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All Journal BALI MEDICAL JOURNAL (BMJ) Sport and Fitness Journal Jurnal Ergonomi Indonesia (The Indonesian Journal of Ergonomic) E-Journal Of Cultural Studies INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES E-Jurnal Medika Udayana Indonesia Medicus Veterinus Majalah Ilmiah Fisioterapi Indonesia JURNAL BIOMEDIK Prosiding Seminar Nasional MIPA Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) Indonesian Journal of Obstetrics & Gynecology Science ISM (Intisari Sains Medis) : Jurnal Kedokteran Jurnal Pendidikan Kesehatan Rekreasi Neurologico Spinale Medico Chirurgico IJAAM (Indonesian Journal of Anti-Aging Medicine) International Journal of Industrial Engineering and Engineering Management Journal of Global Pharma Technology The International Journal of Medical Science and Health Research
J. A. Pangkahila
Department Of Andrology And Sexology, Faculty Of Medicine, Universitas Udayana, Denpasar
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

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Journal : INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES

 1 
SEXUAL ABSTINENCE AND IMMOBILISATION STRESS DECREASED NITRATE + NITRITE CONCENTRATION AND INCREASED NECROTIC OF PENILE CORPUS CAVERNOSUM SMOOTH MUSCLE AND ENDOTHELIAL CELLS OF ADULT MALE MICE Karmaya, I.N. Mangku; I. Pangkahila, Wimpie; Pangkahila, J. Alex
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 4, No. 1 Januari 2010
Publisher : Udayana University

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Abstract

Sexual intercourse in adult people is not only related to reproduction,recreation and better relation but also for maintaining good health. Regular andfrequent sexual intercourse has protective role for cardiovascular disease, malignancyand often related with longevity. On the contrary less frequent sexual intercourse isoften correlated to early death and reproductive organ disorders. One main factorwhich involve in any process related to sexual intercourse is nitric oxide. Thisresearch aims to know the declination of total nitrate and nitrite concentration as themain oxidation product of nitric oxide and necrosis of the endothelial and smoothmuscles of corpus cavernosum after three month sexual intercourse abstinence andstress immobilization.By randomized pretest-posttest control group design, the research wasconducted in adult male mice (Mus musculus) which were divided into four groups.each consisted of seven mice. One group as a control and the other three wereexposed to sexual abstinence, immobilization stress and the combination of sexualabstinence and immobilization stress in three months period. The investigation wascarried out to the penile total nitrate and nitrite concentration and the histologicalchanges of the middle part of the penile shaft. To know the degree of lesion then thecalculation of the histologic features was done in five view fields of every preparat.The result was compared to control group.In this research, the mean of total nitrate and nitrite decline and the lowest wasfound in the combine intervention groups with significance level p < 0,005. Thecorpus cavernosum in the intervention groups showed multifocal necrosis onendothelial and smooth muscle cells of corpus cavernosum with picnotic nuclei,irregular form and dark colour. Some muscle cells are lysis. These features werefound in three among seven samples in sexual abstinence group, two among sevensamples in immobilization stress group and in all samples of combined interventiongroup.Conclusions can be drawn from this research are that the sexual abstinence,immobilization stress and the combine interventions decline the nitrate and nitriteconcentrations and induce endothelial and smooth muscle cells necrosis of the copuscavernosum.
INTERVAL RUNNING EXERCISE REDUCES RUNNING TIME OF 800 METERS DASH WITHOUT CAUSING INCREASED LEVEL OF SGOT – SGPT IN MALE STUDENTS OF THE FACULTY OF SPORTS SCIENCES, MANADO STATE UNIVERSITY Galatang, Alprodit; Alex Pangkahila, Jahja; Ngurah Nala, I Gusti; Tirtayasa, Ketut
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 3, No. 2 Juli 2009
Publisher : Udayana University

