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All Journal Jurnal NERS Indonesian Journal of Tropical and Infectious Disease Majalah Obstetri dan Ginekologi Sari Pediatri Paediatrica Indonesiana Majalah Kesehatan FKUB Health Notions Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Journal of Maternal and Child Health Jurnal Labora Medika JURNAL PHOTON Holistik Jurnal Kesehatan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Pediomaternal Nursing Journal JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH Indian Journal of Forensic Medicine & Toxicology INDONESIAN MIDWIFERY HEALTH AND SCIENCES JOURNAL FRIMA: Festival Riset Ilmiah Manajemen & Akuntansi JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Eduvest - Journal of Universal Studies Journal for Quality in Public Health Folia Medica Indonesiana
Risa Etika, Risa
Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Airlanga Surabaya
Aerospace Engineering Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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Journal : Paediatrica Indonesiana

 1 
Assessment of the quality of general movements in newborn infants: a tool to predict developmental disorders at an early age Ahmad Suryawan; Bambang Permono; Komang Ayu Witarini; Risa Etika; Fatimah lndarso; Moersintowarti B. Narendra
Paediatrica Indonesiana Vol 48 No 5 (2008): September 2008
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (126.968 KB) | DOI: 10.14238/pi48.5.2008.292-8

Abstract

Background Nowadays, quality assessment of general movements(GMs) in infants can be used as a tool to predict developmentaloutcome. Until now, there is no published study in this field inIndonesia.Objectives The aim of this study was to evaluate the quality ofGMs of newborn infants.Methods A prospective study was done at neonatal ward, Dr.Soetomo Hospital in Surabaya, between December 2006 andJanuary 2007. A single supine position video recording of newbornsat GMs preterm and writhing age was made using Precthl's method.Infants were chosen consecutively among singletons above 28week gestational age. The quality of GMs was assessed by meansof Gestalt perception by one of the authors, who had been trainedand certified in GMs. GMs were classified into: normal-optimal,normal-suboptimal, mildly-abnormal, and definitely-abnormal.Correlation tests were used to assess the relationship betweenperinatal conditions and the quality of GMs.Results 106 videos were recorded, and 100 were assessedcompletely. Abnormal GMs were found in both 35 pretermage (normal-optimal 2.9%; normal-suboptimal 28.6%; mildly-abnormal45. 7o/o; definitely-abnormal22.9o/o) and 65 writhing age(3.1 o/o; 41.5%; 41.5%; 13.8%, respectively) (P=0.285). There wasa weak negative correlation between birth weight and the qualityofGMs (r=-0.20, P=0.044).Conclusions The quality ofGMs in Indonesian newborn infants inour study was predominantly abnormal, which puts these infantsat high risk for later developmental disorders. The lower theinfants'birth weight, the more likely for abnormal GMs.
The use of score for neonatal acute physiology perinatal extention II (SNAPPE II) in predicting neonatal outcome in neonatal intensive care unit Mia R A; Risa Etika; Agus Harianto; Fatimah Indarso; Sylviati M Damanik
Paediatrica Indonesiana Vol 45 No 6 (2005): November 2005
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi45.6.2005.241-5

Abstract

Background Scoring systems which quantify initial risks have animportant role in aiding execution of optimum health services by pre-dicting morbidity and mortality. One of these is the score for neonatalacute physiology perinatal extention (SNAPPE), developed byRichardson in 1993 and simplified in 2001. It is derived of 6 variablesfrom the physical and laboratory observation within the first 12 hoursof admission, and 3 variables of perinatal risks of mortality.Objectives To assess the validity of SNAPPE II in predicting mor-tality at neonatal intensive care unit (NICU), Soetomo Hospital,Surabaya. The study was also undertaken to evolve the best cut-offscore for predicting mortality.Methods Eighty newborns were admitted during a four-month periodand were evaluated with the investigations as required for the specifi-cations of SNAPPE II. Neonates admitted >48 hours of age or afterhaving been discharged, who were moved to lower newborn care <24hours and those who were discharged on request were excluded. Re-ceiver operating characteristic curve (ROC) were constructed to derivethe best cut-off score with Kappa and McNemar Test.Results Twenty eight (35%) neonates died during the study, 22(82%) of them died within the first six days. The mean SNAPPE IIscore was 26.3+19.84 (range 0-81). SNAPPE II score of thenonsurvivors was significantly higher than the survivors(42.75+18.59 vs 17.4+14.05; P=0.0001). SNAPPE II had a goodperformance in predicting overall mortality and the first-6-daysmortality, with area under the ROC 0.863 and 0.889. The best cut-off score for predicting mortality was 30 with sensitivity 81.8%,specificity 76.9%, positive predictive value 60.0% and negativepredictive value 90.0%.Conclusions SNAPPE II is a measurement of illness severity whichcorrelates well with neonatal mortality at NICU, Soetomo Hospital.The score of more than 30 is associated with higher mortality
Analytical study of inflammatory cytokines and immunoglobulin expression following dust mite allergen exposure in pregnant mice Risa Etika; Subijanto Marto Sudarmo; Suwarno Suwarno; Muhammad Pradhika Mapindra; Muhammad Pradhiki Mahindra
Paediatrica Indonesiana Vol 61 No 6 (2021): November 2021
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi61.6.2021.336-42

