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All Journal Indonesian Journal of Pharmaceutical Science and Technology Pharmacon INDONESIAN JOURNAL OF PHARMACY Pharmascience JURNAL BIOLOGI INDONESIA JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Majalah Farmaseutik JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline Jurnal Ilmiah Medicamento Jurnal Farmasi Journal of Fundamental and Applied Pharmaceutical Science Molekul: Jurnal Ilmiah Kimia
Arief Nurrochmad
Departement of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy University of Gadjah Mada, Yogyakarta Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Aktivitas Antimikroba Ekstrak Etil Asetat dari Fungi Endofit Schizophyllum commune Diisolasi dari Tanaman Bangun-bangun (Coleus amboinicus Lour.) Romadhonsyah, Fitra; Gemantari, Baiq Maylinda; Nurrochmad, Arief; Wahyuono, Subagus; Astuti, Puji
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, No. 2 (Universitas Halu Uleo Conference)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i2.52598

Abstract

Coleus amboinicus Lour., yang dikenal sebagai tanaman bangun-bangun, merupakan tanaman obat yang memiliki aktivitas sebagai antimikroba. Beberapa studi melaporkan bahwa fungi endofit yang ditemukan dalam beberapa bagian jaringan tanaman mampu memproduksi senyawa aktif yang serupa dengan tanaman inangnya. Schizophyllum commune merupakan fungi endofit yang berasal dari daun C. amboinicus. Penelitian ini bertujuan untuk menguji apakah ekstrak etil asetat dari fungi endofit S. commune mempunyai aktivitas sebagai antimikroba. Produksi metabolit sekunder dari S. commune dilakukan dengan metode fermentasi menggunakan Potato Dextrose Broth (PDB). Pengujian aktivitas antimikroba dilakukan dengan metode mikrodilusi menggunakan mikroba uji yaitu Bacillus subtilis, Pseudomonas aeruginosa, Staphyloccus aureus, serta Candida albicans. Nilai persen viabilitas sel mikroba dan nilai IC50 dianalisis untuk mengkarakterisasi aktivitas antimikroba dari ekstrak etil asetat. KLT bioautografi dilakukan untuk mendeteksi potensi kandungan senyawa dalam ekstrak yang mampu menghambat pertumbuhan mikroba. Ekstrak etil asetat fungi endofit S. commune menunjukkan aktivitas antimikroba yang rendah. Nilai IC50 terbaik ditemukan terhadap B. subtilis dan C. albicans (239,23 ± 20,86 dan 143,05 ± 37,03 μg/mL). KLT bioautografi menunjukkan bahwa terdapat spot penghambatan pada B. subtilis dan C. albicans. Analisis senyawa aktif dengan pereaksi semprot anisaldehid-asam sulfat menunjukkan bahwa ekstrak mengandung senyawa terpenoid. Ekstrak etil asetat dari fungi endofit S. commune memiliki potensi sebagai antimikroba.
Risiko Kejadian Perdarahan Pasca Rawat Inap pada Penggunaan Bersamaan Warfarin dan Antibiotik Rahma, Nazulanita; Andayani, Tri Murti; Nurrochmad, Arief
JSFK (Jurnal Sains Farmasi & Klinis) Vol 8 No 2 (2021): J Sains Farm Klin 8(2), Agustus 2021
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.8.2.164-173.2021

