Article Per Year (5 Year)
p-Index From 2021 - 2026
0.835
P-Index
This Author published in this journals
All Journal e-NERS e-GIGI e-CliniC Jurnal e-Biomedik JURNAL BIOMEDIK Medical Scope Journal (MSJ)
Karel Pandelaki
Universitas Sam Ratulangi
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

Published : 41 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 41 Documents
Search

 1   2   3   4   5 
GAMBARAN PENGETAHUAN TENTANG HALITOSIS PADA BURUH DI PELABUHAN MANADO Irianti, Rizkia; Pandelaki, Karel; Mintjelungan, Christy
e-GiGi Vol 3, No 1 (2015): e-GiGi
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/eg.3.1.2015.6401

Abstract

Abstract: Halitosis is a general term used to describe bad breath odor emanating from the oral cavity that may occur in physiological and pathological. The cause of halitosis much comes from the mouth as much as 80%. People's knowledge of halitosis is needed because it can help to prevent and deal with the halitosis and may be the first step for further diagnosis of the systemic disease. This study aims to describe the knowledge of halitosis in labor at the port of Manado. This research is a descriptive study using cross-sectional approach. The sample size was obtained by using Slovin formula with a total sample obtained 77 samples and sampling techniques using simple random sampling by means of a lottery. Knowledge was measured using a questionnaire containing some questions about the causes and prevention of halitosis. The result is a total of 27 respondents who have a good knowledge, 39 respondents have sufficient knowledge and 11 respondents have less knowledge. Respondents aged 37-48 years is the most respondents had a good knowledge. Based on this study, suggested a good enough knowledge to be maintained and applied in order to maintain and improve the health of your teeth and mouth.Keywords: Halitosis, knowledge, stevedore.Abstrak: Halitosis adalah suatu istilah umum yang digunakan untuk menjelaskan bau nafas tidak sedap yang berasal dari rongga mulut yang dapat terjadi secara fisiologis dan patologis. Penyebab halitosis paling banyak berasal dari dalam mulut sebanyak 80%. Pengetahuan masyarakat terhadap halitosis sangat dibutuhkan karena dapat membantu untuk mencegah dan menanggulangi halitosis serta dapat menjadi langkah awal untuk mendiagnosis lebih lanjut terhadap penyakit sistemik.Penelitian ini bertujuan untuk mengetahui gambaran pengetahuan tentang halitosis pada buruh di pelabuhan Manado. Penelitian ini merupakan penelitian deskriptif dengan menggunakan pendekatan potong lintang. Ukuran sampel diperoleh dengan menggunakan rumus Slovin dengan total sampel yang didapatkan 77 sampel dan teknik pengambilan sampel menggunakan simple random sampling dengan cara lotre. Pengetahuan diukur dengan menggunakan kuesioner yang berisi beberapa pertanyaan tentang penyebab dan pencegahan halitosis. Hasilnya ialah sebanyak 27 responden yang mempunyai pengetahuan baik, 39 responden mempunyai pengetahuan cukup dan 11 responden mempunyai pengetahuan kurang. Responden berusia 37-48 tahun ialah responden paling banyak mempunyai pengetahuan baik. Berdasarkan penelitian ini, pengetahuan yang cukup baik disarankan untuk dapat dipertahankan dan diaplikasikan guna mempertahankan dan meningkatkan derajat kesehatan gigi dan mulut.Kata Kunci : Halitosis, pengetahuan, buruh pelabuhan.
HIPERTIROID PADA KEHAMILAN MOLA HIDATIDOSA Pangkahila, Erwin; Pandelaki, Karel
Jurnal Biomedik : JBM Vol 1, No 2 (2009): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.1.2.2009.826

