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In Silico Screening Inhibitors Histamine H2 Chemical Compounds in Licorice Plants (Glycyrrhiza glabra L.) Using Autodock Vina Najib, Ahmad; Malik, Abd.; Sumartono, Sumartono
Jurnal Fitofarmaka Indonesia Vol 10, No 3 (2023): JURNAL FITOFARMAKA INDONESIA (ENGLISH EDITION)
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i3.1100

Abstract

The inquiry about on in silico screening of chemical compounds of Histamine H2 of Liquorice (Glycyrrhiza glabra L.), aimed to get the potential bioactive compounds found in plants The Liquorice (Glycyrrhiza glabra L.) as a potential inhibitor Histamine H2 with a screening in silico by Autodock Vina Docking process is carried out on enzyme Histamine H2 as receptors and 105 chemical compounds in plants Liquorice (Glycyrrhiza glabra L.) as ligands using Autodock Vina program. ∆Gbind value and lowest RMSD of each compound that has been in the docking taken the value of the free energy change (∆G) as a result of docking. Docking results showed that of the 105 chemical compounds of plant Liquorice (Glycyrrhiza glabra L.)  are all potential as inhibitors Histamine H2  with free energy change (∆G) most low at Glabrene amounted to -9.6 kcal/mol, and the highest Isotachioside amounted to -4.5 kcal/mol.
DAMPAK BULLYING TERHADAP HARGA DIRI INDIVIDU PADA MASA DEWASA MUDA Nadiyah Ameylia; Melyani Sutra Dewi; Callista Alodya J; Sinta Purnamasari; Ahmad Najib; Abdul Rahim; Anggi Agusti; Ratu Tazkiyatun Nufus; Yesi Anggun Sari
Journal of Communication and Social Sciences Vol. 1 No. 1 (2023): Journal of Communication and Social Sciences
Publisher : CV. Doki Course and Training

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61994/jcss.v1i1.132

Abstract

Victim of bullying are always associated with many problem, especially in terms of mental health, one of which is adolescent self-esteem. This research is motivated by the rise of bullying cases that occur among adolescent. Where bullying is an action taken by individuals or groups against other individuals who are considered weak. Bullying can take the form of physical aims to determine the forms of bullying. The causes of bullying, and the impect of bullying. The research subject are students. The data collection technique used was a correlational quantitative method using a sample of 98 students by filling out a questionaire to the perpetratorsvand vicktims of bullying. The method used in this study is Spearment analysis with the help of IBM SPSS application and, based on the result of processing the data, it was found that there was no significant correlation between bullying behavior and self esteem in adolescent among student at Raden Fatah State Islamic University Palembang. The results of the analysis show that the value of the correlation coeficient between the two variables is very low (0.063) and does nor reach the specifiend significance level (ρ < 0,05).
INHIBISI ENZIM α-GLUKOSIDASE PADA SENYAWA TECTOQUINONE YANG DIISOLASI DARI Syzygium oblanceolatum (C.B.ROB.) MERR Najib, Ahmad
Makassar Natural Product Journal (MNPJ) Juli 2024
Publisher : UNIVERSITAS MUSLIM INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mnpj.v2i2.215

Abstract

Syzygium oblanceolatum (C.B.Rob.) Merr. Has several medicinal benefits, empirically its leaf decoction has been used as an antidiabetic. Several representatives of the Syzygium genus have been proposed to possess chemical compounds, nutraceutical values, and biological activities. In particular, previous studies have emphasized the abundance of bioactive chemicals, including flavonoids, phenolic acids, triterpenoids, and volatile compounds. Several representatives of the genus Syzygium have been proposed to possess chemical compounds, nutraceutical values, and biological activities. In particular, previous studies have emphasized the abundance of bioactive chemicals, including flavonoids, phenolic acids, triterpenoids, and volatile compounds. The tectoquinone compound isolated from Syzygium oblanceolatum (C.B. Rob.) Merr based on its chemical structure is a substituted anthraquinone, namely 2-methylanthraquinone. This study aims to determine the Tectoquinone compound as an α-glucosidase inhibitor and determine the IC50 value of the tectoquinone compound. The method of this research was an α-glucosidase inhibition test using ELISA reader instrument by measuring the absorbance at the maximum wavelength of 405 nm using an acarbose comparator. The results of the α-glucosidase inhibition test of the akarbosa comparator had an IC50 value of 0.258 μg/mL and the IC50 value of the tectoquinone compound was 155.184 μg/mL.
Studi In Silico Prediksi Sifat Fisikokimia dan Toksisitas Senyawa Tectoquinone Sebagai α-Glukosidase inhibitor Najib, Ahmad
Makassar Natural Product Journal (MNPJ) Oktober 2024
Publisher : UNIVERSITAS MUSLIM INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mnpj.v2i3.217

