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All Journal Prosiding Seminar Biologi Jurnal Kesehatan Journal of Geoscience, Engineering, Environment, and Technology Jurnal Fitofarmaka Indonesia As-syifaa Jurnal Farmasi Jurnal Mandala Pharmacon Indonesia Amalee: Indonesian Journal of Community Research & Engagement Narra J Sibatik Journal : Jurnal Ilmiah Bidang Sosial, Ekonomi, Budaya, Teknologi, Dan Pendidikan Jurnal Penelitian Ilmu Pendidikan Indonesia Journal of Global Pharma Technology Indonesian Research Journal on Education TOFEDU: The Future of Education Journal Journal of Communication and Social Sciences Makassar Natural Product Journal MPSJ
Ahmad Najib
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Optimasi Ekstrak Daun Salam (Syzygium Polyanthum) Menggunakan Metode Konvensional dan Green Extraction Serta Profil Kimia dan Potensi Antioksidannya Najib, Ahmad; Olli, Audia Triani; Puspitasari, Yanti
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 1 (2025): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i1.717

Abstract

Daun salam (Syzygium polyanthum) adalah tanaman rempah yang dikenal memiliki kandungan fitokimia seperti flavonoid, tanin, dan terpenoid yang bermanfaat untuk kesehatan. Penelitian ini bertujuan untuk mengoptimalkan metode ekstraksi pada daun salam (Syzygium polyanthum) menggunakan metode konvensional (maserasi) dan green extraction, yaitu Ultrasound-Assisted Extraction (UAE) dan Microwave-Assisted Extraction (MAE), serta untuk mengidentifikasi profil senyawa kimia dan potensi antioksidan dari ekstrak yang dihasilkan. Perbandingan langsung antara metode konvensional dan green extraction untuk mengoptimalkan potensi bioaktifnya merupakan kebaruan dari penelitian ini. Penelitian ini berkontribusi dalam pengembangan metode ekstraksi yang ramah lingkungan dan efisien serta mendukung pemanfaatan tanaman lokal sebagai sumber alami antioksidan potensi dalam aplikasi farmasi dan pangan. Analisis karakterisasi senyawa bioaktif dilakukan menggunakan Gas Chromatography-Mass Spectrometry (GC-MS) dan pengujian aktivitas antioksidan dilakukan dengan metode peredaman radikal bebas DPPH.  Hasil penelitian menunjukkan bahwa metode green extraction khususnya UAE dan MAE lebih efektif dalam mengekstrak senyawa bioaktif dengan peningkatan jumlah senyawa terekstraksi dibandingkan metode maserasi. Sebanyak 41 senyawa bioaktif termasuk golongan alkaloid, fenol, terpenoid dan asam lemak hanya ditemukan melalui metode green extraction. Dari pengujian antioksidan, semua ekstrak menunjukkan aktivitas antioksidan yang sangat kuat (nilai IC50 <50 ppm). Ekstrak UAE menunjukkan aktivitas tertinggi dengan IC50 sebesar 10,22 ppm, diikuti MAE dengan IC50 sebesar 19,30 ppm, sedangkan maserasi menghasilkan IC50 sebesar 27,28 ppm.
Chemical Profile Study and Screening in Silico of Cyclooxygenase-2 Inhibitor Chemical Compounds from Ethanol Extract Of Mangosteen Fruit Peel (Garcinia Mangostana L.) Akbar, Harul; Najib, Ahmad; Fawwaz, Muammar
Indonesian Research Journal on Education Vol. 5 No. 1 (2025): Irje 2025
Publisher : Fakultas Keguruan dan Ilmu Pendidikan, Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/irje.v5i1.2091

