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All Journal The Journal of Experimental Life Sciences (JELS) Ulul Albab: Jurnal Studi Islam El-Hayah : Jurnal Biologi El-QUDWAH Prosiding Seminar Biologi Jurnal Biodjati Biosel: Biologi Science and Education Jurnal Biomedika Narra J Berkala Penelitian Hayati Al Karima : Jurnal Studi Ilmu Al Qur'an dan Tafsir Jurnal Kedokteran Hewan Ulil Albab
Bayyinatul Muchtaromah
Department Of Biology, Faculty Of Science And Technology, Universitas Islam Negeri (UIN) Maulana Malik Ibrahim Malang, Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Veterinary Other

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Immunomodulatory Activity of Allium sativum, Curcuma mangga, and Acorus calamus Combination Nanoparticle on Mice Leukocytes Profile Bayyinatul Muchtaromah; Nur Izzah Analisa; Mujahidin Ahmad; Prilya Dewi Fitriasari; Soraya Habibi; Alfiah Hayati; Ely Nuril Fajriyah
Jurnal Biodjati Vol 7, No 1 (2022): May
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v7i1.11879

Abstract

Immunomodulators are substances acting as stimulants or suppressants against the immune system, either to specific or non-specific activity. The non-specific through the production of leukocytes as the first response in fighting against an attacking antigen. Meanwhile, the specific, hrough recognition of antigens by lymphocytes during reattack. This research aimed to determine the immunomodulatory activity of the extracts combination nanoparticles of Allium sativum, Curcuma mangga, and Acorus calamus on the leukocyte profile of mice. This study used 5 treatments and 6 repetitions. The treatment groups were K- (untreated group), P1 (extracts combination nanoparticle dose of 25 mg/kg), P2 (extracts combination nanoparticle dose of 50 mg / kg), P3 (subur kandungan herbal medicine dose of 75 mg / kg), and P4 (Clomiphene citrate dose of 0.9 mg / kgBW). The parameters used included the total number of leukocytes and their differential value. The data that met the parametric assumptions, such as normally distributed and homogeneous were examined using the One Way ANOVA test, and when there was a significant difference, it was processed with the Duncan assessment. While those that did not meet the assumptions were evaluated using a non-parametric analysis. The statistical results showed that administration of extracts combination nanoparticles of A. sativum, C. mangga, and A. calamus at doses of 25 mg/kg and 50 mg/kg were able to suppress the inflammatory reaction by decreasing the total number of leukocytes. However, the differential leukocyte count was able to maintained or modulate immune system, indicating by the percentage of neutrophil, basophil, and eosinophil in the normal range. At a dose of 50 mg/kg, decreased the percentage of lymphocytes, while for monocytes, all dosage ranges were able to increase their number.
Isolasi dan Karakterisasi Protein 100kDa dari Membran Kepala Spermatozoa Kambing Bayyinatul Muchtaromah; Sutiman Bambang Sumitro; Soemarno Soemarno; Trinil Susilawati
The Journal of Experimental Life Science Vol. 2 No. 1 (2012)
Publisher : Postgraduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1053.644 KB) | DOI: 10.21776/ub.jels.2012.002.01.03

