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Journal : Pharmacology and Clinical Pharmacy Research

The Risk of Atherosclerotic Cardiovascular Disease among Hyperlipidaemia Patients and Appropriateness of Statin Therapy Iskandar, Maharani F.; Nurmainah, Nurmainah; Susanti, Ressi
Pharmacology and Clinical Pharmacy Research Vol 3, No 1
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (308.963 KB) | DOI: 10.15416/pcpr.v3i1.16452

Abstract

Patients with hyperlipidaemia is at increased risk of developing atherosclerotic cardiovascular disease (ASCVD). The use of appropriate statin therapy is important to obtain optimal health outcomes. However, there was limited information regarding the risk of ASCVD among Indonesian hyperlipidaemia population and the appropriateness of statin therapy given to these patients. This study aimed to assess the ASCVD risks among the patients and evaluate the use of statin therapy at hospitalized hyperlidaemia patients. This cross sectional study used medical records as data source. This study was conducted at one hospital in Pontianak, Indonesia during Januari-June 2017. We included 50 subjects. The 10-year risk of ASCVD was assessed using ASCVD pooled cohort risk assessment equation (PCRAE). The results showed that 66% of the included subjects had a relatively high risk of developing ASCVD. Subjects with high risk of ASCVD received inappropriate statin therapy. High intensity statin should be given to these patients. In conclusion, large proportion of the subjects were at high risk of developing ASCVD. Nevertheless, inappropriate statin therapy were given to these patients. Improvement in medication practice should be done to prevent complication and increase quality of health outcomes.Keywords: ASCVD, dyslipidemia, statin
Prescription Pattern and Costs of Angiotensin II Receptor Blockers in Hypertensive Outpatients Nurmainah Nurmainah; Nur Anisyah
Pharmacology and Clinical Pharmacy Research Vol 3, No 3
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (361.191 KB) | DOI: 10.15416/pcpr.v3i3.19864

Abstract

Angiotensin II receptor blockers (ARBs) have been widely prescribed for primary hypertension. Nevertheless, the cost of ARBs are relatively expensive. The objective of this study was to describe prescribing pattern and the cost of ARBs in hypertensive outpatients. This study used descriptive observational method based on cross-sectional study. Data source was hypertensive outpatients medical records and prescriptions at Pemangkat General Hospital, West Kalimantan, Indonesia, during 2014-2015. The most frequently prescribed anti-hypertensive medication in 1,506 patients were ARBs. There was an increasing trend in the use of ARBs during 2014-2015 (31-38%). The most frequently prescribed ARBs were 8 mg and 18 mg of candesartan, and 80 mg of valsartan. ACE inhibitors were the least prescribed anti-hypertensive drugs (4-8%). The largest portion of anti-hypertensive drugs expenditure was spent on ARBs, both in 2014 and 2015, respectively accounted for IDR 50,493,876.00 (67%) and IDR 58,903,112.00 (79% ). In conclusion, the prescribing of ARBs increased during study period and it represented the largest contributor on total expenditures of anti-hypertensive drugs.Keywords: Angiotensin II receptor blockers, cost, hypertensive patients