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All Journal HAYATI Journal of Biosciences ACTA VETERINARIA INDONESIANA Hemera Zoa Jurnal Veteriner Padjadjaran Journal of Dentistry ARSHI Veterinary Letters FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Ilmu Kefarmasian Indonesia Indonesian Journal of Applied Research (IJAR) Jurnal Kedokteran Hewan
Eva Harlina
Division Of Pathology, School Of Veterinary Medicine And Biomedical Sciences, IPB University, Bogor
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Evaluasi Radiografi terhadap Kepadatan Tulang Hasil Implan Scaffold 3D Bifasik Kalsium Fosfat Alginat pada Domba Lokal (Ovis aries) Dwi Utari Rahmiati; Gunanti Gunanti; Eva Harlina
Jurnal Veteriner Vol 22 No 2 (2021)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (268.797 KB) | DOI: 10.19087/jveteriner.2021.22.2.285

Abstract

0 based on chages in size of defect and relative bone density, 2) implant response tissue based on relative muscle density peri implant. The BCP used in this study made from hydroxyapatite (HA) 70, tricalcium phosphate (TCP) 30 and alginate as porogen. The implant material made in 3D form and have diameter porous 200-400 ìm which similar size with the bone trabecula. This study used three local sheep (Ovis aries) male 1.5 years old, weight average 20 kg. The implant material is grown on the right sheep tibia. As a control, the left tibia is made defective with no implantable material. Evaluate osteogenesis and implant tissue responses using radiography and assess the grey values of a particular area. Osteogenesis is also assessed based on the size of the defect. Based on the size of the defect, the right defect shows no significant value. The size of the left defect shows a significant value between day 0 and day 30, and 90. The relative bone density of the right defect shows a significant value between day 7 and 30. In the left defect, the relative bone density shows the significant between 0 and 90. The relative density of the muscle does not show significant values either on the right or left defects.
HISTOPATOLOGI HATI MENCIT PASCA PEMBERIAN SUSPENSI KEPEL (Stelechocarpus burahol) SECARA INTRAGASTRIK SELAMA 14 HARI The Histopathology of Mice Liver Treated by Kepel (Stelechocarpus burahol) Suspension Intragastrically for 14 days Eva Harlina; Siti; Huda S Darusman; Gita Alvernita
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 2, No 1 (2012): FITOFARMAKA
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (416.895 KB) | DOI: 10.33751/jf.v2i1.162

Abstract

This aim of this study was to examine the effect of Kepel (Stelechocarpus burahol) to the mice hepatocytes. Thirty male mice of 4 week aged were divided into three groups;control group was treated by aquadest, Dose 1x group was treated by 2.6 mg/g BW/daykepel powder (0.5 ml kepel suspension/day), and Dose 5x group was treated by 13 mg/gBW/day kepel powder (1.0 ml kepel suspension/day). The treatment was intragastricallyfor 14 days. The mice were euthanized and necropsy followed by the liver collection forhistopathology assay. The histopathological examination of liver showed hydropicdegeneration, cell death and extramedullary hematopoietic observed on mice hepatocytes.The ANOVA analysis showed that kepel caused increase significantly (p0.05) ofhydropic degeneration and decrease significantly (p0.05) of cell death of micehepatocytes.Key words: Stelechocarpus burahol, hydropic degeneration, cell death, extramedullary hematopoietic
The Role of Fennel Infusion on Estrous Cycle and Follicles Development of White Rats HERA MAHESHWARI; ARYANI SISMIN SATYANINGTIJAS; EVA HARLINA; UMI CAHYANINGSIH; MULYATI EFFENDI; MUHAMMAD ADIB MUSTOFA; YENI KEZIA BEKALANI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 1 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (502.513 KB)

Abstract

This study aims to describe the estrous cycle and follicles development in female rats given infusion of fennel fruit that known to have phytoestrogen compound. Twenty five of female rats were used in this research and were divided into 5 groups. Group I was negative control group (NC), given 1 mL/100g bw of distilled water, group II was positive control group (PC), given 0.0045 mg/100g bw of ethinyl estradiol, groups III, IV and V were treatment groups (TI, T2 and T3), given fennel infusion at 36.5; 73 and 146 mg/100g bw respectively. All treatments were conducted every morning for 20 days by oral route. Changes of vaginal epithelium were observed through vaginal swabs previously stained with Giemsa stain. Histopathological examination of ovarian swere examined to reveal follicles development. Results showed that fennel fruit infusion extended the duration of estrous and metestrous phases, while shortened the proestrous and diestrous phases. Eventhough the longest estrous phase was found in T3 group, there was no significant effect on the lengthening of estrous cycle. Moreover, infusion of fennel fruit had no effect on the development of ovarian follicles, except tended to increase the number of corpus luteum.
Aktivitas Minyak Ikan dalam Menghambat Preneoplasia Kolon Mencit yang Diinduksi Azoksimetan dan Dextran Sodium Sulfate KUSMARDI KUSMARDI; BAMBANG PONTJO PRIOSOERYANTO; EVA HARLINA; SANTOSO CORNAIN
JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 2 (2014): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (632.063 KB)