Abstract

Antigen adalah protein yang dapat menginduksi terbentuknya antibodi. Berat molekul protein sebesar 100 kDa dapat bertindak sebagai imunogen yang kuat. Tujuan dari penelitian ini adalah untuk mencari kandidat vaksin imunokontrasepsi dan melakukan isolasi serta karakterisasi protein 100 kDa yang diduga mempunyai peranan penting di dalam interaksi spermatozoa-ovum. Penelitian ini merupakan penelitian eksploratif. Materi Protein 100 kDa diisolasi dari membran spermatozoa kambing menggunakan detergen N-Octyl-glycopiranoside kemudian dirunning menggunakan metode SDS-PAGE dan dikoleksi dengan elektroelusi. Karakterisasi Protein 100 kDa meliputi penentuan berat molekul melalui SDS-PAGE, penentuan titik isoelektrik (pI) dengan IEF (isoelectric focusing) dan kandungan protein dengan metode Biuret. Hasil running isolat protein membran spermatozoa kambing menggunakan metode SDS-PAGE diperoleh pita protein yang terdiri atas 7 pita dengan berat molekul 166,7; 122; 100; 82,8;  60,4; 29,9 dan 14,8 kDa. Isolat Protein 100 kDa diperoleh dengan purifikasi menggunakan metode elektroelusi. Hasil IEF gel elektroforesis Protein 100 kDa dari membran spermatozoa kambing yang diejakulasikan ini mempunyai tiga titik isoelektrik yaitu 6,37; 6,05 dan 5,64. Kandungan protein dalam isolat Protein 100 kDa sebesar 2375 ± 5,65 µg/mL. Hasil ini menunjukkan bahwa isolat protein 100 kDa dapat digunakan sebagai imunogen. Kata Kunci : isolasi, karakterisasi, membrane spermatozoa, protein 100kDa
KEMAMPUAN ANTI MAYOR PHYSIOLOGICAL PROTEIN SUBSTRAT ECTO CYCLIC AMP INDEPENDENT SERIN/THEONIN PROTEIN KINASE (MPS ecto-CIK) DALAM MENGHAMBAT VIABILITAS SPERMATOZOA KAMBING DAN SAPI Bayyinatul Muchtaromah; Sutiman B. Sumitro
Jurnal Kedokteran Hewan Vol 5, No 1 (2011): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (340.936 KB) | DOI: 10.21157/j.ked.hewan.v5i1.429

Abstract

Penelitian ini bertujuan mengetahui pengaruh dosis dan lama inkubasi anti MPS ecto-CIK dalam menghambat viabilitas spermatozoa kambing dan sapi. Rancangan penelitian yang digunakan adalah rancangan acak lengkap (RAL) dengan pola faktorial yang terdiri atas 2 faktor yakni dosis pengenceran (0, 5, 10, dan 15 µl) dan lama inkubasi (5, 30, 60, dan 120 menit) masing-masing 6 kali ulangan. Data yang diperoleh dianalisis dengan analisis varian dua arah, yang dilanjutkan dengan uji jarak Duncan dengan taraf signifikansi 5%. Pemberian anti MPS ecto-CIK membran spermatozoa kambing dengan konsentrasi 0, 5, 10, dan 15 µl dan lama inkubasi 5, 30, 60, dan 120 menit berpengaruh signifikan terhadap viabilitas spermatozoa kambing dan sapi (P0,05). Perlakuan anti MPS ecto-CIK pada dosis 15 µl dan lama inkubasi 120 menit terhadap spermatozoa kambing dan sapi merupakan perlakuan yang paling optimal dalam menghambat viabilitas spermatozoa kambing (45,50±11,16 dan 44,87±9,40%) dan sapi (39,08±14,40 dan 36,67±11,93%).
Effect of Chitosan-Coated Centella asiatica Nanoparticles on Kidney Histology Profile of Complicated Diabetic Mice Bayyinatul Muchtaromah; Ana Mar'a Konita Firdaus; Eko Budi Minarno; Prilya Dewi Fitriasari; Mei Rhomawati; Maharani Retna Duhita; Wira Eka Putra
Jurnal Biodjati Vol 8, No 2 (2023): November
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v8i2.21430

Abstract

Gotu kola (Centella asiatica) is a medicinal plant that has potential as an antioxidant and antidiabetic. Its compound is able to protect against diabetic nephropathy through the inhibition of oxidative stress. In terms of increasing drug potency and bioavailability of C. asiatica compounds, nanoparticle technology was used. This study aimed to determine the effect of C. asiatica nanoparticles coated with chitosan on the renal histology profile of complicated diabetic mice using a completely randomized design (CRD) with five treatment groups and five replications. The treatment groups were divided into K- (the experimental animals were not given any treatment), K+ (the experimental animals were induced by STZ), P1 (STZ + C. asiatica nanoparticles 120 mg/kgBW), P2 (STZ + C. asiatica nanoparticles 180 mg/kgBW), P3 (STZ + C. asiatica nanoparticles 240 mg/kgBW). The experimental animal model of complicated diabetes was induced by intraperitoneal STZ at a dose of 40 mg/kgBW for two days and STZ at a dose of 60 mg/kgBW for three days and then left for nine days. The C. asiatica nanoparticle therapy was given for 28 days. The parameters in this study were the results of scoring cell damage in the glomerular and tubular tissues (proximal and distal) of the kidney. The data obtained were tested for normality and homogeneity, then the normal and homogeneous data were tested with one-way ANOVA and further tested with Duncan's test. The statistical analysis results showed that C. asiatica coated with chitosan nanoparticles could reduce the damage to the histological profile of the glomerulus and tubules (proximal and distal) of the kidney of diabetic mice. C. asiatica-coated nanoparticles at a dose of 240 mg/kgBW showed the most optimal reduction in damage to the glomerular and tubular histology profiles.
Immunomodulatory Activity of Robusta Green Coffee Extract on Macrophage Phagocytosis and Lymphocyte Proliferation in Vitro Habibi, Habibi; Lestari, Rahayu Dwi; Muchtaromah, Bayyinatul
El-Hayah:Jurnal Biologi Vol 9, No 3 (2023): EL-HAYAH (VOL 9, NO 3 September 2023)
Publisher : Program Study of Biology, Science and Technology Faculty, UIN Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/elha.v9i3.23944

