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All Journal Jurnal Keperawatan Priority Indonesian Journal of Global Health research An Idea Health Journal Prosiding Konferensi Nasional PKM-CSR Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) JUMANTIK (Scientific Journal of Health research) Promotor: Jurnal Mahasiswa Kesehatan Masyarakat Indonesian Journal of Global Health Research
Juliandi Harahap
Universitas Sumatera Utara
Humanities Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Association of Level Serum Ferritin and Lung Function in Pediatric with Transfusion – Dependent Thalassemia Putri Nahrisa Nasution; Bidasari Lubis; Ririe Fachrina Malisie; Juliandi Harahap; Wisman Dalimunthe; Hendri Wijaya
Indonesian Journal of Global Health Research Vol. 8 No. 1 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i1.342

Abstract

Pulmonary dysfunction in children with thalassemia can be restrictive, obstructive, or diffusion impairment. Elevated serum ferritin levels are a cause of pulmonary dysfunction in transfusion-dependent thalassemia patients. The aim of this study was to assess  relationship between serum ferritin levels and pulmonary dysfunction in transfusion-dependent thalassemia patients.  This cross-sectional study was conducted on 44 transfusion-dependent thalassemia children between May and June 2025 at the Thalassemia Clinic of Adam Malik Hospital, Medan. Demographic characteristics were obtained from interviews and medical records. Lung function was assessed using a spirometer. Associations were analyzed using Shapiro Wilk, Kruskal-Wallis test, and multinomial logistic regression test. A total of 17 children (38.6%) had normal lung function, while 27 children (61.3%) had impaired lung function. Restrictive impairment was present in 24 children (54.5%), and obstructive impairment in 3 children (6.8%). Analysis showed significant differences in serum ferritin levels and splenomegaly in relation to impaired lung function, with p-values of <0.001 and 0.013, respectively. Each 1 ng/mL increase in ferritin levels increased the likelihood of developing restrictive and obstructive pulmonary dysfunction by 0.2% (OR = 1.002; 95% CI: 1.001–1.003). However, gender, hepatomegaly, and duration of transfusion did not show significant differences.
NLR (Neutrophil-To-Lymphocyte Ratio), MLR (Monocyte-To-Lymphocyte Ratio) and NMLR (Neutrophil-Monocyte-To-Lymphocyte Ratio) as Biomarkers for Establishing the Diagnosis of Tuberculosis in Children Nindy Putri Ferisa; Wisman Dalimunthe; Winra Pratita; Juliandi Harahap; Mahrani Lubis; Fathia Meirina
Indonesian Journal of Global Health Research Vol. 8 No. 1 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i1.476

Abstract

Tuberculosis (TB) in children presents a major diagnostic challenge due to the paucibacillary nature of the infection and difficulties in sputum collection. As an alternative, blood cell ratios such as Neutrophil-to-Lymphocyte Ratio (NLR), Monocyte-to-Lymphocyte Ratio (MLR), and Neutrophil-Monocyte-to-Lymphocyte Ratio (NMLR) have been proposed as hematological biomarkers that can support the diagnosis of TB in children. This study aimed to evaluate the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of NLR, MLR, and NMLR in establishing the diagnosis of TB in children at RS Adam Malik. A retrospective observational study was conducted using data from the TB DOTS medical records of children aged 0–18 years during 2024. Hematologic parameters (neutrophils, monocytes, lymphocytes) and the ratios NLR, MLR, and NMLR were analyzed and compared with clinical and bacteriological TB diagnosis (TCM/BTA). Of the 219 children who met the inclusion criteria, NLR showed a sensitivity of 82.3%, specificity of 78.7%, PPV of 84.9%, NPV of 75.3%, and accuracy of 80.8%. MLR showed a sensitivity of 80.8%, specificity of 75.3%, PPV of 82.7%, NPV of 72.8%, and accuracy of 78.5%. NMLR showed a sensitivity of 76.9%, specificity of 66.3%, PPV of 76.9%, NPV of 66.3%, and accuracy of 72.6%. These ratios were significantly associated with TB diagnosis (p < 0.05). The most common clinical symptoms found in positive cases included persistent cough, prolonged fever, weight loss, and night sweats. NLR, MLR, and NMLR demonstrate good diagnostic value in supporting the diagnosis of TB in children. NLR showed the most optimal results, followed by MLR and NMLR. These hematological ratios can be used as quick, inexpensive, and easily accessible diagnostic aids, especially in facilities with limited bacteriological testing capabilities.
Comparison of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Pediatric Acute Lymphoblastic Leukemia Patients Before and After Induction Chemotherapy M. Arie Wibisono; Olga Rasiyanti Siregar; Fera Wahyuni; Juliandi Harahap; Bidasari Lubis; Fathia Meirina
Indonesian Journal of Global Health Research Vol. 8 No. 1 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i1.552