Abstract

Epidemiologic studies of dietary marine n-3 fatty acids and risk of colorectal cancer have been inconsistent. The study was conducted to understand the inhibitory effect of fish oil in mice with colorectal preneoplasia induced by azoxymethane (AOM) and dextran sodium sulfate (DSS). In this study, Balb/c mice was induced by AOM 10 mg/kg body weight followed by administration of 1 % DSS during a week. Fish oil administrated orally at a dose of 1.5, 3, and 6 mg per day. Histopathological examination of the colon tissue (hematoxylin-eosin staining) was done by counting the number of inflammation, and hyperplasia foci, the number of mitosis epithelial cells, and the scores of dysplasia in ten visual fields. In the second month, decreasing in the number of inflammation foci occurred between the control and low dose groups with medium and high dose groups (p<0,05). While in the third and fourth month, decreasing in the number of inflammation foci were observed in all treatment group (p<0.001). The number of mitotic colonic crypt epithelial cells was statistically significant between control group and treatment groups, initially observed since the second month. In the second month to the fourth month, generally increasing of doses of fish oil has decreased the number of hyperplasia foci. Our research indicates that fish oil also inhibits the occurrence of dysplasia. In the third and fourth month, dysplasia was found in the control group. Dysplasia was found only in the fouth month in the treatment group.
Gambaran kristal urin pada hewan model nefrolitiasis hasil induksi etilen glikol Rini Madyastuti Purwono; Ietje Wientarsih; Setyo Widodo; Erni H Purwaningsih; Eva Harlina
ARSHI Veterinary Letters Vol. 3 No. 1 (2019): ARSHI Veterinary Letters - Februari 2019
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (454.24 KB) | DOI: 10.29244/avl.3.1.19-20

Abstract

Tingginya tingkat keterulangan kasus urolitiasis baik pada hewan maupun manusia, menuntut penelitian dalam mencari solusi menurukan angka keterulangan. Penelitian urolitiasis membutuhkan hewan model urolitiasis yang sesuai dengan kondisi sebenarnya. Salah satu metode yang digunakan adalah menciptakan kondisi hiperoksaluria. Penggunaan induksi etilen glikol menjadi metode yang paling umum digunakan. Induksi ini menghasilkan kristal kalsium oksalat monohidrat. 
Pathology of cutaneous blastomycosis in a cat Vetnizah Juniantito; Eva Harlina; . Jumari; Vici Eko Handayani; Iis Ismawati
ARSHI Veterinary Letters Vol. 4 No. 1 (2020): ARSHI Veterinary Letters - Februari 2020
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (418.815 KB) | DOI: 10.29244/avl.4.1.3-4

Abstract

Cats are common as pet animals in Indonesia and live in close vicinity of human neighborhood, which make them potential for transmitting diseases to human. Blastomycosis is infectious disease caused by Blastomyces spp yeast. Here we describe morphopathology of blastomycosis found in skin of a Persian Cat. Grossly, the lesion were characterized by ulcerated wounds and multiple subcutaneous small nodules (2-5 mm in diameter) in the base of tail. Skin biopsy was made and further processed for histopathology. Microscopically, the lesion consist of epidermal necrosis, dermatitis, with coalescing dermal granulomatous inflammation, characterized by epitheloid and foreign type giant cells infiltrates. Numerous spherical-shaped structures and pseudohyphae which are Periodic Acid Schiff (PAS)-positive consistent with yeast morphology were found within the granulomas; morphology is also consistent with Blastomyces spp yeasts. Conclusively, multiple granulomatous dermatitis with evidence of Blastomyces yeasts is a hallmark of cutaneous blastomycosis. Exposure to Blastomyces spp yeast may possess infection threat to pet owners.
Syok Indeks sebagai Penduga Tingkat Syok Hewan Model Kelinci New Zealand White pada Kejadian Syok Hemoragi Dwi Utari Rahmiati; Gunanti Gunanti; Deni Noviana; Eva Harlina
Jurnal Veteriner Vol 24 No 4 (2023)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19087/jveteriner.2023.24.4.422