Abstract

Robusta green coffee contains a large quantity and variety of polyphenols and flavonoids which are known to have antioxidant and anti-inflammatory properties. This research to investigate the immunomodulatory activity of Robusta green coffee extract on macrophage activity stimulated with lipopolysaccharide (LPS) and lymphocyte proliferation. Macrophages were isolated from mice peritoneal tissue, and Lymphocytes were isolated from lymph organs. The immunomodulatory activity on macrophages was evaluated based on Active Phagocytes Cells (APC) and the proliferation of lymphocytes was evaluated by the MTT Assay which was previously given extracts with varying concentrations (20 µg/ml, 40 µg/ml, 50 µg/ml, 60 µg/ml, 70 µg/ml), then the data were analyzed by ANOVA (α=0.05). The aqueous extracts of Robusta green coffee significantly affects macrophage activity and lymphocyte proliferation in vitro. The extract was decrease the percentage of phagocytosis (PP) macrophage stimulated with LPS, however there was increase phagocytosis capacity (PC) and lymphocyte proliferation stimulation index is 3, illustrating the extract has a low immunomodulatory effect on lymphocyte proliferation. Based on these results, Robusta green coffee extract holds potential as an immunomodulatory agent, affecting against macrophage phagocytosis and lymphocyte proliferation.
Effect of pegagan (Centella asiatica) nanoparticle coated with chitosan on the cytokine profile of chronic diabetic mice Muchtaromah, Bayyinatul; Firdaus, Ana MK.; Ansori, Arif NM.; Duhita, Maharani R.; Minarno, Eko B.; Hayati, Alfiah; Ahmad, Mujahidin; Analisa, Izza
Narra J Vol. 4 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i1.697

Abstract

Diabetes is closely related to immune response problems when it occurs chronically. Pegagan (Centella asiatica) is a medicinal plant with active compounds. Madecassoside is beneficial in treating diabetes, and nanoparticle technology is expected to enhance the medicinal potential and availability of pegagan compounds. The aim of this study was to determine the effect of chitosan-coated pegagan nanoparticles on the cytokine profile of chronic diabetic mice, which included CD4+TNF-α+, CD8+TNF-α+, CD4+IFN-γ+, CD8+IFN-γ+ and IL-6+. An experimental study with a randomized complete block design (CRD) consisting of six treatments with seven replicates was conducted. The groups were: healthy mice as negative control; diabetic mice treated with distilled water as positive control and diabetic mice treated with nanoparticle coated with chitosan (NPC) 20 mg/kg, 30 mg/kg, 40 mg/kg, and metformin 130 mg/kgBW. The data were tested using one-way analysis of variance (ANOVA) with a significance level of 5% and continued with the Duncan’s multiple range test. The results showed that pegagan NPC could significantly reduce the relative number of CD4+TNF-α+, CD8+TNF-α+, CD4+IFN-γ+ and CD8+IFN-γ+ and IL-6 in the dose of 20 mg/kg, 30 mg/kg and 40 mg/kg (p<0.05). The treatment dose of 20 mg/kg reduced CD4+TNF-α+, CD8+TNF-α+, CD4+IFN-γ+, CD8+IFN-γ+ to the levels of healthy mice and a dose of 30 mg/kg could reduce IL-6 as in healthy mice. These findings suggest that chitosan-coated pegagan nanoparticles are a promising therapy for diabetes, as they have the potential to modulate the immune response associated with chronic diabetes.
Aplikasi Teknologi Nanopartikel Pada Pengobatan Kanker Handika Nur Arofik; Bayyinatul Muchtaromah
ULIL ALBAB : Jurnal Ilmiah Multidisiplin Vol. 2 No. 4: Maret 2023
Publisher : CV. Ulil Albab Corp