Abstract

Chemical profile studies and screening in silico of cyclooxygenase-2 inhibitor chemical compounds from ethanol extract of mangosteen fruit peel (Garcinia mangostana L.). The purpose of the study was to determine the profile of chemical compounds contained in ethanol extract of mangosteen fruit peel (Garcinia mangostana L.) which has the potential to be a cyclooxygenase-2 inhibitor by the screening method in silico. The extraction of mangosteen peel (Garcinia mangostana L.) was carried out by maceration method using 96% ethanol solvent for 3 days then filtered and thickened with a rotary vacuum evaporator. An extract with a yield value of 8% is produced. The resulting extract was tested using the GC-MS instrument under the following conditions; injector temperature 250°C, initial oven temperature 70°C, up to 325°C in 10°C/min increments. 100 chemical compounds were obtained and a 2D compound structure was created with ACD/ChemSketch. The cyclooxygenase-2 enzyme model was obtained through the Protein Data Bank (PDB) site with the code 1CX2. Optimization is carried out on chemical compounds with the Discovery Visual Studio program. The docking process was carried out on chemical compounds with cyclooxygenase-2 as the receptor target using the Vina method with the help of the Pyrx program. The value of free energy change (∆G) is evaluated as a result of docking. The docking results showed that the compound contained in the ethanol extract of mangosteen fruit peel (Garcinia mangostana L.) has the potential as an inhibitor of cyclooxygenase-2 in silico and the one that has the best free energy change (∆G) in silico is oleana-11,13(18)-diene with a free energy change (∆G) -12,500 kcal/mol.
In Silico Screening Inhibitors Histamine H2 Chemical Compounds in Licorice Plants (Glycyrrhiza glabra L.) Using Autodock Vina Najib, Ahmad; Malik, Abd.; Sumartono, Sumartono
Jurnal Fitofarmaka Indonesia Vol 10, No 3 (2023): JURNAL FITOFARMAKA INDONESIA (ENGLISH EDITION)
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i3.1100

Abstract

The inquiry about on in silico screening of chemical compounds of Histamine H2 of Liquorice (Glycyrrhiza glabra L.), aimed to get the potential bioactive compounds found in plants The Liquorice (Glycyrrhiza glabra L.) as a potential inhibitor Histamine H2 with a screening in silico by Autodock Vina Docking process is carried out on enzyme Histamine H2 as receptors and 105 chemical compounds in plants Liquorice (Glycyrrhiza glabra L.) as ligands using Autodock Vina program. ∆Gbind value and lowest RMSD of each compound that has been in the docking taken the value of the free energy change (∆G) as a result of docking. Docking results showed that of the 105 chemical compounds of plant Liquorice (Glycyrrhiza glabra L.)  are all potential as inhibitors Histamine H2  with free energy change (∆G) most low at Glabrene amounted to -9.6 kcal/mol, and the highest Isotachioside amounted to -4.5 kcal/mol.
DAMPAK BULLYING TERHADAP HARGA DIRI INDIVIDU PADA MASA DEWASA MUDA Nadiyah Ameylia; Melyani Sutra Dewi; Callista Alodya J; Sinta Purnamasari; Ahmad Najib; Abdul Rahim; Anggi Agusti; Ratu Tazkiyatun Nufus; Yesi Anggun Sari
Journal of Communication and Social Sciences Vol. 1 No. 1 (2023): Journal of Communication and Social Sciences
Publisher : CV. Doki Course and Training

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61994/jcss.v1i1.132

Abstract

Victim of bullying are always associated with many problem, especially in terms of mental health, one of which is adolescent self-esteem. This research is motivated by the rise of bullying cases that occur among adolescent. Where bullying is an action taken by individuals or groups against other individuals who are considered weak. Bullying can take the form of physical aims to determine the forms of bullying. The causes of bullying, and the impect of bullying. The research subject are students. The data collection technique used was a correlational quantitative method using a sample of 98 students by filling out a questionaire to the perpetratorsvand vicktims of bullying. The method used in this study is Spearment analysis with the help of IBM SPSS application and, based on the result of processing the data, it was found that there was no significant correlation between bullying behavior and self esteem in adolescent among student at Raden Fatah State Islamic University Palembang. The results of the analysis show that the value of the correlation coeficient between the two variables is very low (0.063) and does nor reach the specifiend significance level (ρ < 0,05).
INHIBISI ENZIM α-GLUKOSIDASE PADA SENYAWA TECTOQUINONE YANG DIISOLASI DARI Syzygium oblanceolatum (C.B.ROB.) MERR Najib, Ahmad
Makassar Natural Product Journal (MNPJ) Juli 2024
Publisher : UNIVERSITAS MUSLIM INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mnpj.v2i2.215