Abstract

Syok hemoragi didefinisikan sebagai kondisi jaringan perifer dan organ tidak mampu melakukan perfusi akibat kehilangan darah dalam volume tertentu. Prediksi tingkat keparahan syok hewan pada fase prehospital masih belum banyak dilaporkan. Kendala keterbatasan alat untuk deteksi tekanan darah, membuat nilai syok indeks (SI) sulit untuk dilakukan. Penelitian ini dilakukan untuk menduga nilai SI berdasarkan volume darah yang dikeluarkan, dengan kondisi syok yang dikonfirmasi dengan gambaran klinis. Penelitian ini menggunakan lima ekor kelinci jenis New Zealand White yang diinduksi syok hemoragi sebanyak 10% dengan cara evakuasi darah melalui arteri carotis. Parameter fisiologi yang teramati yaitu; heart rate (HR), respiration rate (RR), mean arterial pressure (MAP), tekanan sistol dan diastol, dan saturasi oksigen (SPO2 ). Nilai syok indeks (SI) pada penelitian ini yaitu 1,6 ± 0,4 atau dalam level sedang-berat. Level SI berbeda dengan parameter fisiologis, yang menunjukkan perbaikan menuju nilai baseline hampir pada seluruh parameter (HR, RR, MAP, sistol, SPO2 ) pada menit ke-15 pascasyok. Gambaran klinis dan SI, tidak menunjukkan relevansi, sehingga nilai SI belum dapat digunakan sebagai penduga tingkat keparahan syok, karena membutuhkan cut-off point syok atau mempertimbangkan penggunaan modified shock index (MSI) atau simple Shock Index (sSI) sebagai metode untuk penduga/prediksi syok. Dibutuhkan penelitian lebih lanjut untuk membuat klasifikasi syok khusus hewan kelinci.
EFFECTIVENESS OF STEM CELL THERAPY IN MYOCARDIAL INFARCTION BASED ON ENZYME ACTIVITY AND LIVER HISTOPATOLOGY Rahmi, Riska Asria Sa'adatur; Gunanti, Gunanti; Noviana, Deni; Harlina, Eva
Jurnal Kedokteran Hewan Vol 18, No 4 (2024): December
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v18i4.30881

Abstract

This research aims to study the effectiveness of single placenta stem cell therapy (ST) or a combination of cardiomyocyte co-cultures in pigs with myocardial infarction based on enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity as well as liver histopathology. Nine pigs were divided into three treatment groups (K1, K2, and K3) consisting of three pigs per group. Blood sampling was performed one-hour pre-surgery, post-ST-elevation, and eight weeks post-therapy. The experimental animals were treated for eight weeks, then euthanized and necropsied for liver removal. ALT and AST values were analyzed using one-way analysis of variance (ANOVA) and followed by Tukey's test. Histopathological changes in liver tissue were analyzed using Image J 1.53 software, and the measured data were analyzed using oneway ANOVA. The results showed an increase in the ALT and AST values of the three treatment groups on post-ST-elevation blood sampling but were still within normal limits except for K1. ALT and AST values decreased significantly (P0.05) in the group treated with single placental stem cell (K2) or combined cardiomyocyte co-culture (K3). The ALT value of K3 decreased but not significantly (P0.05) compared to K2. The AST value of K3 decreased significantly (P0.05) but was not significantly different (P0.05) compared to K2. The liver tissue showed circulatory disturbances in the central venous congestion, portal vein, sinusoidal dilatation and congestion, and hepatocyte changes in the form of centrilobular necrosis and hydropic degeneration. Stem cell therapy alone (K2) or in combination with cardiomyocyte co-culture (K3) had similar percentage of centrilobular necrosis which was significantly lower than K1 (P0.05). Hepatocyte hydropic degeneration on K2 was classified as mild, whereas on K3 was classified as moderate. As conclusion, administration of placental stem cell therapy alone or in combination with cardiomyocyte co-culture can reduce ALT and AST values and could repair liver tissue.
Indonesian Herb Extracts Inhibit the Replication of Bovine Respiratory Syncytial Virus: In Vitro Study Priosoeryanto, Bambang Pontjo; Sudaryatma, Putu Eka; Lanniari, Nafrina; Setiyaningsih, Surachmi; Harlina, Eva; Wulansari, Retno; Ridho, Rachmi; Rostantinata, Riski; Wiradana, Putu Angga; Okabayashi, Tamaki
HAYATI Journal of Biosciences Vol. 32 No. 3 (2025): May 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.3.727-739

