
Jurnal Veteriner Vol 22 No 2 (2021)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Penelitian ini bertujuan untuk mempelajari efektivitas ekstrak etanol daun keladi tikus (Typhonium flagelliforme) untuk terapi penyakit tumor. Penelitian ini menggunakan enam ekor mencit betina berumur lima minggu dengan bobot badan 20-25 g yang telah diinduksi karsinogen 7.12- dimetilbenz(?)anthracne (DMBA). Mencit dibagi menjadi dua kelompok perlakuan masing-masing kelompok terdiri dari tiga ekor mencit yaitu kelompok yang diberi plasebo (KK) dan kelompok yang diberi ekstrak etanol daun keladi tikus (KE). Kelompok KK diberi plasebo berupa aquabides. Kelompok KE diberi ekstrak etanol daun keladi tikus dengan dosis 120 mg/kg BB. Pengamatan dilakukan secara makroskopik dan mikroskopik. Massa tumor dari kedua kelompok mencit dikoleksi dan difiksasi dalam neutral buffered formalin (NBF) 10%. Kemudian dibuat preparat histopatologi dan diwarnai pewarna Hematoksilin-Eosin (HE). Hasil penelitian menunjukkan gambaran makroskopik permukaan kulit pada daerah tumbuhnya tumor mengalami alopesia, tumbuh benjolan berwarna kemerahan dan keropeng. Hasil pengukuran bobot badan mencit kelompok KK mengalami penurunan, sedangkan berat badan mencit pada kelompok KE mengalami kenaikan setiap minggunya. Diameter tumor kelompok KK mengalami peningkatan, sedangkan diameter tumor pada kelompok KE mengalami penurunan pada minggu ke empat pemberian bahan uji. Gambaran mikroskopik menunjukkan benjolan massa tumor yang terbentuk terdiri atas tiga jenis tumor yaitu anaplastic carcinoma (16,7%), fibrosarcoma (16,7%) dan squamous cell carcinoma (66,6%). Ketiga tumor digolongkan dalam diferensiasi baik 33,4%, diferensiasi sedang 33,4%, diferensiasi buruk 16,7%, dan tidak berdiferensiasi 16,.7%. Laju pertumbuhan tumor selaras dengan tingkat diferensiasi. Tumor yang bermetastasis sebanyak 50% dan tidak bermetastasis sebanyak 50%. Rataan indeks mitosis dan angiogenesis terjadi penurunan yang nyata (p<0.05) pada kelompok mencit yang diberi ekstrak etanol daun keladi tikus dibandingkan kelompok kontrol. Disimpulkan bahwa ekstrak etanol daun keladi tikus menurunkan pertumbuhan tumor dan dapat digunakan untuk terapi tumor.

GAMBARAN DARAH DAN KALSIUM DOMBA LOKAL (Ovis aries) YANG DIIMPLANTASI BIFASIK KALSIUM FOSFAT 70/30 SCAFFOLD 3D BERPOROS Dwi Utari Rahmiati; Gunanti Gunanti; Eva Harlina; Kiagus Dahlan
Jurnal Veteriner Vol 19 No 4 (2018)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

The aim of this research is to study the biocompatibility biphasic calcium phosphate with alginate combination by evaluating blood and calcium concentration. This study used three male sheeps, age 1.5 year old with an average weight of 20 kg. Anaesthesia is using an intravenous anaesthetic combination of 10% ketamine HCl (2 mg / kg BW) and 10% xylaxine HCl (0.1 mg / kg BW). The implant material is grown on the right sheep tibia. As a control, the left sheep tibia was made of defects but not implanted. The incision orientation is the straight line of the tibial femoral joint at medial, 3.6 cm from caudal to cranial and perpendicular from that point 5.7 cm to the distal direction. The defect is made using a bone drill to make a hole according to the size of the implant (diameter 0.8 cm and 0.4 cm long). Blood parameters (erythrocytes, hemoglobin (Hb), hematocrit (Hct), total leukocytes and differentiation of leukocytes; neutrophils, eusinophils, basophils, lymphocytes and monocytes) and calcium evaluations were performed on days 0, 7, 30, 60 and 90 post implantation. Based on complete blood count no significant of blood parameters. Based on the calcium value, there are significant values on the 30th and the 90th. Blood calcium concentration were decreased from day 0 to 90.