Abstract

Tectoquinone is a chemical compound from natural ingredients in the Syzigium oblanceolatum (C.B.Rob) plant. Previous research has proven that Tectoquinone has antidiabetic activity by inhibiting the α-glucosidase enzyme. This research on physicochemistry and toxicity aims to determine the feasibility of tectoquinone if used as an oral drug in silico using the pKCSM Online Tool. The results obtained are that tectoquinone has fulfilled the physicochemical test with parameters based on the Lipinski Rule of Five. However, the results of the toxicity test showed that tectoquinone had ames toxicity, hepatotoxicity, and the LD50 value obtained was 468.92 g/kg.
STUDI KOMPARASI AKTIVITAS ANTIRADIKAL BEBAS ANTARA EKSTRAK METANOL DAUN DAN KULIT KAYU TUMBUHAN KEDONDONG PAGAR (Lannea coromandelica (Houtt.) Merr) DENGAN METODE PEREDAMAN SENYAWA 1,1-DIPHENYL -2-PICRYLHYDRAZIL (DPPH) Alwi, Asma; Najib, Ahmad; Waris, Risda
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 1 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i1.16

Abstract

Lannea coromandelica (Houtt.) Merr is one of the plants that hast he potential to have free antiradical activity. The research aimed to compare the free antiradical activity of methanol extract of the bark and leaves of Lannea coromandelica (Houtt.) Merr using the free radical reduction method 1.1 diphenhyl-2-picrylhydrazil (DPPH). The bark nd the leaves extract of the tree were obtained by maceration using methanol. The methanol extract preliminary tests were conducted by TLC using n-hexane: ethyl acetate (9 : 1) and ( 7: 3). The positive results for free antiradical aoctivity marked with purple to yellow spots after DPPH spraying was obtained. The thick bark and leaves extract were then quantitatively tested for free antiradical activity to obtain lC50 values using spectrophotometry at the maximum wavelength of 516 nm. The results of data analysis showed that methanol extract of its bark and leaves had lC50 of 20.778 µg / mL and 19.819 µg / mL, with ascorbic acid as a comparison having an lC50 value of 6.816 µg / mL. So it can be concluded that the methanol extract of the leaves of"Lannea coromandelica (Houtt) Merr has stronger anti-radical activity than its bark.
Community Based Inundation and Flood Mitigation in Palembang City, Indonesia Indrayani; Saputra, Rahmad Hidayat; Elvaria, Anna; Mirza, Akhmad; Najib, Ahmad; Prakoso, Agung; Anjani, Wenda Latifah
Journal of Geoscience, Engineering, Environment, and Technology Vol. 10 No. 02 (2025): JGEET Vol 10 No 02 : June (2025)
Publisher : UIR PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25299/jgeet.2025.10.02.18139

Abstract

The increasing intensity of rainfall in Palembang City has heightened the risk of hydrometeorological disasters, particularly flooding and inundation. Despite various efforts by the municipal government to mitigate these events, flooding continues to occur following episodes of high or prolonged moderate rainfall. This study analyzes flood mitigation strategies with focus on community participation in addressing recurring inundation. Data from a flood distribution map reveal 196 flood points across the city, with flood heights ranging from 20 to 50 cm, occurring on average 10-15 times annually and typically receding within 2 to 4 hours though longer durations are observed in several sub-districts. Surveys and interviews conducted in 18 sub-districts identified key contributing factors, including drainage obstruction due to waste, sedimentation, vegetation, unauthorized construction, limited catchment areas, and inadequate drainage connectivity. Additional challenges include diminished retention pond capacity caused by vegetation overgrowth, functional conversion, embankment erosion, and topographical disadvantages such as low-lying terrain. The study proposes the optimization and restoration of drainage infrastructure, community empowerment in catchment area management, and the installation of additional pumps and automated sluice gates as integrated solutions. These measures aim to enhance water flow and reduce the frequency and impact of flooding in Palembang City.
Analisis Literatur : Dampak Penggunaan Teknologi Digital Terhadap Konsentrasi Belajar Siswa Farhana, Mardhilla; Najib, Ahmad; Juliansyah, Dzaky; Dinata, Konto Iskandar
Jurnal Penelitian Ilmu Pendidikan Indonesia Vol. 4 No. 4 (2025)
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jpion.v4i4.789

