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All Journal Medali Jurnal : Media Dental Intelektual ODONTO Dental Journal Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Odonto dental journal Jurnal Ilmiah Sultan Agung Jurnal Pengabdian Masyarakat Dentmas Journal of Fisheries & Marine (Medical Scientific Journal) MESINA
Arlina Nurhapsari
Fakultas Kedokteran Gigi, Universitas Islam Sulan Agung
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health

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Antibacterial Effectivity of Nanoemulgel Phaleria macrocarpa’s leaf on the Porphyromonas gingivalis ATCC 33277 Biofilm Thickness Pratiwi, Rosa; Ratnawati, Irma Dewi; Ismail, Ade; Nurhapsari, Arlina; Amelia, Rosalita
Odonto : Dental Journal Vol 11, No 1 (2024): July 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.1.168-174

Abstract

Porphyromonas gingivalis is an oppoturnistic microorganism in periodontal disease that is formed at the stage maturation of biofilm formation. One of the natural materials biofilm reduction is the Phaleria macrocarpa. Phaleria macrocarpa’s leaf contains chemical compounds such as flavonoids, tannins, alkaloids, saponins that function as antibacterials.The aim of this research is to determine the effectiveness of the nanoemulsion of the gel Phaleria macrocarpa’s leaf  on the thickness of the P. gingivalis bacterial biofilm. The research design was carried out with a post test only with a total of 28 samples, then divided into 4 groups of treatment of Phaleria macrocarpa’s leaf extract nanoemulsion gel preparations with variations in concentrations of 30%, 40%, and 50%, as well as a control group of 25% metronidazole gel. The reading of the anti-biofilm thickness test results was measured by OD (Optical density) using an ELISA-reader. One way Anova parametric test among obtained p<0.000 results showing the effect of Phaleria macrocarpa’ leaf gel nanoemulsion extract on the decrease in the thickness of the Porphyromonas gingivalis bacterial biofilm. It can be concluded that the nanoemulsion gel formulation of Phaleria macrocarpa’s leaf extract concentrations of 30%, 40%, and 50% is effective, with a concentration 50% was most effective against reducing the thickness of the bacterial biofilm Porphyromonas gingivalis.
LEVELS OF MALONDIALDEHYDE AND CALCITONIN GENE-RELATED PEPTIDE IN PULP INFLAMMATION DUE TO LPS INDUCTION DURATION Nurhapsari, Arlina; Kusuma, Andina Rizkia Putri
Odonto : Dental Journal Vol 9, No 1 (2022): July 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (282.175 KB) | DOI: 10.30659/odj.9.1.148-152

Abstract

Background: Administration Lipopolysaccharide (LPS) to pulp tissue might produce inflammation. Inflammation occurs, which can lead to oxidative stress and neuropeptides release. Malondialdehyde (MDA) is an oxidative stress measure, while calcitonin gene-related peptide (CGRP) is a neuropeptide found in large amounts in the pulp. This study attempted to analyze levels of CGRP and MDA in LPS inflamed rat pulp tissueMethode: Wistar rats' maxillary incisors were treated to LPS stimulation. A total of 30 mice were separated into six groups, each with five animals. The groups were created by administering LPS to the pulp for 6, 12, 24, 48, and 72 hours. Rat without pulpal exposure (0 hour) served as controls. Enzyme-linked Immunosorbent Assay (ELISA) was used to measure the levels of MDA and CGRP in the pulp tissue.Result : MDA and CGRP levels were found to be significantly different in all groups (p0.05 mohon diberi keterangan apakah </>/=). With LPS administration, MDA levels increased on average, whereas CGRP levels fluctuated. Conclusion: The presence of inflammation in the pulp was shown by changes in MDA and CGRP levels after 6 hours of LPS injection. The effect of rising MDA levels on inflamed pulp tissue did not produce effects that were directly proportional to or vice versa with CGRP levels that showed fluctuated.
LEVELS OF MALONDIALDEHYDE AND CALCITONIN GENE-RELATED PEPTIDE IN PULP INFLAMMATION DUE TO LPS INDUCTION DURATION Nurhapsari, Arlina; Kusuma, Andina Rizkia Putri
Odonto : Dental Journal Vol 9, No 1 (2022): July 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.9.1.148-152