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56799/jim.v2i4.1464

Abstract

Kanker merupakan salah satu penyakit penyebab kematian di dunia. Hingga saat ini kanker masih menjadi salah satu masalah kesehatan yang cukup kompleks. Pemanfaatan nanopartikel dalam pengobatan kanker bertujuan untuk meningkatkan bioavailabilitas dan distribusi obat, serta memperbaiki targeting dan release obat ke sel tumor, sehingga diharapkan dapat meningkatkan efikasi dan mengurangi efek samping. Nanopartikel merupakan semua bentuk material biologis dan sintetik yang dimensinya < 1µm. Nanopartikel dalam penatalaksanaan kanker dikembangkan sebagai drugdelivery vehicle (carrier), contrast agent (imaging), diagnostic device, platform untuk theranostic agents, antioksidan, in vivo tumor targeting dengan spesifisitas dan afinitas yang tinggi, serta sebagai probe pada riset preklinik untuk studi molekuler penyakit. Tujuan review artikel ini adalah untuk mengetahui penggunaan nanopartikel dalam pengobatan kanker. Berdasarkan penelitian menunjukan bahwa nanopartikel dapat menjadi penghantaran obat yang terkontrol dan dapat disesuaikan pada pengobatan kanker.
Immunomodulatory Activity of Allium sativum, Curcuma mangga, and Acorus calamus Combination Nanoparticle on Mice Leukocytes Profile Muchtaromah, Bayyinatul; Analisa, Nur Izzah; Ahmad, Mujahidin; Fitriasari, Prilya Dewi; Habibi, Soraya; Hayati, Alfiah; Fajriyah, Ely Nuril
Jurnal Biodjati Vol 7 No 1 (2022): May
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v7i1.11879

Abstract

Immunomodulators are substances acting as stimulants or suppressants against the immune system, either to specific or non-specific activity. The non-specific through the production of leukocytes as the first response in fighting against an attacking antigen. Meanwhile, the specific, hrough recognition of antigens by lymphocytes during reattack. This research aimed to determine the immunomodulatory activity of the extracts combination nanoparticles of Allium sativum, Curcuma mangga, and Acorus calamus on the leukocyte profile of mice. This study used 5 treatments and 6 repetitions. The treatment groups were K- (untreated group), P1 (extracts combination nanoparticle dose of 25 mg/kg), P2 (extracts combination nanoparticle dose of 50 mg / kg), P3 (subur kandungan herbal medicine dose of 75 mg / kg), and P4 (Clomiphene citrate dose of 0.9 mg / kgBW). The parameters used included the total number of leukocytes and their differential value. The data that met the parametric assumptions, such as normally distributed and homogeneous were examined using the One Way ANOVA test, and when there was a significant difference, it was processed with the Duncan assessment. While those that did not meet the assumptions were evaluated using a non-parametric analysis. The statistical results showed that administration of extracts combination nanoparticles of A. sativum, C. mangga, and A. calamus at doses of 25 mg/kg and 50 mg/kg were able to suppress the inflammatory reaction by decreasing the total number of leukocytes. However, the differential leukocyte count was able to maintained or modulate immune system, indicating by the percentage of neutrophil, basophil, and eosinophil in the normal range. At a dose of 50 mg/kg, decreased the percentage of lymphocytes, while for monocytes, all dosage ranges were able to increase their number.
Health Benefits of Ajwa Dates (Phoenix dactylifera L) : A Qur’anic Thematic Interpretation and Scientific Perspective Fingki Hariyana; Umaiyatus Syarifah; Bayyinatul Muchtaromah; Setyowati, Yes
Al Karima : Jurnal Studi Ilmu Al Quran dan Tafsir Vol. 9 No. 2 (2025): Al Karima : Jurnal Studi Ilmu Al-Quran dan Tafsir
Publisher : Sekolah Tinggi Ilmu Al-Quran Isy Karima Karanganyar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58438/alkarima.v9i2.374

