Article Per Year (5 Year)
p-Index From 2021 - 2026
2.085
P-Index
This Author published in this journals
All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) MPI (Media Pharmaceutica Indonesiana) Journal of Islamic Pharmacy Resona : Jurnal Ilmiah Pengabdian Masyarakat Wikrama Parahita : Jurnal Pengabdian Masyarakat Jurnal Penelitian Pendidikan IPA (JPPIPA) Pharmacology and Clinical Pharmacy Research JFIOnline Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Jurnal Ilmu Kefarmasian Indonesia GUYUB: Journal of Community Engagement Warta LPM Jurnal Sains dan Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Aguslina Kirtishanti
Faculty of Pharmacy Surabaya University, Surabaya Phone: 031-2981112
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Physics Public Health Social Sciences Other

Published : 17 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 17 Documents
Search

 1   2 
Olaparib As Therapy For Metastatic-Castration Resistant Prostate Cancer : Systematic Review And Meta Analysis Putra Gunawan, I Made Rian; Herawati, Fauna; Kirtishanti, Aguslina
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 11 No. 1 (2024): February
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v11i1.5284

Abstract

Prostate cancer is the second most prevalent cancer in men with approximately 1.4 million men worldwide. The main therapy for prostate cancer is androgen deprivation therapy (ADT), but patients who have received ADT may experience a condition of castration resistant prostate cancer (CRPC). More than 84% of patients have metastasized when diagnosed with CRPC (mCRPC) and median survival about 36 months. The Food & Drugs Association (FDA) has approved a new therapy for mCRPC patients, an example is olaparib. The purpose of this systematic review and meta analysis is to assess effectiveness (overall survival) and safety of olaparib in mCRPC. This research is using randomized control trial’s (RCT) article. The literature search process was carried out using the PubMed database. The quality of inclusion was assessed using the Critical Appraisal Skill Program (CASP) checklist and journal reputation. The results of the meta-analysis on the effectiveness of olaparib has showed that there was no significant difference in the patient's overall survival rate (RR=0. 81; 95% CI=0.58-1.13). The results of the meta analysis on the safety level of olaparib has showed a significant difference, seen from the side effects such as anemia (RR=3.47; 95% CI=2.59-4.65), nausea (RR=2.05; 95% CI=1.62-2.60) and fatigue (RR=1.32; 95% CI=1.10-1.59). The conclusion is olaparib as mCRPC therapy does not show significant effectiveness in improving overall survival in mCRPC. In addition, the low safety level of olaparib in mCRPC patients were seen from side effects such as anemia, nausea and fatigue
Program Edukasi Kesehatan dan Perubahan Lingkar Pinggang pada Penderita Diabetes Melitus Tipe 2 Kirtishanti, Aguslina; Lorensia, Amelia; Yudiarso, Ananta; Linggani, Linggani; Agustina, Selvia; Junita, Lidia
Kesmas Vol. 8, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Diabetes melitus adalah penyakit yang menyebabkan morbiditas dan mortalitas di dunia. Hubungan antara diabetes melitus dengan obesitas telah diketahui, tetapi peran distribusi pada daerah abdominal belum sepenuhnya dijelaskan. Tujuan penelitian ini untuk mengetahui pengaruh pemberian edukasi kesehatan terhadap perubahan lingkar pinggang pada pasien diabetes melitus tipe 2. Penelitian ini merupakan studi eksperimental dengan satu kelompok desain pretest-posttest di Surabaya pada bulan Juni - Juli 2013, dan melibatkan 31 subjek yang diberi program edukasi kesehatan selama 1 bulan yang dibagi dalam 4 pertemuan. Data dari pretest dan posttest dikumpulkan dan dianalisis dengan metode wilcoxon signed rank test pada data yang tidak normal (p > 0,05). Hasil penelitian menunjukkan peningkatan pengetahuan dan perilaku pasien serta mengurangi besar lingkar pinggang pasien secara signifikan (p < 0,05). Lingkar pinggang mulai menunjukan perbedaan signifikan pada minggu ketiga edukasi (Z = 12,93; P = 0,003) dibandingkan pretest. Penurunan lingkar pinggang antara posttest dan pretest sebesar 0,94 cm (minggu ke-4) dan 1,68 (4 bulan kemudian). Oleh karena itu, edukasi kesehatan memiliki manfaat dalam meningkatkan self-monitoring diabetes melitus yang dapat mengurangi lingkar pinggang yang berguna untuk mengurangi risiko komplikasi. Diabetes mellitus is a disease that causes morbidity and mortality in the world. Association of diabetes mellitus with obesity are well known, but the role of distribution in the abdominal area has not been fully elucidated. The aim of this study was to determine the relationship of giving education to change waist circumference in type 2 diabetes mellitus. This study is an experimental with one group pretest-posttest design in Surabaya, from June July 2013, and involving 31 subjects whom were given health education program for 1 month which are divided in 4 meetings in Surabaya University. Data from the pretest and posttest were collected and analyzed with the Wilcoxon signed rank test method on the data that isn’t normal (p > 0.05). The results showed an increase in knowledge and behavior of patients and reduced significantly the size of the waist circumference (p <0.05). Waist circumference began to show a significant difference in the third week of education (Z = 12.93, P = 0.003) compared to the pretest. The decrease in waist circumferences between the pretest and posttest were 0.94 cm (week 4) and 1.68 (4 months later). Therefore, health education has benefits in increasing self-monitoring of diabetes mellitus that can reduce waist circumference are useful for reducing the risk of complications.
Penggunaan Obat Herbal untuk Meningkatkan Libido Mencit Jantan (Mus musculus): Tribulus terrestris dan Panax ginseng Kirtishanti, Aguslina; Wulansari, Devyani Diah; Kesuma, Dini; Dwi Putri, I Gusti Ayu Laksmi; Rahmadinar, Amirah Nabila
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1485