Abstract

Abstract: We reported a suspected pregnancy associated with 2-month-vaginal bleeding in a 42-year-old female. She was diagnosed with hyperthyroidism associated with mola hydatidosa. The diagnosis of hyperthyroidism was based on anamnesis, and physical, labo-ratory, and radiological examinations. We found palpitation, weakness, loss of weight, much sweating, tachicardia, and some enlargement of the thyroid glands. The laboratory examina-tion  showed an increase of hCG and free T4, in addition to a decrease of TSHs. In the USG examination we found a snow-like pattern. The histopathological examination showed avas-cularization with hydrophic degeneration of the villi,  and cysterna formation, all of which concluded that it was a mola hydatidosa pregnancy. The patient was treated with PTU 100 mg and propanolol 10 mg three times daily for the hyperthyroidism, and a total hysterectomy operation for the mola hydatidosa pregnancy. Prognosis of the patient was dubious. Key words: hyperthyroid, mola hydatidosa, hCG, FT4, TSHs.     Abstrak: Telah dilaporkan seorang perempuan umur 42 tahun dengan dugaan kehamilan dan mengalami perdarahan  jalan lahir sejak dua bulan lalu, yang kemudian didiagnosis dengan hipertiroid pada mola hidatidosa. Diagnosis hipertiroid pada kehamilan mola hidatidosa dite-gakkan berdasarkan anamnesa, pemeriksaan fisik, laboratorium dan radiologi. Ditemukan ge-jala jantung berdebar, kelemahan badan, penurunan berat badan dan berkeringat banyak, serta tanda takikardi dan pembesaran ringan kelenjar tiroid.  Pemeriksaan laboratorium terdapat pe-ningkatan kadar hCG dan  T4 bebas serta penurunan kadar TSHs. Pemeriksaan USG tampak gambaran snow-like pattern dan histopatologi terdapat vili yang alami degenerasi hidropik, avaskuler dengan pembentukan sisterna yang menyimpulkan suatu kehamilan mola hidati-dosa. Pengobatan dengan pemberian PTU 100 mg dan propanolol 10 mg, kedua-duanya  tiga kali sehari untuk penanganan hipertiroid, serta dilakukan tindakan operasi histerektomi totalis untuk penanganan kehamilan mola hidatidosanya. Prognosis penderita adalah dubia. Kata kunci: hipertiroid, mola hidatidosa, hCG, FT4, TSHs.
ADIPONECTIN AND TUMOR NECROSIS FACTOR ALPHA LEVELS, AND THEIR CORRELATIONS WITH ENDOTHELIAL DYSFUNCTION IN CENTRAL OBESITY Wantania, Frans; Lefrandt, Reginald L.; Pandelaki, Karel
Jurnal Biomedik : JBM Vol 3, No 3 (2011): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.3.3.2011.876

Abstract

Abstract: Background: In obesity, macrophages that infiltrate into adipose tissues create an inflammatory condition.  Besides that, adipose tissues release proinflammatory cytokines such as TNF alpha. These cytokines promote LDL oxydation by ROS, and accelerate NO degradation resulting in endothelial dysfunction. Adiponectin which could prevent endothelial dysfunction is decreased secondarily to TNF alpha’s action. Objectives: To determine the serum levels of TNF alpha and adiponectin, and their correlations with the endothelial dysfunction. Methods: This was an observational, descriptive, and analytic study with cross sectional. Samples were students of senior high schools in Manado.  Sampling method was carried out consecutively until the required number was enough. Data consisted of age, blood pressure, waist circumference, body weight, lipid profile, creatinin, TNF alpha, adiponectin, and albumin creatinine ratio. We used the Spearman Correlation to analyze the data. Result: Over a 4-month period, there were 35 obese male subjects with ages of 16-18 years old. The average of body weights was 83.23 kg, and of waist circumferences was 103.94 cm.  Endothelial dysfunction was found in 5.72% of samples, high levels of TNF alpha in 68.57% of samples, and low levels of adiponectin in 62.8% of samples.  We found a significant positive correlation between TNF alpha and endothelial dysfunction (r=0.554, p<0.000), and an inverse correlation between adiponectin level and endothelial dysfunction (r = -0.349, p=0.020). Conclusion: There were high levels of TNF alpha in 68.57% of samples and low levels of adiponectin in 62.86% of samples. There was a significant correlation between TNF alpha level and endothelial dysfunction. There was an inverse correlation between adiponectin level and endothelial dysfunction. Key words: obesity, adiponectin TNF alpha, endothelial dysfunction.
Gambaran Status Gingiva Pada Penderita Diabetes Melitus Tipe 2 Di Rumah Sakit Umum GMIM Pancaran Kasih Manado Monoarfa, Olyvia Octaviany; Pandelaki, Karel; Mintjelungan, Christy N.
e-GiGi Vol 3, No 1 (2015): e-GiGi
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/eg.3.1.2015.6400