Abstract

Acute Lymphoblastic Leukemia (ALL) is the most common hematologic malignancy in children. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are simple inflammatory biomarkers that may serve as prognostic and therapeutic response indicators. The aim of this research is to evaluate the differences in NLR and PLR before and after induction chemotherapy and to determine optimal cut-off values for predicting treatment response in pediatric ALL patients. An observational analytic study with a retrospective design was conducted on 48 pediatric ALL patients at Adam Malik General Hospital, Medan. Data were obtained from medical records between January 2023 and December 2024. Consecutive sampling was applied on this study. The Wilcoxon test was applied to assess differences in NLR and PLR, while ROC analysis was used to determine cut-off values, sensitivity, and specificity. Most patients were under 10 years of age (66.7%) and male (58.3%). Following induction chemotherapy, 87.5% achieved complete remission. Significant differences in NLR and PLR were observed before and after therapy (p<0,001). The optimal cut-off for NLR was 2.33 (sensitivity 45.2%, specificity 83.3%), while for PLR it was 219.98 (sensitivity 42.9%, specificity 83.3%). NLR and PLR significantly changed after induction chemotherapy in pediatric ALL patients. Despite limited sensitivity, both markers may serve as simple hematological tools for evaluating treatment response.
Pneumonia among Children with Congenital Heart Disease: Patterns by Shunt Type in A Tertiary Hospital in Indonesia Aris Bayu Retnaningsih Alisyah Maria; Putri Amelia; Fathia Meirina; Juliandi Harahap; Lily Irsa; Olga Rasiyanti Siregar
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1297

Abstract

Congenital Heart Disease (CHD) in children is frequently associated with lower respiratory tract infections, particularly pneumonia. Pneumonia risk in CHD is influenced by shunt type, defect size, nutritional status, yet local data regarding these associations remains limited. To determine the incidence of pneumonia in children with CHD and to analyze its association with shunt type and defect size. This retrospective cross-sectional study consecutively extracted demographic and clinical data—including CHD shunt type and defect size, nutritional status, and pneumonia diagnosis—from 134 echocardiography-confirmed medical records of hospitalized and outpatient pediatric CHD treated at Adam Malik General Hospital, Medan, from January 2022 to December 2024. Data associations were analyzed using Chi-square or Fisher’s exact tests, and prevalence ratios (PR) were calculated. Pneumonia occurred in 32.8% (44/134) of children with CHD. A higher proportion of pneumonia was observed in acyanotic CHD compared with cyanotic CHD (40.3% vs. 25.4%; PR 1.57; p = 0.066). Among acyanotic CHD, pneumonia was more frequent in children with large defects than in those with moderate to small defects (47.0% vs. 38.0%; PR 1.24; p = 0.511). Pneumonia is a frequent complication in children with CHD. Acyanotic CHD and larger defect size show a tendency toward increased pneumonia risk, although no statistically significant associations were identified.
Determinant Factors of Noncompliant Behavior in Treatment with Tuberculosis (TB) Patients Asriwati Amirah; Juliandi Harahap; Khairatunnisa Khairatunnisa; Dian Mayasari Siregar; Senang Hati Bazikho
An Idea Health Journal Vol 6 No 03 (2026)
Publisher : PT.Mantaya Idea Batara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53690/ihj.v6i03.767

Abstract

Background: Pulmonary tuberculosis (TB) is a directly transmitted disease and poses a major threat to human resource development, thus requiring more serious attention from all parties. The objective of this study is to analyze the determinants of treatment non-compliance among pulmonary tuberculosis patients in South Nias Regency. Methods: This study uses a quantitative research design with a cross-sectional approach. The sample in this study used stratified sampling of 6 community health centers with the highest number of TB cases. The sample size was 72 respondents with pulmonary tuberculosis in the working area of the South Nias Regency Health Office. Results: Based on the analysis results, knowledge (p=0.003), duration of treatment (p=0.004), medication supervision (p=0.000) are related to the support of traditional leaders (p=0.001) towards tuberculosis treatment adherence in South Nias district. Conclusions: The recommendations in this study are for health workers to collaborate with various sectors, especially traditional leaders, families, and community organizations, to help provide education and reduce stigma in order to support TB treatment adherence and strengthen medication supervision (PMO) to prevent drug resistance, which can lead to prolonged treatment and the risk of TB transmission.
Co-Authors ardiana ardiana Aris Bayu Retnaningsih Alisyah Maria Arisonang Hutagalung Arlinda Sari Wahyuni Asriwati Amirah Asyiah Simajorang Belni Pulpilasari Bidasari Lubis Dian Mayasari Siregar Dina Keumala Sari Erika Maryanti Harahap Fathia Meirina Fera Wahyuni Fujiati, Isti Ilmiati Hartati Zuraidah Rangkuti Hendri Wijaya Hervina Hervina Ika Citra Dewi Tanjung Ismail Efendy Johannes Harlan Saing Juli Yosa Mega Khairatunnisa Khairatunnisa Kiking Ritarwan Lily Irsa M Ridho M. Arie Wibisono Mahrani Lubis Nindy Putri Ferisa Olga Rasiyanti Siregar Putri Amelia Putri Amelia Putri Chairani Eyanoer, Putri Chairani Putri Nahrisa Nasution R. Lia Kusumawati Rina Amelia Ririe Fachrina Malisie Rita Evalina Senang Hati Bazikho Siska Mayasari Lubis Sudiro Sudiro Syamsidah Lubis Syamsul, Darwin Tria Diana Lestari Warli, Syah Mirsya Winra Pratita Wisman Dalimunthe Yunanda, Yuki Yuniati Yuniati