Abstract

Background: Administration Lipopolysaccharide (LPS) to pulp tissue might produce inflammation. Inflammation occurs, which can lead to oxidative stress and neuropeptides release. Malondialdehyde (MDA) is an oxidative stress measure, while calcitonin gene-related peptide (CGRP) is a neuropeptide found in large amounts in the pulp. This study attempted to analyze levels of CGRP and MDA in LPS inflamed rat pulp tissueMethode: Wistar rats' maxillary incisors were treated to LPS stimulation. A total of 30 mice were separated into six groups, each with five animals. The groups were created by administering LPS to the pulp for 6, 12, 24, 48, and 72 hours. Rat without pulpal exposure (0 hour) served as controls. Enzyme-linked Immunosorbent Assay (ELISA) was used to measure the levels of MDA and CGRP in the pulp tissue.Result : MDA and CGRP levels were found to be significantly different in all groups (p0.05 mohon diberi keterangan apakah </>/=). With LPS administration, MDA levels increased on average, whereas CGRP levels fluctuated. Conclusion: The presence of inflammation in the pulp was shown by changes in MDA and CGRP levels after 6 hours of LPS injection. The effect of rising MDA levels on inflamed pulp tissue did not produce effects that were directly proportional to or vice versa with CGRP levels that showed fluctuated.
Analysis of Patient Satisfaction and Quality of Life (OHRQoL) in Pulp Necrosis Patients After Root Canal Treatment Styaningrum, Yunita; Ratnawati, Irma Dewi; Rizky, Novi Sagita; Nurhapsari, Arlina; Amalina, Rizki; Akbar, Davia Kurnia
Jurnal Medali Vol 8, No 1 (2026): Media Dental Intelektual February 2026
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/medali.8.1.46-53

Abstract

Background: Pulp necrosis, a common dental issue, significantly impacts quality of life, making effective root canal treatment essential for addressing pain, infection, and psychological distress. This study aimed to analyze the relationship between patient satisfaction and Oral Health-Related Quality of Life (OHRQoL) following root canal treatment, providing insights to improve dental care and patient outcomes.Methods: This study employed a cross-sectional design, involving 118 patients with pulp necrosis who had completed root canal treatment at Sultan Agung Dental and Oral Hospital in Semarang. Data were collected using a validated patient satisfaction questionnaire and the OHIP-14 to assess Oral Health-Related Quality of Life (OHRQoL). Descriptive analysis and Spearman’s correlation test were used to evaluate demographic characteristics, satisfaction levels, and the relationship between satisfaction and OHRQoL, with significance set at p<0.05.Results: The study found that most respondents were female (59.3%), aged 26–35 years (35.6%), and held a diploma or bachelor's degree (53.4%), with an average high patient satisfaction score of 4.33 ± 0.6. Significant improvements in Oral Health-Related Quality of Life (OHRQoL) were observed after root canal treatment, with all OHIP-14 domain scores decreasing significantly (p < 0.001).Conclusion: The study concluded that the success of root canal treatment was closely linked to patient satisfaction and quality of life improvements, influenced by clinical effectiveness, dentist-patient interactions, and non-clinical factors like cost and accessibility.
Co-Authors Ade Ismail Ade Ismail A.K Akbar, Davia Kurnia Alphania Esty Luthfaida Amelia, Rosalita Andhika Ambo Andina Rizkia Putri Kusuma Anggun Feranisa Ani Labibah Aning Susilowati Anitalia Sukma Permata Sari Atiek Amalia Ahsanti Balqis Nureska Khomsiana Benni Benyamin Berti Silviana Intani Beti Ratnasari Chariza Hanum Mayvita Iskandar Denis Yusfa Dewi, Pentha Ayu Kusuma Dimas P. P., Muhammad Diyah Fatmasari Erwid Fatchur Rahman Ferry Gustiningrum Grahita Aditya Hafid Nur Arzanudin Helmi Fathurrahman, Helmi Hesty Pradini Ibrahim, Zurairah Indasari, Novia Indrawati, Silvia Vera Indriastanti, Rikha Islamy Rahma Hutami, Islamy Rahma Kris Adityawarman Kusuma, Andina Rizkia P M. Dian Firdausy Mayangsari, Regilia Shinta Mayya Nailullathifah Moh. Baehaqi Mohammad Yusuf, Mohammad Muh. Dian Firdausy Novia Indasari Rahma, Destari Amelia Rahmawati Sri Praptiningsih Rama Putranto Ratnawati, Irma Dewi Recita Indraswary Recita Indraswary Rifqi Wahyu Febrian Rizki Amalina Rizky, Novi Sagita Rochmah, Yayun Siti Rochmah Rochman Mujayanto Rosa Pratiwi, Rosa Rr. Sarah Ladytama Rusna Fiki Kafalia Sandy Christiono Sari, Meilenia Muftika Savira Nurazky Yuniar Seno Pradopo Seno Pradopo Setyaningrum, Yunita shella indri novianty Styaningrum, Yunita Suparmi Suparmi Sutji Asri Tjitra A Syarifah Nur Laili Siyam Uswatun N.A Darjono Widyasari, Ferina Yayun Siti Rochmah Yayun Siti Rochmah Rochmah Yuniar, Savira Nurazky Zurairah Ibrahim