Abstract

Abstract: Diabetes Mellitus (DM) is a metabolic disease group with the characteristic blood glucose levels than normal (hyperglycemia) that occurs because abnormalities in insulin secretion, insulin recognized when payable disorders, or combination of both. Regular blood glucose levels cause patients uncontrolled type 2 diabetes are at greater risk for experiencing problems of oral health, including gingivitis. Purpose of this research was to know the description of gingival status in patients of type 2 diabetes at RSU GMIM Pancaran Kasih Manado. This research is an observational descriptive with cross sectional study approach. The research population is all patients of type 2 diabetes outpatient clinic Interna RSU GMIM Pancaran Kasih Manado in September 2014. The research method is by using a Consecutive sampling with a sample of 100 people. The result of this research showed that the gingival status in patients of type 2 diabetes calculated based gingival index that most occur severe gingivitis was 45 respondents (45%). The gingival status that showed the severe gingivitis in patients of type 2 diabetes based on age 17 respondents (48,6%) in the age range of 51-60 years old, based on gender that most occur in women 27 respondents (49,1%), based on duration of suffering 25 respondents (55,6%) in the age range >10 years, and based on blood glucose control (HbA1c) that most numerous in patients with poor blood glucose 30 respondents (60%). Conclusion: The gingival status in patients of type 2 diabetes most occur severe gingivitis, and recommended in patients of type 2 diabetes to improve their healthy lifestyle in order to normalize blood glucose levels so as to reduce the occurrence of diabetes, more attention and maintain oral hygiene, especially the gingival health.Keywords: gingival status, patients of type 2 diabetes.Abstrak: Diabetes Melitus (DM) adalah suatu kelompok penyakit metabolik dengan karakteristik kadar glukosa darah yang melebihi normal (hiperglikemia) yang terjadi karena kelainan sekresi insulin, gangguan kerja insulin, ataupun kombinasi dari keduanya. Kadar gula darah yang tidak terkontrol menyebabkan penderita DM tipe 2 beresiko lebih tinggi mengalami masalah kesehatan mulut, termasuk gingivitis. Penelitian ini bertujuan untuk mengetahui gambaran status gingiva pada penderita Diabetes Melitus tipe 2 di Rumah Sakit Umum GMIM Pancaran Kasih Manado. Penelitian ini merupakan penelitian deskriptif observasional dengan pendekatan cross sectional study. Populasi penelitian yaitu seluruh pasien DM tipe 2 rawat jalan di Poliklinik Interna Rumah Sakit Umum GMIM Pancaran Kasih Manado pada bulan September 2014. Metode penelitian yaitu Consecutive sampling dengan sampel penelitian berjumlah 100 orang. Hasil penelitian menunjukkan bahwa status gingiva yang dihitung berdasarkan indeks gingiva paling banyak menunjukkan gingivitis berat 45 subjek penelitian (45%). Status Gingiva berdasarkan umur paling banyak 17 subjek penelitian (48,6%) pada rentang umur 51–60 tahun, berdasarkan jenis kelamin paling banyak pada perempuan 27 subjek penelitian (49,1%), berdasarkan lamanya menderita paling banyak selama >10 tahun 25 subjek penelitian (55,6%), dan berdasarkan kontrol gula darah (HbA1c) paling banyak pada pasien dengan kontrol gula darah buruk (>9%) 30 subjek penelitian (60%). Simpulan: Penderita DM tipe 2 di Rumah Sakit Umum GMIM Pancaran Kasih Manado paling banyak mengalami gingivitis berat, serta disarankan bagi penderita agar lebih meningkatkan pola hidup sehat guna menormalkan kadar glukosa darah sehingga dapat mengurangi terjadinya diabetes, lebih memperhatikan dan menjaga kebersihan gigi dan mulut, terutama kesehatan gingivanya.Kata kunci: status gingiva, penderita diabetes melitus tipe 2
HUBUNGAN STATUS PERIODONTAL DAN DERAJAT REGULASI GULA DARAH PASIEN DIABETES MELITUS DI RUMAH SAKIT UMUM PUSAT PROF DR. R. D. KANDOU MANADO Emor, Stephanie F.; Pandelaki, Karel; Supit, Aurelia S. R.
e-GiGi Vol 3, No 1 (2015): e-GiGi
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/eg.3.1.2015.7664

