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All Journal Global Medical and Health Communication ODONTO Dental Journal Padjadjaran Journal of Dentistry Journal of Medicine and Health Alami Journal (Alauddin Islamic Medical) Journal Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Abdimas Kartika Wijayakusuma Journal of Health and Dental Sciences Cakradonya Dental Journal Journal of Medicine and Health
Florence Meliawaty
Fakultas Kedokteran Gigi, Universitas Jenderal Achmad Yani, Cimahi, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Analysis of FOXE1 rs4460498 and GSTP-1 I105V associated with non syndromic cleft lip and palate among Deutero Malay Subrace in Indonesia Nasroen, Saskia Lenggogeni; Meliawaty, Florence; Tammama, Tichvy; Prasdiaz, Putri Indriani; Choirunnisa, Tias; Maskoen, Ani Melani
Padjadjaran Journal of Dentistry Vol 34, No 3 (2022): November 2022
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol34no3.39296

Abstract

ABSTRACTIntroduction: FOXE1 rs4460498 and GSTP-1 I105V gene polymorphisms are suspected of having a role in some of the non-syndromic cleft lip and palate (NS CLP) populations worldwide. This study aims to analyze FOXE1 rs4460498 and GSTP-1 I105V polymorphisms associated with NS CLP as the risk factor among Deutero Malay Subrace in Indonesia. Methods: This study was a case-control design, using samples from the venous blood of 102 NS CLP subjects and 102 healthy control subjects. After DNA was extracted, the PCR-RFLPs method was performed using TasI restriction enzyme on 100 blood samples of FOXE1 rs4460498 group and Alw26I restriction enzyme on 105 blood samples of the GSTP-1 I105V group. The Chi-Square test was used with the Kolmogorov Smirnov and Exact Fisher alternatives. Results: T mutant allele (OR= 0.926, p>0.05) and CT genotype (OR= 0.0, p>0.05) of FOXE1 rs4460498 and the G mutant allele (OR= 0.988,p>0.05) and AG genotype (OR= 0.675,p>0.05) of the GSTP-1 I105V are not the risks of NS CLP. Conclusion: FOXE1 rs4460498 and GSTP-1 I105V gene polymorphisms are not associated with non-syndromic cleft lip and palate among Deutero Malay Subrace in the Indonesian population.Key words: deutero malay; FOXE1 rs4460498; GSTP-1 I105V; NS CLP
Maternal Education Level and Child's Anxiety on Dental Extraction Jeffrey Jeffrey; Florence Meliawaty; Asih Rahaju
Journal of Medicine and Health Vol 2 No 1 (2018)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v2i1.738

Abstract

Dental extraction can cause anxiety in children, observed in vital signs changes. If occursexcessively, it can be regarded as an obstacle and may affect a child's behavior that can furtherdetermine the success of dental treatment. Anxiety that occurs in children can usually be influencedby various factors, including the level of parental education. This study aimed to observe maternaleducation level and anxiety in children receiving dental extraction treatments. This is a descriptivestudy, involving 60 subjects aged 7-12 that went for dental extraction at Rumah Sakit Gigi MulutPendidikan Universitas Jenderal Achmad Yani (RSGMP UNJANI) Cimahi Juli-Desember 2016. Theparameters examined for measuring anxiety are body temperature, respiration frequency, and pulsebefore and after the procedure. This study found that 63.3% of mother of the subject had high schooleducation, 16.7% of junior high school, 8.3% S1, 6.7% D1/D3, and 5% SD. Increased bodytemperature was obtained in 36 subjects, increased respiration frequency in 46 subjects, andincreased pulse in 34 subjects. We concluded that the majority of maternal education levels in thisstudy are high school graduates and the anxiety parameters in the majority of subjects increase whenreceiving dental extraction procedure.Keywords: child's anxiety, dental extraction, mother education level
Effectiveness of Sage Leaf Gel on Neutrophil Count in Wound Healing Meliawaty, Florence; Djohan, Frita Ferlita Shafri; Ramdhani, Muhamad Syahrul
Global Medical & Health Communication (GMHC) Vol 13, No 1 (2025)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v13i1.14302