Abstract

Bovine respiratory syncytial virus (BRSV) is highly prevalent in cattle. It is a major viral cause of bovine respiratory disease complex, which is associated with morbidity, mortality and substantial economic impact. Currently available treatments are only symptomatic, but no specific treatments are available for BRSV infection. This study aimed to identify new antiviral agents against BRSV, which could be used to control bovine respiratory disease complex in cattle with Indonesian herb extracts. Ethanol extracts prepared from Indonesian herbs including Andrographis paniculata, Phyllanthus niruri, Curcuma aeruginosa, and Curcuma xanthorrhiza were evaluated for anti-BRSV activity in A549 cells. The cytotoxicity of the herb extracts was evaluated using a CCK-8 cell viability assay. Antiviral activities of the herb extracts were examined using cell activity and cytopathic assays. The effect on virus production was evaluated by qRT-PCR and plaque-formation assays. Extracts of Curcuma xanthorrhiza (125 μg/ml), Andrographis paniculata (250 μg/ml), and Phyllanthus niruri (62.5 μg/ml) inhibited BRSV activity in A549 in pre-, simultaneously-, and post-infection treatment assays, respectively, as measured by the selective index. Reduction of BRSV activities by the herb extracts correlated with inhibition of viral gene expression and inhibition of plaque formation in a concentration- and time-dependent manner. Our findings suggest that these herb extracts have sufficient potency to be used not only as a therapeutic agent but also as a preventive agent to limit BRSV infection.
Efficacy differences of Queen’s crepe-myrtle (Lagerstroemia speciosa) and aloe vera extract on the interleukin-6 and osteoblast levels in the healing process of alveolar osteitis Bernadi, Willy; Hardianto, Andri; Yuza, Abel Tasman; Harlina, Eva
Padjadjaran Journal of Dentistry Vol 33, No 2 (2021): July 2021
Publisher : Faculty of Dentistry Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol33no2.21310

Abstract

Introduction: Alveolar osteitis is the most common complication after tooth extraction, which occurs 2 to 4 days after and causes disruption of wound healing. Pucuk Bungur/Queen’s crepe myrtle  (Lagerstroemia speciosa) and aloe vera have biological and pharmacological benefits in experimental animals: antimicrobial, anti-inflammatory, and antioxidant. They also affect the wound healing process.  These benefits are a good combination as an alternative remedy for alveolar osteitis treatment. This study was aimed to analyse the effect of Lagerstroemia speciosa compared to aloe vera extracts gel on the wound healing process after tooth extraction in Sprague-Dawley mice with alveolar osteitis. Methods:  This research was an experimental laboratory. Twenty-seven Sprague-Dawley mice were randomly divided into three groups. The first group was the osteitis (control) group treated with 1:1000 adrenaline insertion for 1 minute on the left maxillary first molars socket; the second group was the osteitis group administered with the application of Lagerstroemia speciosa, and the third group was the osteitis group administered with the application of aloe vera gel. Normal mice in the control group were not given any treatment, only osteitis mice. The interleukin-6 level was examined after, and the number of osteoblasts was also calculated on the 3rd, 5th and 14th day after the necropsy was performed. Data were analysed with one-way ANOVA to compare the effectiveness of wound healing of alveolar osteitis in each group. Results: From the data analysis, the osteitis group applied with  Lagerstroemia speciosa gel had good activity in the inflammation phase of the healing process of alveolar osteitis compared to other groups. Conclusion: Lagerstroemia speciosa can be a potential alternative treatment to reduce inflammation and accelerate the healing of osteitis because it shortens the inflammatory phase and accelerates collagen production in wound healing.
Co-Authors . Jumari A.S. Satyaningtijas Abel Tasman Yuza, Abel Tasman Alvernita, Gita Andri Hardianto Ardi Sandriya Az Zahra, Shafiyyah Bambang Pontjo Priosoeryanto Bernadi, Willy Deni Noviana DIMAS ANDRIANTO Dwi Utari Rahmiati Erni H Purwaningsih Erni H Purwaningsih Gita Alvernita Gunanti . Gunanti Gunanti HERA MAHESHWARI Heryudianto Vibowo Huda S Darusman IETJE WIENTARSIH Iis Ismawati Ikrar Trisnaning Hardi Utami Kiagus Dahlan KUSMARDI KUSMARDI Lanniari, Nafrina Lina Noviyanti Sutardi Madyastuti, Rini MUHAMMAD ADIB MUSTOFA MULYATI EFFENDI Okabayashi, Tamaki Putu Angga Wiradana Putu Eka Sudaryatma Rachmi Ridho Rahmi, Riska Asria Sa'adatur Retno Wulansari Riski Rostantinata Riski Rostantinata Rizki Rostantinata Rostantinata, Riski S Darusman, Huda SANTOSO CORNAIN Sa’diah, Siti Setyo Widodo Setyo Widodo Siti Subangkit, Mawar Surachmi Setiyaningsih TATI NURHAYATI Umi Cahyaningsih Vetnizah Juniantito Vici Eko Handayani Waras Nurcholis Wilujeng, Retno Wiranti, Rahayu Woro YENI KEZIA BEKALANI