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All Journal VALENSI Jurnal Biologi Udayana Biotropika Indonesian Journal of Chemistry Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Jurnal Penelitian Jurnal Pengabdian Masyarakat Bhinneka Jurnal Sains dan Teknologi Farmasi Indonesia Kartika : Jurnal Ilmiah Farmasi al Kimiya : Jurnal Ilmu Kimia dan Terapan
Dewi Astriany
Sekolah Tinggi Farmasi Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Nutritional value and contamination testing assistance for the improvement of the processed food products quality Syarif Hamdani; Adang Firmansyah; Muhammad Ismail Faruqi; Dewi Astriany; Sri Gustini; Wiwin Winingsih; Melvia Sundalian; Nur Asni Setiani; Putri Afiyanti
Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Vol 8, No 4 (2023): November 2023
Publisher : University of Merdeka Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26905/abdimas.v8i4.11295

Abstract

Micro, Small, and Medium Enterprises (MSMEs) are one of the business sectors driving the country's economy. MSMEs produce many quality products that can compete in the market, where one of the products that is marketed quite a lot is food products. Several MSMEs in the Purwakarta Regency area have not included information on nutritional value and contamination on labels or packaging so these products cannot be widely marketed or traded in official stores and can only be marketed in their production areas. The Community Service activities carried out aim to carry out nutritional value and contamination tests, followed by improving product quality through workshops and mentoring. The food products targeted are simping and instant turmeric drinks produced by MSMEs in Pondoksalam District, Purwakarta Regency. Laboratory test results show that instant turmeric does not meet several SNI standard parameters, so quality improvement is still needed to be able to adapt it to become a product that meets standards. The results of the questionnaire show that several MSME owners in the Purwakarta area have a poor understanding of food product quality standards and ways to improve them. The coaching program for community service activities shows an increase in knowledge and understanding so that food products from Purwakarta MSMEs are expected to meet product quality standards in the future.
ANALISIS FRAGMEN DNA DARI BAKTERI PSEUDOMONAS FLUORESCENS SEBELUM DAN SESUDAH IMOBILISASI DALAM κ-KARAGENAN Syarif Hamdani; Isma Oktadiana; Dewi Astriany
Kartika : Jurnal Ilmiah Farmasi Vol 6 No 2 (2018)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v6i2.153

Abstract

Abstrak Imobilisasi merupakan pengurungan fisik atau lokalisasi bakteri utuh dalam lingkungan tertentu untuk memaksimalkan aktivitas biokatalis yang diinginkan. Imobilisasi mampu menyediakan bakteri sebagai biokatalis dalam konsentrasi tinggi sehingga dapat  meningkatkan efisiensi serta produktivitas. Penelitian ini dilakukan untuk mengamati efek imobilisasi terhadap fragmen DNA bakteri setelah penyimpanan dingin selama lima bulan, bakteri yang digunakan adalah Pseudomonas fluorescens yang diimobilisasikan pada κ-karagenan lokal yang berasal dari perairan Karimun Jawa. Pengamatan dilakukan terhadap fragmen DNA setelah direstriksi oleh enzim EcoRI dan dianalisis menggunakan elektroforesis gel. Bakteri diimobilisasi dalam karagenan pada konsentrasi 1% dan 2% (b/v). Hasil menunjukkan bahwa DNA P.fluorescens memberikan fragmen identik antara bakteri terimobilisasi dan tanpa imobilisasi. Kata Kunci :  Imobilisasi, Pseudomonas fluorescens, Karagenan, Elektroforesis Gel. Analysis of Pseudomonas fluorescens’s  DNA fragments before and after immobilize in κ-carrageenan  Abstract Immobilization is physical confinement or localization of bacteria in a particular environment to maximize biocatalyst activity. Immobilization provide bacteria as biocatalysts in high concentrations in order to increase efficiency and productivity. This study was conducted to observe the effect of immobilization to bacterial DNA fragments after cool storage for five months, bacteria used was Pseudomonas fluorescens that immobilized in local κ-carrageenan from Karimun Jawa. Observations conducted to DNA fragments after being restricted by EcoRI enzymes and analyzed using gel electrophoresis. The bacteria were immobilized in carrageenan on concentrations of 1% and 2% (w / v), respectively. Result shown that P.fluorescens's DNA gave similar fragments between immobilized and without immobilized. Keywords:  Immobilization, Pseudomonas fluorescens, Carrageenan, Gel Electrophoresis.
PENAMBATAN MOLEKUL MUTAN TOKSIN DIFTERI TERHADAP SENYAWA NAD+ SEBAGAI ALTERNATIF CRM197 PADA VAKSIN KONJUGAT Baroroh, Umi; Fauziyah, Hanifa; Astriany, Dewi; Yusuf, Muhammad; Novianti, Mia Tria
JURNAL SAINS DAN TEKNOLOGI FARMASI INDONESIA Vol 9, No 2 (2020)
Publisher : Sekolah Tinggi Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (668.996 KB) | DOI: 10.58327/jstfi.v9i2.148