Abstract

Tribulus terrestris and Panax ginseng are two therapeutic plants that might increase libido. The aim of the study was to see the effects of herbal medicine containing Tribulus terrestris and Panax ginseng on increasing male mice libido. This study used mice divided into two sets of 7 and 14 days. Each group was divided into four parts: control (solvent), comparator (Vitan), and test 1 (herbal medicine). Parameters measured were mice sexual behaviour (introduction, climbing, coitus), sperm concentration, sperm motility, and testicular weight. Except for coitus behaviour, there were no significant changes between groups in the 7 days of treatment. There were significant differences in introduction and climbing behaviour between the control group and test 2 after 14 days of treatment, but not in other parameters. There were no significant variations in any parameters of the mice’s libido between 7 and 14 days of treatment with 1x dose of herbal medicine; however, with 2x doses, only introduction behaviour showed a significant difference. Based on the research results, it can be concluded that administering two doses of herbal medicine can increase the frequency of treatment for 14 days.
Studi Penggunaan Kemoterapi pada Pasien Kanker Serviks di RSPAL Dr. Ramelan Surabaya: Study of the Use of Chemotherapy in Cervical Cancer Patients at RSPAL Dr. Ramelan Surabaya Tukan, Listiani Anggraeni Palang; Herawati, Fauna; Kirtishanti, Aguslina; Yulia, Rika; Octavia, Stefani Kartika
Jurnal Sains dan Kesehatan Vol. 6 No. 3 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i3.1801

Abstract

Chemotherapy treatment is the most widely chosen method of treatment. The chemotherapy given not only shows effectiveness, but also has a detrimental impact on patients, namely side effects. The purpose of this study was to determine the profile of cancer patients based on stage, duration of cancer, family history of cervical cancer, and treatment cycles, determine the profile of drug use, determine the suitability of drug use, and determine side effects after administration of chemotherapy. This research is an observational study with the direction of data collection retrospectively. The research was conducted at RSPAL Dr. Ramelan Surabaya with research samples from the period August 2021 - September 2022. The results of the study with a sample of 101 samples, showed that the most results were 100% female and married sample, age range 46 - 55 years totaling 38.61%, last education level Elementary schools accounted for 34.65%, 100% payment with BPJS, Stadium IIIB was the largest stadium in the sample, namely 94.06%, the cycle that received the most samples was cycle III, which amounted to 30.69%. The suitability of the use of chemotherapy showed 100% according to the type, and 90.57% according to the dose. The most common side effect that appeared after chemotherapy was nausea with a total of 52.48%. Further research needs to be done using a prospective method to ensure the side effects that occur. Keywords:          Cervical Cancer, Chemotherapy, Suitability, Side effect   Abstrak Pengobatan kemoterapi merupakan metode pengobatan yang paling banyak dipilih. Kemoterapi yang diberikan tidak hanya menunjukkan efektivitas, namun juga memberikan dampak yang merugikan bagi pasien, yaitu efek samping. Tujuan penelitian ini adalah untuk mengetahui profil pasien kanker berdasarkan stadium, lama menderita kanker, riwayat keluarga yang mempunyai kanker serviks, dan siklus pengobatan, mengetahui profil penggunaan obat, mengetahui kesesuaian penggunaan obat, dan mengetahui efek samping setelah pemberian kemoterapi. Penelitian ini merupakan penelitian observational dengan arah pengambilan data secara retrospektif. Penelitian dilakukan di RSPAL Dr. Ramelan Surabaya dengan sampel penelitian dari periode Agustus 2021 – September 2022. Hasil penelitian dengan sampel berjumlah 101 sampel, menunjukkan hasil terbanyak adalah sampel 100% berjenis kelamin perempuan dan sudah menikah, rentang usia 46 – 55  tahun berjumlah 38,61%, tingkat pendidikan terakhir Sekolah Dasar berjumlah 34,65%, pembayaran 100% denga BPJS, Stadium IIIB merupakan stadium terbanyak pada sampel yaitu 94,06%, siklus yang diterima sampel terbanyak adalah siklus III yang berjumlah 30,69%. Kesesuaian penggunaan kemoterapi menunjukkan 100% sesuai jenis, dan 90.57% sesuai dosis. Efek samping terbanyak yang muncul setelah pemberian kemoterapi adalah mual dengan jumlah 52,48%. Penelitian lebih lanjut perlu dilakukan menggunakan metode prospektif untuk memastikan efek samping yang terjadi. Kata Kunci:         Kanker Serviks, Kemoterapi, Kesesuaian, efek samping
PEMETAAN PENGETAHUAN PESERTA POSYANDU DESA DUYUNG TENTANG NUTRISI DAN OBAT SELAMA 1000 HARI PERTAMA KEHIDUPAN (HPK) Kirtishanti, Aguslina; Irawati, Sylvi; Marzuki HY, Jefman Efendi; Hidayah, Isnaini Nurul; Nurhidayah, Widya
RESONA : Jurnal Ilmiah Pengabdian Masyarakat Vol 8, No 2 (2024)
Publisher : Lembaga Penerbitan dan Publikasi Ilmiah (LPPI) Universitas Muhammadiyah Palopo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35906/resona.v8i2.2199

