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Antibacterial Effectivity of Nanoemulgel Phaleria macrocarpa’s leaf on the Porphyromonas gingivalis ATCC 33277 Biofilm Thickness Pratiwi, Rosa; Ratnawati, Irma Dewi; Ismail, Ade; Nurhapsari, Arlina; Amelia, Rosalita
Odonto : Dental Journal Vol 11, No 1 (2024): July 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.1.168-174

Porphyromonas gingivalis is an oppoturnistic microorganism in periodontal disease that is formed at the stage maturation of biofilm formation. One of the natural materials biofilm reduction is the Phaleria macrocarpa. Phaleria macrocarpa’s leaf contains chemical compounds such as flavonoids, tannins, alkaloids, saponins that function as antibacterials.The aim of this research is to determine the effectiveness of the nanoemulsion of the gel Phaleria macrocarpa’s leaf on the thickness of the P. gingivalis bacterial biofilm. The research design was carried out with a post test only with a total of 28 samples, then divided into 4 groups of treatment of Phaleria macrocarpa’s leaf extract nanoemulsion gel preparations with variations in concentrations of 30%, 40%, and 50%, as well as a control group of 25% metronidazole gel. The reading of the anti-biofilm thickness test results was measured by OD (Optical density) using an ELISA-reader. One way Anova parametric test among obtained p<0.000 results showing the effect of Phaleria macrocarpa’ leaf gel nanoemulsion extract on the decrease in the thickness of the Porphyromonas gingivalis bacterial biofilm. It can be concluded that the nanoemulsion gel formulation of Phaleria macrocarpa’s leaf extract concentrations of 30%, 40%, and 50% is effective, with a concentration 50% was most effective against reducing the thickness of the bacterial biofilm Porphyromonas gingivalis.

Antibacterial Effectivity of Nanoemulgel Phaleria macrocarpa’s leaf on the Porphyromonas gingivalis ATCC 33277 Biofilm Thickness Pratiwi, Rosa; Ratnawati, Irma Dewi; Ismail, Ade; Nurhapsari, Arlina; Amelia, Rosalita
Odonto : Dental Journal Vol 11, No 1 (2024): July 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.1.168-174

Porphyromonas gingivalis is an oppoturnistic microorganism in periodontal disease that is formed at the stage maturation of biofilm formation. One of the natural materials biofilm reduction is the Phaleria macrocarpa. Phaleria macrocarpa’s leaf contains chemical compounds such as flavonoids, tannins, alkaloids, saponins that function as antibacterials.The aim of this research is to determine the effectiveness of the nanoemulsion of the gel Phaleria macrocarpa’s leaf on the thickness of the P. gingivalis bacterial biofilm. The research design was carried out with a post test only with a total of 28 samples, then divided into 4 groups of treatment of Phaleria macrocarpa’s leaf extract nanoemulsion gel preparations with variations in concentrations of 30%, 40%, and 50%, as well as a control group of 25% metronidazole gel. The reading of the anti-biofilm thickness test results was measured by OD (Optical density) using an ELISA-reader. One way Anova parametric test among obtained p<0.000 results showing the effect of Phaleria macrocarpa’ leaf gel nanoemulsion extract on the decrease in the thickness of the Porphyromonas gingivalis bacterial biofilm. It can be concluded that the nanoemulsion gel formulation of Phaleria macrocarpa’s leaf extract concentrations of 30%, 40%, and 50% is effective, with a concentration 50% was most effective against reducing the thickness of the bacterial biofilm Porphyromonas gingivalis.