Abstract

Penggunaan warfarin dan antibiotik bersamaan diketahui dapat meningkatkan risiko perdarahan. Kejadian perdarahan mayor terkait warfarin dapat berupa perdarahan fatal hingga menyebabkan kematian. Penelitian ini bertujuan untuk menganalisis interaksi warfarin dan antibiotik dan efeknya terhadap kejadian perdarahan pada pemeriksaan pertama pasca rawat inap di RSUD Wates. Desain studi berupa kohort retrospektif pada 67 kasus penggunaan warfarin dengan/tanpa antibiotik oleh pasien rawat inap. Data berupa diagnosis, terapi, pemeriksaan pendukung, dan kejadian perdarahan saat rawat inap hingga pemeriksaan pertama diambil dari rekam medik pasien tertanggal Januari 2018 hingga September 2020. Analisis data dilakukan secara statistika menggunakan ­uji Chi-square atau uji Fisher exact test dan uji independent t-test atau uji Mann Whitney U test. Terdapat perbedaan bermakna pada kejadian perdarahan dalam waktu 7 hari pasca rawat inap antara kelompok antibiotik dan kontrol (16%; 0%; p = 0.017). Antibiotik yang digunakan oleh pasien dengan kejadian perdarahan yaitu golongan sefalosporin, kuinolon, azitromisin, dan ampisilin-sulbaktam. Kejadian perdarahan yang terjadi meliputi hematemesis melena (25%), hematuria (50%), tidak diketahui (25%). Studi ini menyimpulkan bahwa penggunaan bersamaan warfarin dan antibiotik saat rawat inap dapat berpengaruh terhadap kejadian perdarahan dalam waktu 7 hari setelah pasien dipulangkan.Penggunaan warfarin dan antibiotik bersamaan diketahui dapat meningkatkan risiko perdarahan. Kejadian perdarahan mayor terkait warfarin dapat berupa perdarahan fatal hingga menyebabkan kematian. Penelitian ini bertujuan untuk menganalisis interaksi warfarin dan antibiotik dan efeknya terhadap kejadian perdarahan pada pemeriksaan pertama pasca rawat inap di RSUD Wates. Desain studi berupa kohort retrospektif [A1] [A2] pada 67 kasus penggunaan warfarin dengan/tanpa antibiotik oleh pasien rawat inap. Data berupa diagnosis, terapi, pemeriksaan pendukung, dan kejadian perdarahan saat rawat inap hingga pemeriksaan pertama diambil dari rekam medik pasien tertanggal Januari 2018 hingga September 2020. Analisis data dilakukan secara statistika menggunakan ­uji Chi-square atau uji Fisher exact test dan uji independent t-test atau uji Mann Whitney U test. Terdapat perbedaan bermakna pada kejadian perdarahan dalam waktu tujuh hari pasca rawat inap antara kelompok antibiotik dan kontrol (16%; 0%; p = 0.017). [A3] [A4] Antibiotik yang digunakan oleh pasien dengan kejadian perdarahan yaitu azitromisin, ampisilin-sulbaktam, golongan sefalosporin, dan golongan kuinolon.[A5] [A6]  Kejadian perdarahan yang terjadi meliputi hematemesis melena (25%), hematuria (50%), tidak diketahui (25%). Studi ini menyimpulkan bahwa penggunaan bersamaan warfarin dan antibiotik saat rawat inap dapat berpengaruh terhadap kejadian perdarahan dalam waktu tujuh hari setelah pasien dipulangkan [A1]Penulis disarankan mempelajari artikel https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398292/ untuk lebih memahami penulisan artikel dengan desain kohort. [A2]Baik, terimakasih [A3]Tampilan hasil uji dalam studi kohort (adjusted hazard ratio [AHR] = ?; 95% CI, ?; p-value = ) [A4]Tidak dilakukan analisis survival, sementara kejadian perdarahan pada control group adalah 0 sehingga RR adalah tidak terbatas [A5]Ini bukan golongan obat; untuk menghindari multitafsir..kedua obat ini ditulis di awal, sementara yang golongan obat di bagian setelahnya [A6]Sudah kami ubah redaksionalnya
Aktivitas Hepatoprotektif Ekstrak Kunyit (Curcuma domestica Val.) dan Ekstrak Meniran (Phyllantus niruri Linn.) Pada Tikus yang Diinduksi Parasetamol Kajian Histopatologi Liver Novianto, Agil; Nurrochmad, Arief; Puspitasari, Ika
Jurnal Farmasi (Journal of Pharmacy) Vol. 3 No. 1 (2014): Jurnal Farmasi (Journal of Pharmacy), October 2014
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Curcuma domestica and Phyllanthus niruri was two plants which has been shown to have an effect hepatoprotective. This research was conducted to determine mechanism study of hepatoprotective combination of Curcuma domestica and Phyllanthus niruri extract to animals induced by paracetamol. Animals devide into 8 groups in random order of 5 each rats. Normal groups were give aquadest, negative groups (Paracetamol) were give CMC Na 0,5 %, positive goups were give silimarin with dose 100 mg/kg, Curcuma domestica groups with a dose of 100 mg/kg, Phyllanthus niruri groups with 200 mg/kg BW as well as a combination of I-III with Curcuma domestica and Phyllanthus niruri extract comparison of each of 75: 50; 50: 100; and 25: 150 mg/kg in BW. Test preparations are given for 7 days. On day 7, all groups except normal induced with paracetamol single dose2.5 g/kg for peroral 30 minutes after administering the test preparations. Hepatoprotective activity were analyzed using liver histopathology. The results showed that the combination I can inhibited liver necrosis and gives better hepatoprotective activity comparable with single dose with optimal Curcuma domestica and Phyllanthus niruri extract dose of 75 and 50 mg/kg.
PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN SIRIH MERAH (Piper Crocatum Ruiz & Pav) TERHADAP EKSPRESI GLUKOSA TRANSPORTER 2 PADA HATI DAN PANKREAS YANG DIINDUKSI STREPTOZOTOCIN-NIKOTINAMIDA Wisnu Kusuma, Eka; Herowati, Rina; Nurrochmad, Arief
Jurnal Farmasi (Journal of Pharmacy) Vol. 6 No. 1 (2017): Jurnal Farmasi (Journal of Pharmacy), October 2017
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Diabetes mellitus is a metabolic disease characterized by hyperglycemia, decreased expression of GLUT-2 in pancreatic, and increased expression of GLUT-2 in liver. Red betel leaf seed is useful for treatment of diabetes. This study aims to determine the effect of antihyperglycemic, increased expression of GLUT-2 in pancreas, and decrease in liver of the red betel leaf ethanol extract in STZ-NA induced rats. This research used 25 male white wistar rats, which randomly divided into five groups, normal control, negative control, positive control, EEDSM dose of 50 mg/kg bw and 100 mg/kg bw. Induced STZ-NA days 0, measured glucose levels next day 5 and treated were for 14 days. Measured parameters were GLUT-2 expression in pancreas and liver. The results showed that EEDSM for 14 days qualitatively able to increase the expression of GLUT-2 in pancreatic cells with those in the normal control, negative control, positive control, EEDSM 50 mg/kg bw, and 100 mg/kg bw respectively to 100%, 32,31%, 67,67%, 52,73% and 60,01%. EEDSM qualitatively able to reduce the expression of GLUT-2 in liver cells with those in the normal control, negative control, positive control, EEDSM 50 mg/kg bw, and 100 mg/kg bw respectively to 13,21%, 100%, 52,05%, 87,08%, dan 78, 09%.
Profile of Dermatologic Side Effects of Tyrosine Kinase Inhibitor (EGFR-TKIs) in Lung Cancer Patients Napitupulu, Elfrida; Nurrochmad, Arief; Hanafi, Arif Riswahyudi; Wahyudi, Danang Tri
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 14, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.91322