Abstract

Difteri merupakan penyakit pernapasan menular yang menjadi salah satu penyebab utama kematianpada anak-anak. Penggunaan formaldehid pada pembuatan toksoid difteri dinilai merusak sejumlahsitus antigenik penting pada toksoid. CRM197 merupakan komponen vaksin yang mengalami mutasiasam amino pada toksin difteri. Adanya efek sitotoksisitas CRM197 terhadap sel mamalia dan sel ragimenandakan bahwa mutasi yang terjadi belum menurunkan toksisitas secara optimal, sehinggadiperlukan studi lebih lanjut untuk pengembangan mutan toksin difteri baru. Penelitian ini bertujuanuntuk memodelkan mutan tersebut dan menguji afinitasnya terhadap ligan NAD+. Pendekatanbioinformatika dilakukan dengan penambatan molekul menggunakan program AutoDock 4.2.Diperoleh energi bebas ikatan terendah pada natif sebesar -7,62 kcal/mol. Asam amino Ile31 dan Tyr65dirancang dengan mensubstitusi menjadi Lys31 dan Gln65 (I31K/Y65Q). Hasil penambatan molekulmutan uji menunjukkan nilai energi ikatan meningkat menjadi -5,91 kcal/mol, menandakan adanyapenurunan afinitas NAD+. Titik mutasi ini dapat diusulkan untuk pengembangan mutan toksin difteridengan afinitas rendah terhadap NAD+ sebagai kandidat vaksin difteri.Kata kunci: toksin difteri, CRM197, penambatan molekul, vaksin, bioinformatika
OPTIMASI EKSPRESI SCFV-BAD ANTI-NS1 VIRUS DENGUE PADA ESCHERICHIA COLI ORIGAMI MENGGUNAKAN RESPONSE SURFACE METHOD Astriany, Dewi; Effendi, Syulastri; Febriani Aji Kusuma, Sherlynda; Kusumawardhani, Shinta; Permana Maksum, Iman; Natalia, Dessy; Subroto, Toto
JURNAL SAINS DAN TEKNOLOGI FARMASI INDONESIA Vol 11, No 1 (2022)
Publisher : Sekolah Tinggi Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (510.556 KB) | DOI: 10.58327/jstfi.v11i1.183

Abstract

Dengue merupakan penyakit menular yang masih menjadi masalah kesehatan di dunia. Manifestasi klinis infeksi dengue sulit dibedakan dengan penyakit infeksi lainnya. Uji diagnostik infeksi virus dengue yang cepat dan akurat sangat diperlukan untuk konfirmasi penyakit dan penanganan pasien yang tepat. NS1 adalah glikoprotein yang paling imunogenik dan lestari, disekresikan ke dalam aliran darah. Oleh karena itu, pemeriksaan antigen dari virus dengue NS1 telah diidentifikasi sebagai salah satu penanda spesifik dalam uji diagnostik laboratorium, yang dapat digunakan untuk mendeteksi infeksi dengue primer atau sekunder pada stadium awal. Penelitian ini bertujuan untuk menentukan kondisi optimum ekspresi protein fusi scFv-BAD rekombinan untuk deteksi antigen NS1 virus dengue menggunakan Response Surface Method. Ekspresi protein diinduksi oleh berbagai konsentrasi IPTG (0,1, 0,5, dan 1 mM) pada beberapa suhu selama 18 jam dalam medium Luria Bertani dengan penambahan biotin. ScFv terbiotinilasi rekombinan yang dimurnikan dikarakterisasi dengan metode SDS-PAGE. Hasil penelitian menunjukkan bahwa protein fusi scFv-BAD rekombinan sebagian berada dalam bentuk terlarut dan sebagian berupa badan inklusi. Analisis Central Composite Design menunjukkan bahwa konsentrasi IPTG yang sesuai untuk memproduksi protein scFv rekombinan adalah 0,5 mM pada suhu 28 ºC pada media Luria Bertani.
Molecular Docking of Brazilin from Secang Wood Plant (Caesalpinia sappan L.) as an Anti-Breast Cancer Astriany, Dewi; Baroroh, Umi; Umam, Khotibul
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol 11, No 1 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v11i1.35590