Abstract

Abstract: Diabetes mellitus (DM) is a disorder characterized by hyperglycemia and impaired metabolism of carbohydrates, fats, and proteins. These are caused by insulin deficiency, relative or absolute. Diabetes mellitus is a long-term chronic disease with a risk of the occurence of diabetic complications, such as oral diabetic. The study aimed to analyze the relationship between periodontal status and the degree of blood sugar regulation in diabetic patients in Prof. Dr. R. D. Kandou Hospital Manado. Data were obtained from the Endocrine clinic of Prof. Dr. R. D. Kandou Hospital. This was a descriptive analytical study with a cross sectional approach. Samples consisted of 37 patients (total sampling) aged 20-60 years. The analytic methods used in this study was the chi-square test (univariate and bivariate). Periodontal pocket depths were clinically examined. The results showed that there was no healthy periodontal state among diabetic patients. Uncontrolled diabetic patients with poor HbA1c (17 patients, 46%) had bad periodontal status. The chi-square test showed that there was a significant relationship between periodontal status and the degree of blood sugar regulation in diabetic patients (p < 0.05). Conclusion: There was a significant relationship between periodontal status and the degree of blood sugar regulation in diabetic patients.Keywords: periodontal status, diabetes mellitus, degree of regulation blood sugar.Abstrak: Diabetes melitus (DM) adalah kelainan yang ditandai hiperglikemia dan gangguan metabolisme karbohidrat, lemak, dan protein yang disebabkan oleh kekurangan hormon insulin secara relatif maupun absolut. DM merupakan penyakit kronis yang bila diabaikan dapat terjadi komplikasi diabetic, antara lain oral diabetic. Penelitian ini bertujuan untuk menganalisis hubungan status periodontal dan derajat regulasi gula darah pasien diabetes melitus di RSUP Prof. Dr. R. D. Kandou Manado. Pengumpulan data dilakukan di Poliklinik Endokrin RSUP Prof. Dr. R. D. Kandou. Penelitian ini bersifat deskriptif analitik dengan pendekatan potong lintang. Besar sampel sebanyak 37 orang (total sampling) usia 20-60 tahun. Analisis data secara univariat dan bivariat (uji chi-square). Pemeriksaan kedalaman poket periodontal dilakukan terhadap subjek penelitian. Hasil penelitian menunjukkan tidak adanya status periodontal yang sehat pada pasien DM. Pasien DM dengan HbA1c yang buruk memiliki status periodontal yang buruk pula yaitu sebanyak 17 pasien (46%). Berdasarkan hasil uji chi-square terdapat hubungan bermakna antara status periodontal dan derajat regulasi gula darah (p < 0,05). Simpulan: Terdapat hubungan bermakna antara status periodontal dan derajat regulasi gula darah pasien diabetes melitus.Kata kunci: status periodontal, diabetes melitus, derajat regulasi gula darah
Hubungan Lama Berobat dan Keteraturan Berobat dengan Kadar HbA1c Pasien DM Tipe 2 di Poli Endokrin RSUP Prof. Dr. R. D. Kandou Manado Sumakul, Ridhel G.; Pandelaki, Karel; Wantania, Frans E. N.
e-CliniC Vol 7, No 1 (2019): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v7i1.23540