Abstract

Background: Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor (EGFR-TKIs) drugs are commonly used target therapies in patients with advanced-stage non-small cell carcinoma lung cancer (NSCLC).Objectives: This study aims to provide an overview of dermatologic side effects and quality of life index of NSCLC patients who received EGFR-TKIs targeted therapy at Dharmais Cancer Hospital.Methods: This study used a cross-sectional design. Inclusion criteria were patients who received EGFR-TKIs targeted therapy, namely gefitinib, erlotinib, and afatinib, in September - October 2023, who were willing to be research subjects, and patients who were not in a medical emergency. In total, 52 patients filled out the dermatology life quality index (DLQI) questionnaire through interviews and medical records. Data evaluation was performed descriptively in the form of percentages.Results: The most common occurrence of dermatologic side effects was skin hypersensitivity reactions with mild severity (grade 1) by 59.6%, moderate severity (grade 2) by 19.2%, and severe severity (grade 3) by 1.9%, and no drug dermatologic side effects by 19.2%. In comparison, the most DLQI was in the category of not affecting patient life. In general, side effects with moderate (grade 2) and severe (grade 3). The severity will decrease to mild severity (grade 1) when already getting topical corticosteroid drugs or combinations with oral antibiotics and antihistamine drugs.Conclusion: The most severe side effect was grade 1, which slightly affected the patient's quality of life. Education and monitoring of side effects and management of symptoms are necessary to reduce the severity and improve patients' quality of life.
Validation of Analytical Method LC MS/MS for Determination Isoniazid in Rats Serum Suhendi, Andi; Rohman, Abdul; Wahyono, Djoko; Nurrochmad, Arief; Manggo, Tasya Faradillah
Pharmacon: Jurnal Farmasi Indonesia Vol 20, No 2 (2023)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v20i2.23293