Abstract

Penelitian ini bertujuan untuk melihat bagaimana penggunaan teknologi digital memengaruhi konsentrasi belajar anak, dengan membahas sisi positif dan negatifnya. Teknologi digital dalam pendidikan dapat membantu anak mengembangkan kemampuan literasi digital, memudahkan akses ke informasi, serta membuat proses belajar menjadi lebih menarik dan interaktif. Namun, jika penggunaannya tidak diawasi dengan baik, teknologi ini bisa menurunkan fokus belajar, menimbulkan kecanduan terhadap gawai, mengurangi interaksi sosial, dan membuka peluang anak terpapar konten yang tidak sesuai. Selain itu, faktor dari dalam diri anak, seperti kondisi fisik dan mental, serta faktor luar seperti lingkungan belajar, juga berpengaruh terhadap tingkat konsentrasi mereka. Meskipun teknologi membawa banyak manfaat, penggunaan yang berlebihan atau tanpa pengaturan bisa mengganggu kedisiplinan belajar, menurunkan fokus, bahkan memengaruhi pembentukan karakter anak. Penelitian ini juga menemukan beberapa keterbatasan, seperti kurangnya penelitian jangka panjang dan sedikitnya perhatian terhadap aspek sosial-ekonomi serta pengaruh media sosial. Untuk penelitian di masa depan, disarankan agar para peneliti meninjau dampak penggunaan teknologi digital dalam jangka waktu yang lebih panjang dan memperhatikan peran penting orang tua serta guru dalam pengawasan anak. Penelitian lanjutan juga bisa menelusuri perbedaan dampak berdasarkan usia, jenis kelamin, dan latar belakang sosial-ekonomi anak. Agar manfaat teknologi digital bisa dirasakan secara optimal, dibutuhkan kerja sama antara keluarga, sekolah, dan masyarakat untuk menjaga serta meningkatkan konsentrasi belajar anak di sekolah
Formulasi dan Evaluasi Fisik Sediaan Emulgel Ekstrak Kulit Buah Manggis (Garcinia mangostana L.) sebagai Tabir Surya Nurjanah, Mirda Kharisma; Mirawati, Mirawati; Najib, Ahmad
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.988

Abstract

Paparan sinar ultraviolet (UV) secara berlebihan dapat memicu berbagai masalah kulit, termasuk penuaan dini hingga resiko kanker kulit. Penggunaan tabir surya menjadi salah satu langkah protektif yang penting. Kulit buah manggis (Garcinia mangostana L.) diketahui memiliki senyawa aktif, seperti xanton, yang memiliki potensi sebagai antioksidan dan pelindung UV alami. Xanton yang berkhasiat sebagai antioksidan mempunyai potensi sebagai tabir surya yang mampu menyerap sinar UV-A maupun UV-B sehingga mengurangi intensitas pada kulit. Penelitian ini bertujuan untuk memformulasi dan mengevaluasi sifat fisik sediaan emulgel tabir surya ekstrak etanol kulit buah manggis. Metode penelitian meliputi proses ekstraksi kulit buah manggis secara maserasi dengan etanol 96%, dilanjutkan dengan optimasi formulasi emulgel menggunakan gelling agent Carbopol 940 dengan variasi konsentrasi 0,5%; 0,75%; 0,85% dan 1%. Selanjutnya, dilakukan formulasi sediaan emulgel hasil optimasi yang optimal (paling baik) yaitu dengan penambahan Carbopol 940 0,75%; 0,85% dan 1% dan penambahan ekstrak kulit buah manggis sebagai zat aktif tabir surya. Evaluasi dilakukan terhadap beberapa parameter fisik sebelum dan sesudah kondisi dipaksakan (cycling test) dengan jumlah sampel triplo untuk masing-masing formula yang meliputi uji : organoleptis, homogenitas, pH, viskositas, daya sebar, daya lekat, dan tipe emulsi serta uji nilai SPF secara in vitro menggunakan spektrofotometer UV-Vis.  Hasil menunjukkan bahwa seluruh formula menghasilkan emulgel yang stabil secara fisik dan memenuhi persyaratan sediaan topikal. Nilai SPF sediaan mengalami penurunan jika dibandingkan ekstrak (nilai SPF ekstrak = 45,17), tetapi nilai SPF sediaan (nilai SPF sediaan [F1= 25,03], [F2= 25,67], [F3= 25,75]) lebih tinggi dibanding dengan nilai SPF kontrol negatif / sediaan tanpa ekstrak (nilai SPF = 16,90). Dari nilai SPF tersebut, dapat diketahui bahwa emulgel yang dihasilkan memiliki aktivitas sebagai tabir surya dengan kategori proteksi ultra.
Infinitude in The Qur’an: A Rhetorical-Rational Approach to Qur’anic Exegesis Ahmad Najib; Mekki Klaina
International Journal of Humanities, Education, and Social Sciences Vol 4 No 1 (2026): International Journal of Humanities, Education, and Social Sciences
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ijhess.v4i1.7977