Abstract

Abstract: Type 2 diabetes mellitus (T2DM) is caused due to insulin target cells fail or are unable to respond to insulin normally (insulin resistance). Acute or chronic complications can occur in DM patients. Complications of DM can be prevented by optimal control of glycemia, in this case, the concentration of blood glucose and HbA1c. Regularity in medication consumption is important to prevent the occurence of diabetic complications. This study was aimed to determine the relationship of the duration and the regularity of diabetes treatment with HbA1c levels in T2DM patients at Endocrinology Polyclinic at Prof. Dr. R. D. Kandou Hospital Manado. This was a descriptive analytical study with a cross sectional design, using paients’ medical record data. There were 60 samples obtained by using purposive sampling technique. The results of Chi-Square test showed that there was no corelation between duration of treatment and HbA1c level (P=0.111) and there was no corelation between the regularity of treatment and HbA1c level (P=0.224). Conclusion: There was no relationship between the duration and regularity of treatment with HbA1c levels of T2DM patients in the Endocrinology Polyclinic at Prof. Dr. R. D. Kandou Hospital Manado.Keywords: T2DM, duration of treatment, regularity of treatment, HbA1c Abstrak: Diabetes melitus tipe 2 (DMT2) disebabkan karena sel-sel sasaran insulin gagal atau tak mampu merespon insulin secara normal (resistensi insulin). Komplikasi yang terjadi pada pasien DM dapat bersifat akut maupun kronis. Komplikasi DMT2 dapat dicegah dengan kontrol glikemia yang optimal yaitu terkendalinya konsentrasi glukosa dalam darah dan HbA1c. Keteraturan minum obat pada pasien DM merupakan hal penting dalam mencegah terjadinya komplikasi. Penelitian ini bertujuan untuk mengetahui hubungan lama berobat diabetes dan keteraturan berobat dengan kadar HbA1c pasien DMT2 di Poli Endokrin RSUP Prof . Dr. R. D. Kandou Manado. Jenis penelitian ialah deskriptif analitik dengan desain potong lintang, menggunakan data rekam medik. Teknik pengambilan sampel menggunakan purposive sampling dengan jumlah sampel sebanyak 60 pasien. Hasil uji Chi-Square menunjukkan tidak terdapat hubungan lama berobat DMT2 dengan kadar HbA1c (P=0,111). Juga tidak terdapat hubungan keteraturan berobat dengan kadar HbA1c (P=0,224). Simpulan: Tidak terdapat hubungan antara lama berobat dan keteraturan kunjungan berobat dengan kadar HbA1c pasien DM tipe 2 di Poli Endokrin RSUP Prof . Dr. R. D. Kandou Manado.Kata kunci: DMT2, lama berobat, keteraturan berobat, HbA1c
Perbedaan Kadar HDL dan Trigliserida antara Penderita Ulkus Diabetik dan Tanpa Ulkus Diabetik pada Pasien DM Tipe 2 di RSUP Prof. Dr. R. D. Kandou Manado Kirojan, Debora; Pandelaki, Karel; Wongkar, Maarthen C.P.
e-CliniC Vol 5, No 2 (2017): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v5i2.18581

Abstract

Abstract: The number of people with diabetes mellitus (DM) is increasing every year, as well as the risk of its chronic complications inter alia diabetic ulcer. Peripheral artery disease caused by atherosclerosis is one of the major risk factors for developing diabetic ulcer, and low HDL is associated with atherosclerosis. High triglyceride increases the risk for neuropathy, a diabetic ulcer risk factor. This study was aimed to analyze the difference in HDL and triglyceride levels among type 2 DM (T2DM) patients with and without diabetic ulcers. This was a descriptive comparative study with a case control design. Data were secondarily obtained from patients in the period of January 1st to September 30th 2017. Purposive technique sampling was applied to attain 30 T2DM patients with ulcers and 30 T2DM patients without ulcers. Data were analyzed by using independent t-test and P <0.05 was determined as statistically significant level. The results showed that the mean HDL level in T2DM patients with diabetic ulcers was 20.47 mg/dl, lower than of T2DM patients without diabetic ulcers with a mean HDL level of 32.33 mg/dl (P=0.000). The mean triglyceride level in T2DM patients with diabetic ulcers was 150.43 mg/dl, higher than of T2DM patients without diabetic ulcers with a mean triglyceride level of 121.16 mg/dl (P= 0.141). Conclusion: There was a statistically significant difference in the mean level of HDL between T2DM patients with and without ulcers. There was no statistically significant difference in the mean level of triglyceride between T2DM patients with and without diabetic ulcers.Keywords: diabetic ulcer, HDL, triglyceride, type 2 DM. Abstrak: Jumlah penderita penyakit diabetes melitus (DM) setiap tahun meningkat, diikuti peningkatan risiko terjadinya komplikasi kronik, salah satunya ialah ulkus diabetik. Penyakit arteri perifer yang disebabkan oleh proses aterosklerosis merupakan salah satu faktor risiko terjadinya ulkus diabetik, dan kadar HDL dianggap berhubungan dengan proses aterosklerosis. Kadar trigliserida yang tinggi meningkatkan risiko kejadian neuropati yang merupakan salah satu faktor risiko terjadinya ulkus. Penelitian ini bertujuan untuk menganalisis perbedaan kadar HDL dan trigliserida pada pasien DM tipe 2 (DMT2) dengan dan tanpa ulkus. Jenis penelitian ialah deskriptif komparatif dengan desain kasus kontrol (case control) menggunakan data pasien yang berobat mulai 1 Januari sampai 30 September 2017. Digunakan teknik purposive sampling untuk mendapatkan sampel sebanyak 30 pasien DMT2 dengan ulkus diabetik dan 30 pasien DMT2 tanpa ulkus diabetik sebagai pembanding. Analisis penelitian ini menggunakn uji t-tidak berpasangan, dan dinyatakan bermakna jika P < 0,005. Hasil penelitian mendapatkan rerata kadar HDL pada pasien DMT2 dengan ulkus diabetik ialah 20,47 mg/dl, lebih rendah dibandingkan pasien tanpa ulkus dengan rerata 32,33 mg/dl (P=0,000). Rerata kadar trigliserida pada pasien DMT2 dengan ulkus diabetik ialah 150,43 mg/dl, lebih tinggi dibandingkan pasien tanpa ulkus dengan rerata 121,16 mg/dl (P=0,141). Simpulan: Terdapat perbedaan bermakna rerata kadar HDL antara penderita DMT2 dengan dan tanpa ulkus diabetik. Tidak terdapat perbedaan bermakna rerata kadar trigliserida antara penderita DMT2 dengan dan tanpa ulkus diabetik.Kata kunci: ulkus diabetik, DM Tipe 2, HDL, trigliserida
Gambaran Indeks Eritrosit Rerata pada Laki-laki Dewasa dengan Diabetes Melitus Tipe 2 Saraswati, Talitha D.; Rotty, Linda W. A.; Pandelaki, Karel
e-CliniC Vol 7, No 2 (2019): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.7.2.2019.26832