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Abstract

The effort to gain best achievement in sports by means of exercise has twodilemmatic sides, both for the coaches and sport promoters. On one side, exercise shouldbe done intensely and maximally, but on the other side, it is a known fact that excessiveand maximal exercises can damage the body organs. The purposes of this study were toobserve the side effects of interval running exercise of 800 meters, to find out level offatigue by examining lactate acid produced by each model, and to assess the negativeeffects on organs as indicated by the level of SGOT-SGPT. The exercise model appliedin the study comprised interval running of 2 x 800 meters, 4 x 400 meters, 8 x 200meters, 16 x 100 meters and one standard of comparison exercise, which was runningexercise of 2 x 800 meters with passive rest. This study was true experimental usingrandomized pre-test-post-test control group design. Samples of this study were 27 malestudents of the Faculty of Sports Sciences, Manado State University, who were dividedinto five groups. Group 1 was with interval running exercise of 2 x 800 meters. Group 2was assigned to interval running exercise of 4 x 400 meters. Group 3 was with intervalrunning exercise of 8 x 200 meters. Group 4 was with interval running exercise of 16 x100 meters. Group 5 as comparison standard was with running exercise of 2 x 800 meterspassive rest. All the exercise models were carried out for six weeks, each with afrequency of three times a week. Results of the study showed that the five groupsdemonstrated reduction of running time of 800 meters dash (p<0.05), lactate acidproduction differed in some of the groups (p>0.05), levels of SGOT and SGPT of allgroups did not show significant increase (p>0.05). From the above findings, it can beconcluded that all exercise models of interval running 2 x 800 meters, 4 x 400 meters, 8 x200 meters, 16 x 100 meters and 2 x 800 meters with passive rest lowered the runningtime of 800 meters dash and did not increase level of SGOT-SGPT.
MODEL AKTIVITAS PRAKTIKUM LAPANGAN BERBASIS ERGONOMI (APeLErg) MEMPERBAIKI RESPON FISIOLOGIS TUBUH, MENURUNKAN KELELAHAN, DAN MENINGKATKAN KINERJA, DIBANDINGKAN DENGAN MODEL LAMA (APeL), PADA MAHASISWA FMIPA UNIMA Palilingan, Rolles; Manuaba, Adnyana; Adiputra, Nyoman; Pangkahila, Alex
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 3, No. 1 Januari 2009
Publisher : Udayana University

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Abstract

Aktivitas praktikum lapangan merupakan kegiatan yang dilakukan sebagaiimplementasi kurikulum akademik di Jurusan Fisika FMIPA UNIMA. Sebagaiimplementasi kurikulum tersebut telah dibuat model aktivitas praktikum lapangan (modelAPeL) dan telah digunakan sejak tahun 2001. Namun model APeL ternyata menimbulkanrisiko yang merugikan bagi mahasiswa dilihat dari respon fisiologis dan kelelahansehingga mahasiswa belum dapat mencapai kinerja yang diharapkan. Untuk itu telahdiupayakan dengan penerapan pendekatan ergonomi total (PET) suatu model baru yaitumodel APeLErg. Untuk menguji keandalan model APeLErg dibandingkan dengan modelAPeL, telah dilakukan penelitian dengan hipotesis: model APeLErg, dibandingkan denganmodel APeL; memperbaiki respon fisiologis tubuh; menurunkan kelelahan; danmeningkatkan kinerja mahasiswa di daerah dataran rendah/panas dan di daerah datarantinggi/dingin. Penelitian ini dilakukan dalam dua tahap dengan menggunakan rancangansama subjek. Penelitian pada tahap pertama dilakukan di daerah panas denganmenggunakan 15 orang subjek sedangkan penelitian tahap kedua di daerah dinginmenggunakan 18 orang subjek. Hasil penelitian tahap I dan tahap II menunjukkan bahwaaktivitas dengan model APeLErg dapat: memperbaiki respon fisiologis mahasiswa secarasignifikan (p<0,05); menurunkan rata-rata skor kelelahan umum secara signifikan(p<0,05); meningkatkan kecepatan, kekonstanan dan ketelitian mahasiswa secarasignifikan (p<0,05); dan meningkatkan kinerja mahasiswa secara signifikan (p<0,05). Darihasil penelitian ini dapat disimpulkan bahwa model APeLErg dapat: memperbaiki responfisiologis mahasiswa; menurunkan tingkat kelelahan mahasiswa; dan meningkatkankinerja mahasiswa dalam melakukan aktivitas praktikum lapangan.
VARIES SHUTTLE RUN EXERCISE METHODS INCREASE AGILITY OF STUDENTS OF SMK NEGERI 2 TONDANO KABUPATEN MINAHASA Sarapung, M; Pangkahila, J. A.; Adiputra, N.; Adiatmika, IPG
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 6, No. 1 Januari 2012
Publisher : Udayana University

