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All Journal Medali Jurnal : Media Dental Intelektual ODONTO Dental Journal Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Odonto dental journal Jurnal Ilmiah Sultan Agung Jurnal Pengabdian Masyarakat Dentmas Journal of Fisheries & Marine (Medical Scientific Journal) MESINA
Arlina Nurhapsari
Fakultas Kedokteran Gigi, Universitas Islam Sulan Agung
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health

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The Effect of Red Algae (Eucheuma cottonii) Nanoemulgel on Cytokine Il-1 Beta Expression for Traumatic Ulcers Healing Feranisa, Anggun; Nurhapsari, Arlina; Indriastanti, Rikha; Amalina, Rizki
Insisiva Dental Journal: Majalah Kedokteran Gigi Insisiva Vol. 13 No. 2 (2024): November
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/di.v13i2.23398

Abstract

Red algae (Eucheuma cottonii) is a type of seaweed (Rhodophyceae). Eucheuma cottonii contains flavonoids and florotanin as an anti-inflammatory agent. The extracted red algae were formulated into nanoemulgel. This study aimed to determine the effect of red algae nanoemulgel (Eucheuma cottonii) in the expression of IL-1β cytokines on the healing of traumatic ulcers. The researcher applied true experimental research with a post-test-only control group design. This research was conducted by giving Eucheuma cottonii nanoemulgel concentrations of 20%, 35%, 50%, positive control, and negative control at the labial once a day, followed by evaluation using the IHC method. The results revealed that Eucheuma cottonii nanoemulgel extract affected the expression of IL-1β cytokines in healing traumatic ulcers by decreasing the amount of IL-1β cytokine expression. The results obtained a p-value of 0.05, which indicates a significant difference in the expression of the number of IL-1β cytokines in traumatic ulcers. This study concluded that the 20% Eucheuma cottonii extract nanoemulgel treatment group affected the amount of IL-1β by decreasing the expression of IL-1β cytokines. Nanoemulgel of 20% Eucheuma cottonii extract is considered effective as an anti-inflammatory material for traumatic ulcer healing.
Saltwater Fish Powder for Amelogenesis in Zebrafish Larvae (Danio rerio) Sandy Christiono; Seno Pradopo; Islamy Rahma Hutami; Novia Indasari; Arlina Nurhapsari; Yayun Siti Rochmah Rochmah; Zurairah Ibrahim; Savira Nurazky Yuniar; Suparmi
Jurnal Ilmiah Perikanan dan Kelautan Vol. 16 No. 2 (2024): JURNAL ILMIAH PERIKANAN DAN KELAUTAN
Publisher : Faculty of Fisheries and Marine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jipk.v16i2.54677

Abstract

Graphical Abstract Highlight Research 1. The saltwater fish powder is rich in omega3, vitamin D, and calcium which helps tooth amelogenesis. 2. LC50 Toxicity Test was carried out using zebrafish larvae (Danio rerio) with negative control, positive control using 3,4-dichloroanilin, and treatment groups with saltwater fish powder solution in 6 different concentration. 3. No signs of zebrafish embryo mortality or developmental abnormalities on treatment group from the lowest (125μg/ml) nor highest concentration (4000μg/ml). 4. Saltwater fish powder has proven lack of toxicity. Abstract Many nutrients found in saltwater fish are thought to promote amelogenesis in ameloblast cells during tooth development. Although its toxicity is uncertain, saltwater fish powder provided benefits for amelogenesis. Zebrafish embryos have complex metabolic pathways and comprehensive physiological reactions. The LC50 toxicity of saltwater fish powder on zebrafish embryos was investigated in this study. The aim of the of the study is to determine the effect of LC50 toxicity on saltwater fish powder on zebrafish embryos. The experimental research method was a post-test-only control group design, consisting of eight groups, namely the negative control and the internal group using embryo media, the positive control using 3,4-dichloroanillin, and the treatment group 125μg / ml, 250μg / ml, 500μg / ml, 1000μg / ml, 2000μg / ml, and 4000μg / ml using 384 zebrafish embryos. Saltwater fish powder is diluted and observed for 96 hours, controlled every 24 hours. It was found that saltwater fish powder was not toxic because there were no dead zebrafish embryos from various concentrations, negative control, and internal control.
POTENSI EKSTRAK MENGKUDU (MORINDA CITRIFOLIA L.) SEBAGAI BAHAN ALTERNATIF SALURAN AKAR – A NARRATIVE SYSTEMATIC REVIEW Nurhapsari, Arlina; Setyaningrum, Yunita; Sari, Meilenia Muftika
Jurnal Ilmiah Penelitian Mahasiswa Vol 4, No 2 (2025): JUNI 2025
Publisher : Jurnal Ilmiah Sultan Agung

