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All Journal Medical Journal of Indonesia Jurnal Ruas (Review of Urbanism and Architectural Studies) Indonesian Journal of Cancer Journal of Industrial Engineering Management Jurnal Kajian Ilmiah Quantitative Economics and Management Studies International Journal of Engineering, Science and Information Technology Arsitekno Humantech : Jurnal Ilmiah Multidisiplin Indonesia International Journal of Accounting, Management, Economics and Social Sciences (IJAMESC)
Bambang Karsono
RS. Kanker Dharmais
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T-lineage blast crisis of chronic myelogenous leukemia: simple record of 4 cases Taroeno-Hariadi, Kartika W.; Tatsumi, Eiji; Hardianti, Mardiah S.; Furuta, Kaho; Syampurnawati, Meilani; Karsono, Bambang; Ishikawa, Takayuki; Yabe, Hiroki; Nagai, Ken-Ichi; Takahashi, Takayuki; Kishimoto, Yuji
Medical Journal of Indonesia Vol 14, No 3 (2005): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (385.291 KB) | DOI: 10.13181/mji.v14i3.189

Abstract

Blast crisis (BC) transformation in chronic myelogenous leukemia (CML) can involve each differentiation lineage of the hematopoietic system, i.e. granulocyte, monocyte, erythrocyte, megakaryocyte, and lymphocyte lineage. The lymphoid blast crisis (BC) leukemia cells usually belong to B-lineage, commonly having the phenotype of Pre-B stage of the B-lineage, in which cell-surface immunoglobulin (sIg) is not yet expressed. In contrast, T-lineage BC of CML is extremely rare. The objective of this study is to describe the fenotype, fusion transcript of bcr-abl, TdT, and cytoplasmic CD3 in T-lineage BC CML cases. Case report study. This report shows a simple summary of 4 cases of T-lineage BC of CML which have been collected in the phenotypic and genotypic analysis study for 17 years (1987-2004). In all cases, the chromosomal analysis revealed the presence of t(9;22)(q34;q11) at presentation. Cell surface analysis were done at diagnosis. Cases’ mononuclear cells stored as 10% DMSO were retrieved to be performed reverse transcription (RT) PCR BCR-ABL multiplex to demonstrate the presence of the fusion transcript of bcr-abl. RT-PCR was also performed for detecting the expression of cytoplasmic CD3ε and terminal deoxynucleotydil transferase (TdT). The results of cell surface antigen (CSA) at presentation showed that 1 case was CD7+, CD5-, and CD2-; 1 case CD7+, CD5+, and CD2-; and 2 cases CD7+, CD5+ and CD2+ indicating that all these T-lineage BC of CML cells show the phenotype of pre-(pro-) thymic stage phenotype. In the present study, two cases showed b2a2, one e1a2, and one negative bcr-abl transcript. The RT-PCR revealed the presence of CD3ε mRNA in all cases, and TdT mRNA in only one case. These results can constitute a basis for the future analysis of T-lineage BC of CML from now on. (Med J Indones 2005; 14: 184-9)Keywords: chronic myelogenous leukemia (CML), blastic crisis (BC), T-lineage, bcr-abl fusion gene, CDε, TdT
Efficacy and Safety of In-Asia-Manufactured rhG-CSF 300 mcg As Primary Prophylaxis for Prevention of CHOP Chemotherapy-induced Severe Neutropenia in Elderly Patients with Lymphoma Non-Hodgkin Reksodiputro, Harryanto; Djoerban, Zubairi; Tambunan, Karmel L.; Sudoyo, Aru W.; Widjanarko, Abidin; Atmakusuma, Djumhana; Syafei, Syafrizal; Prayogo, Nugroho; Hukom, Ronald; Ranuhardy, Dody; Jack, Zakifman; Harsal, Asrul; -, Noorwati S; Karsono, Bambang; Effendi, Shufrie; Tadjoedin, Hilman
Indonesian Journal of Cancer Vol 3, No 1 (2009): Jan - Mar 2009
Publisher : "Dharmais" Cancer Center Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (790.74 KB)