Abstract

Breast cancer is a disease characterized by abnormal cell growth, which can invade adjacent tissues or metastasize to other organs. Secang (Caesalpinia sappan L.) is a plant that has been used as an alternative medicine for a variety of health conditions, including some types of cancer. This study aims to determine whether the brazilin compound found in secang wood can interact with the target receptors estrogen alpha, 17-β-HSD-1, and NUDT5, potentially serving as an anticancer candidate. Molecular docking simulations were employed to identify the molecular interactions of brazilin against estrogen receptor alpha (ERα) (PDB ID: 3ERT), 17β-HSD-1 (PDB ID: 3HB5), and NUDT5 (PDB ID: 5NQR) using AutoDockTools software. The results showed that the best free-binding energy (ΔG) value obtained for brazilin against the 17-β-HSD-1 receptor was -9.16 kcal/mol, with an inhibition constant of 192.45 nM. The ΔG value of brazilin with estrogen alpha was -6.68 kcal/mol, and the ΔG value for brazilin against NUDT5 was -4.8 kcal/mol. Brazilin has a higher potency compared to innate ligands based on the docking result of estrogen alpha receptor and NUDT5. Some structural similarities and interactions occurred between the amino acids GLY186 and TYR155 in brazilin with the binding of amino acids formed in the innate ligand against the 17-β-HSD-1 receptor, thus showing similar affinity to the 17-β-HSD1 receptor. In silico approaches provided valuable insights into the potential of brazilin as an anti-breast cancer agent.
In silico study of Andrographolide from Andrographis paniculata (Burm F.) Ness as an anti-colorectal cancer agent Viranti, Milfa; Baroroh, Umi; Astriany, Dewi
Jurnal Penelitian Vol. 21 No. 1 (2024): June 2024
Publisher : University of Merdeka Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26905/jp.v21i1.13279

Abstract

Cancer is one of the leading causes of death in the world, one of which is colorectal cancer, a malignant tumor in the epithelial tissue of the colon and rectum. Cancer treatment is long-term, so it has an impact on physical and psychological changes for patients. There was many exploration of anticancer drug candidates from natural ingredients such as andrographolide compounds. The in silico method can be done to predicts the absorption, distribution, metabolism, and excretion (ADME) of andrographolide compounds and meets Lipinski Rule of Five. The toxicity of andrographolide compounds was classified in class 4, which needs dose supervision. The prediction of activity potential is quite good based on the Structure-Activity Relationship (SAR). The results of molecular tethering of the three target receptors, namely Cyclooxigenase-2 (COX-2), caspase-3, and Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2), showed that caspase-3 has the best binding value or affinity of -5.36 kcal/mol, with quite a lot of hydrogen bonds of 7. The amino acids formed in andrographolide compounds are the same as the baseline ligands, so it can be concluded that andrographolide has colorectal anticancer activity and can increase caspase-3 activity in colorectal cancer cells.
Molecular Docking of Brazilin from Secang Wood Plant (Caesalpinia sappan L.) as an Anti-Breast Cancer Astriany, Dewi; Baroroh, Umi; Umam, Khotibul
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol. 11 No. 1 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v11i1.35590

Abstract

Breast cancer is a disease characterized by abnormal cell growth, which can invade adjacent tissues or metastasize to other organs. Secang (Caesalpinia sappan L.) is a plant that has been used as an alternative medicine for a variety of health conditions, including some types of cancer. This study aims to determine whether the brazilin compound found in secang wood can interact with the target receptors estrogen alpha, 17-β-HSD-1, and NUDT5, potentially serving as an anticancer candidate. Molecular docking simulations were employed to identify the molecular interactions of brazilin against estrogen receptor alpha (ERα) (PDB ID: 3ERT), 17β-HSD-1 (PDB ID: 3HB5), and NUDT5 (PDB ID: 5NQR) using AutoDockTools software. The results showed that the best free-binding energy (ΔG) value obtained for brazilin against the 17-β-HSD-1 receptor was -9.16 kcal/mol, with an inhibition constant of 192.45 nM. The ΔG value of brazilin with estrogen alpha was -6.68 kcal/mol, and the ΔG value for brazilin against NUDT5 was -4.8 kcal/mol. Brazilin has a higher potency compared to innate ligands based on the docking result of estrogen alpha receptor and NUDT5. Some structural similarities and interactions occurred between the amino acids GLY186 and TYR155 in brazilin with the binding of amino acids formed in the innate ligand against the 17-β-HSD-1 receptor, thus showing similar affinity to the 17-β-HSD1 receptor. In silico approaches provided valuable insights into the potential of brazilin as an anti-breast cancer agent.
Exploring Brazilin as a Potential Breast Cancer Therapy via Molecular Dynamics Simulation Targeting ERα, 17β-HSD1, and NUDT5 Receptors Baroroh, Umi; Dasilva, Jasmine Aulia; Sundalian, Melvia; Astriany, Dewi; Ansori, Arif Nur Muhammad; Yee, Jonie C.
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 11, No. 2, November 2025
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i2.46465

