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SITI NURUL HIDAYATI
Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Airlangga/RSUD Dr.Soetomo, Surabaya
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : The Indonesian Biomedical Journal

 1 
Zinc Administration Affects Bronchial Mucosal NF-κB p105/p50, p-NF-κB p65, IL-8, and IL-1β of Zinc-deficient Rats Reza Gunadi Ranuh; Andy Darma; Alpha Fardah Athiyyah; Ergia Latifolia; Retno Asih Setyoningrum; Boerhan Hidajat; Siti Nurul Hidayati; Anang Endaryanto; Ferry Sandra; Subijanto Marto Sudarmo
The Indonesian Biomedical Journal Vol 12, No 3 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i3.1041

Abstract

BACKGROUND: Risk of acute respiratory infections in children less than 5 years of age is up to 95%. Zinc deficiency is one of the main risk factors. This study aimed to explore the effect of zinc on the bronchial mucosae inflammatory status expressed by nuclear factor (NF)-κB p105/p50, NF-κB p65, interleukin (IL)-8, and IL-1β.METHODS: Twenty-four Wistar rats were divided into 4 groups: normal zinc diet group without zinc supplementation (Z1), normal zinc diet group with zinc supplementation (Z2), zinc deficient diet group without zinc supplementation (Z3), and zinc deficient diet group with zinc supplementation (Z4). NF-κB p105/p50, p-NF-κB p65, IL-8, and IL-1β were measured by immunohistochemical staining.RESULTS: The inflammatory status of bronchial mucosae between Z1 and Z2 groups showed no difference (p=0.055). However, the inflammatory status of bronchial mucosae between Z3 and Z4 groups showed significant difference (p<0.01). Multivariate factorial design showed that zinc supplementation was beneficial when given to zinc deficient diet group with regard to decrease p-NF-κB p65, IL-8 and IL-1β levels (p<0.001) and increase dendritic cell (p=0.022).CONCLUSION: Zinc administration under conditions of zinc deficiency affects the inflammatory status, as shown by the decrease of p-NF-κB p65, IL-8 and IL-1β and the increase of NF-κB p105/p50.KEYWORDS: zinc, NF-κB, p105/p50, p65, IL-8, IL-1β, rat
Zinc Supplementation Effect on the Bronchial Cilia Length, the Number of Cilia, and the Number of Intact Bronchial Cell in Zinc Deficiency Rats Andy Darma; Alpha Fardah Athiyyah; Reza Gunadi Ranuh; Wiweka Merbawani; Retno Asih Setyoningrum; Boerhan Hidajat; Siti Nurul Hidayati; Anang Endaryanto; Subijanto Marto Sudarmo
The Indonesian Biomedical Journal Vol 12, No 1 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i1.998

Abstract

BACKGROUND: Airway epithelium is the first line of defense against a variety of exposures. Inflammatory processes, hyperresponsiveness and zinc deficiency cause epithelial damage. Zinc is involved in apoptosis and microtubule formation. However, its role in the integrity of bronchial mucosa and cilia is unclear.METHODS: To assess the effect of zinc on the integrity of the bronchial epithelium, 24 male Rattus norvegicus strain Wistar rats were randomized into four experimental groups: normal zinc diet group without zinc supplementation, normal zinc diet group with 60 ppm zinc supplementation, zinc deficient diet group without zinc supplementation, and zinc deficient diet group with 120 ppm zinc supplementation. Bronchial mucosal integrity was measured with the number of epithelial cells, and the number and length of cilia.RESULTS: Number of cell in normal zinc diet group was 8.8±1.82, while it was only 8.1±1.08 in zinc deficient diet group (p<0.001). Number of cilia per cell was 4.6±1.08 in normal zinc diet group, compared to 4.0±0.79 in zinc deficient diet group (p<0.001). Ciliary length also differ by 7.68±0.66 μm in normal zinc diet group and only 5.16±0.91 μm in zinc deficient diet group (p<0.001).CONCLUSION: Zinc supplementation of the normal zinc diet group affected the length of bronchial cilia. Zinc supplementation of the zinc deficient diet group affected the integrity of the bronchial epithelium, which was shown by the number and length of cilia, and the number of epithelial cells.KEYWORDS: zinc, bronchial epithelial integrity, cilia length, number of cilia, epithelial cell 
Co-Authors Adien, Reyhana Talitha AINUL ROZIQIN, ACHMAD Alpha Fardah Athiyyah Anang Endaryanto Andy Darma Ardianah, Eva Arief Wibowo Asma' Athifah Aulia, Ernita Vika BALQIS, ADELINA Boerhan Hidayat, Boerhan BUNGA SARI SURYA ATMAJA, PUTRI Cholis Hidayati Damayanti, Martha DEWI LARASATI, ARDIA Diah Indriani Diana Indah Sri Lestari P. A Dina Angelika Ergia Latifolia Eva Lestari FADHILAH, LAELATUL FATMAWATI, EVADIYAH FAUZA RAHMADHANI ADIYAH, SITI Ferry Sandra Hamam Hadi Hanindita, Meta Herdiana Hari Basuki Notobroto Hari Basuki Notobroto Hartojo Hartojo HASAN SUBEKTI Hidajat, Boerhan Hidayat, Amelia Tsabitah Hiyatma, Shaffa Hwihanus Hwihanus Hwihanus I Gusti Made Reza Gunadi Ranuh I Wayan Dasna Janah, Febriana Roikhatul Jumaidah, Ismi Septia Karennina Putri Aristyani KUNTORO Mahardika, Sekar Putri Maria Ulfah Masayu Ramadhani Polanunu Munzil Murliyanti Murliyanti Nanda Hudawarrahmah Nur Aisiyah Widjaja, Nur Aisiyah Nur Aisiyah Wijaya Nurandini, Anggelia Nurfidaus, Yasmine Nurkholis Nurkholis NURUL HIDAYAH Pandin, Maria Yovita R. Pebriaini, Prisma Andita Pratiwi, Zuliana Eka Putri Rahayu Rachmah Indawati Rahayu, Putri Retno Asih Setyoningrum Ria Puspitasari Rina Sulistiyani Roedi Irawan Rojab Siti Rodliyah Sabilatuzzahra, Putri Alifiyah Sabtiawan, Wahyu Budi Salsabila, Ainus Santoso, Febrina Mustika Saputra, Ardiansyah Dharma Sarifah, Rosa Latus Septia Winariani, Pradnya Sigit Ari Saputro Soenarnatalina Melaniani Sri Wahyuni Sudarmo, Subijanto Marto Sulistiawati Sulistiawati Surjani Wonorahardjo TATI NURHAYATI VERNANDA, SISKA VIKA AULIA, ERNITA W. Lestariana Wardana, Rizky Amelia Windhu Purnomo Wiweka Merbawani Yanuar, Daffa Ramadhani Zahroh, Mu'nisatuz