Abstract

Penelitian open-label, non-komparatif ini dilakukan untuk mengevaluasi efektivitas dan keamanan recombinant human G-CSF produksi Asia sebagai profilaksis primer dalam pencegahan neutropenia derajat berat pada pasien usia lanjut (>60 tahun) dengan limfoma non-Hodgkin (LNH) derajat sedang dan lanjut (stadium II,III,IV) yang mendapat terapi CHOP (siklofosfamid, doksorubisin, vinkristin). Profilaksis primer recombinant human G-CSF (rhG-CSF) produksi Asia dapat mengurangi median durasi neutropenia derajat 4 pada siklus sitostatistika ke-1 dan ke-2 menjadi tiga hari, sementara median durasi neutropenia derajat 3 pada siklus sitostistika ke-1 menjadi dua hari dan pada siklus sitostatistika ke-2 menjadi dua setengah hari, dari median durasi neutropenia grade 4 dan grade 3 tanpa G-CSF, yaitu empat dan lima hari berurutan. Febrile neutropenia ditemukan pada 7 pasien yang mendapat rhG-CSF produksi Asia (24.1%), lebih rendah jika dibandingkan studi tanpa rhG-CFS (31.3-34% FN). Tiga pasien mendapat rhG-CSF produksi Asia (10,3%) dirawat inap akibat febrile neutropenia, lebih rendah jika dibandingkan rawat inap pada studi tanpa rhG-CSF (24-28%). Kejadian yang tidak diinginkan terbanyak adalah mual dan muntah yang terjadi pada 9 (31%) pasien. Sebagai kesimpulan, penggunaan rhG-CSF produksi Asia untuk profilaksis primer pada pasien LNH usia lanjut yang mendapat regimen CHOP dapat mengurangi durasi neutropenia, mengurangi kejadian febrile neutropenia, dan angka rawat inap akibat febrile neutropenia.Kata kunci : Efektivitas, keamanan, G-CSF, LNH pada usia lanjut
Preoperative Neoadjuvant Hormonal Therapy and Neoadjuvant Chemotherapy for Stage 3B and 4 Breast Cancer Patients in Dharmais Hospital-National Cancer Center, Indonesia: A Cohort Study Karsono, Ramadhan; Purwanto, Denni Joko; Haryono, Samuel J.; Karsono, Bambang; Sari, Lenny; Pratiwi, Yulia; Aryandono, Teguh
Indonesian Journal of Cancer Vol 12, No 4 (2018): October-December
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (891.03 KB) | DOI: 10.33371/ijoc.v12i4.604

Abstract

Background: There are no data of efficacy comparison between primary systemic therapy in stage 3B and 4 breast cancer patients in Indonesia. This study compared long term outcomes of breast cancer patients treated with neoadjuvant hormonal therapy (NAHT) and those treated with neoadjuvant chemotherapy (NACT)Methods: This was a cohort study conducted from 2011 to 2017. A total of 122 patients with stage 3B and 4 breast cancer received NAHT (n = 62) or NACT (n = 60) within a 6 cycles for NACT and 6 months for NAHT were included. Patients were excluded if they had a mastectomy before treatment, were pregnant, had been given hormonal therapy or chemotherapy before, had a contra-indication of chemotherapy, had a contra-indication of salpingo-oophorectomy bilateral for premenopausal patients, and declined to enter this study. The primary outcome of this study was overall survival. The outcomes were analysed using Kaplan-Meier for survival analysis and cox proportional hazard regression to estimate the hazard ratio.Results: There was a statistically significant difference in overall survival (p = 0.038). Median overall survival for NAHT patients was 1265 days and for NACT patients was 654 days. The hazard ratio showed NACT patients had a higher risk than NAHT patients (1.7 95% CI 1.03 – 2.9). Pathological complete response rate was higher in the NACT group than in the NAHT group (3.3% vs. 0%).Conclusions: Neoadjuvant hormonal therapy was superior to neoadjuvant chemotherapy in term of overall survival.
HISTORICAL ANALYSIS OF URBANITY ON THE WATERFRONT Karsono, Bambang
Arsitekno Vol 2, No 2 (2013): Jurnal Arsitekno
Publisher : Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/arj.v2i2.1244

