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All Journal ACTA VETERINARIA INDONESIANA Indonesian Journal of Electronics and Instrumentation Systems Jurnal Ilmu Dasar AL KAUNIYAH BERKALA SAINSTEK Biogenesis: Jurnal Ilmiah Biologi UNEJ e-Proceeding Jurnal Ilmiah Biosaintropis (Bioscience-Tropic) Universa Medicina Jurnal Bioteknologi & Biosains Indonesia (JBBI) BIOEDUKASI Warta Pengabdian Jurnal Biolokus: Jurnal Penelitian Pendidikan Biologi dan Biologi Bioma : Jurnal Biologi dan Pembelajaran Biologi J-Dinamika: Jurnal Pengabdian Kepada Masyarakat SULUH: Jurnal Abdimas Jurnal Riset Biologi dan Aplikasinya Life Science and Biotechnology Bioeksperimen Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia Berita Biologi
Rike Oktarianti
Biology Department, Faculty Of Mathematic And Natural Sciences, University Of Jember
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Control & Systems Engineering Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Veterinary Other

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Pola Sidik Jari Tangan dan Ciri Fisik Penderita Sindrom Down di Sekolah Luar Biasa (SLB) Kota Jember Oktarianti, Rike; Yunitasari, Indah; Mahriani, Mahriani
BERKALA SAINSTEK Vol 7 No 2 (2019)
Publisher : Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/bst.v7i2.12441

Abstract

Sindrom down merupakan kelainan akibat penambahan jumlah kromosom tubuh nomor 21 sehingga mempengaruhi ciri fisik, pola dan jumlah sulur ujung jari tangan. Tujuan dari penelitian ini untuk mengetahui ciri fisik, pola sidik jari dan jumlah sulur penderita sindrom down. Pengambilan sampel dilakukan di SLB Kota Jember, data ciri fisik didokumentasikan, dideskripsikan dan dianalisis dengan Uji Wilcoxon untuk mengetahui signifikansi perbedaan dengan orang normal. Pola dan jumlah sulur dilakukan perekaman dengan menempelkan ujung jari pada bantalan tinta selanjutnya ditempelkan pada kertas HVS. Selanjutnya ditentukan pola sidik jari dan dihitung jumlah sulurnya. Jumlah sulur selanjutnya diuji Independent Sampel T-Test untuk mengetahui perbedaan dengan orang normal. Hasil penelitian menunjukkan bahwa ciri fisik siswa SLB Kota Jember mempunyai perbedaan yang signifikan dengan orang normal meliputi hidung pesek, mulut kecil dan cenderung membuka, jari tangan pendek. Ketiga parameter tersebut pada Uji Wilcoxon menunjukkan perbedaan yang nyata dengan orang normal. Karakter lain yaitu mata sipit dan membujur keatas serta terdapat lipatan mata (epikantus), ujung lidah yang melebar, telapak tangan siswa umumnya mempunyai garis simian, jari kelingking yang bengkok, serta pada jari kaki pertama dan kedua mempunyai jarak lebar. Pola sidik jari siswa adalah loop ulnar (84,17%) dengan jumlah sulur rata-rata 145,59 sulur, lebih banyak dari orang normal. Hasil uji Independent Sampel T-Test menunjukkan perbedaan yang signifikan antara siswa penderi sindrom down dengan orang normal
KARAKTERISASI PARSIAL FAKTOR IMUNOMODULATOR KELENJAR SALIVA Aedes aegypti (DIPTERA: CULICIDAE) SEBAGAI KANDIDAT Transmission Blocking Vaccine (TBV) DEMAM BERDARAH DENGUE Wathon, Syubbanul; Senjarini, Kartika; Widajati, Sri Mumpuni Wahyu; Oktarianti, Rike
BERKALA SAINSTEK Vol 2 No 1 (2014)
Publisher : Universitas Jember