LEVELS OF MALONDIALDEHYDE AND CALCITONIN GENE-RELATED PEPTIDE IN PULP INFLAMMATION DUE TO LPS INDUCTION DURATION Nurhapsari, Arlina; Kusuma, Andina Rizkia Putri
Odonto : Dental Journal Vol 9, No 1 (2022): July 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Background: Administration Lipopolysaccharide (LPS) to pulp tissue might produce inflammation. Inflammation occurs, which can lead to oxidative stress and neuropeptides release. Malondialdehyde (MDA) is an oxidative stress measure, while calcitonin gene-related peptide (CGRP) is a neuropeptide found in large amounts in the pulp. This study attempted to analyze levels of CGRP and MDA in LPS inflamed rat pulp tissueMethode: Wistar rats' maxillary incisors were treated to LPS stimulation. A total of 30 mice were separated into six groups, each with five animals. The groups were created by administering LPS to the pulp for 6, 12, 24, 48, and 72 hours. Rat without pulpal exposure (0 hour) served as controls. Enzyme-linked Immunosorbent Assay (ELISA) was used to measure the levels of MDA and CGRP in the pulp tissue.Result : MDA and CGRP levels were found to be significantly different in all groups (p0.05 mohon diberi keterangan apakah </>/=). With LPS administration, MDA levels increased on average, whereas CGRP levels fluctuated. Conclusion: The presence of inflammation in the pulp was shown by changes in MDA and CGRP levels after 6 hours of LPS injection. The effect of rising MDA levels on inflamed pulp tissue did not produce effects that were directly proportional to or vice versa with CGRP levels that showed fluctuated.

LEVELS OF MALONDIALDEHYDE AND CALCITONIN GENE-RELATED PEPTIDE IN PULP INFLAMMATION DUE TO LPS INDUCTION DURATION Nurhapsari, Arlina; Kusuma, Andina Rizkia Putri
Odonto : Dental Journal Vol 9, No 1 (2022): July 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.9.1.148-152

Background: Administration Lipopolysaccharide (LPS) to pulp tissue might produce inflammation. Inflammation occurs, which can lead to oxidative stress and neuropeptides release. Malondialdehyde (MDA) is an oxidative stress measure, while calcitonin gene-related peptide (CGRP) is a neuropeptide found in large amounts in the pulp. This study attempted to analyze levels of CGRP and MDA in LPS inflamed rat pulp tissueMethode: Wistar rats' maxillary incisors were treated to LPS stimulation. A total of 30 mice were separated into six groups, each with five animals. The groups were created by administering LPS to the pulp for 6, 12, 24, 48, and 72 hours. Rat without pulpal exposure (0 hour) served as controls. Enzyme-linked Immunosorbent Assay (ELISA) was used to measure the levels of MDA and CGRP in the pulp tissue.Result : MDA and CGRP levels were found to be significantly different in all groups (p0.05 mohon diberi keterangan apakah </>/=). With LPS administration, MDA levels increased on average, whereas CGRP levels fluctuated. Conclusion: The presence of inflammation in the pulp was shown by changes in MDA and CGRP levels after 6 hours of LPS injection. The effect of rising MDA levels on inflamed pulp tissue did not produce effects that were directly proportional to or vice versa with CGRP levels that showed fluctuated.

Edukasi Makanan dan Minuman Kariogenik untuk Meningkatkan Pengetahuan Siswa SMK di Kabupaten Batang Yunita Styaningrum; Arlina Nurhapsari; Muhammad Dian Firdausy; Erdianto Setya Wardhana
Abdimas Awang Long Vol. 9 No. 2 (2026): Juni, Abdimas Awang Long
Publisher : Sekolah Tinggi Ilmu Hukum Awang Long

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56301/awal.v9i2.2179

Masalah kesehatan gigi, khususnya karies dan erosi gigi, masih menjadi beban kesehatan masyarakat yang serius di Indonesia. Kebiasaan mengonsumsi makanan dan minuman kariogenik pada remaja berkontribusi besar terhadap tingginya angka kejadian karies, namun tingkat pengetahuan tentang risiko tersebut umumnya masih rendah. Kegiatan pengabdian ini bertujuan untuk mengevaluasi efektivitas program edukasi bertajuk “Musuh dalam Selimut” dalam meningkatkan pengetahuan siswa SMK tentang makanan dan minuman kariogenik. Kegiatan dilaksanakan di Yayasan Islam Al Sya’iriyah Plumbon, Kabupaten Batang, Jawa Tengah, melibatkan 25 siswa kelas 2 SMK (17 perempuan, 8 laki-laki, usia 16–18 tahun). Metode pelaksanaan menggunakan desain pre-post test melalui kuesioner 20 pertanyaan, disertai sesi edukasi interaktif yang mencakup pengenalan kategori makanan kariogenik, diskusi kelompok, dan lokakarya camilan sehat. Tingkat konsumsi kariogenik awal peserta dikelompokkan menjadi rendah (n=6), sedang (n=6), dan tinggi (n=13). Uji Korelasi Spearman menunjukkan hubungan negatif yang signifikan antara tingkat konsumsi kariogenik dan skor pengetahuan awal (r=−0,918; p<0,001). Uji Wilcoxon menunjukkan peningkatan pengetahuan yang signifikan dari rerata pretest 49,2 (SD=14,4) menjadi rerata posttest 84,0 (SD=8,3) setelah intervensi (p<0,001). Program edukasi ini terbukti efektif meningkatkan pengetahuan siswa tentang bahaya makanan dan minuman kariogenik terhadap kesehatan gigi.