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Abstract

Latar Belakang: Keberhasilan terapi saluran akar sangat bergantung pada debridemen dan disinfeksi yang efektif, terutama pada area yang tidak dapat dijangkau oleh instrumen mekanis. Meskipun irigan konvensional seperti natrium hipoklorit (NaOCl) dan EDTA efektif, sifat sitotoksik dan potensi erosi dentinnya membatasi penggunaannya. Perhatian yang meningkat telah diberikan pada alternatif berbahan herbal, termasuk Morinda citrifolia (MC), yang dikenal memiliki sifat antimikroba, antiinflamasi, dan antioksidan.Tujuan: Ulasan ini mengevaluasi potensi jus Morinda citrifolia (MCJ) sebagai bahan irigasi saluran akar alternatif.Metode: Tinjauan pustaka dilakukan menggunakan database PubMed, Scopus, ScienceDirect, EBSCO, dan Google Scholar. Artikel yang dipilih berasal dari tahun 2015–2024 dengan kriteria berbasis PICO, yang berfokus pada studi in vitro, ex vivo, dan beberapa studi in vivo terbatas yang menilai MC sebagai bahan irigasi saluran akar.Hasil: MCJ menunjukkan efektivitas antimikroba, khususnya terhadap E. faecalis dan C. albicans, dengan tingkat sitotoksisitas minimal pada konsentrasi 6%. MCJ juga menunjukkan biokompatibilitas terhadap sel hPDLF dan hSCAP, serta mempertahankan ekspresi penanda odontogenik. Dibandingkan dengan EDTA, MCJ lebih mampu mempertahankan kekerasan mikro dentin dan menyebabkan kerusakan struktur yang lebih sedikit. Ketika dikombinasikan dengan EDTA atau XP-Endo Finisher, MCJ meningkatkan penghilangan lapisan smear dan memperkuat kekuatan adhesi sealer.Kesimpulan: MCJ menunjukkan potensi sebagai bahan irigasi endodontik yang biokompatibel. Studi in vivo dan klinis lanjutan diperlukan untuk mengonfirmasi keamanan dan efektivitasnya.Kata Kunci: Endodontik, M. citrifolia, irigasi, antimikroba, biokompatibilitas.
Co-Authors Ade Ismail Ade Ismail A.K Alphania Esty Luthfaida Andhika Ambo Andina Rizkia Putri Kusuma Anggun Feranisa Ani Labibah Aning Susilowati Anitalia Sukma Permata Sari Atiek Amalia Ahsanti Balqis Nureska Khomsiana Benni Benyamin Berti Silviana Intani Beti Ratnasari Chariza Hanum Mayvita Iskandar Denis Yusfa Dewi, Pentha Ayu Kusuma Dimas P. P., Muhammad Diyah Fatmasari Erwid Fatchur Rahman Ferry Gustiningrum Grahita Aditya Hafid Nur Arzanudin Helmi Fathurrahman, Helmi Hesty Pradini Indrawati, Silvia Vera Indriastanti, Rikha Islamy Rahma Hutami, Islamy Rahma Kris Adityawarman Kusuma, Andina Rizkia P M. Dian Firdausy Mayangsari, Regilia Shinta Mayya Nailullathifah Moh. Baehaqi Mohammad Yusuf, Mohammad Muh. Dian Firdausy Novia Indasari Rahma, Destari Amelia Rahmawati Sri Praptiningsih Rama Putranto Ratnawati, Irma Dewi Recita Indraswary Recita Indraswary Rifqi Wahyu Febrian Rizki Amalina Rochman Mujayanto Rosa Pratiwi, Rosa Rosalita Amelia Rr. Sarah Ladytama Rusna Fiki Kafalia Sandy Christiono Sari, Meilenia Muftika Savira Nurazky Yuniar Seno Pradopo Setyaningrum, Yunita shella indri novianty Styaningrum, Yunita Suparmi Sutji Asri Tjitra A Syarifah Nur Laili Siyam Uswatun N.A Darjono Widyasari, Ferina Yayun Siti Rochmah Yayun Siti Rochmah Rochmah Yuniar, Savira Nurazky Zurairah Ibrahim