Abstract

A wound involves damage to the epithelial layer of the skin, extending to the subcutis and surrounding tissues. The body initiates a healing process starting with inflammation. Neutrophils play a crucial role in this phase; excessive neutrophils can cause tissue necrosis, while insufficient neutrophils may lead to infection. Neutrophils are essential for bacterial eradication during inflammation. Sage leaf extract, known for its anti-inflammatory, antioxidant, and antibacterial properties, may aid in wound healing. This study evaluates the effectiveness of 5% sage leaf extract gel on neutrophil count during the wound healing process in Wistar rats. This study was conducted in several Universitas Jenderal Achmad Yani Cimahi laboratories from 29 May 2023 to 23 February 2024. A post-test-only control group design was used with 25 samples divided into five groups: (K-1) no treatment, tissue sampled at 13 minutes; (K-2) no treatment, tissue sampled at 103 minutes; (KN) healthy/normal control; (KP1) 5% sage leaf extract gel, tissue sampled at 13 minutes; (KP2) 5% sage leaf extract gel, tissue sampled at 103 minutes. Data analysis was performed using the Kruskal-Wallis test followed by the Mann-Whitney post hoc test (p≤0.05), indicating a statistically significant difference. The highest mean neutrophil count was observed in the KP2 group, which received 5% sage leaf extract gel and had tissue sampled at 103 minutes. The study concludes that a 5% sage leaf extract gel is effective in increasing neutrophil counts during the healing of punch wounds in Wistar rats, which contributes to accelerated wound healing.
Penyuluhan Kesehatan Gigi Mulut untuk Meningkatkan Pengetahuan Keluarga Pasien Celah Bibir dan Langit-Langit sebagai Implementasi Program Merdeka Belajar Kampus Merdeka Nasroen, Saskia Lenggogeni; Yuslianti, Euis Reni; Meliawaty, Florence; Ardan, Rachman; Isnaeni, Rheni Safira; Irsyad, Widya; Irfianti, Isti
Jurnal Abdimas Kartika Wijayakusuma Vol 3 No 1 (2022): Jurnal Abdimas Kartika Wijayakusuma
Publisher : LPPM Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jakw.v3i1.172

Abstract

Masyarakat yang keluarganya mengalami kondisi bibir sumbing atau celah bibir dan langit-langit mayoritas berasal dari kalangan ekonomi lemah. Kelainan bawaan yang bermanifestasi dari bibir atas ke gusi, dan langit-langit yang tidak sepenuhnya menyatu atau berkembang secara terpisah yang dapat disebabkan oleh faktor genetik dan lingkungan. Keluarga yang memiliki riwayat dengan celah bibir dan langit-langit penting mengetahui pengetahuan tentang celah bibir dan langit-langit. Kegiatan pengabdian masyarakat ini dilakukan sebagai implementasi program Merdeka Belajar Kampus Merdeka (MBKM) dosen dan mahasiswa Fakultas Kedokteran Gigi Unjani untuk membantu masyarakat luar kampus yang tidak terjangkau edukasi dari pelayanan kesehatan dengan intensif. Selain itu dilakukan penelitian dengan metode kuesioner kepada para orang tua penderita di Yayasan Pembina Penderita Celah Bibir dan Langit-langit Bandung. Data dianalisis T-test dependent (p<0,05). Hasil menunjukkan terdapat pengaruh signifikan terhadap peningkatan pengetahuan setelah penyuluhan dibandingkan dengan sebelum penyuluhan pada keluarga pasien celah bibir dan langit-langit (p=0,00). Dapat disimpulkan bahwa program MBKM yang dilaksanakan dapat berperan pada perubahan pengetahuan keluarga mengenai kesehatan gigi dan mulut pasien dengan riwayat celah bibir dan langit-langit setelah dilakukannya penyuluhan.
PROSPECTIVE USE OF REUNDEU LEAVES (Staurogyne elongata) ON INFLAMMATORY MACROPHAGES IN SKIN EXCISION WOUND Meliawaty, Florence; Nur Robbani , Mistli; Endrowahyudi, Hartanto; Reni Yuslianti , Euis
Journal of Health and Dental Sciences Vol. 5 No. 2 (2025): Journal of Health and Dental Sciences
Publisher : Fakultas Kedokteran Gigi Unjani

