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All Journal BALI MEDICAL JOURNAL (BMJ) journal of internal medicine Majalah Ilmiah Peternakan E-Jurnal Medika Udayana Jurnal Veteriner ISM (Intisari Sains Medis) : Jurnal Kedokteran Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Bali Medika Jurnal Journal of Global Pharma Technology Biosaintifika: Journal of Biology & Biology Education
Anak Agung Ngurah Subawa
Bagian Patologi Klinik RSUP Sanglah Fakultas Kedokteran Universitas Udayana/Rumah Sakit Umum Pusat Sanglah Denpasar
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Journal : Journal of Global Pharma Technology

 1 
Comparison of the effects of ethanol extract with aqueous extract of purple sweet potato tuber in expression of SOD-2, SOD-3, and eNOS on human vascular endothelial cells exposed by H2O2 in-Vitro I Made Jawi; I G K Arijana; I Wayan Putu Sutirta Yasa; AAN Subawa
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Aqueous extract of purple sweet potato tubers have antioxidant potential in animal and human vascular endothelial, through increased expression of superoxide dismutase. This study aims to prove the comparison between ethanol extract and aqueous extract of purple sweet potato tubers increasing the expression of superoxide dismutase -2, superoxide dismutase -3, and endothelial nitric oxide synthase in human vascular endothelium. This study was an experimental study of the vascular endothelial cells which underwent oxidative stress in vitro, which is protected by ethanol extract or aqueous extract of purple sweet potato tuber at various concentrations. Observation of the superoxide dismutase -2, superoxide dismutase -3, and endothelial nitric oxide synthase in endothelial cells is done using the method immunohistochemistry with monoclonal antibodies. The results showed an increase in superoxide dismutase - 2, superoxide dismutase -3, and endothelial nitric oxide synthase was significantly (p < 0.05) in endothelium protected by ethanol extract or water extract of purple sweet potato tubers. The ethanol extract only showed its effect at concentration of 1.5625 µg/ml for superoxide dismutase -2 and superoxide dismutase -3. The effect of aqueous extract were at a concentration of 1.5625–3.125µg/ml. From these results it can be concluded that the ethanol extract or aqueous extract of purple sweet potato tubers can protect endothelial cells from oxidative stress through increased expression of superoxide dismutase -2 and superoxide dismutase -3. The ethanol extract requires much lower concentrations to show its effect compared with aqueous extracts. Keywords: Aqueous extract or ethanol  extract of purple sweet potato, Superoxide dismutase, Human umbilical vein endothelial cells.
A Seventeen-year-old Boy Patient with Lupus Nephritis as a Complication of Systemic Lupus Erythematosus (SLE) at Sanglah General Hospital, Bali, Indonesia: a Case Report Anak Agung Ngurah Subawa
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Background: The systemic lupus erythematosus (SLE) is an autoimmune disease with various clinical manifestations. SLE indicated by the presence of autoantibodies to the nucleus components and immune complex deposits. Prevalence ratio of SLE is higher in women than in men, but male patients seem to have a higher frequency of symptoms and more aggressive disease. So, this case study aims to evaluate A seventeen-year-old boy patient with lupus nephritis as a complication of Systemic Lupus Erythematosus (SLE) based on laboratory evaluation. Case Description: A seventeen-year-old male patients referred to the emergency department in Sanglah General Hospital with swelling on both eyelids and legs for two weeks before admission. The patient has high blood pressure, discolouration of urine and significant weight gain about 14 kilograms in two weeks due to swelling. Several examinations performed and the results were indicating anaemia, proteinuria, hematuria, hypoalbuminemia, high BUN and creatinine level, hyperkalemia, hyperphosphatemia and high titer of ANA-IF and anti-ds-DNA level. The patient diagnosed with lupus nephritis and treated with antihypertension and diuretic. Conclusion. The most common complication of SLE is lupus nephritis, and its prevalence varies significantly by region, race and tribe. Although overall improvements in the treatment of SLE patients have increased in kidney survival rates, the prognosis remains unsatisfactory. Early detection and diagnosis should be done so that the patient’s condition worsens not occur because the late diagnosis of LN can increase the risk of End-Stage Renal Disease.Keywords: Autoimmune Disease, Lupus Nephritis, Systemic Lupus Erythematosus. 
Co-Authors Ali Djamhuri Anak Agung Wiradewi Lestari Anggraeni Suarsana Ardana I B K, Ardana Christian Nurtanto Putra Claudia Anastasia Desak Gde Diah Dharma Santhi Desak Laksmi Dewa Ayu Putu Rasmika Dewi Dewa Ngurah Suprapta Felicia Suryanto Gopi Krishnan I Dewa Ketut Harya Putra I Gede Soma I Gede Widhiantara I Gusti Kamasan Arijana I Made Bagus Cahya Wibawa I Made Dwikayana I Made Jawi I Made Kardana I NYOMAN MANTIK ASTAWA I Nyoman Wande I Wayan Agus Surya Pradnyana I Wayan Putu Sutirta Yasa I.B.GDE ANANTA MAHESVARA Ida Ayu Putri Wirawati Ida Bagus Komang Ardana Ida Bagus Ngurah Indira Pratiwi Kadek Pipin Rahina Soethama Ketut Suega Komang Agus Widhy Utama Putra Komang Vika Nariswari Ratna Kinasih Made Wulan Utami Dewi Made Yuliantari Dwi Astiti Mahardika, Ketut Indah Karina Naw, Sin War Ni Kadek Mulyantari Ni Kadek Nita Utami Ni Made Evitasari Dwitarini Ni Made Linawati Ni Nyoman Mahartini Ni Nyoman Yuliantini Nugraha, Ketut Yoga Wira Putra D K H, Putra Putu Angga Wiradana Putu Ayu Krisna Cahyaning Putri Putu Bihan Surya Kinanta Putu Devita Sucitawati Putu Purna Astika Utama Raka-Sudewi A. A. S. Herawati, S. Sari, Lia Cahya Sianny Herawati Sianny Herawati Stephanie Inge Wijanarko Sudewa Djelantik Tjokorda Gede Oka Wikananda, Made Argyanta