Abstract

This study focuses on the health benefits of Ajwa dates (Phoenix dactylifera L.) through a Qur’anic thematic interpretation combined with relevant scientific findings. Unlike previous studies that broadly discuss plant diversity, this research specifically highlights Ajwa dates, which are mentioned in hadith and valued in Islamic tradition for their protective and therapeutic properties. The thematic interpretation (tafsīr maudhū‘ī) method was applied by collecting and analyzing Qur’anic verses and hadith related to dates, then synthesizing their meanings in light of classical exegesis and contemporary scientific literature. Scientific data were obtained through a qualitative literature review of medical and nutritional studies. The results indicate that Ajwa dates are rich in nutrients, antioxidants, and bioactive compounds with proven health benefits, such as enhancing immunity, reducing blood pressure, supporting women’s reproductive health, and providing protective effects against toxins. Theologically, the Qur’an and hadith emphasize dates as blessings and sources of healing, which are now further supported by scientific evidence. This study concludes that Ajwa dates hold significant value as both a Qur’anic health guidance and a scientifically supported natural remedy, offering insights into integrating faith-based perspectives with modern health sciences.
KEMAMPUAN ANTI MAYOR PHYSIOLOGICAL PROTEIN SUBSTRAT ECTO CYCLIC AMP INDEPENDENT SERIN/THEONIN PROTEIN KINASE (MPS ecto-CIK) DALAM MENGHAMBAT VIABILITAS SPERMATOZOA KAMBING DAN SAPI Muchtaromah, Bayyinatul; Sumitro, Sutiman B.
Jurnal Kedokteran Hewan Vol 5, No 1 (2011): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v5i1.429

Abstract

Penelitian ini bertujuan mengetahui pengaruh dosis dan lama inkubasi anti MPS ecto-CIK dalam menghambat viabilitas spermatozoa kambing dan sapi. Rancangan penelitian yang digunakan adalah rancangan acak lengkap (RAL) dengan pola faktorial yang terdiri atas 2 faktor yakni dosis pengenceran (0, 5, 10, dan 15 l) dan lama inkubasi (5, 30, 60, dan 120 menit) masing-masing 6 kali ulangan. Data yang diperoleh dianalisis dengan analisis varian dua arah, yang dilanjutkan dengan uji jarak Duncan dengan taraf signifikansi 5%. Pemberian anti MPS ecto-CIK membran spermatozoa kambing dengan konsentrasi 0, 5, 10, dan 15 l dan lama inkubasi 5, 30, 60, dan 120 menit berpengaruh signifikan terhadap viabilitas spermatozoa kambing dan sapi (P0,05). Perlakuan anti MPS ecto-CIK pada dosis 15 l dan lama inkubasi 120 menit terhadap spermatozoa kambing dan sapi merupakan perlakuan yang paling optimal dalam menghambat viabilitas spermatozoa kambing (45,5011,16 dan 44,879,40%) dan sapi (39,0814,40 dan 36,6711,93%).
Co-Authors Ahmad Barizi Alfiah Hayati Ana Mar&#039;a Konita Firdaus Analisa, Izza Analisa, Nur Izzah Ansori, Arif NM. Didik Wahyudi Duhita, Maharani R. Eko Budi Minarno Ely Nuril Fajriyah Erna Agustina Fajriyah, Ely Nuril Fathorrohman Fathorrohman Fingki Hariyana Firdaus, Ana Mar'a Konita Firdaus, Ana MK. Habibi Habibi Habibi, Soraya Handika Nur Arofik Hasan, M. Nur Jayawarsa, A.A. Ketut LENY RUSVITA UMAMI Lina Ainun Nazilah Maharani Retna Duhita Mei Rhomawati Minarno, Eko B. Mujahidin Ahmad Nayla Alin Naja Nur Izzah Analisa Prilya Dewi Fitriasari Rahmi Annisa Rhomawati, Mei Rizal Maarif Rukmana Romaidi Romaidi Setyowati, Yes Soemarno Soemarno Sofiya Sofiya Soraya Habibi Sutiman B. Sumitro Sutiman B. Sumitro Sutiman Bambang Sumitro Umaiyatus Syarifah Wira Eka Putra