Aktivitas Ekstrak Etanol Daun Alpukat Terhadap Zat Nefrotoksik Ginjal Tikus (ACTIVITIES STUDY OF ETHANOL EXTRACTS OF AVOCADO LEAVES (PERSEA AMERICANA MILL) TO NEPHROTOXIC COMPOUND OF RAT’S KIDNEY) Ietje Wientarsih; Eva Harlina; Rini Madyastuti Purwono; Ikrar Trisnaning Hardi Utami
Jurnal Veteriner Vol 15 No 2 (2014)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (212.647 KB)

Based on WHO’s data, about 80% peoples in the word use plant’s extract as herbal medicine. Avocadoleaves has used as herbal medicine which is works as diuretikum, reduce stone in renal, and cure sprue.The purpose of this research is to study activities of ethanol extract of avocado leaves to ethylene glycolinduction on rat’s kidney by histopatologically. This experiment was continuing Adha’s research (2009)with research design as follows: twenty male rats were divided into 4 groups, negative control group (KN),positive control group (KP), treated group I by ethanol extract of avocado leaves 100 mg/kg BW (E100), andtreated group 2 by 300 mg/kg BW (E300). Sampling kidney were fixed in BNF 10% for histopathologicalslide and stained by Hematoxylin-Eosin. The kidney histopathological changes were edema of glomerulus,and protein deposit in the lumen, hyalin droplet and necrotic tubules. The results showed that ethanolextract of avocado leaves can’t significantly to reduce glomerulus edema with percentage cases 31.9% and33.5% for E100 and E300 and tend not to reduce the occurrence of protein deposits in the lumen of thetubule. Ethanol extract of avocado leaves tend to reduce the incidence of tubular necrosis and it wassignificantly different from the KP group (p <0.05). It is caused by flavonoid in etanol extract of avocadoleaves works as diuretikum and antioxidant.

Infusum Daun Alpukat Sebagai Inhibitor Kristalisasi Kalsium Oksalat pada Ginjal (THE AVOCADO LEAVES INFUSUM AS INHIBITOR ON RENAL CALCIUM OXALATE CRYSTALIZATION) Rini Madyastuti; Setyo Widodo; Ietje Wientarsih; Eva Harlina
Jurnal Veteriner Vol 16 No 4 (2015)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (603.328 KB)

Urine crystal is a crystal nucleus which tend to form urine stone. The case of urine stone seems to beincreased every year. Crystallization could induce acute tubular necrosis which impact on renal dysfunction.The signs of this condition are high level of urea, creatinine and decrease glomerulus filtration rate. Theobjective of this research was to evaluate the effects of infusum Persea americana Mill as an inhibitorcrystallization which induced by ethylene glycol on white male rats. 20 male rats were divided into 4groups; K1 as negative group received only distilled water ad libitum, K2 as positive group receiveddistilled water containing ethylene glycol, K3 (dose 5%) and K4 (dose 10%) as treatment groups receivedwater containing ethylene glycol and avocado leaves infusion. Phytochemsitry screening of infusion avocadoleaves consisted of flavonoid, saponin, tanine and quinone. Result of analysis showed that the level ofureum and creatinine on K2 was higher than K3 and K4 group. The increased level could be inhibited byinfusion avocado leaves. The measurement of glomerular filtration rate in treatment groups wassignificantly different (p<0.05). Descriptive histopathology observation showed that renal lesio in grouptreatment (K3 and K4) were declined. Large crystal calcium oxalate on K2 group was observed by usingpolarized microscope, whereas small crystal calcium oxalate were seen in the infusion of avocado leavesgroups. These result showed the ability of infusion of avocado leaves as an inhibitor on the growth ofcrystallization calcium oxalate

Evaluasi Radiografi terhadap Kepadatan Tulang Hasil Implan Scaffold 3D Bifasik Kalsium Fosfat Alginat pada Domba Lokal (Ovis aries) Dwi Utari Rahmiati; Gunanti Gunanti; Eva Harlina
Jurnal Veteriner Vol 22 No 2 (2021)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

0 based on chages in size of defect and relative bone density, 2) implant response tissue based on relative muscle density peri implant. The BCP used in this study made from hydroxyapatite (HA) 70, tricalcium phosphate (TCP) 30 and alginate as porogen. The implant material made in 3D form and have diameter porous 200-400 ìm which similar size with the bone trabecula. This study used three local sheep (Ovis aries) male 1.5 years old, weight average 20 kg. The implant material is grown on the right sheep tibia. As a control, the left tibia is made defective with no implantable material. Evaluate osteogenesis and implant tissue responses using radiography and assess the grey values of a particular area. Osteogenesis is also assessed based on the size of the defect. Based on the size of the defect, the right defect shows no significant value. The size of the left defect shows a significant value between day 0 and day 30, and 90. The relative bone density of the right defect shows a significant value between day 7 and 30. In the left defect, the relative bone density shows the significant between 0 and 90. The relative density of the muscle does not show significant values either on the right or left defects.