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Abstract

Penyakit Demam Berdarah Dengue (DBD) disebabkan oleh infeksi virus dengue yang dibawa Aedes aegypti (Ae. aegypti) sebagai vektor primernya. Pengendalian vektor pada penyakit DBD masih belum maksimal. Selain itu vaksin yang belisensi untuk penyakit DBD masih belum dilaporkan. Melalui pengembangan TBV salah satunya dengan memanfaatkan komponen saliva vektor. aliva vektor memiliki potensi dalam meningkatkan transmisi patogen ke tubuh inang, maka perlu adanya karakterisasi molekul dalam saliva nyamuk termasuk faktor imunomodulator. Karakterisasi faktor imunomodulator saliva Ae. aegypti dilakukan melalui uji reaksi silang antara protein kelenjar saliva Ae. aegypti dengan beberapa plasma darah manusia. Hasil penelitian menunjukkan adanya protein spesifik yang dikenali antibodi dalam plasma darah orang endemik dengan berat molekul ~ 37 kDa. Hal ini megindikasikan bahwa di dalam tubuh penduduk endemik telah mengembangkan antibodi anti-saliva Ae. aegypti yang diduga berperan penting dalam resistensi terhadap infeksi virus dengue. Kata Kunci: Ae. aegypti, DBD, faktor imunomodulator, kelenjar saliva, TBV
Prevalence of Phenylthiocarbamide (PTC) Taste Sensitivity and Colour Blindness in Tengger Tribe Population, Ranupani Village, Senduro, Lumajang Oktarianti, Rike; Putra, Iguh Widigda; Arofa, Resmining Mega; Lelono, Asmoro
BERKALA SAINSTEK Vol 9 No 4 (2021)
Publisher : Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/bst.v9i4.26435

Abstract

The taste of sensitivity of phenylthiocarbamide (PTC), is autosomal dominant trait inherited while the colour blindness is a sex linked genetic trait on the X chromosome. The purpose of this study was to determine the distribution of taster and non taster phenotypes, prevalence of color blindness, frequency of taster and non taster alleles, and frequency of color blind alleles, as well as pedigree analysis in non taster and color blind families. The research was conducted on the Tengger tribe, in Ranupani village, Senduro, Lumajang. Determination of the sample is carryout randomly. Detection of the ability to taste PTC was respondents to taste the PTC solution from the lowest concentration of 0.32mg/L (P13) to the highest concentration of 1300 mg/L (P1). Color blindness detection by the Ishihara method. The results of the study showed that the distribution of the taster was 98.1% while the non-taster was 1.9%. The allele frequency of the dominant taster (T) was 0.86 and the recessive allele non taster (t) is 0.14. The prevalence of color blindness in the population of the Tengger tribe was 0.63% and the allele frequency for color blindness was 0.013. The pedigree analysis of non taster family showed that non taster individuals were born from taster couple (Tt) or from couple of non taster (tt) with tasters (Tt) heterozigot. While the pattern of inheritance of color blindness was criss-cross inheritance pattern, which is passed from mother to son.
Molecular characterization of proteolytic bacteria associated with Malaria vectors: Anopheles sundaicus and Anopheles vagus Senjarini, Kartika; Labes, Antje; Wathon, Syubbanul; Oktarianti, Rike; Raras, Tri Yudani Mardining; Ardyah, Naura Paramitha Cindy; Agustin, Dita Paramytha; Ainiyah, Durotun; Utami, Diah Ayu
Universa Medicina Vol. 43 No. 2 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.202-212

Abstract

BACKGROUNDAnopheles (An.) sp. transmits Plasmodium parasites that cause malaria. In its life cycle in the mosquito’s body, Plasmodium passes through 2 mosquito organs, namely the salivary glands and midgut. The bacterial community (symbiont bacteria) in these organs has been known to influence and/or inhibit the development of the Plasmodium life cycle by producing specific proteases. This research aims to isolate and characterize symbiotic bacteria with proteolytic activity from 2 important malaria vectors in Indonesia: An. sundaicus and An. vagus. METHODSA total of 183 bacterial originating from the salivary glands and midgut were successfully isolated. Initial screening was carried out based on morphological differences, followed by purification of the selected isolates to obtain single colonies. The selected isolates were then subjected to an initial proteolytic ability test using skim milk agar media. Only isolates with proteolytic activity were further characterized with the 16SrDNA molecular marker. The isolates were pabs5 from the salivary glands and pabs3 from the midgut of An. vagus, while pdbs3 and ecbs4 were isolates from the salivary glands and midgut of An. sundaicus. RESULTSMorphological and molecular characterization showed that both pabs5 and pabs3 isolates were Pseudomonas(Ps.) aeruginosa, while ecbs4 was Enterobacter cloacae and pdbs3 was Pantoea dispersa. These species werefirst discovered in Anopheles vagus and Anopheles sundaicus. CONCLUSIONThe ability of Ps. aeruginosa and Pantoea dispersa to produce proteases indicated their potential role in the exploration of new strategies to control mosquito vectors that transmit pathogens.
IN-SILICO ANALYSIS OF SYMBIONT BACTERIA DIVERSITY IN THE MIDGUT OF Aedes aegypti USING 16S rDNA MOLECULAR MARKERS DATABASE Syubbanul Wathon; Aufar Finasrullah; Rike Oktarianti; Kartika Senjarini
Jurnal Bioteknologi dan Biosains Indonesia Vol. 10 No. 2 (2023)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