Abstract

Syzygium oblanceolatum (C.B.Rob.) Merr. Has several medicinal benefits, empirically its leaf decoction has been used as an antidiabetic. Several representatives of the Syzygium genus have been proposed to possess chemical compounds, nutraceutical values, and biological activities. In particular, previous studies have emphasized the abundance of bioactive chemicals, including flavonoids, phenolic acids, triterpenoids, and volatile compounds. Several representatives of the genus Syzygium have been proposed to possess chemical compounds, nutraceutical values, and biological activities. In particular, previous studies have emphasized the abundance of bioactive chemicals, including flavonoids, phenolic acids, triterpenoids, and volatile compounds. The tectoquinone compound isolated from Syzygium oblanceolatum (C.B. Rob.) Merr based on its chemical structure is a substituted anthraquinone, namely 2-methylanthraquinone. This study aims to determine the Tectoquinone compound as an α-glucosidase inhibitor and determine the IC50 value of the tectoquinone compound. The method of this research was an α-glucosidase inhibition test using ELISA reader instrument by measuring the absorbance at the maximum wavelength of 405 nm using an acarbose comparator. The results of the α-glucosidase inhibition test of the akarbosa comparator had an IC50 value of 0.258 μg/mL and the IC50 value of the tectoquinone compound was 155.184 μg/mL.
Studi In Silico Prediksi Sifat Fisikokimia dan Toksisitas Senyawa Tectoquinone Sebagai α-Glukosidase inhibitor Najib, Ahmad
Makassar Natural Product Journal (MNPJ) Oktober 2024
Publisher : UNIVERSITAS MUSLIM INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mnpj.v2i3.217

Abstract

Tectoquinone is a chemical compound from natural ingredients in the Syzigium oblanceolatum (C.B.Rob) plant. Previous research has proven that Tectoquinone has antidiabetic activity by inhibiting the α-glucosidase enzyme. This research on physicochemistry and toxicity aims to determine the feasibility of tectoquinone if used as an oral drug in silico using the pKCSM Online Tool. The results obtained are that tectoquinone has fulfilled the physicochemical test with parameters based on the Lipinski Rule of Five. However, the results of the toxicity test showed that tectoquinone had ames toxicity, hepatotoxicity, and the LD50 value obtained was 468.92 g/kg.
STUDI KOMPARASI AKTIVITAS ANTIRADIKAL BEBAS ANTARA EKSTRAK METANOL DAUN DAN KULIT KAYU TUMBUHAN KEDONDONG PAGAR (Lannea coromandelica (Houtt.) Merr) DENGAN METODE PEREDAMAN SENYAWA 1,1-DIPHENYL -2-PICRYLHYDRAZIL (DPPH) Alwi, Asma; Najib, Ahmad; Waris, Risda
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 1 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i1.16

Abstract

Lannea coromandelica (Houtt.) Merr is one of the plants that hast he potential to have free antiradical activity. The research aimed to compare the free antiradical activity of methanol extract of the bark and leaves of Lannea coromandelica (Houtt.) Merr using the free radical reduction method 1.1 diphenhyl-2-picrylhydrazil (DPPH). The bark nd the leaves extract of the tree were obtained by maceration using methanol. The methanol extract preliminary tests were conducted by TLC using n-hexane: ethyl acetate (9 : 1) and ( 7: 3). The positive results for free antiradical aoctivity marked with purple to yellow spots after DPPH spraying was obtained. The thick bark and leaves extract were then quantitatively tested for free antiradical activity to obtain lC50 values using spectrophotometry at the maximum wavelength of 516 nm. The results of data analysis showed that methanol extract of its bark and leaves had lC50 of 20.778 µg / mL and 19.819 µg / mL, with ascorbic acid as a comparison having an lC50 value of 6.816 µg / mL. So it can be concluded that the methanol extract of the leaves of"Lannea coromandelica (Houtt) Merr has stronger anti-radical activity than its bark.
Community Based Inundation and Flood Mitigation in Palembang City, Indonesia Indrayani; Saputra, Rahmad Hidayat; Elvaria, Anna; Mirza, Akhmad; Najib, Ahmad; Prakoso, Agung; Anjani, Wenda Latifah
Journal of Geoscience, Engineering, Environment, and Technology Vol. 10 No. 02 (2025): JGEET Vol 10 No 02 : June (2025)
Publisher : UIR PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25299/jgeet.2025.10.02.18139

