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All Journal JBIO: jurnal biosains (the journal of biosciences) Biology, Medicine, & Natural Product Chemistry Journal of Biology Education Jurnal Pendidikan Biologi Jurnal Penelitian Pendidikan IPA (JPPIPA) BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains Bioscientist : Jurnal Ilmiah Biologi Jurnal Tarbiyah dan Ilmu Keguruan Borneo Jurnal Pendidikan Indonesia (Japendi) Journal of Pharmaceutical and Sciences. Symbiotic: Journal of Biological Education and Science Al-Musannif
Melva Silitonga
Universitas Negeri Medan
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Pengembangan Modul Anatomi dan Fisiologi Tubuh Manusia Berbasis Case Method untuk Mahasiswa Jurusan Biologi Siti Aisyah Siti; Melva Silitonga; Syahmi Edi
BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains Vol. 8 No. 4 (2025): Bioedusains: Jurnal Pendidikan Biologi dan Sains
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/tgextr52

Abstract

This research aims to develop and produce a case-based Human Anatomy and Physiology module that is suitable for use as a learning resource for students. This research is a research and development (R&D) study using the Five-Stage Level 1 model, with 84 Biology Education students, class of 2021, as the target subjects. Data collection techniques and instruments used were expert validation sheets and lecturer and student response questionnaires. The research data were analyzed using feasibility analysis techniques based on the feasibility of the material, design, language, and learning. The study concluded that the case-based Human Anatomy and Physiology module was deemed feasible based on assessments from material expert validators (4.35), design expert validators (4.00), and learning expert validators (4.29), and was deemed quite feasible based on assessments from language expert validators (3.78). The lecturers and students of the Biology Education Study Program generally gave good responses (4.36 and 4.14) to the case-based Human Anatomy and Physiology module. Keywords: Human Anatomy and Physiology, Case Method, Five-Stage Model, Module.
The Ameliorative Effect of Apigenin in Plectranthus amboinicus Lour Spreng in the Treatment of Hepato-renal Carcinogenesis Induced Benzo(a)pyrene Melva Silitonga; Hendro Pranoto; Erlintan Sinaga; Feimmy Ruth Pratiwi Sipahutar; Adriana Yulinda Dumaria LumbanGaol; Fajar Apollo Sinaga
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1483-1490

Abstract

Benzo(a)pyrene (B(a)P) is the major cause of hepato-renal carcinogenesis. Apigenin in Plectranthus amboinicus (EPA), has indicated some biological activities such as antioxidant and antimutagenic activity. The aim of this study is to investigate the potential of apigenin in EPA as anti-cancer against chronic hepatorenal damage exposed to B(a)P. The rats of 4 groups (n=6) were divided as follows: Group I (P0) was given food and water ad-libitum; Group II (PB) was administered orally B(a)P 2 mg/kg BW; Group III (PB+E) received orally B(a)P 2 mg/kg BW and EPA 500 mg/kg; Group IV (PE) was administered orally EPA 500 mg/kg BW. The therapeutic effect of EPA was explored using network pharmacology and molecular docking. The results showed that Group III could significantly improve (P < 0.05) the hepatorenal function parameter, including DNA concentration. SGPT, SGOT, blood urea nitrogen, and creatinine compared to those treated with B(a)P. The outcome data pharmacology revealed 6 targets could be the main core target. The good binding affinity indicated Apigenin docked to AKT1 protein with -10.00 kcal/mol relevant to Doxorubicin as control drug. Our results provide a new insight of apigenin in EPA potentially suppressing the regulation of chemical carcinogenesis by B(a)P.
The Effectiveness of an Environment-Based Biodiversity Flipbook E-Module on Students’ Biology Understanding and Scientific Process Skills in Grade X of SMA Negeri 21 Medan Lusiana Rumapea; Masdiana Sinambela; Melva Silitonga
Bioscientist : Jurnal Ilmiah Biologi Vol. 14 No. 1 (2026): March
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v14i1.19762