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Healing of skin excision wounds involves complex stages, with inflammatory macrophages playing a key role in regulating the inflammatory response and tissue regeneration. Staurogyne elongata (Reundeu leaves), a medicinal plant native to Indonesia, contains bioactive compounds such as flavonoids, saponins, steroids, triterpenoids, and polyphenols, which exhibit antioxidant and antibacterial properties. This literature review aimed to explore the prospective role of S. elongata in modulating inflammatory macrophage activity during skin excision wound healing. Articles published within the last 10 years were retrieved from ProQuest, PubMed, ScienceDirect, and Science Publishing Group databases. The scientific implication is that Staurogyne elongata (Reundeu leaves) has potential therapeutic effects on skin excision wound healing by modulating inflammatory macrophage activity. Specifically, its bioactive compounds may promote the transition of macrophages from a pro-inflammatory (M1) to an anti-inflammatory (M2) state, leading to reduced inflammation and enhanced tissue regeneration. The results suggest that S. elongata could be developed as a natural, cost-effective adjunct treatment to improve wound healing outcomes, highlighting the need for further experimental validation, clinical studies, and pharmaceutical formulation development. DOI : 10.54052/jhds.v5n2.p213-226
DENTIGEROUS CYST IN CHILDREN: A RARE CASE REPORT Meliawaty, Florence
Journal of Health and Dental Sciences Vol. 3 No. 3 (2024): Journal of Health and Dental Sciences
Publisher : Fakultas Kedokteran Gigi Unjani

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Dentigerous cysts are growths of the jaw's epithelial lining that develop from the dental follicle of unerupted teeth. These cysts are usually found during routine radiography exams, associated with immature teeth. Dentigerous cysts typically don't cause symptoms unless they get big enough to swell. Third, molars and maxillary canines are frequently associated with most dentigerous cysts. A diagnosis is made based on histopathological, radiological, and clinical findings. We describe an instance of a dentigerous cyst that was connected to two immature mandibular premolar teeth. This rare case report discusses the treatment of a dentigerous cyst in the lower premolar region of the left mandible. Under local anesthesia, the patient had surgical treatment that included the removal of two primary teeth and enucleation of the cyst. The evaluation revealed that one week after surgery, the recovery was complete. DOI : 10.54052/jhds.v3n3.p273-280
Comparison of the effects of hexetidine and chlorhexidine mouthwash on the plaque index Jeffrey, Jeffrey; Novamaura, Regyta; Meliawaty, Florence
Odonto : Dental Journal Vol 9, No 2 (2022): December 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.9.2.327-333

Abstract

Background: Plaque can cause damage to the tooth structure and supporting tissues, so it is necessary to take plaque control measures. The use of mouthwash such as hexetidine and chlorhexidine in chemical plaque control is effective in reducing plaque formation. Both of these mouthwashes were proven to have antibacterial activity against Streptococcus mutans which is one of the bacteria that causes plaque, so it is necessary to compare the effectiveness of the two ingredients to determine the difference in the effectiveness of the two types of mouthwash on the plaque index.Methods: This research method is a pre-test post-test control group design. The plaque index examination was carried out before and after gargling. The subjects in this study consisted of 32 students of state junior high school (SMPN) 2 Cimahi aged 13-15 years. This research was conducted by examining the Silness and Loe plaque index. Chi-square was used to test the normality of the data and then analyzed by t-test.Results: The results showed that there was a difference in the mean plaque index after rinsing with hexetidine and chlorhexidine of 0.077 and 0.167, respectively.Conclusion: There was a significant difference in the comparison of plaque index after gargling using hexetidine and chlorhexidine mouthwash, where hexetidine showed more effective results as an antibacterial agent in reducing plaque in the oral cavity.
Co-Authors Afifah B Sutjiatmo Afifah B. Sutjiatmo Afifah B. Sutjiatmo Ani Melani Maskoen Ariana Pradita Asih Rahaju Azkya Patria Nawawi Choirunnisa, Tias Djohan, Frita Ferlita Shafri Endrowahyudi, Hartanto Euis Reni Yuslianti Euis Reni Yuslianti, Euis Frita Ferlita Shafri Djohan Irfianti, Isti Irsyad, Widya Isnaeni, Rheni Safira Jeffrey ., Jeffrey Jeffrey Jeffrey Karlina Hardjawinata, Karlina Kertamaya Sundawan Mega Zhafarina Nasroen, Saskia Lenggogeni Novamaura, Regyta Nur Robbani , Mistli Prasdiaz, Putri Indriani Putri Mentari Putriani, Wivda Rachman Ardan, Rachman Ramdhani, Muhamad Syahrul Reni Yuslianti , Euis Rina Putri Noer Fadilah Sunardhi Mangundjaja, Sunardhi Tichvy Tammama, Tichvy Vivin Wijami Putri Yuslianti, Euis Reni