Syok Indeks sebagai Penduga Tingkat Syok Hewan Model Kelinci New Zealand White pada Kejadian Syok Hemoragi Dwi Utari Rahmiati; Gunanti Gunanti; Deni Noviana; Eva Harlina
Jurnal Veteriner Vol 24 No 4 (2023)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19087/jveteriner.2023.24.4.422

Syok hemoragi didefinisikan sebagai kondisi jaringan perifer dan organ tidak mampu melakukan perfusi akibat kehilangan darah dalam volume tertentu. Prediksi tingkat keparahan syok hewan pada fase prehospital masih belum banyak dilaporkan. Kendala keterbatasan alat untuk deteksi tekanan darah, membuat nilai syok indeks (SI) sulit untuk dilakukan. Penelitian ini dilakukan untuk menduga nilai SI berdasarkan volume darah yang dikeluarkan, dengan kondisi syok yang dikonfirmasi dengan gambaran klinis. Penelitian ini menggunakan lima ekor kelinci jenis New Zealand White yang diinduksi syok hemoragi sebanyak 10% dengan cara evakuasi darah melalui arteri carotis. Parameter fisiologi yang teramati yaitu; heart rate (HR), respiration rate (RR), mean arterial pressure (MAP), tekanan sistol dan diastol, dan saturasi oksigen (SPO2 ). Nilai syok indeks (SI) pada penelitian ini yaitu 1,6 ± 0,4 atau dalam level sedang-berat. Level SI berbeda dengan parameter fisiologis, yang menunjukkan perbaikan menuju nilai baseline hampir pada seluruh parameter (HR, RR, MAP, sistol, SPO2 ) pada menit ke-15 pascasyok. Gambaran klinis dan SI, tidak menunjukkan relevansi, sehingga nilai SI belum dapat digunakan sebagai penduga tingkat keparahan syok, karena membutuhkan cut-off point syok atau mempertimbangkan penggunaan modified shock index (MSI) atau simple Shock Index (sSI) sebagai metode untuk penduga/prediksi syok. Dibutuhkan penelitian lebih lanjut untuk membuat klasifikasi syok khusus hewan kelinci.

Co-Authors . Jumari A.S. Satyaningtijas Abel Tasman Yuza, Abel Tasman Alauddin, Daffa Rizal Dzulfaqaar Alvernita, Gita Andri Hardianto Ardi Sandriya Az Zahra, Shafiyyah Bambang Pontjo Priosoeryanto Bayu Febram Prasetyo Bernadi, Willy Deni Noviana DIMAS ANDRIANTO Dwi Utari Rahmiati Erni H Purwaningsih Erni H Purwaningsih Gita Alvernita Gunanti . Gunanti Gunanti Hamidi, Zikri HERA MAHESHWARI Heryudianto Vibowo Huda S Darusman IETJE WIENTARSIH Iis Ismawati Ikrar Trisnaning Hardi Utami Kasmi, Adinda Zahra Marissa Kiagus Dahlan KUSMARDI KUSMARDI Lanniari, Nafrina Lina Noviyanti Sutardi Madyastuti, Rini Mega Safithri MUHAMMAD ADIB MUSTOFA MULYATI EFFENDI Okabayashi, Tamaki Prayogo, Yanico Hadi Putu Angga Wiradana Putu Eka Sudaryatma Rachmi Ridho Raden Mohamad Herdian Bhakti Rahmi, Riska Asria Sa'adatur Retno Wulansari Riski Rostantinata Riski Rostantinata Rita Kartika Sari Rizki Rostantinata Rostantinata, Riski S Darusman, Huda SANTOSO CORNAIN Sa’diah, Siti Setyanto Tri Wahyudi Setyo Widodo Setyo Widodo Siti Subangkit, Mawar Surachmi Setiyaningsih TATI NURHAYATI Umi Cahyaningsih Vetnizah Juniantito Vici Eko Handayani Waras Nurcholis Wasrin Syafii Wilujeng, Retno Wiranti, Rahayu Woro YENI KEZIA BEKALANI

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