Abstract

Since the dawn of the civilization, water plays an important role in human life. Water covers 75% of the earth surface and sustains virtually every life form on it. From the early days of human settlement, the banks of themajor rivers such as the Nile, Tigris, Euphrates, Indus and Hwang Ho became the cradle of civilizations. It is here the culture developed and the pattern and morphology of urban settlement became the source of ourknowledge. This paper attempts to overview the main developmental periods of waterfronts around the world. It discusses on the fundamental periods and events which shaped the city water-borne activities and explained how those events influenced the nature of public space on the waterfronts. The port-city that developed since then will be analyzed corresponding to the historical events that are related to the city development. A few cases studies will be shown in order to present a valuable descriptive situation. Corresponding to the above issues, a continuous process that took place in the development of the waterfront will be discussed extensively.
Evaluasi aksesibilitas difabel pada ruang terbuka Kota Tebing Tinggi Maharani, Ayunda; Karsono, Bambang; Andriana, Dela
Humantech : Jurnal Ilmiah Multidisiplin Indonesia Vol. 3 No. 1 (2023): Humantech : Jurnal Ilmiah Multidisiplin Indonesia
Publisher : Program Studi Akuntansi IKOPIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32670/ht.v3i1.3733

Abstract

Ruang terbuka publik pada suatu kota merupakan wadah bagi masyarakat umum untuk melakukan berbagai aktivitas dan kepentingan publik. Aksesibilitas pada ruang terbuka publik seharusnya dapat memenuhi kebutuhan seluruh pengguna ruang meliputi anak-anak, remaja, dewasa, lansia hingga difabel. Pada Taman Kota Tebing Tinggi aksesibilitas bagi pengguna difabel masih kurang memadai secara kualitas maupun kuantitasnya sehingga dikhawatirkan ruang terbuka publik tidak menjadi publik lagi karena hanya diperuntukkan bagi masyarakat non difabel saja. Penelitian ini bertujuan untuk menganalisis dan mengevaluasi kualitas aksesibilitas difabel pada ruang terbuka publik di Kota Tebing Tinggi berdasarkan ketentuan yang ada dan perspektif difabel sebagai pengguna ruang tersebut. Penelitian ini menggunakan metode kualitatif dengan deskriptif evaluatif yaitu dengan cara observasi, dokumentasi dan mewawancarai pengguna difabel untuk mengevaluasi aksesibilitas difabel melalui parameter desain universal, PERMEN PU No. 14 tahun 2017 dan perspektif dari pengguna difabel. Hasil penelitian menunjukkan bahwa Taman Kota Tebing Tinggi belum sepenuhnya ramah bagi aksesibilitas pengguna difabel.
Fenomena keberadaan warung kopi bagi masyarakat produktif Kota Lhokseumawe Pasaribu, Suci Untari Putri Handayani; Karsono, Bambang; Fidyati, Fidyati
Humantech : Jurnal Ilmiah Multidisiplin Indonesia Vol. 3 No. 1 (2023): Humantech : Jurnal Ilmiah Multidisiplin Indonesia
Publisher : Program Studi Akuntansi IKOPIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32670/ht.v3i1.3734

Abstract

Experience of space erat kaitannya terhadap suatu topik yang berhubungan dengan eksistensi/keberadaan suatu tempat. Warung kopi merupakan salah satu tempat yang eksistensi/keberadaannya terus terjaga sampai saat ini. Keberadaan warung kopi merupakan suatu fenomena mendunia yang tidak dapat dipisahkan dari masyarakat produktif. Banyak dari Masyarakat produktif yang menjadikan warung kopi sebagai tempat untuk melakukan berbagai aktivitas dan kegiatan karena pada warung kopi terdapat makana/nilai tersendiri yang dapat membedakannya dengan tempat lain. Hal itu menyebabkan eksistensi/keberadaan warung kopi terus terjaga, terlepas dari kondisi warung kopi tersebut. Adapun artikel ini untuk mengetahui seberapa bernilai warung kopi bagi masyarakat produktif di Kota Lhokseumawe. Jenis penelitian menggunakan kualitatif, dan pendekatan eksploratif deskriptif, dengan menggunakan metode observasi juga wawancara. Hasil dari observasi dan wawancara dianilis dengan menggunakan variabel-variabel pembentuk place, sehingga mengetahui bahwa keberadaan warung kopi bagi masyarakat produktif sangat bernilai, dan tidak dapat tergesar dan tergantikan dengan tempat lainnya. Makna yang terdapat pada warung kopi terbentuk berdasarkan experience of space yang dapat merubah space menjadi place sehingga dapat membentuk suatu nilai pada warung kopi.
Dokumentasi arsitektur dalam upaya pelesatrian rumah administratur perkebunan PTPN II Putra, Muhammad Sandi; Karsono, Bambang; Saputra, Eri
Humantech : Jurnal Ilmiah Multidisiplin Indonesia Vol. 3 No. 1 (2023): Humantech : Jurnal Ilmiah Multidisiplin Indonesia
Publisher : Program Studi Akuntansi IKOPIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32670/ht.v3i1.3806

