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All Journal Medicina E-Jurnal Medika Udayana Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Berkala Ilmu Kesehatan Kulit dan Kelamin ISM (Intisari Sains Medis) : Jurnal Kedokteran Jurnal Biomedika dan Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research Bali Dermatology and Venereology Journal Neurologico Spinale Medico Chirurgico MAHESA : Malahayati Health Student Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran Journal of General-Procedural Dermatology & Venereology Indonesia Bali Dermatology Venereology and Aesthetic Journal Indonesian Journal of Biomedicine and Clinical Sciences Cermin Dunia Kedokteran
Nyoman Suryawati
Departemen Dermatologi And Venereologi, Fakultas Kedokteran, Universitas Udayana-RSUP Sanglah Denpasar, Bali, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Jurnal Biomedika dan Kesehatan

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Kadar Transforming Growth Factor- Serum Berkorelasi Positif dengan Kadar Immunoglobulin M Anti-Phenolic Glycolipid-1 pada Narakontak Serumah Pasien Kusta Multibasiler Primasari, Putu Yunita; Rusyati, Luh Made Mas; Karmila, I Gusti Ayu Agung Dwi; Winaya, Ketut Kwartantaya; Suryawati, Nyoman; Karna, Ni Luh Putu Ratih Vibriyanti
Jurnal Biomedika dan Kesehatan Vol 6 No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.146-157

Abstract

Background Leprosy is a chronic progressive infectious disease. Phenolic glycolipid-1 (PGL-1) is an antigen of Mycobacterium leprae, which can trigger the host’s antibody response. Transforming growth factorβ (TGF-β) plays an immunosuppressive role when the host is exposed to PGL-1 antigen or other M. leprae antigens. This study aims to determine the correlation of TGF-β levels with IgM anti-PGL-1 levels in patients with multibacillary leprosy household contacts. Methods Observational analytical study with a cross-sectional approach. The study subjects consisted of 48 household contact subjects and 24 non-household contact subjects aged 15-65 years old who were selected by consecutive sampling based on inclusion and exclusion criteria. 3 mL of venous blood samples were taken and then examined for IgM anti-PGL-1 and TGF-β with the ELISA kit. Data analysis was carried out using SPSS version 23, and a p-value <0.05 was significant. Results The mean level of IgM anti-PGL-1 in the household contact group was 685.46 ± 290.79 u/mL, while in the non-household contact group was 345.50 ± 206.58 u/mL. The mean TGF-β level in household contact groups was 256.69 ± 127.41 pg/mL, while in the non-household contact group was 144.85 ± 36.73 pg/mL (p<0.001). This study found a moderate positive relationship (r=0.450, p<0.001) between levels of TGF-β and IgM anti-PGL-1 household contacts and non-household contacts group. Conclusions The mean level of IgM anti-PGL-1 and TGF-β in household contacts is higher than in non-household contacts, with a significant difference. There is a moderate positive significant relationship between levels of TGF-β and IgM anti-PGL-1 household contacts and non-household contacts group.
Co-Authors Aditya Permana Aditya Permana Anang Endaryanto Andrew Wicaksono Aurelia Stephanie Bagus Bagus Bharata, Putu Evindya Vipascitadewi Nandanaya Christiana Paramita Cita Rosita Sigit Prakoeswa Darmaputra, I Gusti Nyoman Djuanda, Kevin Jonathan Duarsa, Putu Laksmi Anggari Putri Elis Indira, I Gusti Ayu Agung Evy Ervianti Gede Mahadika Pradipta Atmaja Gunawan, Regina Hasri Dewi Herman Saputra Herman Saputra Herman Saputra I Gde Nengah Adhilaksman I Gde Nengah Adhilaksman I Gusti Ayu Agung Dwi Karmila I Gusti Ayu Agung Elis Indira I Gusti Ayu Agung Praharsini I Gusti Ayu Agung Praharsisni I Gusti Nyoman Darmaputra I. G. A. A. Elis Indira Ida Ayu Uttari Priyadarshini IGAA Ellis Indira IGAA Praharsini Indira, I Gusti Ayu Agung Elis Indira, IGAA Ellis Jason Jonathan Jihan Prani Wibowo Juliari, Gusti Ayu Made Juliyanti Juliyanti - Juliyanti -, Juliyanti Ketut Kwartantaya Winaya Khathreen, Corry Laksmi, I Gusti Ayu Agung Mini Linda Astari, Linda Luh Gede Melia Puspita Sari Luh Made Mas Rusyati Made Martina Windari Made Swastika Adiguna Made Wardhana Mohana Naravenah Ni Kadek Yunita Arsita Dewi Ni Luh Putu Ratih Vibriyanti Karna Ni Made Dwi Puspawati Ni Putu Melda Dharmahayu Nyoman Upadana Nyoman Yoga Maya Pramita Paramahamsa, Shirdi Paramita, Christiana Praharsini, IGAA Pramita, I Gusti Ayu Sattwika Prima Saraswati Sanjiwani Sudarsa Primasari, Putu Yunita Putu Yonika Budiarisma Ricky Fernando Maharis Sanjiwani, Saraswati Prima Saraswati Prima Sanjiwani Saraswati Sudarsa, Prima Sanjiwani Sutiawan, Indry Salonika Wicaksono, Rafael Lilik Winaya, Ketut Kwartantaya