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Abstract

ABSTRACT Achievment of Indonesian athletes at international level are only resting on badminton, archery, and weight lifting. Meanwhile, other sports do not exhibit encouraging achievement. Agility is one of the important factor on sports including group and individual sports. This is an experimental research with randomized pretest posttest conrol group design. Sample are 75 students recruited from SMK Negeri 2 Tondano Kabupaten Minahasa. Sample was grouped into 5 groups, each group composed of 15 students. The five groups observed were group 1 with treatment of 4 x 30 m shuttle run, group 2 treated with 8 x 15 m shuttle run, group 3 with 12 x 10 m shuttle run, group 4 within 16 x 7.5 m shuttle run, and the last is control group. Exercise was carried out for 6 weeks with a frequent of 3 time per week. Agility pre and posttest data were analysed using anova oneway followed by LSD Post Hoct Test at 5% significant level. This study obtained that there were a significant different among the five groups observed. Shuttle run exercise method with dose of 16x7.5 m increase the highest agility.
GARCINIA MANGOSTANA L. RIND EXTRACT AND PHYSICAL TRAINING REDUCE OXIDATIVE STRESS IN WISTAR RATS DURING MAXIMAL PHYSICAL ACTIVITY Arsana, I N.; Adiputra, N.; Pangkahila, J. A.; Putra-Manuaba, and I. B.
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol 7 No 2 (2013): IJBS Vol2 No2
Publisher : Udayana University

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Abstract

Oxidative stress is a condition of imbalance between the production of free radicals or reactive oxygen species (ROS) and antioxidants, in which the levels of free radicals higher than antioxidants. One causes of oxidative stress is the maximum physical activity. Oxidative stress can be reduced by antioxidants. One source of antioxidants is mangosteen rind (Garcinia mangostana L). This study aimed to investigate the role of mangosteen rind extract and physical training in reducing Malondialdehyde (MDA, increasing Superoxide dismutase (SOD) and Glutathione Peroxidase (GPx). This study used a randomized block design with factorial pattern of 6 x 2 with four repetitions. The first treatments are mangosteen rind extract with doses; 0, 50, 100; 200; 300, and 400 mg/kg bodyweight/day for four weeks. The second treatments are the physical training consists of; without and with physical training. MDA, SOD and GPx were assessed in the end of treatment. Data were analyzed with GLZ. The results showed that average of MDA, SOD and GPx different significantly (p<0.05) after administration of extracts as well as physical training. Extracts and physical training concurrently also showed effect significant (p<0.05). However, at doses 0 until 300 mg/kg bodyweight, MDA levels more higher while SOD and GPx lower significantly (p<0.05) at training group compared with without training. Whereas at dose 400 mg/kg bw, MDA lower at training (p>0.05), while SOD and GPx were recorded significantly (p<0.05) higher than the group without training. Overall, it could be concluded that physical training with administration of mangosteen rind extract reduce oxidative stress through reduction of MDA, as well as increased both SOD and GPx.
EXERCISE REDUCE OXIDATIVE DAMAGE IN PREGNANCY Wagey, F. W; Pangkahila, A.; Surya, I.G.P; Bagiada, A
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 5, No. 2 Mei 2011
Publisher : Udayana University

