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All Journal e-NERS e-GIGI e-CliniC Jurnal e-Biomedik JURNAL BIOMEDIK Medical Scope Journal (MSJ)
Karel Pandelaki
Universitas Sam Ratulangi
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Hubungan Lingkar Pinggang, Homeostasis Model Assessment of Insulin Resistance, dan Prostaglandin-I2 dengan Test Agregasi Trombosit pada Subyek Obesitas Sentral Renata, Lucrezia; Pandelaki, Karel; Rotty, Linda W. A.
Medical Scope Journal Vol 2, No 2 (2021): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.2.2.2021.32597

Abstract

Abstract: Overweight and obese are global health problems and tend to increase in Indonesia. Central obesity is associated with inflammation, insulin resistance, and increased reactive oxidative stress. Insulin resistance can cause a decrease in prostaglandin I2 (PGI2) and nitric oxide (NO) levels, and an increase in platelet aggregation. Its effect in platelet aggregation may increase thrombus formation in blood vessels. This study was aimed to determine the relationship between waist circumference (WC) with HOMA-IR, PGI2 and platelet aggregation test (PAT) in central obese subjects. This was an observational and analytical correlational study with a cross-sectional design conducted at Prof. dr. R. D. Kandou Hospital, Manado. Samples were 33 central obese subjects, 19 were male and 14 were female. Insulin resistance was measured by using HOMA- IR, urine PGI2, and PAT. The Spearmann and Pearson correlation test showed a positive correlation between WC and HOMA-IR (r=0.366, p=0.036). There was a negative correlation but not significant between WC and PGI2 (r=-0.169, p=0.347); between WC and PAT (r=0.094, p=0.603); between HOMA-IR and PGI2 (r=-0.218, p=0.223); and between HOMA-IR and PAT (r=0.080, p=0.658). In conclusion, in central obese people, there  is a relationship between WC and HOMA-IR, but there is no relationship between WC, PGI2, and PAT.Keywords: central obesity, HOMA-IR, prostaglandin-I2, platelet aggregation test Abstrak: Berat badan berlebih atau obesitas merupakan masalah kesehatan global dan terus meningkat di Indonesia. Pada obesitas sentral terjadi inflamasi, resistensi insulin, dan mening-katnya reaktif oksidatif stress. Resistensi insulin mampu menyebabkan penurunan kadar prostaglandin I2 (PGI2) dan nitrik oksida (NO). Penurunan kadar PGI2 dapat menyebabkan peningkatan agregasi trombosit yang selanjutnya meningkatkan kemungkinan terjadinya trombus dalam pembuluh darah. Penelitian ini bertujuan untuk mengetahui hubungan antara lingkar pinggang dengan HOMA-IR, PGI2, dan test agregasi trombosit (TAT) pada subyek obes sentral. Jenis penelitian ialah observasional analitik bentuk korelasional dengan desain potong lintang. Penelitian dilakukan di RSUP Prof. dr. R. D. Kandou Manado. Total sampel 33  subyek dengan obesitas sentral, 19 laki-laki dan 14 perempuan. Pengukuran resistensi insulin menggunakan HOMA-IR, PGI2 urin, dan TAT. Uji korelasi Spearmann dan Pearson. mendapatkan korelasi positif antara LP dengan HOMA-IR (r=0,366; p=0,036). Terdapat korelasi negatif tidak bermakna pada hubungan antara LP dengan PGI2 (r=-0,169; p=0,347); hubungan antara LP dengan TAT (r=0,094; p=0,603); hubungan antara HOMA-IR dengan PGI2 (r=-0,218;p=0,223); dan hubungan antara HOMA-IR dengan TAT (r=0,080; p=0,658). Simpulan penelitian ini ialah pada subyek obes sentral terdapat hubungan antara lingkar pinggang dengan HOMA-IR, tetapi tidak terdapat hubungan antara lingkar pinggang dengan PGI2 dan TAT.  Kata kunci: obesitas sentral, HOMA-IR, prostaglandin-I2, tes agregasi trombosit
Co-Authors Agens L. Panda Agustinus Rihando Rumbino Amudi, Tulus Arthur E. Mongan Aurelia S. R. Supit Berhandus, Catrien Bradley J. Waleleng Cerelia Sugeng Christianto A. Y Lumingkewas Christy Mintjelungan Christy N. Mintjelungan Daniel Ruscianto, Daniel Dwi A. Primadana, Dwi A. Dwi P. Palimbunga Emma S. Moeis, Emma S. Emma Sy. Moeis Enjalita Karujan Erwin Pangkahila Ezra G. R. Tambunan, Ezra G. R. Firginia Manoppo Frans E. N. Wantania, Frans E. N. Frans E. Wantania Frans Wantania Glorya Stevani Cicilia Loei Harlinda Haroen Irene Moudy Sumayku Kekenusa, Gita C. Kirojan, Debora Linda W. A Rotty Linda W. A. Rotty Lucyana Leonita Pongoh M. C. P. Wongkar M. C.P Wongkar Maria Simatupang Marthen C.P. Wongkar, Marthen C.P. Meggy R. Kowaas Meibie M Taghulihi Mentari Simbar Monica L. Meloh Murtiningsih, Made K. Nadyah Awad Ni Wayan Mariati Nugroho, Agung Olyvia Octaviany Monoarfa Ongkowijaya, Jeffrey A. Ongkowijaya, Jeffry Patulak, Fitriyanti Pradika H. Koampa, Pradika H. Reginald L. Lefrandt Renata, Lucrezia Rivelino Hamel Rivelino S. Hamel Rixi Gahung, Rixi Rizkia Irianti Rotty, Linda W.A. Salsabila, Tasha Saraswati, Talitha D. Sarjono, Lillian Satriyani . Sedli, Bisuk P. Siti Chodijah Stella Palar Stephanie F. Emor Sumakul, Ridhel G. Tuegeh Destyana Veny Mandang Villarsi, Devinda Wariki, Windy M. V. Wongkar, Maarthen C.P. Wowor, Kartika Yauri, Livia F. Yohanes I Gede K.K Yuanita A. Langi Yuanita Langi