Abstract

This study aimed to analyze the effectiveness of an environment-based Biodiversity Flipbook E-Module in improving tenth-grade students’ understanding of biology and their scientific process skills at SMA Negeri 21 Medan. The study employed a one-group pretest–posttest design involving 36 students. Research instruments included a validated biology comprehension test and an observation sheet used to assess students’ scientific process skills during three environment-based learning sessions. Data were analyzed using the N-gain score and descriptive statistics. The results showed that the mean pretest score of 33.81 increased to 83.88 in the posttest, resulting in an N-gain score of 0.76, which falls into the high category. Students’ scientific process skills were classified as very good across all learning sessions and demonstrated an increasing trend during the final meeting. These findings indicate that the environment-based Biodiversity Flipbook E-Module is effective in enhancing students’ understanding of biological concepts and their scientific process skills through contextual learning grounded in real environmental exploration.
Factors Affecting The Interest Of Women Of Reproductive Age Regarding Visual Inspection Of Acetic Acid (IVA) Maida Pardosi; Melva Silitonga
Jurnal Penelitian Pendidikan IPA Vol 10 No 6 (2024): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i6.5326

Abstract

Reproductive health is a multidimensional state of physical, mental, and social well-being, covering all aspects of the reproductive system, functions, and processes. Cervical cancer is abnormal cell growth and development, which can lead to abnormal function of the reproductive organs and generally affects women of reproductive age, so the impact on the family is very significant. This study aims to determine the factors between the level of knowledge, access to information, and husband/family support with low Acetic Acid Visual Inspection (IVA) visits. This type of research is survey research with an analytical approach cross-sectional. The samples taken were 67 respondents obtained by the technique of purposive Sampling. The instrument used is a questionnaire. The data obtained is processed using a test Chi Square with a degree of significance (α) = 0.05. The results showed that there was a significant influence between the factors associated with the low number of IVA visits, namely the level of knowledge, access to information, and husband/family support. In the statistical test, the p-value is 0.000. The conclusions of WUS researchers who are married should always pay attention to their reproductive health, one of which is the IVA examination.
Pengembangan Booklet Keanekaragaman Jenis Amphibia Geosite Silahisabungan sebagai Sumber Belajar Keanekaragaman Hayati Berri Situmorang; Binari Manurung; Melva Silitonga
Bioscientist : Jurnal Ilmiah Biologi Vol. 13 No. 4 (2025): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v13i4.19063

Abstract

This study aims to examine the feasibility and effectiveness of a booklet on amphibian species diversity in the Silahisabungan Geosite as a teaching material for biodiversity topics. The research employed a Research and Development (R&D) method using the 4D model, which consists of the Define, Design, Develop, and Disseminate stages. The feasibility of the booklet was evaluated based on expert validation, teacher responses, and student responses, while its effectiveness was assessed through improvements in students’ learning outcomes. Data were collected through interviews, needs analysis questionnaires, booklet validation questionnaires, teacher and student response questionnaires, and cognitive learning achievement tests. The results of the study indicate that: (1) the booklet validation results were categorized as good to very good, with scores of 79.4 from the content expert, 96 from the instructional design expert, and 94 from the graphic design expert; (2) teacher responses were very positive with a score of 96.8, while student responses in individual, small-group, and large-group trials obtained scores of 97.2, 96.2, and 93.75, respectively; (3) the effectiveness test conducted on 27 students showed an N-Gain value of 0.74, classified as high; and (4) the t-test revealed a significant difference between pretest and posttest scores (t = 6.213; p < 0.05). Therefore, the developed booklet is effective in improving students’ cognitive knowledge and is feasible for use as a supplementary teaching material in biodiversity learning.
The Effect Of Solar System Scope Learning Media on Student’s Learning Outcomes In The Solar System Material Silviani Sembiring; Melva Silitonga
Jurnal Tarbiyah dan Ilmu Keguruan Borneo Vol. 7 No. 1 (2026): Jurnal Tarbiyah dan Ilmu Keguruan Borneo, 7(1), Februari 2026
Publisher : Fakultas Tarbiyah dan Ilmu Keguruan UIN Sultan Aji Muhammad Idris Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21093/jtikborneo.v7i1.13766