Abstract

Breast cancer remains one of the leading causes of cancer-related mortality worldwide, suggesting the need for novel therapeutic agents with greater efficacy and fewer side effects. Brazilin, a natural flavonoid compound isolated from Caesalpinia sappan L., has shown promising anticancer activity, particularly against breast cancer cells. This study explores the therapeutic potential of brazilin by evaluating its interactions with three key molecular targets: estrogen receptor alpha (ERα), 17β-hydroxysteroid dehydrogenase 1 (17β-HSD1), and Nudix hydrolase 5 (NUDT5). Using molecular dynamics (MD) simulations, the study assesses the stability and binding interactions of complex systems. The results indicate that brazilin forms a stable complex with ERα, demonstrated by a low RMSD (2.6 Å) and strong hydrogen bonding with Glu353, occupancies of 97.8%, and minimal flexibility at the binding site (average RMSF < 2.5 Å). The binding free energy (ΔG Total) for the ERα–brazilin complex was -54.28 kcal/mol, indicating a stronger affinity than the reference ligand 4-hydroxytamoxifen. Brazilin also showed favorable binding with 17β-HSD1 and NUDT5, with binding energies of -39.71 kcal/mol and -23.23 kcal/mol, respectively. These findings suggest that brazilin may modulate critical targets involved in breast cancer progression, particularly in hormone receptor-positive subtypes. Further experimental validation is necessary to confirm its efficacy and optimize its therapeutic potential.
Penguatan Kapasitas Komunitas sebagai Strategi Pencegahan Stunting di Desa Karyamukti Fitriansyah, Sani Nurlaela; Astriany, Dewi; Riasari, Hesti; Nelvi, Nelvi; Nanda, Nanda; Widowaty, Windy
Jurnal Pengabdian Masyarakat Bhinneka Vol. 4 No. 2 (2025): Bulan November
Publisher : Bhinneka Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58266/jpmb.v4i2.824

Abstract

Stunting masih menjadi masalah kesehatan masyarakat yang signifikan di Desa Karyamukti, Kabupaten Garut. Berbagai upaya telah dilakukan namun prevalensi tetap tinggi. Program pengabdian kepada masyarakat oleh STFI yang berkerjasama dengan Rumah Tangguh Stunting (RTS) bertujuan untuk meningkatkan kesadaran dan pengetahuan masyarakat terkait pencegahan stunting. Program ini mentargetkan ibu-ibu serta kader posyandu melalui kegiatan edukasi terstruktur dan pendampingan langsung. Metode yang digunakan mencakup Focus Group Disussion (FGD), penyebaran kuisioner pre-test dan post-test, serta pengenalan produk tambahan gizi berbasis lokal seperti serbuk telur dan madu curcumin. Hasil program ini menunjukkan peningkatan yang signifikan dalam pengetahuan dan kesadaran peserta, dengan kader posyandu menjadi lebih proaktif dalam memantau tumbuh kembang anak. Inisiatif ini membuktikan bahwa edukasi terarah dan intervensi yang tepat dapat meningkatkan upaya pencegahan stunting, sekaligus menekankan pentingnya keterlibatan komunitas dan pemantauan berkelanjutan untuk mencapai hasil yang berkesinambungan
Co-Authors Achmad - Zainuddin Adang Firmansyah Adi Sofyan Ansori, Muhammad Baroroh, Umi Dasilva, Jasmine Aulia DESSY NATALIA Diki Prayugo Wibowo Effendi, Syulastri Fauziyah, Hanifa Febriani Aji Kusuma, Sherlynda Feronia - Reni Fitri Nurwinda Fitriansyah, Sani Nurlaela Hamdani, Syarif Ika Fatimah Iman Permana Maksum Irma Mardiah Isma Oktadiana Khotibul Umam Kusumawardhani, Shinta Melvia Sundalian Muhammad Ismail Faruqi Muhammad Yusuf Nanda Nanda Nelvi, Nelvi Nia Agustina Niken - Muldiyani Novianti, Mia Tria Nur Asni Setiani Nur Asni Setiani Nur Asni Setiani Nur Asni Setiani Nur Asni Setiani Nurwinda, Fitri Putri Afiyanti Reta Julan Mentari Riasari, Hesti Setiani, Nur Asni Sri Gustini Sri Gustini Husein Syarif - Hamdani Syarif Hamdani Syarif Hamdani Toto Subroto Umi Baroroh Umi Baroroh, Umi Viranti, Milfa Widowaty, Windy Wiwin Winingsih Wiwit - Pamuji Yee, Jonie C. Yusuf - Bahtiar