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All Journal Journal of Food and Pharmaceutical Science Elkawnie Journal of Islamic Pharmacy Jurnal Buana Farma Jurnal Abdimas Kartika Wijayakusuma AJAD : Jurnal Pengabdian kepada Masyarakat Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Room of Civil Society Development Riset Informasi Kesehatan Journal of Food and Pharmaceutical Sciences kawanad Kartika : Jurnal Ilmiah Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Galenika Room of Civil Social Development Journal of Pharmascience
Ari Sri Windyaswari
Universitas Jenderal Achmad Yani
Aerospace Engineering Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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In Vitro Anti-Bacterial Activity And Network Pharmacology Analysis of Aqueous Extract of Marsdenia Tinctoria R.Br. Leaves agains Staphylococcus aureus Anna Choirunnisa; Ari Sri Windyaswari; Guntur Berlian; Andrian Rafliana Supriatnaputra; Suryani
Journal of Food and Pharmaceutical Sciences Vol 14, No 4 (2026): J.Food.Pharm.Sci (In Press)
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.27290

Abstract

Staphylococcus aureus is a major Gram-positive microorganism implicated in a wide range of skin infections. The increasing prevalence of antimicrobial resistance among S. aureus emphasizes the need for the development of novel therapeutic interventions. This study evaluated the antibacterial efficacy and analysis the molecular mechanism of Marsdenia tinctoria R.Br. (Tarum Areuy) leaf aqueous extract against S. aureus through integrated in vitro and network pharmacology analyzed. The aqueous extract was prepared by infusion, and its metabolite profile was characterized using UPLC-HRMS. Antibacterial activity was quantitatively investigated using the agar well diffusion method against S. aureus ATCC 6538. Network pharmacology identified ten secondary metabolites with antibacterial potential, seven of which exhibited pharmacokinetic properties that met the established bioavailability criteria (BOILED-Egg method). Protein-protein interaction (PPI) analysis indicated that fifteen key proteins interact with the seven compounds, with quercetin identified as the major bioactive compound activating specific bacterial pathways (SAV0081 and pkrC) in S. aureus. The highest antibacterial effect was observed at an 8% extract concentration with an inhibition zone of 17.03 ± 1.78 mm. Overall, these results confirm that the aqueous extract of M. tinctoria leaves contains potential metabolites as antibacterials that could be further developed as therapeutic agents for the treatment of S. aureus infections.
Co-Authors Adinda Fitriani Adriana, Reyhan Akbar, Tzazkia Febriyana Akhirul Kahfi Syam Amedea, Esanda Zulfi Ami Soega Dwigantina Ananda Tunjung Pertiwi Andrian Rafliana Supriatnaputra Anggita Esa Putri Fitrichia Anna Choirunnisa, Anna Aprilia, Trialisa Ayu, Inna Puspa Azhar, Farah Salsabilla Saidah Chandani Nurul Hafizah Dessy Ratnasari dessy ratnasari Dewi, Renti Mutiara Dewilestari, Meyra Pratami Dhimas Ariya Wibiksana Dwi Ayu Pratiwi Dwigantina, Ami Soega Elfahmi Elfahmi, Elfahmi Ema Mutya Esanda Zulfi Amedea Fahrauk Faramayuda Fahrauk Faramayuda Fahrauk Faramayuda Fahrauk Faramayuda Fahrauk Faramayuda, Fahrauk Faizal Hermanto Febrinella, Catellya Fifi Gus Dwiyanti Fitriani, Adinda Fitrichia, Anggita Esa Putri Guntur Berlian Inna Puspa Ayu Ismail, Nursafira Khairunnisa Julia Ratnawati Julia Ratnawati Julia Ratnawati, Julia Khairunisa Harizqi Nurul Husna Lahagu, Helga Nitulo Berliana Limbong, Remare Halomoan Luthfi Fauziah Majariana Krisanti Mardiana, Grace Selly Maria Tri Miarsih Muhamad Raihan Maulana Mutya, Ema Niken Tunjung Murti Pratiwi Niken Tunjung Murti Pratiwi Nurhayati, Viola Aditya Nursafira Khairunnisa Ismail Nurul Safirah Safrudin Oktiyas Muzaky Luthfi Paramita, Veronika Santi Pertiwi, Ananda Tunjung Pratiwi, Dwi Ayu Purwoko, Agus Putri, Dhiffa Namira Alifia Ramdhani, Amalia Kusuma Remare Halomoan Limbong Renti Mutiara Dewi Reyhan Adriana Deris Ridwan Ilyas Ridzka Magfirah Rifaz Muhammad Sukma RIZKA KHOIRUNNISA GUNTINA, RIZKA KHOIRUNNISA Salsa Rizqyana Billa Septiani, Usi Sigid Pamungkas Wicaksono Soraya Riyanti Soraya Riyanti Soraya Riyanti, Soraya Suci Nar Vikasari, Suci Nar SURYANI Trialisa Aprilia Tzazkia Febriyana Akbar Usi Septiani Viola Aditya Nurhayati Wulandari, Yesi Yeni Karlina Yeni Karlina Yeni Karlina, Yeni Yesi Wulandari