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Abstract

Dengue Hemorrhagic Fever (DHF) is caused by the dengue virus, which is transmitted through Aedes aegypti mosquitoes when they feed on human blood.  To effectively control the DHF vector, it is crucial to accurately characterize the symbiont bacteria associated with Ae. aegypti through an in-silico approach to identify potential targets. This study utilized in- silico analysis based on the 16S rDNA molecular marker to explore the diversity of symbiont bacteria obtained from bioinformatics databases. The analysis and visualization of bacterial diversity were conducted using the Pathosystem Resource Integration Center (PATRIC). The analysis results revealed that bacterial diversity in the midgut of Ae. aegypti, categorized as culturable and non-culturable bacteria, exhibited similar abundance patterns at the family level, albeit with varying detection rates. The most dominant taxa included the phylum Proteobacteria, class Gammaproteobacteria, order Enterobacterales, and family Enterobacteriaceae. Within the culturable bacteria category, the dominant taxa were the genus Salmonella and species Salmonella enterica, whereas the non-culturable bacteria category indicated the prevalence of the genus Escherichia and species Escherichia coli.
Pemberdayaan Umkm Gerabah Kesilir Melalui Pembentukan Komunitas Pra Koperasi Eva Tyas Utami; Rike Oktarianti; Dwi Setyati; Anik Swandari
SULUH: Jurnal Abdimas Vol 6 No 2 (2025): SULUH: Jurnal Abdimas Februari
Publisher : FEB-UP Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/suluh.v6i2.7064

Abstract

The creative industry is an economic sector that does not require a large scale of production. One of the creative industries that is developing in Demangan Babatan, Kesilir Village, Wuluhan District, Jember Regency is the pottery industry with raw materials made of clay. There are quite a number of pottery products with quite varied designs. However, there are still problems faced by pottery craftsmen in the area, namely the lack of capital, marketing networks and the absence of regeneration in this business. To overcome these problems, it is necessary to provide training and the formation of pre-cooperatives for craftsmen. Service activities are carried out by forming a pre-cooperative community to facilitate the availability of capital for craftsmen.
Characterization of marine bacteria isolates GaN 2 and RaN 2 from Papuma Coastal, Jember Wathon, Syubbanul; Senjarini, Kartika; Oktarianti, Rike; Hasanah, Fitrianti Milhatul; Oktavia, Melinda Dwi Putri; Puspitasari, Endah; Labes, Antje
Jurnal Biolokus : Jurnal Penelitian Pendidikan Biologi dan Biologi Vol 8, No 1 (2025): June
Publisher : Universitas Islam Negeri Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30821/biolokus.v8i1.4289