Abstract

Abstract: Diabetes mellitus (DM) is a metabolic disease indicated by high level of blood sugar resulting from a defect in insulin secretion, insulin activity, or both. The prevalence of DM in Indonesia is 1.9%, making it the 7th leading cause of deaths worldwide. In diabetic patients it is common to find any disorder in several systems, inter alia disorder of erythrocytes. An important indicator in portraying the erythrocytes state is the average erythrocyte indices (MCV, MCH, and MCHC). This study was aimed to provide an overview of the average erythrocyte indices in young adult males with type 2 DM (T2DM) at the Endocrine Polyclinic of Prof. Dr. R. D. Kandou Hospital. This was a descriptive and retrospective study using medical records of diabetic patients at the Endocrine Policlinic from September 2018 to September 2019. The results obtained a total of 1.432 medical records consisting of 550 males and 882 females. However, only 22 samples met the inclusion criteria, with a majority of samples were 40 to 45 years old (50%). Generally, the erythrocyte indices were still in normal range. Albeit, a few samples showed a decrease in hemoglobin level, MCV, and MCH. In conclusion, there was no significant change in the erythrocyte indices among adult males with type 2 diabetes mellitus at the Endocrine Polyclinic of Prof. Dr. R. D. Kandou Hospital.Keywords: average erythrocyte indices, type 2 diabetes mellitus Abstrak: Diabetes melitus (DM) merupakan penyakit metabolik yang ditandai dengan tingginya kadar gula darah akibat defek sekresi insulin, kerja insulin, atau keduanya. Prevalensi DM di Indonesia sebesar 1,9% menjadikan DM sebagai penyebab kematian urutan ke tujuh di dunia. Pada pasien DM seringkali ditemukan gangguan pada berbagai sistem, salah satunya pada eritrosit. Indikator penting yang dapat mencerminkan keadaan eritrosit ialah indeks eritrosit rerata (MCV, MCH, dan MCHC). Penelitian ini bertujuan untuk mengetahui gambaran indeks eritrosit rerata pada pasien laki-laki dewasa penyandang DM tipe 2 di Poliklinik Endokrin RSUP Prof. Dr. R. D. Kandou. Jenis penelitian ialah deskriptif retrospektif menggunakan data rekam medik pasien di Poli Endokrin RSUP Prof. Dr. R. D. Kandou periode September 2018 hingga September 2019. Hasil penelitian mendapatkan 1.432 rekam medis, terdiri dari 550 laki-laki dan 882 perempuan, namun hanya 22 data yang memenuhi kriteria penelitian, dengan mayoritas berusia 40-45 tahun (50%). Secara umum nilai indeks eritrosit rerata masih dalam rentang normal, namun terdapat beberapa sampel dengan penurunan kadar hemoglobin, MCV, dan MCH. Simpulan penelitian ini ialah tidak terdapat gambaran bermakna pada indeks eritosit pasien laki-laki dewasa dengan DM tipe 2 di Poliklinik Endokrin RSUP Prof. Dr. R. D. KandouKata kunci: indeks eritrosit rerata, diabetes melitus tipe 2
Gambaran kadar trombosit dan hematokrit pada pasien diabetes tipe 2 dengan kaki diabetik di BLU RSUP Prof. Dr. R. D. Kandou Manado Ruscianto, Daniel; Rotty, Linda W. A.; Pandelaki, Karel
e-CliniC Vol 4, No 1 (2016): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v4i1.10937