Abstract

Determination of isoniazid concentration for therapeutic drug monitoring must produce valid values, so validation of the analytical method of LC-MS/MS needs to be carried out. This research aims to obtain valid method of LCMS/MS in order to determination isoniazid in rats serum. Sample preparation was carried out using the liquid-liquid extraction method using acetonitrile and methanol (2:1). The chromatography system was developed with a C18 column (ACQUITY UPLC® HSS T3 1.8 µm, 2.1 × 100 mm), the mobile phase was 70% acetonitrile with 0.1% formic acid (A), water with 0.1% formic acid (B), as well as methanol (C) with a flow rate of 0.3 mL/min, with gradient elution, detection in ESI+ mode with multiple reaction monitoring (MRM) at the transition 138 m/z → 121 m/z. The research results showed that the method was accurate with a % recovery of 96 - 113% and an RSD of 2.4 ± 0.9%. The precision value was obtained with an average RSD of 3.7 ± 2.4% for intra-day and 4.1 ± 2.3% for inter-day. Linearity showed good results with a correlation coefficient of 0.9956 in tests with 5 different concentrations. The LOQ and LOD values obtained from the linear regression equation were 0.1987 µg/mL and 0.0656 µg/mL respectively. The results showed that the LC-M/MS method was valid for determining isoniazid levels in rat serum
Integrated LC-HRMS Analysis, Network Pharmacology, and Molecular Docking to Predict the Potential of Syzygium polyanthum in Alleviating Rheumatoid Arthritis Nurlely, Nurlely; Nurrochmad, Arief; Fakhrudin, Nanang; Widyarini, Sitarina
Journal of Pharmascience Vol 12, No 2 (2025): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v12i2.23762

Abstract

Rheumatoid arthritis (RA) adalah penyakit autoimun kronis dengan hasil terapi yang terbatas dan efek samping yang signifikan terkait dengan pengobatan saat ini. Studi ini menggunakan LC–HRMS, farmakologi jaringan, dan docking molekuler untuk menganalisa senyawa bioaktif dan mekanisme dasar Syzygium polyanthum sebagai terapi komplementer potensial untuk RA. Ekstrak diperoleh dengan metode maserasi menggunakan etanol 90% selama 2x24 jam  Profiling metabolit menggunakan LC–HRMS mengidentifikasi tujuh senyawa kandidat dengan kelimpahan relatif lebih dari 1%, di mana 2,6-dimethylquinoline memiliki kelimpahan paling tinggi (5,77%). Farmakologi jaringan mengungkapkan 121 target tumpang tindih antara target RA dan senyawa-senyawa ini, dengan PTGS2 dan MAPK14 dipilih untuk docking molekuler terhadap tiga ligan representatif: 2,6-dimethylquinoline, 6-methylquinoline, dan myricetin. Myricetin menunjukkan afinitas ikatan terkuat terhadap PTGS2 dan MAPK14, dengan energi ikatan masing-masing –8,915 dan –7,849 kcal/mol. Studi menemukan bahwa ekstrak etanol S. polyanthum (EESP) memiliki potensi terapeutik untuk mengurangi inflamasi pada RA. Kata Kunci: Daun Salam, Inflamasi, Penyakit Autoimun, Siklooksigenase 2, Hasil Terapi  Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disease with limited therapeutic outcomes and considerable adverse effects associated with current treatments. This study employed LC–HRMS, network pharmacology, and molecular docking to investigate the bioactive compounds and underlying mechanisms of Syzygium polyanthum as a potential complementary therapy for RA. The extract was obtained by maceration using 90% ethanol for 2x24 hours. Metabolite profiling by LC–HRMS identified seven candidate compounds with relative abundance greater than 1%, of which 2,6-dimethylquinoline was the most abundant (5.77%). Network pharmacology revealed 121 overlapping targets between RA and these compounds, with PTGS2 and MAPK14 selected for molecular docking against three representative ligands: 2,6-dimethylquinoline, 6-methylquinoline, and myricetin. Myricetin exhibited the strongest binding affinity to PTGS2 and MAPK14, with binding energies of –8.915 and –7.849 kcal/mol, respectively. These findings suggest that S. polyanthum ethanol extract (EESP) possesses therapeutic potential in attenuating RA-related inflammation.
Understanding the Safety Profile of Imatinib in Asian Chronic Myeloid Leukemia Patients: A Systematic Review Budiarti, Niky; Ikawati, Zullies; Nurrochmad, Arief; Arief, Thendi Abdul
Jurnal Ilmiah Medicamento Vol 12 No 1 (2026): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v12i1.13296