Abstract

Seribu hari pertama kehidupan (1000 HPK) adalah masa yang sangat krusial untuk perkembangan dan pertumbuhan anak setelah usia dua tahun. Kurangnya nutrisi dan perhatian serta ketidaksesuaian penggunaan obat selama masa ini akan meningkatkan risiko terjadinya stunting dan gangguan kesehatan yang kemudian dapat mempengaruhi masa depan anak. Sasaran program adalah seluruh peserta kegiatan posyandu di Desa Duyung. Program dilaksanakan pada 5 Agustus dan 3 September 2024. Komponen program terdiri dari dua kegiatan, yaitu pendampingan pentingnya nutrisi selama 1000 HPK dan penggunaan obat yang aman selama masa kehamilan. Materi diberikan dalam bentuk presentasi oleh dokter, leaflet obat yang aman untuk ibu hamil, poster 1000 HPK dan poster obat yang aman untuk ibu hamil. Tingkat pengetahuan peserta sebelum dan sesudah kegiatan pendampingan dinilai menggunakan kuesioner. Program ini menghasilkan peningkatan pengetahuan terhadap materi yang diberikan pada proporsi tertentu dari kelompok sasaran. Proporsi sasaran yang paling banyak mengalami peningkatan pengetahuan ditemukan pada kegiatan penggunaan obat yang aman selama kehamilan yaitu sebesar 62%. Terdapat indikasi perlunya dilakukan tindak lanjut untuk mengevaluasi faktor yang mempengaruhi perbedaan tingkat pengetahuan antarmateri yang diberikan agar pengetahuan sasaran dapat ditingkatkan lebih lanjut.  Abstract. The first 1000 days (1000 HPK) is a very crucial period for the development and growth of children after the age of two years. Lack of nutrition and attention, as well as inappropriate use of medication during this period, will increase the risk of stunting and health problems, which can then affect the child's future. The program targets are all participants in posyandu activities in Duyung Village. The program will be implemented on August 5th and September 3rd, 2024. The program component consists of two activities, namely assistance with the importance of nutrition during 1000 HPK and safe use of medication during pregnancy. The material is provided through presentations by doctors, leaflets on medicines that are safe for pregnant women, posters on 1000 HPK, and posters on medicines that are safe for pregnant women. Participants' level of knowledge before and after mentoring activities was assessed using a questionnaire. This program increases knowledge of the material provided in a certain proportion of the target group. The proportion of targets who experienced the greatest increase in knowledge was found in the safe use of drugs during pregnancy, namely 62%. There are indications that follow-up is needed to evaluate the factors that influence differences in the level of knowledge between the materials provided so that target knowledge can be further improved.
Molecular Docking: Study of Chalcone Derivatives from Boesenbergia pandurata Targeting Estrogen Receptor Alpha (ER–a) for Breast Cancer Amelia, Marsha Anggita; Kesuma, Dini; Kirtishanti, Aguslina; Sumartha, I Gede Ari; Claudya, Maria
Jurnal Penelitian Pendidikan IPA Vol 10 No 11 (2024): November
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i11.8734