Abstract

Belanda memilih usaha perkebunan sebagai upaya meningkatkan perekonomian mereka di Indonesia. Pada akhir abad ke-19, mulailah usaha perkebunan mulai berkembang dan menyebar hingga ke Sumatera Utara. Pada masa itu suatu wilayah perkebunan Deli Maatschapij dipimpin oleh seorang Administrateur perkebunan atau juga disebut Administartur/Manajer. Administratur perkebunan Deli Maatschapij memiliki rumah untuk menjalankan aktivitasnya sebagai pimpinan perusahaan. Selain usianya yang sudah melebihi 50 tahun sebagai warisan sejarah, rumah ini juga telah memenuhi kriteria cagar budaya untuk didokumentasikan. Penelitian ini bertujuan untuk melestarikan warisan sejarah dari segi arsitektur bangunan Rumah Administratur Perkebunan PTPN-II dengan cara mendokumentasikan secara digital yang meliputi data ukuran yang terukur dengan menggunakan salah satu pedoman standar ICOMOS. Dalam pengumpulan dan menganalisis data pada penelitian ini menggunakan pendekatan penelitian ini menggunakan deskriptif survei dengan mengikuti panduan HABS. Rumah Administratur Perkebunan PTPN II merupakan bangunan hasil dari peninggalan perusahaan perkebunan terbesar di Sumatera pada akhir abad ke-19. Rumah tersebut memiliki gaya khas Kolonial Belanda dengan kombinasi rumah panggung sebagai bentuk adaptasi terhadap lingkungan.
The Divergence Between Prophet’s Masjid and Present Masjid: An Architectural Essay Deni, Deni; Karsono, Bambang; Mirsa, Rinaldi; Safyan, Adi; Saputra, Eri
International Journal of Engineering, Science and Information Technology Vol 1, No 2 (2021)
Publisher : Department of Information Technology, Universitas Malikussaleh, Aceh Utara, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (681.314 KB) | DOI: 10.52088/ijesty.v1i2.136

Abstract

Basically, functional aspect in masjid can easily understand that there are divergence phenomena between the present masjid compared to the physical appearance and function of the Prophet's Masjid in the beginning. The objective of study is to reveals the existence of the Prophet's Masjid regarding the process and physical description of the masjid through hadith, sirah nabawiyah and related references as a guideline for comparative thinking on the present masjid. Critical descriptive research method is used as an analytical instrument to     assess present masjid by adopting the idea of function in architecture knowledge and collaborate with the idea of social values as a  reflection of the paradigm of Muslims towards the present masjid. Discussion find out that the people's perspective on present masjid tends to be statically trapped in the shape, form and visuals from the legacy of Islamic civilization after the time of the Prophet’s Muhammad PBUH.
The Effect Of Limestone and Fly on Clay Stabilization of CBR and Soil Compressive Strength Syafwandi, Syafwandi; Lonarissa Harditya Putri, Vandika Nadia; Karsono, Bambang
International Journal of Engineering, Science and Information Technology Vol 2, No 2 (2022)
Publisher : Department of Information Technology, Universitas Malikussaleh, Aceh Utara, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (481.683 KB) | DOI: 10.52088/ijesty.v2i2.251