Abstract

Abstract: Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia due to impaired insulin activity, or both. Uncontrolled DM will lead to chronic complication, such as microangiopathy, macroangiopathy. and neuropathy. Diabetic foot is one of the chronic complications. This complication is associated with abnormality of thrombocyte and hematocrit levels that influence the blood flow. This study aimed to find out the profile of thrombocyte and hematocrit levels in patients with type 2 DM with diabetic foot at Prof. Dr. R. D. Kandou Hospital Manado. There were 25 patients type 2 DM with diabetic foot as samples consisted of:10 males (40%) and 15 females (60%). The mean of hematocrit level in males was 35.20% and in females was 28.40%. The mean of thrombocyte level was 391.4 x 103/mm3.Keywords: diabetic foot, thrombocyte, hematocritAbstrak: Diabetes melitus (DM) merupakan suatu kelompok penyakit metabolik dengan karakteristik hiperglikemia yang terjadi karena kelainan sekresi insulin, kerja insulin atau keduannya. Hiperglikemi pada DM yang tidak terkontrol menyebabkan komplikasi kronis, seperti mikroangiopati,makroangiopati dan neuropati. Kaki diabetes merupakan salah satu komplikasi kronis. komplikasi ini berkaitan dengan kelainan kadar trombosit dan hematokrit yang mempengaruhi peredaran darah. Tujuan penelitian ini adalah untuk mengetahui gambaran kadar trombosit dan hematokrit pada pasien diabetes tipe 2 dengan kaki diabetik di BLU RSUP Prof. R. D. Kandou Manado. Terdapat 25 pasien dengan DM tipe 2 yang memiliki komplikasi kaki diabetes yang menjadi sampel penelitian ini. Berdasarkan distribusi jenis kelamin perempuan sebanyak 15 pasien (60%) dan pada pasien laki-laki sebanyak 10 pasien (40%). Rata-rata kadar hematokrit pasien laki-laki adalah 35.20% dan perempuan adalah 28.40%. Rata rata kadar trombosit pasien adalah 391,4 x 103/mm3.Kata kunci: kaki diabetes, trombosit, hematokrit
HUBUNGAN LAMA TERJADINYA DMT2 DENGAN HEMATOKRIT PADA PASIEN DMT2 DI POLIKLINIK ENDOKRIN BLU RSUP PROF. DR. R. D. KANDOU MANADO Lumingkewas, Christianto A. Y; Rotty, Linda W. A; Pandelaki, Karel
e-CliniC Vol 2, No 2 (2014): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v2i2.5193