Efektivitas Ekstrak Eceng Gondok (Eichornia Crassipes) terhadap Bakteri Streptococcus Mutans (In Vitro) Ismatul Haerunnisa; Yunita Styaningrum; Arlina Nurhapsari
Quantum Wellness : Jurnal Ilmu Kesehatan Vol. 3 No. 2 (2026): Juni: Quantum Wellness : Jurnal Ilmu Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/quwell.v3i2.3122

Dental caries is an oral health problem associated with the activity of Streptococcus mutans. Water hyacinth (Eichhornia crassipes) contains bioactive compounds such as flavonoids, tannins, and alkaloids with antibacterial potential. This study aimed to evaluate the effectiveness of water hyacinth extract against the growth of Streptococcus mutans. The research method used was an in vitro experimental study with a post test only group design. A total of 24 samples were divided into four treatment groups with extract concentrations of 6.25%, 12.5%, 25%, and 50%. Antibacterial activity was tested using the disc diffusion method on Mueller Hinton Agar media. Data were analyzed using the Kruskal-Wallis and Mann-Whitney tests. The results showed that water hyacinth extract inhibited the growth of Streptococcus mutans. The largest inhibition zone was observed at 50% concentration, while the smallest was found at 6.25% concentration. Kruskal-Wallis analysis showed significant differences among groups (p<0.05). In conclusion, water hyacinth (Eichhornia crassipes) extract has antibacterial activity against Streptococcus mutans.

Analysis of Patient Satisfaction and Quality of Life (OHRQoL) in Pulp Necrosis Patients After Root Canal Treatment Yunita Styaningrum; Irma Dewi Ratnawati; Novi Sagita Rizky; Arlina Nurhapsari; Rizki Amalina; Davia Kurnia Akbar
Jurnal Medali Vol 8, No 1 (2026): Media Dental Intelektual February 2026
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/medali.8.1.46-53

Background: Pulp necrosis, a common dental issue, significantly impacts quality of life, making effective root canal treatment essential for addressing pain, infection, and psychological distress. This study aimed to analyze the relationship between patient satisfaction and Oral Health-Related Quality of Life (OHRQoL) following root canal treatment, providing insights to improve dental care and patient outcomes.Methods: This study employed a cross-sectional design, involving 118 patients with pulp necrosis who had completed root canal treatment at Sultan Agung Dental and Oral Hospital in Semarang. Data were collected using a validated patient satisfaction questionnaire and the OHIP-14 to assess Oral Health-Related Quality of Life (OHRQoL). Descriptive analysis and Spearman’s correlation test were used to evaluate demographic characteristics, satisfaction levels, and the relationship between satisfaction and OHRQoL, with significance set at p<0.05.Results: The study found that most respondents were female (59.3%), aged 26–35 years (35.6%), and held a diploma or bachelor's degree (53.4%), with an average high patient satisfaction score of 4.33 ± 0.6. Significant improvements in Oral Health-Related Quality of Life (OHRQoL) were observed after root canal treatment, with all OHIP-14 domain scores decreasing significantly (p < 0.001).Conclusion: The study concluded that the success of root canal treatment was closely linked to patient satisfaction and quality of life improvements, influenced by clinical effectiveness, dentist-patient interactions, and non-clinical factors like cost and accessibility.