Abstract

The subgrade is the road access construction project must have a firm soil bearing capacity to withstand its load. Clay soil has high water content and expands quickly. Various ways have been done to overcome it; one is improving the original soil properties using the stabilization method. The research was conducted to stabilize expansive clay soil using fly ash and limestone with a percentage of fly ash of 5%, 10%, 15%, 20% fly ash, and 25% limestone. Existing soil was used from a good pad construction project in Ujung Pangkah, Gresik, East Java. The tests carried out are specific gravity, Atterberg, compaction, CBR, and UCT tests. The CBR test was conducted to determine the appropriate CBR value to support DDT. The compressive strength of the soil was tested using the UCT test. The study results of the effect of fly ash and limestone are an increase in the dry weight of the earth and a decrease in soil water content. The rise in CBR and maximum soil compressive strength with a mixture variation of 20% fly ash + 25% limestone, Qu is 2.98 kg/cm 2, and CBR is 10.56%. This is due to a decrease in the water content, thereby increasing the dry weight of the soil.
The Level of Sense of Place in Inpres Market Karsono, Bambang; Rekha Putri, Khana; Olivia, Sisca; A, Hendra
International Journal of Engineering, Science and Information Technology Vol 2, No 2 (2022)
Publisher : Department of Information Technology, Universitas Malikussaleh, Aceh Utara, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (425.551 KB) | DOI: 10.52088/ijesty.v2i2.238

Abstract

Physical intervention in a market area tends to change user habits in responding to the space. This situation can ruin the authenticity of the sense of place and the loss of local identity for generations. This study aims to reveal the authenticity and understanding of the Inpres Market, a traditional market in Lhokseumawe. Re-development has been carried out at the Inpres Market to improve the layout of the stalls, change the architectural form of the building with a contemporary image, and increase the floor of the building vertically into two levels. Apprehensively this physical intervention will erode the meaning of place that has been attached to people's memories for a long time. This study must be conducted before any other new physical intervention occurs for any renovation or revitalization reason. This study is place-based research by choosing Inpres Market in Lhokseumawe as the case study. The research variable uses physical (tangible) and social (intangible) variables to reveal the sense of place in the market. The data was obtained using quantitative and qualitative methods, while the analysis was carried out in an exploratory, descriptive manner. The data collection method was conducted in two stages: observation, interviews, and questionnaires. The second stage of data collection involved 134 respondents, and a random sampling method was implemented to determine the respondents. The results showed that physical and social variables' influence in creating a sense of place is revealed.
Co-Authors A, Hendra Abidin Widjanarko Ahmad Padhil Andriana, Dela Aru W. Sudoyo Asrul Harsal, Asrul Atmoko, Dwi Deni Deni DENNI JOKO PURWANTO, DENNI JOKO Djumhana Atmakusuma, Djumhana Dody Ranuhardy, Dody Eiji Tatsumi Eri Saputra Fidyati, Fidyati Harryanto Reksodiputro, Harryanto Haryono, Samuel J. HILMAN TADJOEDIN, HILMAN Hiroki Yabe Junianti, Emmy Kaho Furuta Karmel L. Tambunan Karsono, Ramadhan Kartika W. Taroeno-Hariadi Ken-Ichi Nagai Lenny Sari, Lenny Liana, Indah Lonarissa Harditya Putri, Vandika Nadia Maharani, Ayunda Mangkupradja, Didi Rochyadi Mardiah S. Hardianti Meilani Syampurnawati Mirsa, Rinaldi Nadia Farhanah Syafhan Noorwati S -, Noorwati S Nugroho Prayogo Olivia, Sisca P, A. Dwi Wahyuni Pasaribu, Suci Untari Putri Handayani Putra, Muhammad Sandi Rachmat Pramukty Rekha Putri, Khana Ronald Hukom Safyan, Adi Shufrie Effendi, Shufrie Sri Wulandari Syafrizal Syafei, Syafrizal Syafwandi, Syafwandi Syauket , Amalia Takayuki Ishikawa Takayuki Takahashi Taufiq Immawan, Taufiq Teguh Aryandono Tri Widyastuti Yahdiana Harahap Yayan Hendayana Yuji Kishimoto Yulia Pratiwi Zakifman Jack, Zakifman Zubairi Djoerban