Abstract

Abstract: Diabetes mellitus is a metabolic disease characterized by hyper glycemia due to impaired insulin secretion, impaired insulin activity, or both. Chronic hyperglycemia in diabetes is associated with chronic damage and dysfunction of various organs, especially the eyes, kidneys, nerves, heart, and blood vessels. Increased hematocrit can result in impaired blood flow velocity. It is associated with increased blood viscosity causes vasoconstriction of blood vessels due to thickening of the membrane. Research purpose: To determine the correlation between hematocrit and duration of Diabetes Mellitus Type 2 in the polyclinic of endocrinology BLU RSUP Prof. Dr. R. D. Kandou Msnado. Method: The type of this research is descriptive research with cross-analytic sectional study design. In this research intended to analyzing the correlation between hematocrit with long occurs DM type 2. Research results: By using purposive sampling method found 32 people as sample who had been diagnosed with Diabetes Mellitus Type 2. The test result statistic using Speatman Correlation duration of diabetes to hematocrit is obtained numerical coefficients -0.191 and p value of 0.294. Conclusion: From the results of this research indicate that there is no correlation or significant correlation (p>0.294) between hematocrit with long occurs Diabetes Mellitus Type 2. Keywords: Diabetes Mellitus Type 2, hematocrit.     Abstrak: Diabetes melitus merupakan suatu penyakit metabolik yang ditandai dengan hiperglikemi akibat gangguan sekresi insulin, gangguan aktivitas insulin, atau keduanya. Hiperglikemi kronis pada diabetes berhubungan dengan kerusakan kronis dan disfungsi berbagai organ terutama mata, ginjal, syaraf, jantung, dan pembuluh darah.Peningkatan hematokrit dapat mengakibatkan kecepatan aliran darah terganggu. Hal ini berkaitan dengan viskositas darah yang meningkat menyebabkan terjadinya vasokonstriksi akibat penebalan membran pembuluh darah. Tujuan penelitian: Untuk mengetahui hubungan antara hematokrit dan lama terjadinya diabetes melitus tipe-2 di poliklinik endokrin BLU RSUP Prof. Dr. R. D Kandou Manado. Metode: Jenis Penelitian ini adalah penelitian Deskriptif Analitik dengan rancangan penelitian Cross Sectional. Dalam penelitian dimaksudkan untuk menganalisis hubungan antara Hematokrit dengan lama terjadinya DM Tipe-2. Hasil penelitian: Dengan menggunakan metode purrpossive sampling didapatkan 32 orang sebagai sampel yang telah didiagnosis Diabetes Melitus tipe 2. Hasil Uji Statistik Spearman Correlation lamanya diabetes terhadap hematokrit didapatkan angka koefisien sebesar -0,191 dan p value 0,294. Simpulan: Dari hasil penelitian ini menunjukkan bahwa tidak terdapat  korelasi atau hubungan yang bermakna (p>0,294) antara Hematokrit dengan Lama Terjadinya DM tipe 2. Kata kunci: Diabetes Melitus Tipe-2, hematokrit.
Co-Authors Agens L. Panda Agustinus Rihando Rumbino Amudi, Tulus Arthur E. Mongan Aurelia S. R. Supit Berhandus, Catrien Bradley J. Waleleng Cerelia Sugeng Christianto A. Y Lumingkewas Christy Mintjelungan Christy N. Mintjelungan Daniel Ruscianto, Daniel Dwi A. Primadana, Dwi A. Dwi P. Palimbunga Emma S. Moeis, Emma S. Emma Sy. Moeis Enjalita Karujan Erwin Pangkahila Ezra G. R. Tambunan, Ezra G. R. Firginia Manoppo Frans E. N. Wantania, Frans E. N. Frans E. Wantania Frans Wantania Glorya Stevani Cicilia Loei Harlinda Haroen Irene Moudy Sumayku Kekenusa, Gita C. Kirojan, Debora Linda W. A Rotty Linda W. A. Rotty Lucyana Leonita Pongoh M. C. P. Wongkar M. C.P Wongkar Maria Simatupang Marthen C.P. Wongkar, Marthen C.P. Meggy R. Kowaas Meibie M Taghulihi Mentari Simbar Monica L. Meloh Murtiningsih, Made K. Nadyah Awad Ni Wayan Mariati Nugroho, Agung Olyvia Octaviany Monoarfa Ongkowijaya, Jeffrey A. Ongkowijaya, Jeffry Patulak, Fitriyanti Pradika H. Koampa, Pradika H. Reginald L. Lefrandt Renata, Lucrezia Rivelino Hamel Rivelino S. Hamel Rixi Gahung, Rixi Rizkia Irianti Rotty, Linda W.A. Salsabila, Tasha Saraswati, Talitha D. Sarjono, Lillian Satriyani . Sedli, Bisuk P. Siti Chodijah Stella Palar Stephanie F. Emor Sumakul, Ridhel G. Tuegeh Destyana Veny Mandang Villarsi, Devinda Wariki, Windy M. V. Wongkar, Maarthen C.P. Wowor, Kartika Yauri, Livia F. Yohanes I Gede K.K Yuanita A. Langi Yuanita Langi