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All Journal VALENSI Jurnal Sains dan Teknologi Kimia Indonesian Journal of Biotechnology IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Jurnal Tadris Kimiya Science and Technology Indonesia Jurnal Penelitian Pendidikan IPA (JPPIPA) Chimica et Natura Acta Indonesian Journal of Chemistry Paedagoria : Jurnal Kajian, Penelitian dan Pengembangan Kependidikan Jurnal Kartika Kimia Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Journal of Vocational Education Studies Jurnal Ilmiah Farmako Bahari Jurnal Insan Farmasi Indonesia Indonesian Journal Of Educational Research and Review ICONESTH Jurnal Pengabdian Isola Jurnal Riset dan Praktik Pendidikan Kimia
Iqbal Musthapa
Universitas Pendidikan Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : VALENSI

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Lignan (+)-Piperitol-γ,γ-Dimethylallylether from Stem Bark of Zanthoxylum rhetsa (Roxb.) DC (Rutaceae) Ruchiyat Ruchiyat; Al Arofatus Naini; Tati Herlina; Iqbal Musthapa; Unang Supratman
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 8, No. 2, November 2022
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v8i2.26964

Abstract

Lignans are a group of phenylpropanoid dimers in which the phenylpropane units are linked by their propyl side chains' central carbon (C8). Lignans have various biological activities, including antiviral, anticancer, cancer preventive, and cytotoxic. Zanthoxylum rhetsa (Roxb.) DC is a tree with prickly branchlets belonging to the Zanthoxylum genus, commonly known as panggal buaya in Indonesia. Asian tribes have used this plant as traditional medicine. In this study, (+)-piperitol-γ,γ-dimethylallylether, a furofuran lignan, was successfully isolated. The chemical structure of compound 1 was determined based on spectroscopic data, including 1D- and 2D-NMR, mass spectroscopy, and by comparing with previous spectral data. In addition, compound 1 was tested for its cytotoxic activity against MCF-7 breast cancer cell lines in vitro and showed weak activity with the IC50 value of 261.37 µg/mL.
Experimental and Molecular Docking Study of 3′,4′,5′-Trimethoxychalcones Targeting Overexpressed Protein in HCT-116 Colon Cancer Cells Danova, Ade; Wonganan, Piyanuch; Hermawati, Elvira; Kurniadewi, Fera; Musthapa, Iqbal; Chavasiri, Warinthorn
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 11, No. 2, November 2025
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i2.46483

Abstract

Cancer poses a substantial global health challenge. Colorectal cancer (CRC) is the second leading cause of cancer-related mortality after lung cancer and is associated with high mortality rates worldwide. Chalcones have attracted significant interest because of their diverse biological properties, including potential anticancer effects. In this study, five 3′,4′,5′-trimethoxychalcones (1-5) were tested against HCT-116 colon cancer cells using an MTT assay for the first time. Molecular docking was conducted to predict molecular interactions targeting three proteins (tubulin, EGFR, and CDK2). Among the five, four compounds (1, 3, 4, and 5) exhibited strong inhibitory activity against HCT-116 colon cells, with IC50 values < 10 µM. Compounds 1-5 showed potency as drug candidates based on the Lipinski rules and pharmacokinetic profiles using SwissADME and pkCSM online tools. Moreover, molecular docking was performed on compound 5 against three protein targets (tubulin, EGFR, CDK2) with binding affinities of -7.4, -7.3, and -8.5 kcal/mol, respectively, and showed major H-bond interactions. Therefore, these results suggest that compound 5 could be a potential inhibitor to be developed in future studies, both in vitro and in vivo, to understand its inhibition mechanism and efficacy.
Co-Authors - Ruchiyat Ade Danova Ahmad Aminudin Ahmad Sanusi Al Arofatus Naini Asep Supriatna Atep Rian Nurhadi Cecep Jaenudin Chavasiri, Warinthorn Danova, Ade Dessi Nur Adiska Desti Nursaleh Dhini Anisa Didin Mujahidin Fadilawati, Siti Fajar Fauzi Abdullah Fajar Fauzi Abdullah Fajeriyati, Nurul Fandi Ahmad Fitri Khoerunnisa Florentina Maria Titin Supriyanti Galuh Yuliani Gun Gun Gumilar Gun Gun Gumilar Gun Gun Gumilar Hasanah, Ika Heli Siti Halimatul Hendrawan Hendrawan Herlan Herdiawan Hermawati, Elvira HERNANI - Humairo, Ristvi Iis Rosliana Ika Nurhayati Irawan, Nisrina Zahira Putri Kurniadewi, Fera Lestari, Nanda Ayu Liliasari Liliasari Liliasari Mahmudah, Eneng Mr Sjaeful Anwar Nenden Fauziah NFN Noviyanti Nuky Dwifirly Pratiwi Arhatha Nur Indah Sari Nuraini, Vidia Afina Perdana, Farid Pratiwi, Eka Nikita Ratnaningsih Eko S. Riza Apriani Rosi Oktiani Ruchiyat Ruchiyat Sa'adah, Pipih Lutfi Siti Aisyah Sjaeful Anwar Soja Siti Fatimah Soja Siti Fatimah Tati Herlina Unang Supratman Wonganan, Piyanuch Yaya Sonjaya Yayan Sunarya