Abstract

Background Allergen tolerability due to allergic immune reactions could be transferred through the placenta from maternal to fetal circulation. Hence, a further investigation regarding the tolerability following mite allergen exposures is desirable. Objective To evaluate various doses of mite allergens and cytokines associated with Th1, Th2, and Treg cells with regards to possible allergic tolerance in neonatal mice. Methods This study used an experimental design with a post-test only control group, to assess the effect of mite allergens on pregnant BALB/C mice and their newborns. In this study female BALB/C mice aged 10 weeks were mated with male mice, then pregnant BALB/C mice were exposed to allergens at 4 weeks gestation. During pregnancy, pregnant females’ blood specimens were taken to measure cytokines and immunoglobulins. Meanwhile, neonatal blood specimens were taken at 2 weeks postnatally to measure cytokines and immunoglobulins. Blood specimens from pregnant BALB/C mice and their newborns were evaluated using ELISA kits for the following cytokines: interleukin (IL)-2, interferon (IFN)-γ, interleukin (IL)-4, IL-5, IL-10, TGF-β1, as well as immunoglobulins (Ig)G-1, IgG-2a, IgG-2b, IgG3 subclass, IgM, IgA, and IgE. The case group was the group that received high and low doses of exposure, while the control group did not get exposure. Results In response to low dose mite allergen exposure, there were significant increases of IL-2, IFN-y, and IL-4, IL-5, and TGF-β1 in mothers and neonates. Pregnant mices that received high doses of allergens, however, had significant increases in IL-5 and TGF-B1; results were likewise for their offspring. Mothers and neonates, had significantly increased expression of IgG subclasses after a low dose of dust mite allergen. Following a ten-fold increase in allergen dose, the mothers showed significant increases in IgA, IgM, IgE, and IgG subclasses, whereas in neonatal mice, those immunoglobulin levels were not significantly different from control mice. Conclusion Exposure to mite allergens can trigger regulatory functions of Th1, Th2, and Tregs cells to activate their cytokines, except IL-10. The regulatory function of Tregs is dominated by TGFβ in maternal and neonatal mice, at low and high doses. Th1 cytokines express cytokines during exposure only to low-dose allergens and Th2 cells regulate IL-5 levels to both low- and high-dose allergens.
Co-Authors . Suwarno Aditiawarman Aditiawarman, Aditiawarman AGUS HARIANTO Agus Sulistyono Ahmad Suryawan Aldika Akbar, Muhammad Ilham Alexander Leonard Caesar Josediputra Alit Utamayasa Aminuddin Harahap Aprilawati, Dwi Aprilia Indra Kartika Aprilia Laraswati Armawa, Syihab Armedian Oktaviani Puspaningrum Avianti, Dwi Lestari Bambang Permono Bambang Purwanto Bangkit Putrawan Basuki, Setio Chiquita Febby Pragitara Denai Wahyuni Desy Jein Rimelda Masombe Devina Callista Ayungga Dina Angelika Dominicus Husada Dwiyanti Puspitasari, Dwiyanti Eighty Mardiyan K, Eighty Elisia, Latiful Erlina Suci Astuti Ernawati Ernawati Esti Yunitasari Fatchul Wahab Fatimah Indarso Fatimah Indarso Fatimah lndarso HERAWATI, LILIK Herlisa Anggraini Hermanto Tri Joewono Ilya Krisnana, Ilya Irwanto Irwanto Irwanto, Irwanto Ismoedijanto Iwan S. Handoko Izzati, Dwi Jenica Hillary Eka Firnanda MCRP Jianti Fina Lestari Kartika Darma Handayani Kartina, Leny Komang Ayu Witarini Mahiroh, Hodimatum Mahrus A Rahman, Mahrus A Martono Martono Martono Tri Utomo Martono TU Melinda Masturina Mellisa Kristanti Hosea, Mellisa Kristanti Mia R A Moersintowarti B. Narendra Moersintowati B. Narendra Muhammad Pradhika Mapindra Muhammad Pradhiki Mahindra Muhammad Reza Muhammad Reza Ni Made Mertaniasih Nimas Anggie Auliasari Ningrum, Astika Gita Nurmeyda Lentina Nursalam, Nursalam Nyilo Purnami Oktavian Prasetya Pamarga Priyambodo Pudji Lestari Puspa Wardhani Rahayu Catur Ria Wati Rize Budi Amalia Rizky Arisanti Maharani Roedi Irawan Rohma, Annisa Nur Ruth A. Alexander Salsabila Hansa Kamal Sampurna, Mahendra Tri Arif Sari, Ernita Sari, Trias Kusuma Sarmanu, Sarmanu Setya Mithra Hartiastuti Shanty Djajakusli Shrimarti Rukmini Devy Sudarmo, Subijanto Marto Sunny Mariana Samosir Syamsul Arifin Sylviati M Damanik Sylviati M. Damanik Talitha Y. Aden Teddy Ontoseno Tuti Herawati Virani Diana Woro Setia Ningtyas Yulida Mufidah