Abstract

This study explores the concept of infinitude in the Qur’an from a rhetorical–rational perspective, emphasizing its significance for understanding the text and its theological and intellectual dimensions. Its importance lies in presenting, for the first time, an integrated treatment of infinitude within Qur’anic discourse, thereby uncovering foundational aspects central to creed and offering exegetical implications that enrich both method and interpretation. The research problem arises from the absence of comprehensive studies that combine rhetorical analysis with rational reasoning in tafsīr, a gap that has at times led to literalist readings or interpretations that appear to conflict with Islamic theological principles. Employing an inductive methodology, the study collects relevant verses, examines them through tafsīr and Qur’anic sciences, and analyzes them in dialogue with the views of exegetes and theologians to refine meanings and intentions. The findings reveal three main contributions. First, six principal themes of infinitude in Allah’s attributes are identified: pre-eternity and everlastingness, comprehensiveness of knowledge, absoluteness of power, transcendence beyond limit and place, vastness of mercy, and the comprehensive negation of all forms of limitation. Second, the Qur’an presents infinitude across three dimensions: divine attributes, eschatological realities such as the eternity of Paradise and Hell, and the discourse of obligation that magnifies divine words, blessings, and warnings. Third, the study underscores the necessity of integrating rhetorical and rational methodologies, as reliance on literal wording alone risks anthropomorphism or apparent contradiction, whereas a combined rhetorical–rational approach safeguards divine transcendence and clarifies the intended meaning.
EFEKTIVITAS PENGGUNAAN APLIKASI MICROSOFT EXCEL TERHADAP PENGOLAHAN DATA PENELITIAN MAHASISWA UIN ALAUDDIN MAKASSAR Musdalifah, Musdalifah; Satriani, Satriani; Najib, Ahmad; Abadi, Andi Umar
Educational Leadership: Jurnal Manajemen Pendidikan Vol 1 No 2 (2022): JANUARY
Publisher : Department of Islamic Education Management

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/edu.v1i2.26713

Abstract

Abstract: The Effectiveness of Using Microsoft Excel Applications on Data Processing for Final Year Student Research in the Department of Islamic Education Management, Faculty of Tarbiyah and Teacher Training, UIN Alauddin Makassar This study aims to determine the level of effectiveness of the use of Microsoft Excel on research data processing for final year students in the Department of Islamic Education Management, Faculty of Tarbiyah and Teacher Training, UIN Alauddin Makassar. This research is a quantitative study using a quantitative descriptive approach, with the population in this study all final year students in the Department of Islamic Education Management, Faculty of Tarbiyah and Teacher Training at UIN Alauddin Makassar, and for sampling in this study using random sampling technique and resulted in 31 students. The data collection technique in this study used a questionnaire or questionnaire, then the data obtained were analyzed using descriptive analysis techniques. And the results of the research obtained show that as many as 74.2% of respondents categorize that the use of Microsoft Excel is quite effective in processing research data for final year students in the Department of Islamic Education Management, Faculty of Tarbiyah and Teacher Training at UIN Alauddin Makassar. Abstrak: Efektivitas Penggunaan Aplikasi Microsoft Excel terhadap Pengolahan Data Penelitian Mahasiswa UIN Alauddin Makassar Penelitian ini bertujuan untuk mengetahui tingkat efektivitas dari penggunaan Microsoft Excel terhadap pengolahan data penelitian mahasiswa tingkat akhir di jurusan Manajemen Pendidikan Islam Fakultas Tarbiyah dan Keguruan UIN Alauddin Makassar. Penelitian ini merupakan penelitian kuantitatif dengan menggunakan pendekatan deskriptif kuantitatif, dengan populasi dalam penelitian ini yaitu semua mahasiswa tingkat akhir di jurusan Manajemen Pendidikan Islam Fakultas Tarbiyah dan Keguruan UIN Alauddin Makassar, dan untuk pengambilan sampel dalam penelitian ini menggunakan teknik random sampling dan menghasilkan sebanyak 31 Mahasiswa. Teknik pengumpulan data pada penelitian ini menggunakan angket atau kuesioner kemudian data yang diperoleh dianalisis menggunakan teknik analisis deskriptif. Dan hasil penelitian yang diperoleh menunjukan bahwa sebanyak 74,2% responden yang mengkategorikan bahwa penggunaan Microsoft Excel cukup efektif digunakan dalam pengolahan data penelitian mahasiswa tingkat akhir di jurusan Manajemen Pendidikan Islam Fakultas Tarbiyah dan Keguruan UIN Alauddin Makassar.