Abstract

The exploration of secondary metabolites for various human needs has now extended to aquatic environments. The fluctuating and dynamic nature of aquatic environments can stimulate marine bacteria to adapt by producing secondary metabolites. The diversity of marine bacteria has become increasingly promising as a target for obtaining various potential secondary metabolites. This study aims to isolate potential marine bacteria that produce secondary metabolites from the Papuma Beach area in Jember. Marine bacterial characterization can be carried out through morphological and molecular approaches. In this study, bacterial isolates were collected from marine algae at aquatic sites. Bacteria were isolated from the algae using the spread plate and streak plate methods on nutrient agar dissolved in artificial seawater as the medium until single colonies were obtained. Morphological characterization of the single colonies was conducted by observing colony shape and color, as well as performing Gram staining. Molecular characterization of selected single colonies was performed by amplifying the 16S rDNA as a bacterial molecular marker. The results of this study showed that marine bacteria that grew well and remained stable on artificial media were successfully isolated from green and red algae samples, labeled GaN 2 and RaN 2, respectively. The GaN 2 bacterial isolate was identified as Fictibacillus barbaricus strain SQ5-4, while the RaN 2 bacterial isolate was identified as Bacillus altitudinis strain 41KF2bT.26. According to previous studies, Fictibacillus barbaricus is known to have potential as a bioremediation agent, while Bacillus altitudinis has potential applications as an antitumor, antimicrobial, and antioxidant-producing agent.
IN-SILICO ANALYSIS OF THE INTERACTION BETWEEN D7 PROTEIN FROM THE SALIVARY GLAND OF Ae. albopictus AND Thromboxane A2 FOR DEVELOPING ANTIPLATELET AGENT Wathon, Syubbanul; Senjarini, Kartika; Oktarianti, Rike; Lelono, Asmoro
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 12 No. 1 (2025)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2025.8176

Abstract

The salivary glands of mosquito vector diseases contain various biological components which facilitate blood-feeding into the host's body. These components are mostly protein molecules. Numerous protein molecules in the salivary glands have gained substantial research emphasis to determine their role and function, including those in the salivary glands of Ae. albopictus. D7 protein is the main component in Aedes salivary glands, which aids in inhibiting platelet aggregation by binding to the Thromboxane A2 (TxA2) during the blood-feeding. TxA2 is a eicosanoid molecule that stimulates platelet aggregation. The protein's ability to bind TxA2 shows that this protein has potential as a new antiplatelet agent. The examination of the D7 protein in binding TxA2 was performed through an in-silico approach using the molecular docking method. This research included selecting the 3D model of the D7 protein and the TxA2 ligand, preparing the 3D model of the D7 protein, native ligands, and test ligands, targeted molecular docking method, validating the molecular docking, analysis and visualization of the docking results. The molecular docking validation shows an RMSD value of 1.657 Å. The results of molecular docking show an ΔG value of -5.60 kcal/mol, meaning that the D7 protein can bind to the TxA2 ligand stably and spontaneously. The active site of the D7 protein in binding the TxA2 ligand consists of several amino acid residues, namely THR 190, GLU 268, TYR 178, PHE 154, ILE 175, ARG176, VAL 293, TYR 248, and TYR 178. The ability of D7 protein to bind TxA2 as an inducer of platelet aggregation has demonstrated its potential as a novel antiplatelet agent. These results can pave further development of drug discovery in the medical and pharmaceutical fields.
Characterization of Apyrase from the Salivary Glands of Ae. aegypti Based on Bioinformatics Database Wathon, Syubbanul -; Laili, Alvina Nur; Iflaha, Adriana; Widyadana, Kaysha Rahmadita; Zahniar, Zahniar; Saraswati, Dyah Rahmadhani; Oktarianti, Rike; Senjarini, Kartika
Life Science and Biotechnology Vol. 2 No. 1 (2024): May 2024
Publisher : Department of Biology, Faculty Mahematics and Natural Sciences, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/lsb.v2i1.48353

Abstract

The salivary glands of mosquitoes, which act as disease vectors, contain biological components that facilitate the blood-feeding process and transmit pathogens to the human body. Apyrase, a protein from the salivary glands of Ae. aegypti, is known to be an immunogenic protein that influences the host's immunity. It can prevent platelet aggregation by hydrolyzing ATP or ADP into AMP and thus facilitate the blood-feeding process. This mechanism is also exploited by pathogens to obtain entry into the host's body. Vaccination with the apyrase protein could control dengue virus transmission by enhancing the immune response to inhibit the pathogen's entry. To examine the potential of apyrase, it is critical to explore its nature and characteristics by using bioinformatics databases. This quantitative descriptive study involved apyrase protein from the salivary glands of Ae. aegypti obtained from several bioinformatics databases, namely UniProt, SWISSMODEL, ENZYME, Rhea, CFSSP, GlyCosmos, STRING, and QuickGo. The findings contribute to a more fine-cut understanding of apyrase as a potential vaccine to inhibit dengue transmission.
IN-SILICO ANALYSIS OF SYMBIONT BACTERIA DIVERSITY IN THE MIDGUT OF Aedes aegypti USING 16S rDNA MOLECULAR MARKERS DATABASE Wathon, Syubbanul; Finasrullah, Aufar; Oktarianti, Rike; Senjarini, Kartika
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 10 No. 2 (2023)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2023.2841

