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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Kesehatan Andalas Syntax Literate: Jurnal Ilmiah Indonesia MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Jurnal Respirologi Indonesia Majalah Kedokteran Andalas Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Respiratory Science PROFESSIONAL HEALTH JOURNAL Bioscientia Medicina : Journal of Biomedicine and Translational Research Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Irvan Medison
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Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Differences In Interleukin-6 and Liver Enzyme Level Based On Clinical Severity of COVID-19 Patients at Dr. M. Djamil General Hospital, Padang Elsesmita, Elsesmita; Medison, Irvan; Herman, Deddy
Respiratory Science Vol. 5 No. 3 (2025): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v5i3.171

Abstract

Background: COVID-19 pathogenesis involves the release of proinflammatory cytokines and chemokines, known as a "cytokine storm." Interleukin-6 (IL-6) plays a key role in initiating cytokine storms. Cytokine storm causes multiple organ complications. Liver injury affects 14% to 53% of COVID-19 patients and is manifested by increased liver enzymes. This study evaluated differences in IL-6 and liver enzyme levels based on clinical severity in COVID-19 patients. Method: A retrospective cross-sectional study was conducted. COVID-19 patients treated at Dr. M. Djamil General Hospital, Padang, from January 1, 2021, to December 31, 2021, and who met the inclusion and exclusion criteria, were the research subjects. The Kruskal-Wallis test was performed to analyze differences in IL-6, SGOT, and SGPT levels based on clinical severity. Results: Most participants (42.06%) were under 50 years old, half were female (56.15%), obesity was the most common comorbidity (41.39%), and moderate severity was most common (42.06%). The majority of the subjects, 87.47%, had elevated IL-6 levels (≥7 pg/mL). SGOT levels of ≥32 IU/L (46.76%) and SGPT levels of ≥31 IU/L (41.39%) were found in less than half of the subjectsClinical severity was significantly associated with IL-6 levels, resulting in a significant difference in IL-6 levels (P<0.05). The clinical severity of COVID-19 patients at Dr. M. Djamil General Hospital, Padang, resulted in a significant difference in SGOT and SGPT levels (P<0.05). Conclusion: IL-6 levels differed based on clinical severity in COVID-19 patients. SGOT and SGPT levels also differed by clinical severity.
Cultural and Religious Belief Approaches of a Tuberculosis Program for Hard-to-Reach Populations in Mentawai and Solok West Sumatera, Indonesia Machmud, Rizanda; Medison, Irvan; Yani, Finny Fitry
Kesmas Vol. 15, No. 4
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Tuberculosis (TB) is a leading public health concern in Indonesia. It ranks second on the list of high-burden TB countries. In West Sumatra, 47% of TB cases are undetected, late diagnosed, and received incomplete treatment because of low-level awareness and knowledge and stigma, especially among the hardest to reach populations. The study aims to identify the best communication channel to reach those who live in vulnerable and remote areas. This study was a qualitative study applying in-depth interviews to the informal leaders, health officers, cultural artists, and religious leaders across districts in Mentawai and Solok Districts, which are remote and had the lowest case detection rates compared with other districts. The questionnaire was prepared with the perception of the channel to identify TB cases. The data were analyzed using the content analysis technique. Involving religious and informal leaders and using traditional music as a communication channel improved the population's awareness of TB symptoms and access to TB testing and treatment, as well as reduced TB-related stigma. This study found that the cultural and religious contexts play a major role in health communication on TB control for hard-to-reach populations in West Sumatera, Indonesia.
Aspergilloma Mimicry of Lung Cancer: A Case Report Bagus HS, Muhammad; Irvan Medison; Dewi Wahyu Fitrina; Dessy Mizarti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 7 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i7.1018