Abstract

This study aims to determine the learning outcomes of students who use the Solar System Scope, to determine the learning outcomes of students who use conventional learning media, and to determine the effect of using the Solar System Scope on student learning outcomes in the Solar System subject. This study was conducted at the UPT SMP Negeri 29 Medan from November 2025 to February 2026. The research design used was quantitative research with a quasi-experimental method with a non-equivalent pretest-posttest control group design. The study population consisted of all seventh-grade students at UPT SMP Negeri 29 Medan, which consists of 8 classes. The research sample was selected using purposive sampling, with Class VII-6 as the experimental class and Class VII-7 as the control class, totaling 64 students. The research instrument consisted of a multiple-choice test with 20 questions to measure students' cognitive learning outcomes. The results of the study showed that the average pretest score of the experimental class increased from 61 to 79 in the posttest, while the score of the control class increased from 51 to 72. The results of the independent sample t-test showed a significance value of 0.002 < 0.05 with a calculated t-value of 3.322. Based on these results, it can be concluded that the use of Solar System Scope learning media has a significant influence on student learning outcomes in the Solar System material.
Pengembangan Buku Ajar Berbasis Deep Learning pada Materi Bioteknologi Untuk Meningkatkan Kemampuan Berpikir Kritis Siswa SMP: Developing a Deep Learning-Based Textbook on Biotechnology to Improve Junior High School Students' Critical Thinking Skills Revi Ruth Susanty; Melva Silitonga; Herbet Sipahutar
Al-Musannif Vol. 8 No. 1 (2026)
Publisher : Madrasah Tsanawiyah DDI Cilellang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.65046/msn.v8i1.58

Abstract

The development of students’ critical thinking skills remains a challenge in science learning, particularly in biotechnology topics that require conceptual understanding and higher-order thinking. This study aimed to develop a biotechnology textbook based on deep learning pedagogy to improve junior high school students’ critical thinking skills. The study employed a Research and Development (R&D) approach using the 4D model, consisting of define, design, develop, and disseminate stages. The research involved material experts, instructional design experts, layout experts, language experts, science teachers, and seventh-grade students. Data were collected through validation sheets, questionnaires, and critical thinking tests based on higher-order thinking skills (HOTS) at the cognitive levels of C4 (analyzing), C5 (evaluating), and C6 (creating). The findings indicated that the developed textbook met the criteria of validity, practicality, and effectiveness. Expert validation results showed very good qualifications, while teacher and student responses indicated excellent practicality. Furthermore, the textbook significantly improved students’ critical thinking skills, as reflected in the higher posttest scores and N-gain results in the experimental class. The findings imply that a deep learning-based textbook can support meaningful science learning and strengthen critical thinking skills in the implementation of the Merdeka Curriculum.
Efek protektif ekstrak etanol Bidens pilosa L. terhadap sistem imun tubuh berdasarkan histologis limpa Rattus norvegicus yang diinduksi alkohol Mieky Grasiaella Marpaung; Melva Silitonga
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1183

Abstract

This study aims to determine the protective activity of Bidens pilosa L. leaf ethanol extract (EEDK) on the immune system based on the white pulp diameter, and histopathology of the spleen of white rats given alcohol. The study was conducted experimentally using a completely randomized design (CRD), with treatments divided into 5 groups: negative control (K-) without EEDK or alcohol administration, positive control (K+) administered 10 ml/kg body weight of alcohol, treatment 1 (P1) administered 250 mg/kg body weight of EEDK and 10 ml/kg body weight of alcohol, treatment 2 (P2) given 500 mg/kgbb EEDK and 10 ml/kgbb alcohol, and treatment 3 (P3) given 750 mg/kgbb EEDK and 10 ml/kgbb alcohol. EEDK was administered 1 hour after alcohol administration and was given orally every day for 43 days. The parameters observed in this study were diameter of the white pulp, and histopathology of the white rat spleen. The observation data were analyzed using one-way ANOVA and followed by a post hoc test with the DMRT test to see the differences between treatments. The results showed that the ethanol extract Bidens pilosa L. potential as an immunomodulator by increasing the diameter of the white pulp of the spleen, and had a significant effect on spleen histology by showing protective activity with a decrease in the level of spleen tissue damage due to alcohol, particularly tissue fibrosis, lymphocyte apoptosis, and necrosis (p£0.05).
Co-Authors Adriana Yulinda Dumaria LumbanGaol Agatha Cecilia Sihite Berri Situmorang Binari Manurung Erlintan Sinaga Erlintan Sinaga Eunike Manurung Fauziyah Harahap Feimmy Ruth Pratiwi Sipahutar Githa Indriana Herbet Sipahutar Idramsa Idramsa Indra Jaya Purba Khairiza Lubis Lusiana Rumapea Maida Pardosi Marina Azzahra Nasution Masdiana Sinambela Meida Nugrahalia Mieky Grasiaella Marpaung Morina Wati Novayanti Gultom Pasar Maulim Silitonga Pranoto, Hendro Restuati, Martina Revi Ruth Susanty Silviani Sembiring Siti Aisyah Siti Sri Enita Ginting Syahmi Edi