Abstract

The increasing number of cancer patients and the challenge of multidrug resistance (MDR) demand more effective drugs, which can be developed by modifying compounds derived from natural resources, such as the flavonoid-rich temu kunci rhizome (Boesenbergia pandurata (Roxb.) Schlecht.). This study aims to predict the cytotoxicity and toxicity of 20 Pinostrobin derivatives and 19 Chalcone derivatives as potential anticancer candidates. Estrogen receptor alpha (ER-α), a validated cancer therapy target, was used for molecular docking in in silico tests using Molecular Graphics Laboratory (MGL) Tools (including, AutoDock Vina, AutoDock Tools 4.1, and Python 2.5.2) and PyRx Program. Toxicity was predicted using the pkCSM program and Protox online tool. The docking process involved binding the compounds to ER-α (PDB IDs 6CHZ and 3ERT), with the binding energy indicating activity; lower binding energy values suggest greater cytotoxic potential and stronger ligand-receptor interactions. The results showed that Chalcone derivatives from temu kunci exhibited lower toxicity and higher cytotoxic activity compared to Pinostrobin derivatives and the reference compound, Tamoxifen (TAM). Notably, Bis-3-chlorobenzyloxychalcone and Bis-2-chlorobenzyloxychalcone demonstrated the highest predicted cytotoxic activity. In conclusion, Chalcone derivatives are promising candidates for further development as more effective anticancer drugs, especially those that outperform Tamoxifen. These findings highlight the potential of natural compounds, particularly Chalcone derivatives, in combating cancer while addressing the growing challenge of MDR in clinical treatments.
Activities of Chalcone Derivatives from Boesenbergia rotunda Against Human Estrogen Receptor Alpha of Breast Cancer by In Silico Claudya, Maria; Kesuma, Dini; Kirtishanti, Aguslina; Sumartha, I Gede Ari; Amelia, Marsha Anggita
Jurnal Penelitian Pendidikan IPA Vol 10 No 10 (2024): October
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i10.8865

Abstract

The high prevalence of cancer must be overcome with prompt and appropriate prevention and treatment. New drug design is an effort to develop existing drugs, and their molecular structure and biological activity have been known through structural modification. It encourages researchers to explore Indonesia's natural resources, especially plants with anticancer activity, namely by synthesizing chalcone-derived compounds derived from the isolation of Fingerroot rhizomes (Boesenbergia rotunda). The most common flavonoid compound found in rhizomes fingerroot plants is pinostrobin. Pinostrobin compounds and their derivatives are synthesized, resulting in chalcone compounds and their derivative modifications. The author conducted an in-silico test on pinostrobin compounds and 19 of their derivatives, chalcone compounds, and 18 derivatives using estrogenic-a receptors with PDB codes 3ERD and 1G50. The author hoped that from this silico test, compounds with more potential as anticancer for breast cancer would be obtained based on the results of docking with 3ERD and 1G50 receptors and can then be synthesized. In the results of this study, the compounds Bis-4-bromobenzyoxychalcone and Bis-4-chlorobenzyloxychalcone are the most appropriate compounds to be synthesized. It is hoped that in the future, they can be continued with activity tests of these compounds, both in vitro and in vivo, because these compounds are predicted to have the best activity and do not have hepatotoxic or other toxicity effects
Co-Authors Amelia Lorensia Amelia, Marsha Anggita Ananta Yudiarso Anggara, I Gede Yudi Anita Dahliana Anita Purnamayanti Ardhia Deasy Rosita Dewi Buono, Iqhro’ Samudro Thirto Buono, Khresno Bhirowo Ghusti C, Fadita Trisa Claudya, Maria Devyana Dyah Wulandari Dwi Putri, I Gusti Ayu Laksmi Eko Setiawan Emma Savitri Gondokesumo, Marisca E. Herawati, Fauna Hidayah, Isnaini Nurul Hidayati, Siti Hafida Nur I Gede Ari Sumartha Isfandiari, Fitria Isfandiari, Fitria Kesuma, Dini Lidia Junita Linggani Linggani Marzuki HY, Jefman Efendi Mulyono Putri Wibowo, Ika Nastiti, Widhi Novansca, Tiara Prima Ninting Nurhidayah, Widya Octavia, Stefani Kartika Putra Gunawan, I Made Rian Raden Joko Kuncoroningrat Susilo Rahmadinar, Amirah Nabila Rahman, Diana Ratih, . Ratih, . Rika Yulia Ryanto Budiono, Ryanto Selvia Agustina Sukmantoro, Agung Anjar Susilo, Astrid Pratidina Susilo, Astrid Pratidna Sylvi Irawati Trisnawati, Chatarina Yayuk Tuga, Maria Claudia Dwiyanti Tukan, Listiani Anggraeni Palang Wiana, Viera Permatasari Wibowo, Ika Mulyono Putri Wicaksono, Y. Adhimas Setyo Wijayaningrum, Wijayaningrum Wulansari, Devyani Diah Wuryaningsih, Lucia Endang Yuliastuti, Reny