Abstract

Background: Aspergilloma and lung cancer have similar risk factors, clinical features, and supporting features. Special supporting examinations are needed to rule out the differential diagnosis of aspergilloma. Case presentation: A 52-year-old male patient with coughing up blood and risk factors for smoking had a chest X-ray and computed tomography scan (CT scan) of the thorax and found a picture of a lung tumor. Bronchoscopy was carried out, and a bronchial lavage culture was carried out for the impression of Aspergillosis, given 1x150 mg of fluconazole for 6 months with improved clinical results and chest radiographs as well as negative sputum culture results. Conclusion: This patient showed the condition of aspergilloma mimicking lung cancer.
Rare Presentation of Non-Tuberculous Mycobacteria: A Case of Lung Infection with Pleural Effusion Ventiani, Nadia; Dewi Wahyu F.; Irvan Medison; Dessy Mizarti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 11 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i11.1122

Abstract

Background: Non-tuberculous mycobacteria (NTM) are environmental organisms that can cause pulmonary infections, particularly in individuals with predisposing conditions. While NTM lung disease is increasingly recognized, pleural effusion as a complication remains uncommon, posing diagnostic and therapeutic challenges. This case emphasizes the importance of a high index of suspicion, comprehensive microbiological investigations, and bronchoscopy in the diagnosis of NTM lung disease with pleural effusion. Case presentation: We present the case of a 55-year-old male farmer with a history of smoking, who presented with progressive dyspnea, cough, and constitutional symptoms. Initial investigations suggested tuberculosis, but sputum tests were negative. Chest imaging revealed a right pleural effusion and cavitary lung lesions. Pleural fluid analysis showed an exudative pattern with elevated adenosine deaminase (ADA) but negative for acid-fast bacilli. Bronchoscopy with bronchoalveolar lavage culture yielded Mycobacterium other than tuberculosis (MOTT). The patient was diagnosed with NTM lung disease complicated by pleural effusion and initiated on multidrug therapy. Conclusion: This case highlights the diagnostic challenges of NTM lung disease, particularly when presenting with pleural effusion. A high index of suspicion, comprehensive microbiological investigations, and bronchoscopy are crucial for accurate diagnosis. Prompt initiation of appropriate multidrug therapy is essential for optimal outcomes.
Leukopenia as a Prognostic Factor in Severe Community-Acquired Pneumonia with Sepsis: A Case Report Irawan, Dandy; Irvan Medison; Dewi Wahyu Fitrina; Dessy Mizarti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 12 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i12.1149

Abstract

Background: Community-acquired pneumonia (CAP) is a major cause of sepsis, and severe CAP with sepsis is associated with significant morbidity and mortality. Leukopenia, a decrease in white blood cell count, has been identified as a potential prognostic factor in sepsis, suggesting a poorer outcome. This case report aims to evaluate the role of leukopenia in predicting the clinical course and outcome of a patient with severe CAP and sepsis. Case presentation: A 73-year-old male presented with complaints of shortness of breath, cough, fever, and altered mental status. He was diagnosed with severe CAP with sepsis and sepsis-associated encephalopathy (SAE). Laboratory investigations revealed leukopenia. The patient's clinical condition improved over 10 days of treatment, coinciding with an improvement in his white blood cell count. Conclusion: This case report highlights the potential prognostic value of leukopenia in patients with severe CAP and sepsis. The patient's clinical improvement paralleled the recovery of his white blood cell count, suggesting that leukopenia may serve as a marker of disease severity and treatment response. Further studies are needed to validate these findings and establish the role of leukopenia in the management of severe CAP with sepsis.
Pleural Amebiasis Mimicking Pleural Effusion: A Case Report Sari Handayani Utami; Irvan Medison; Dewi Wahyu Fitrina; Dessy Mizarti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 1 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i1.1168