Abstract

Dengue Hemorrhagic Fever (DHF) is caused by the dengue virus, which is transmitted through Aedes aegypti mosquitoes when they feed on human blood.  To effectively control the DHF vector, it is crucial to accurately characterize the symbiont bacteria associated with Ae. aegypti through an in-silico approach to identify potential targets. This study utilized in- silico analysis based on the 16S rDNA molecular marker to explore the diversity of symbiont bacteria obtained from bioinformatics databases. The analysis and visualization of bacterial diversity were conducted using the Pathosystem Resource Integration Center (PATRIC). The analysis results revealed that bacterial diversity in the midgut of Ae. aegypti, categorized as culturable and non-culturable bacteria, exhibited similar abundance patterns at the family level, albeit with varying detection rates. The most dominant taxa included the phylum Proteobacteria, class Gammaproteobacteria, order Enterobacterales, and family Enterobacteriaceae. Within the culturable bacteria category, the dominant taxa were the genus Salmonella and species Salmonella enterica, whereas the non-culturable bacteria category indicated the prevalence of the genus Escherichia and species Escherichia coli.
Co-Authors Agustin, Dita Paramytha Ahmad Tosin Aida Mursyidah Ainiyah, Durotun Ali Maziun, Iffa Amania, Novita Aminuyati Anam, Khairul Anik Swandari Ardyah, Naura Paramitha Cindy Ari Satia Nugraha Arofa, Resmining Mega Aufar Finasrullah Azkiyah, Siti Fat'hiyatul Berlian Permata Dewi Erlambang Cizein Tri Cahyanti Devi Astikaningrum Devi Astikaningrum Dewi Masruroh Dita Paramytha Agustin Dwi Setyati Endah Puspitasari Eva Tyas Utami Febriyantiningsih, Dwi Esti Finasrullah, Aufar Fitria Mutiah Fitria Muti’ah Hasanah, Fitrianti Milhatul Hidayat Teguh Wiyono Iflaha, Adriana Ihsanul Azmi Indriani, Fenny Intan Fitri Indrasari Kartika Senjarini Khasanah, Rochmatul Nuryu Kirana Eka Rezki Labes, Antje Labes, Antje Laili, Alvina Nur Lailly Nur Uswatul Hasanah Lelono, Asmoro Lutfia Azizah Mahriani Mahriani Mamik Pristiwindari MAsruroh, Binti Maulana Jauharil Habib Miatin Alvin Septianasari Mochtar Gunawan Wibisono Muhammad Khalid Abdullah Mutiah, Fitria Nadya Rismana Fitriani Nailatur Rifdah Naura Paramitha Cindy Ardyah Naura Paramitha Cindy Ardyah Nihayah, Husnatun Novita Amania Nur Aisyah Septiana Nuril Azizah Oktavia, Melinda Dwi Putri Purwatiningsih Purwatiningsih Putra, Iguh Widigda Rahmawati, Itsna Ratis Nour Sholichah Rehmann, Holger Renam Putra Arifianto Rendy Setiawan Riana Agatha Listiani Saraswati, Dyah Rahmadhani Silvya Fitri Nur Azizah Siti Agustina Wulandari Sri Mumpuni Sri Mumpuni Wahyu Widajati, Sri Mumpuni Wahyu Syubbanul Waton Syubhanul Wathon Tri Yudani MR Utami, Diah Ayu Wahyu Tri Agustin Wathon, Syubanul Wathon, Syubbanul Widya Cahyadi Widyadana, Kaysha Rahmadita Wijaya, Rizky Surya Wulandari, Ayu Dwi Yasir Mubarok Yenny Febriana Ramadhan Abdi Zahniar, Zahniar