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All Journal Jurnal Kedokteran Diponegoro Berkala Ilmu Kesehatan Kulit dan Kelamin Indonesian Journal of Tropical and Infectious Disease Syntax Literate: Jurnal Ilmiah Indonesia International Journal of Health Science & Medical Research Media Dermato-Venereologica Indonesiana
Medhi Denisa Alinda, Medhi Denisa
Department Of Dermatology And Venereology, Faculty Of Medicine/Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
Humanities Dentistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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THE ROLE OF ENVIRONMENTAL FACTORS IN SUPPORTING THE SPREAD OF LEPROSY IN DR SOETOMO HOSPITAL Putri, Dyfe Alisya; Widia, Yuri; Alinda, Medhi Denisa; Romadhon, Pradana Zaky
International Journal of Health Science & Medical Research Vol 5, No 1 (2026): February 2026
Publisher : UNG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/ijhsmr.v5i1.32263

Abstract

Leprosy is a chronic infectious disease caused by Mycobacterium leprae, primarily transmitted through respiratory droplets during prolonged and close contact with untreated individuals. Although it has a relatively low transmission rate, unfavorable environmental conditions can significantly increase the risk of disease spread. This study aims to identify and analyze the environmental factors that contribute to leprosy transmission. A descriptive quantitative study with a cross-sectional observational design was conducted. The study involved 222 leprosy patients with type 1 (reversal) reactions who were registered at the Morbus Hansen Outpatient Clinic from January 2015 to September 2024. Data were collected using structured questionnaires, field observations, and secondary data from medical records. Data were analyzed using descriptive and inferential statistics, with the Mann–Whitney test used to examine the relationship between environmental factors and leprosy cases. The results show that high population density, poor sanitation, inadequate household ventilation, limited access to clean water, and low socioeconomic status are factors significantly correlated with the high incidence of leprosy in the area. These findings highlight the importance of improving environmental conditions, alongside community education and enhanced access to healthcare services, as key components in the prevention and control of leprosy. Therefore, environment-based interventions should be integrated into a comprehensive strategy to eliminate leprosy in Indonesia.
Renal Dose Adjustment Management for Herpes Zoster in Immunocompromised Patient with Renal Impairment: A Case Report and Literature Review Hapsari Kinanti; Hasnikmah Mappamasing; Trisiswati Indranarum; Medhi Denisa Alinda; Linda Astari; Afif Nurul Hidayati
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 14, No 2 (2025): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v14i2.48430

Abstract

  Background: Herpes zoster is a reactivation of varicella-zoster virus that is characterized by a painful dermatomal vesicle eruption. Herpes zoster can bring several burdens including a painful rash and complications such as herpetic neuralgia and other neurological disorder. Herpes zoster commonly affects persons with decreased immunity levels which can caused by several conditions including malignancy. Multiple myeloma is one of the haematological malignancies commonly associated with renal impairments. Acyclovir is excreted in an unchanged form through renal, thus in patients with renal impairment could decrease the excretion level and can increase the possibility of renal toxicity. Case Presentation: We present a case report of a 46-year-old herpes zoster patient with multiple myeloma and renal impairment. The renal dose adjustment for acyclovir was done in this patient becomes 800mg three times daily. One week after the administration of acyclovir this patient showed remarkable results, there was no new lesion was found. This patient resolved after 10 days of renal dose adjustment of oral acyclovir and continued the multiple myeloma treatment on day fourteen. Conclusion: The management of herpes zoster infection in a patient with multiple myeloma commonly accompanies with renal impairment thus the consideration of adjusting the dose for renal impaired condition is important to reduce the possibility of renal toxicity in concordance with maintaining its adequate dose to prevent the possibility of complication
Co-Authors Abdullah, Salsabilla Putri Kinanti Afif Nurul Hidayati Afif Nurul Hidayati, Afif Nurul Agnes Sri Siswati Anum, Qaira Auliya, Arsya Bagus Haryo Kusumaputra Bagus Haryo Kusumaputra Bagus Haryo Kusumaputra, Bagus Haryo Budiono Budiono Cindy Fransisca, Cindy Cita Rosita Sigit Prakoeswa Damayanti Damayanti Damayanti Dhelya Widasmara Diah Mira Indramaya DINAR ADRIATY Donis, Ghefira Sonia Dwi Murtiastutik Dwiyanti Puspitasari, Dwiyanti Evy Ervianti Fadila, Arisia Fifa Argentina Hapsari Kinanti Hasnikmah Mappamasing Iswahyudi Jayawarsa, A.A. Ketut Kinanti, Hapsari Laura Navika Yamani Linda Astari, Linda Lubis, Ramona Sari Luh Made Mas Rusyati M. Yulianto Listiawan Machin, Abdullah Mamuaja, Enricco Hendra Marsudi Hutomo Marsudi Hutomo, Marsudi Maylita Sari, Maylita Muchtar, Vitayani Mulianto, Nur Rachmat Novianti Rizky Reza Nurasrifah, Dewi Priangga Adi Wiratama Puput Ade Wahyuningtyas Putri, Dyfe Alisya Ratna Wahyuni Regitta Indira Agusni Renni Yuniati Reza, Novianti Rizky Romadhon, Pradana Zaky Sawitri Silvani Geani Sri L. Menaldi Tengku Riza Zarzani N Trisiswati Indranarum Trisniartami Setyaningrum Yuri Widia, Yuri