Abstract

Background: Pleural amebiasis is a rare manifestation of extraintestinal amebiasis, primarily occurring due to the rupture of an amebic liver abscess into the pleural space. We present an unusual case of pleural amebiasis in an elderly woman without any evidence of liver involvement. Case presentation: A 78-year-old female presented with a two-month history of progressive dyspnea, cough, and right-sided chest pain. She had a history of consuming raw vegetables. Examination revealed right-sided pleural effusion, which was confirmed by chest radiography and thoracic ultrasound. Pleural fluid analysis showed exudative effusion and microscopic examination demonstrated the presence of Entamoeba histolytica trophozoites. Despite the absence of a liver abscess on abdominal ultrasound, the patient was diagnosed with pleural amebiasis based on the pleural fluid findings. She was successfully treated with metronidazole and drainage of the pleural fluid. Conclusion: This case highlights the importance of considering pleural amebiasis as a differential diagnosis in patients with pleural effusion, even in the absence of liver involvement. Early diagnosis and prompt treatment with metronidazole and drainage are crucial for a favorable outcome.
Do Ventilator Bundles Reduce Ventilator-Associated Pneumonia? A Meta-Analysis of Randomized Controlled Trials Reski Anugrah Zuandra; Irvan Medison; Russilawati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 3 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i3.1233

Abstract

Background: Ventilator-associated pneumonia (VAP) is a serious complication in mechanically ventilated patients, leading to increased morbidity, mortality, and healthcare costs. Ventilator bundles are evidence-based practices aimed at preventing VAP. This meta-analysis evaluated the effectiveness of ventilator bundles in reducing VAP incidence in critically ill adults. Methods: A systematic search of PubMed, Embase, and Cochrane Central Register of Controlled Trials was conducted from January 2013 to December 2024. Randomized controlled trials (RCTs) comparing ventilator bundles to standard care in adult patients receiving mechanical ventilation were included. The primary outcome was the incidence of VAP. Secondary outcomes included mortality, length of intensive care unit (ICU) stay, and duration of mechanical ventilation. Pooled risk ratios (RR) with 95% confidence intervals (CI) were calculated using a random-effects model. Results: Nine RCTs involving 2,850 patients met the inclusion criteria. The implementation of ventilator bundles was associated with a significant reduction in VAP incidence (RR 0.68, 95% CI 0.55-0.84, p=0.0002). Mortality (RR 0.89, 95% CI 0.75-1.05, p=0.16) and duration of mechanical ventilation (mean difference -1.2 days, 95% CI -2.8 to 0.4, p=0.13) did not significantly differ between groups. However, a significant reduction in ICU length of stay was observed in the ventilator bundle group (mean difference -2.1 days, 95% CI -3.5 to -0.7, p=0.004). Conclusion: This meta-analysis demonstrates that ventilator bundles are effective in reducing VAP incidence in critically ill adults. While no significant impact on mortality was observed, ventilator bundles were associated with a shorter ICU length of stay. These findings reinforce the importance of implementing ventilator bundles as a standard of care in ICUs to improve patient outcomes.
High-Frequency Chest Wall Oscillation versus Conventional Airway Clearance Techniques in Non-Cystic Fibrosis Bronchiectasis: A Meta-Analysis Dzaki Murtadho; Irvan Medison; Deddy Herman
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 4 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i4.1255