Abstract

The increasing intensity of rainfall in Palembang City has heightened the risk of hydrometeorological disasters, particularly flooding and inundation. Despite various efforts by the municipal government to mitigate these events, flooding continues to occur following episodes of high or prolonged moderate rainfall. This study analyzes flood mitigation strategies with focus on community participation in addressing recurring inundation. Data from a flood distribution map reveal 196 flood points across the city, with flood heights ranging from 20 to 50 cm, occurring on average 10-15 times annually and typically receding within 2 to 4 hours though longer durations are observed in several sub-districts. Surveys and interviews conducted in 18 sub-districts identified key contributing factors, including drainage obstruction due to waste, sedimentation, vegetation, unauthorized construction, limited catchment areas, and inadequate drainage connectivity. Additional challenges include diminished retention pond capacity caused by vegetation overgrowth, functional conversion, embankment erosion, and topographical disadvantages such as low-lying terrain. The study proposes the optimization and restoration of drainage infrastructure, community empowerment in catchment area management, and the installation of additional pumps and automated sluice gates as integrated solutions. These measures aim to enhance water flow and reduce the frequency and impact of flooding in Palembang City.
Analisis Literatur : Dampak Penggunaan Teknologi Digital Terhadap Konsentrasi Belajar Siswa Farhana, Mardhilla; Najib, Ahmad; Juliansyah, Dzaky; Dinata, Konto Iskandar
Jurnal Penelitian Ilmu Pendidikan Indonesia Vol. 4 No. 4 (2025)
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jpion.v4i4.789

Abstract

Penelitian ini bertujuan untuk melihat bagaimana penggunaan teknologi digital memengaruhi konsentrasi belajar anak, dengan membahas sisi positif dan negatifnya. Teknologi digital dalam pendidikan dapat membantu anak mengembangkan kemampuan literasi digital, memudahkan akses ke informasi, serta membuat proses belajar menjadi lebih menarik dan interaktif. Namun, jika penggunaannya tidak diawasi dengan baik, teknologi ini bisa menurunkan fokus belajar, menimbulkan kecanduan terhadap gawai, mengurangi interaksi sosial, dan membuka peluang anak terpapar konten yang tidak sesuai. Selain itu, faktor dari dalam diri anak, seperti kondisi fisik dan mental, serta faktor luar seperti lingkungan belajar, juga berpengaruh terhadap tingkat konsentrasi mereka. Meskipun teknologi membawa banyak manfaat, penggunaan yang berlebihan atau tanpa pengaturan bisa mengganggu kedisiplinan belajar, menurunkan fokus, bahkan memengaruhi pembentukan karakter anak. Penelitian ini juga menemukan beberapa keterbatasan, seperti kurangnya penelitian jangka panjang dan sedikitnya perhatian terhadap aspek sosial-ekonomi serta pengaruh media sosial. Untuk penelitian di masa depan, disarankan agar para peneliti meninjau dampak penggunaan teknologi digital dalam jangka waktu yang lebih panjang dan memperhatikan peran penting orang tua serta guru dalam pengawasan anak. Penelitian lanjutan juga bisa menelusuri perbedaan dampak berdasarkan usia, jenis kelamin, dan latar belakang sosial-ekonomi anak. Agar manfaat teknologi digital bisa dirasakan secara optimal, dibutuhkan kerja sama antara keluarga, sekolah, dan masyarakat untuk menjaga serta meningkatkan konsentrasi belajar anak di sekolah
Co-Authors ABD. MALIK Abdul Rahim Agung Prakoso Akbar, Harul Alwi, Asma Anggi Agusti Anisatul Khoiriyah Anjani, Wenda Latifah Arafat, Septrial Arba, Muhammad Asbah, Asbah Bahar, Muhammad A. Callista Alodya J Dinata, Konto Iskandar Elvaria, Anna Farhana, Mardhilla Filmaharani, Filmaharani Firzan Nainu Habibie Habibie Indra Pahala Indrayani Juliansyah, Dzaky Kafabih, An’im Latada, Nadila P. Melyani Sutra Dewi Mirza, Akhmad Muammar Fawwaz Mudjahid, Mukarram Nadiyah Ameylia Olli, Audia Triani Pakpahan, Kristina Pakpahan, Kristina Evana Puspitasari, Yanti Putri, Annisa A. Ratu Tazkiyatun Nufus Risda Waris, Risda Saputra, Rahmad Hidayat Selpida Handayani Sinta Purnamasari Siti Aisaroh Sumartono Sumartono Utami Sri Hastuti Wahono, Puji Wisdawati Wisdawati Yesi Anggun Sari Zubair, Muhammad S.