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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Biology, Medicine, & Natural Product Chemistry Biomedika Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Herb-Medicine Journal Health Information : Jurnal Penelitian Medica Arteriana (Med-Art) Lontara: Journal of Health Science and Technology Proceeding ISETH (International Summit on Science, Technology, and Humanity) Prosiding University Research Colloquium Jurnal Pengabdian Masyarakat Medika JHeS (Journal of Health Studies) Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Lontara Journal Of Health Science And Technology Biomedika
Devi Usdiana Rosyidah
Universitas Muhammadiyah Surakarta
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Biomedika

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INVESTIGATION OF THE ANTIBACTERIAL EFFICACY OF DERSONO WATER APPLE LEAVES (SYZYGIUM MALACCENSE) AS A SUBSTITUTE THERAPY FOR STREPTOCOCCUS PYOGENES INFECTIONS Rosyidah, Devi Usdiana; Mahmudah, Nur; Fithriyah, Sa’idatul; Sintowati, Retno
Biomedika Vol 17, No 2 (2025): Biomedika August 2025
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v17i2.12007

Abstract

Streptococcus pyogenes caused different illnesses, including pharyngitis and dermatological infections. The Dersono water apple leavesSyzygium malaccense) are recognized for their bioactive ingredients, which may serve as antibacterial agents. This study purpose was to determine the antibacterial potential of ethanol extract and acetone fraction of Syzygium malaccense against Streptococcus pyogenes infection. This research was a laboratory xperiment, a post-test only with control group design. Assessing growth inhibition by measuring the diameter of halo around the well of blood agar plate. Statistical tests using the Sapiro-Wilk test, Lavene test, Kruskal Wallis est and Mann-Whitney test. The study's findings demonstrated that the ethanol extract 25% (11.80 mm) and 50% (16.51) concentrations and acetone fraction of Dersono water apple leaves, at 25% (11.25 mm) and 50% (12.08) concentrations, had strong inhibitory power. The concentrations of 6.25% (8.15 mm) and 12.50% (9.63 mm), the ethanol extract's inhibitory power was superior than the concentrations of 6.25% (4.42 mm) and 12.50% (3.38 mm) acetone fraction, had moderate range. Both the ethanol extract and the acetone fraction's phytochemical analyses identified alkaloids, tannins, and saponins. The conclusion was ethanol extract and acetate fraction of Dersono water apple leaves have antibacterial effects against Streptococcus pyogenes.
Co-Authors Afif Iqbal Hibatullah Ahmad Rosid Nasrulloh Arifqi Alghozi, Muhammad Hilmi Amalia, Riza Anam, Zahra Hafizha Fitria Ananda Asriany Perdana Ananda Asriany Perdana, Ananda Asriany Anika Candrasari Anshar, Rizadin Azwar, Muhammad Thoriq Burhannudin Ichsan Burhanuddin Ichsan E. M. Sutrisna El Mubaraq, Syahrun Em Sutrisna Erika Diana Risanti Erna Herawati Erna Herawati, Erna Faatiha, Arsyal Wanda Fadhila, Zahra Hayuna Farid Santya Budi Febrian Dwi Cahyo Fithriyah, Sa’idatul Futana, Ninda Pradani Goprani, Lidya Graffico Eryza Oldiara Hibatullah, Afif Iqbal Hidayah Karuniawati Hutami, Norma Putri Iin Novita Nurhidayati Mahmuda Ilham Fahrudin Indra Nuroso Indwiani Astuti Indwiani Astuti Iwan Setiawan Jayanti Wulansari Jayanti Wulansari, Jayanti Kusumaningrum, Tanjung Anitasari Indah Lestari, Nining Listiana Masyita Dewi Listyana Masyita Dewi Maulana , Iqbal Nugrahaen, Sarwasri Fajra Nur Mahmudah Oktein Satriyani Prameswari, Elza Primayanti, Yustika Qasthari Rahmawati, Nailena Widya Ratih Pramuningtyas Retno Sintowati - Riandini Aisyah Rif'aini, Fidhia Nur Rizadin Anshar Rochmadina Suci Bestari Safari Wahyu Jatmiko Santosa, Talitha Ulima Santoso, Talitha Ulima Sari, Nur Amalia Satriyani, Oktein Setyo Nurwaini Sitarina Widyarini Sulistiyo, Azka Hafiy Sulistyani Sulistyani Sulistyani, S Supraba, Intan Pratiwi Susanto, Syarafina Ayu Putri Syah, Devan Adil Syahrun El Mubaraq Talitha Ulima Santoso Tanjung Anitasari Indah Kusumaningrum Tri Agustina Tri Agustina, Tri Utami, Indari Wibowo, Muhammad Irfan Sulystyo Yustika Qasthari Primayanti Yusuf Alam Romadhon Zelindrah, Virgil