Abstract

Background: Non-cystic fibrosis bronchiectasis (NCFB) is a chronic lung disease characterized by irreversible airway dilation and impaired mucociliary clearance, leading to chronic cough, sputum production, and recurrent infections. This meta-analysis aims to compare the efficacy of high-frequency chest wall oscillation (HFCWO) with conventional airway clearance techniques (CACT) in adults with NCFB. Methods: A systematic search of PubMed, Embase, Cochrane Library, Web of Science, and Scopus databases was conducted from January 2013 to March 2024. Randomized controlled trials (RCTs) comparing HFCWO with CACT (postural drainage, percussion, active cycle of breathing technique, positive expiratory pressure therapy) in adults with NCFB were included. The primary outcomes were a change in forced expiratory volume in one second (FEV1) and sputum weight. Secondary outcomes included quality of life, exacerbation frequency, and adverse events. The risk of bias was assessed using the Cochrane Risk of Bias 2 tool. Data were pooled using a random-effects model, and heterogeneity was assessed using the I² statistic. Results: Nine RCTs involving a total of 485 participants were included. The meta-analysis showed no statistically significant difference in FEV1 change between HFCWO and CACT (mean difference [MD] 0.05 L, 95% confidence interval [CI] -0.02 to 0.12; I² = 45%). HFCWO was associated with a statistically significant increase in sputum weight compared to CACT. SGRQ total score showed a statistically significant improvement in the HFCWO group compared to CACT (MD -4.21, 95% CI -7.88 to -0.54; I² = 58%). Conclusion: HFCWO may provide a modest benefit in terms of increased sputum clearance and improved quality of life compared to CACT in adults with NCFB. However, there was no significant difference in lung function (FEV1) or exacerbation frequency. The moderate to high heterogeneity in some outcomes suggests that further research is needed to confirm these findings and identify patient subgroups who may benefit most from HFCWO.
Pulmonary Syphilis: A Narrative Review Kamil, Aulia; Medison, Irvan; Wahyu Fitrina, Dewi; Mizarti, Dessy
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v11i3.64177

Abstract

Pulmonary syphilis is a rare medical condition characterized by lung tissue involvement caused by infection with Treponema pallidum. According to the 2024 WHO report, approximately eight million men and women aged 15–49 years are infected with syphilis globally. Although uncommon, pulmonary involvement has been reported in 1%–12.5% of syphilis cases based on autopsy studies. The main risk factors include untreated syphilis, immunocompromised conditions, and co-infections. This study aims to describe the characteristics, diagnostic approach, and management of pulmonary syphilis to improve understanding of early detection and appropriate treatment. This study used a literature review approach by analyzing epidemiological data and previous studies discussing clinical, radiological, and laboratory findings in the diagnosis of pulmonary syphilis, as well as its therapeutic management. The findings indicate that the diagnosis of pulmonary syphilis requires a comprehensive approach, including clinical evaluation, radiological imaging of the lungs, and laboratory confirmation. Pharmacological management through antibiotic therapy remains the primary treatment to control infection and prevent disease progression. Pulmonary syphilis is a rare but potentially serious complication of syphilis infection. Early detection through comprehensive diagnostic evaluation and appropriate antibiotic treatment is essential to prevent complications and reduce the spread of infection.
Co-Authors Afriani Afriani Amelin, Fitrisia Andani Eka Putra Anggraini, Fenty Anggrainy, Fenty aribowo, kornelis Bagus HS, Muhammad Berliana Islamiyarti Hydra Demas Nico M Manurung Dessy Mizarti Desy Nofita Sari Detty Iryani Dewi Wahyu F. Dewi Wahyu Fitrina Dzaki Murtadho Eka Irawan Ellyza Nasrul Elsesmita, Elsesmita Eni Yulvia Susilayanti Erkadius Erkadius Erlina Rustam Erly Erly Fadhil el Naser Fathiyyatul Khaira Fenty Anggraini Fenty Anggrainy Finny Fitry Yani Fitrina, Dewi Wahyu Hafni Bachtiar Handayani, Friska Hardisman Herman, Deddy Intan Irfa Irawan, Dandy Kamil, Aulia Katerine Katerine Leona, Denada Florencia Linosefa Linosefa Mahata, Liganda Endo Mizarti, Dessy Nadia Ventiani, Nadia Nurmadya Nurmadya Oea Khairsyaf Rahmat Syawqi Reski Anugrah Zuandra Rifki YS Rizanda Machmud Rizki, Fitri Amelia Rufi'i Russilawati Russilawati, Russilawati Sabrina Ermayanti Sari Handayani Utami Sari Nikmawati Sari, Elsa Purnama Selfi Renita Rusjdi Suyastri Suyastri Wahyu Fitrina, Dewi Wulan Prisilla Prisilla Yefri Zulfiqar Yessy Susanty Sabri Yuni Kartika