Abstract

Background: The treatment of chronic myeloid leukemia has advanced substantially since the introduction of tyrosine kinase inhibitors, particularly imatinib. However, adverse events associated with imatinib may affect adherence and quality of life, highlighting the importance of understanding safety outcomes across populations.Objective: This systematic review aimed to synthesize evidence on hematologic and non-hematologic adverse events associated with imatinib use among chronic myeloid leukemia patients in Asia.Methods: A systematic literature search was conducted in PubMed, Scopus, and ScienceDirect for studies published between January 2020 and July 2025. Eligible studies were synthesized narratively due to methodological heterogeneity. Adverse events were extracted as reported and graded using standardized toxicity criteria, and causality assessment was applied when available. Study quality was evaluated using established critical appraisal tools. Five studies from India, China, and Taiwan met the inclusion criteria.Results: The most frequent hematologic adverse event was anemia, followed by neutropenia and thrombocytopenia. Common non-hematologic adverse events included gastrointestinal symptoms, peripheral or periorbital edema, muscle cramps, and hyperpigmentation, with regional variations. Most events were mild to moderate (grades 1–2), while severe fluid retention, including pleural and pericardial effusions, was reported in isolated cases. No studies reported permanent discontinuation of imatinib due to adverse events.Conclusion: This review summarizes imatinib-related adverse events among chronic myeloid leukemia patients from selected Asian regions—East and South Asia, specifically India, China, and Taiwan—showing predominantly mild to moderate toxicities and providing practice-informed insights for clinical monitoring. However, the absence of data from other Asian regions precludes generalization to the entire Asian continent.
UJI IN-VITRO PENGHAMBATAN ENZIM ASETILKOLINESTERASE DAN IDENTIFIKASI FITOKIMIA FRAKSI AKTIF EKSTRAK ETANOL BUAH MENGKUDU (Morinda citrifolia L.) Dina, Shela Puzi; Herowati, Rina; Nurrochmad, Arief
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 6 No. 1 (2019)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v6i1.2994

Abstract

Asetilkolin adalah neurotransmitter yang berperan dalam pengaturan fungsi kognitif terutama pembentukan memori baru. Hidrolisis berlebihan asetilkolin oleh enzim asetilkolinesterase dapat menyebabkan gangguan pada pembentukan memori. Mengkudu merupakan tanaman yang banyak terdapat di Indonesia dan telah teruji memiliki kemampuan penghambatan enzim asetilkolinesterase. Penelitian ini bertujuan untuk mengetahui kemampuan penghambatan aktivtas enzim acetylcholinesterase fraksi-fraksi dari ekstrak etanol buah mengkudu dan identifikasi senyawa yang terkandung dalam fraksi aktif dari ekstrak etanol buah mengkudu melalui analisis liquid chromathography-mass spectrometry. Pemisahan senyawa dilakukan melalui dua tahap yaitu ekstraksi menggunakan metode maserasi dan fraksinasi menggunakan kromatografi cair vakum. Pengujian penghambatan enzim asetilkolinesterase dilakukan dengan menggunakan metode Ellman (kolorimetri) pada konsentrasi 1000, 500, 250, 125 µg/mL. Identifikasi senyawa kimia fraksi teraktif dilakukan dengan analisis liquid chromathography-mass spectrometry. Nilai IC50 ekstrak etanol, fraksi 1, fraksi 2 dan fraksi 3 buah mengkudu secara berturut-turut sebesar 4882,29, 947,99, 1726,99, 18673,82 µg/mL. Fraksi teraktif diduga mengandung asam linolenat, asam linoleat, pinoresinol, metil linoleat dan metil oleat.
Co-Authors Abdul Rohman Agil Novianto, Agil Agung Endro Nugroho Alexxander, . Alexxander, . Andi Suhendi Anggraeni, Nuniek Arief Rahman Hakim Arief, Thendi Abdul Baiq Maylinda Gemantari Budiarti, Niky Dina, Shela Puzi Dirman, Arifin Djoko Wahyono Edy Meiyanto Endang Lukitaningsih Fita Rahmawati Hanafi, Arif Riswahyudi Harjaningsih, Woro Ida Ayu Putu Sri Widnyani Ika Puspitasari Imono Argo Donatus, Imono Argo Laras Widawaty Putri Manggo, Tasya Faradillah Marbun, Prajona Mukrinin, Walit Uhkri Nanang Fakhrudin, Nanang Napitupulu, Elfrida Nurlely Nurlely Puji Astuti Rahma, Nazulanita Rahmawati, Adillah Retno Murwanti Romadhonsyah, Fitra Sitarina Widyarini Subagus Wahyuono Tiaravista, Amanda Gita Titik Nuryastuti Tri Murti Andayani Wahyuddin, Munifah Wahyudi, Danang Tri Wirasti, Wirasti Wisnu Kusuma, Eka Yundari, Yundari