Peningkatan Pengetahuan Karies Gigi melalui Penyuluhan Interaktif pada Siswa Arlina Nurhapsari; Irma Dewi Ratnawati; Erdianto Setya Wardhana
JURNAL INOVASI DAN PENGABDIAN MASYARAKAT INDONESIA Vol 5 No 3 (2026): Juli
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Semarang

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Latar belakang: Karies gigi merupakan penyakit infeksi kronis dengan prevalensi yang masih sangat tinggi di Indonesia, yaitu mencapai 88,8%. Namun, hanya 10,2% penderita yang memanfaatkan layanan perawatan gigi. Rendahnya pemanfaatan layanan tersebut dipengaruhi oleh persepsi yang keliru bahwa gigi berlubang yang tidak menimbulkan nyeri tidak memerlukan perawatan serta tingginya kecemasan terhadap perawatan gigi pada remaja. Kondisi ini menunjukkan pentingnya upaya edukasi untuk meningkatkan pengetahuan mengenai sifat progresif karies gigi, konsekuensi penundaan perawatan, dan pentingnya intervensi dini. Tujuan: Meningkatkan pengetahuan siswa mengenai sifat progresif karies gigi, konsekuensi penundaan perawatan, dan pentingnya intervensi dini. Metode: Kegiatan pengabdian kepada masyarakat dilaksanakan melalui program edukasi interaktif SI PETUALANG pada 16 Juli 2025 selama 120 menit dengan metode ceramah, media visual, diskusi, dan tanya jawab. Peserta terdiri atas 30 siswa berusia 16–18 tahun. Tingkat pengetahuan diukur menggunakan kuesioner sebelum dan sesudah edukasi, sedangkan kepuasan peserta dievaluasi setelah kegiatan. Data dianalisis menggunakan uji Wilcoxon dan korelasi Spearman. Hasil: Sebanyak 27 peserta (90%) mengalami peningkatan pengetahuan setelah mengikuti edukasi. Proporsi peserta dengan kategori pengetahuan tinggi dan sangat tinggi meningkat dari 23,3% sebelum intervensi menjadi 76,7% setelah intervensi. Hasil uji Wilcoxon menunjukkan perbedaan yang bermakna antara skor pre-test dan post-test (p<0,001). Selain itu, terdapat hubungan yang signifikan antara tingkat kepuasan peserta dan peningkatan pengetahuan (r=0,381; p=0,038), dengan 90% peserta menyatakan puas atau sangat puas terhadap pelaksanaan program. Kesimpulan: Program edukasi SI PETUALANG efektif meningkatkan pengetahuan siswa mengenai karies gigi dan pentingnya penanganan dini. Program ini berpotensi diimplementasikan secara berkelanjutan sebagai salah satu strategi promosi kesehatan gigi di lingkungan sekolah. Kata kunci: edukasi kesehatan gigi, karies gigi, perawatan dini, pengetahuan, remaja ______________________________________________________________________ Abstract Background: Dental caries remains one of the most prevalent chronic infectious diseases worldwide. In Indonesia, its prevalence reaches 88.8%, yet only 10.2% of affected individuals utilize dental care services. This treatment gap is partly attributed to the misconception that asymptomatic carious lesions do not require treatment and to the high prevalence of dental anxiety among adolescents. Educational interventions that improve awareness of the progressive nature of dental caries and the importance of early treatment are therefore needed. Objective: This community-based educational program aimed to improve students' knowledge of the progressive nature of dental caries, the consequences of delaying treatment, and the importance of early intervention. Method: An interactive educational program entitled SI PETUALANG was implemented on July 16, 2025, through visual presentations, discussions, and question-and-answer sessions over a 120-minute period. Thirty students aged 16–18 years participated in the program. Knowledge was assessed using a five-category ordinal questionnaire administered before and after the intervention. Participant satisfaction was evaluated following the program. Changes in knowledge were analyzed using the Wilcoxon signed-rank test, while the association between participant satisfaction and knowledge improvement was examined using Spearman's correlation. Result: Knowledge scores improved in 27 of the 30 participants (90.0%) following the intervention. The proportion of students with high or very high knowledge increased from 23.3% at baseline to 76.7% after the program. Wilcoxon analysis demonstrated a statistically significant improvement in knowledge (p<0.001). Participant satisfaction was positively associated with knowledge improvement (r=0.381, p=0.038), and 90.0% of participants reported being satisfied or very satisfied with the educational program. Conclusion: The SI PETUALANG educational program effectively improved adolescents' knowledge of dental caries and the importance of early treatment. These findings support the integration of interactive, school-based oral health education into preventive oral health promotion programs to enhance adolescents' oral health literacy and encourage timely dental care utilization. Keywords: adolescents, early treatment, dental caries, knowledge, oral health education

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