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Abstract

Pregnancy is a vulnerable condition to all kinds of "stress", resulting in changes of physiological and metabolic functions. This research aims to determine effect of exercise during pregnancy in reducing oxidative demage marked by decrease of malondialdehyde and 8-hydroxy-diguanosine levels. Randomized pre and posttest control group design was employed in this study. A number of 66 pregnant women were recruited in this study and grouped to two groups, i.e 30 of them as control group and the rest as treatment group. Pregnancy exercise was performed to all 36 pregnant women from 20 weeks gestation on treatment group. The exercise was performed in the morning for about 30 minutes, twice a weeks. On the other hand, daily activities was sugested for control group. Student’s t-test was then applied to determine the mean different of treatment and control group with 5 % of significant value. This study reveals that there were significantly higher decrease of (MDA) and 8-OHdG about 0.15 nmol/ml and 0.08 ng/ml, respectively, amongs treatment and control groups (p < 0.05). Clinical outcomes, such as strengten of pelvic muscle and quality of life of treatment group were significantly better compared to control group (p < 0.05). This means that exercise during pregnancy ages of 20 weeks decrease MDA and 8-OHdG levels higher compare to control group without exercise.
Co-Authors - Yuniar ., Zenitalia A Bagiada A.A.G.P. Wiraguna adiartha g Adiputra, IN. Adiputra, LMI. Sri Handari Adiputra, LMIS. Handari Adnyana Manuaba Agus Eka Darwinata AL UM ANISWATUN KHASANAH Alprodit Galatang Anak Agung Gede Sugianthara and I. B. Putra-Manuaba Ariati, N.N. Bagus Komang Satriyasa Bambang Widayanto Benediktus Nahak Boedi Prihatini Yenniastoeti Catarina Budi P Chandra, Aji B. Christine Icasia Cornalius O. Lenati D A inten Delly Dahlia Dian Andrieany Husodo Dian Damayanti Dianika Putri Puspitasari Edelweishia, Melissa Eko Wibowo Emiliana Mariyah F. W Wagey Fatqur Rochman Ferbian M. Siswanto, Ferbian M. Ferbian Milas Siswanto Gimbar Adiputra Griadi, IP. Adiartha Hapy Ardiaviandaru Siamy HARA, MARIA KARERI Hening Laswati Heny Widiyowati S I Dewa Ayu Inten Dwi Primayanti I Dewa Putu Sutjana I Gede Widhiantara I Gede Widjanegara I Gusti M. Aman I Gusti Made Aman I Gusti Ngurah Nala I Ketut Suada I Made Ady Wirawan I Made Bakta I Made Jawi I Made Krisna Dinata I MADE MULIARTA . I Nengah Sandi I Nyoman Adi Putra I Nyoman Adiputra I Nyoman Arsana I Nyoman Mangku Karmaya I Nyoman Nuada I Putu Adiartha Griadhi I Putu Agus Budi Sudarsana I Putu Gede Adiatmika I Wayan Rasmen Adikusuma I Wayan Sugianta I Wayan Suryawan I Wayan Weta I.B. Adnyana Manuaba I.G.P Surya Ida Bagus Ngurah Ida Sri Iswari IKW. Suryawan Imam Subadi, Imam IN. Adiputra indah adiputra Indah Pramita Indra Lesmana IP. Adiartha Griadi Irtanto, Okky Iswita Ariestianti Jasmine Kartiko Pertiwi K tirtayasa Kadek Tresna Adhi Ketut Tirtayasa Klaudius H. M. Meti Komang Ayu Tri Widhiyanti La Ode Muhammad Gustrin Syah Leandra Erdina Usmany LMI. Sri Handari Adiputra LMIS. Handari Adiputra Luh Made Indah Luh Made Indah Sri Handari Adiputra Luh Putu Ratna Sundari M Sarapung M. Ali Imron M. Irfan Made Oka Negara Mangestuti Agil Manuaba, I.B.P MB. Redy Utama Meisy Andriana, Meisy Moh Ali Imron Mohammad Syahroni Muh Irfan Muh. Ali Imron Muh. Irfan Muh. Irfan Muhammad Irfan Muhammad Irfan Muhammad Irfan Mutiah Munawarah N. Adiputra N. Adiputra N. Sandi, N. Ni Ketut Dewita Putri Ni Komang Ayu Juni Antari Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Putu Widarini Ni Putu Widya Astuti Ni Wayan Tianing Nurmalia Fitria Ningrum NW. Tianing Nyoman Suarjana Oktovianus Fufu Oktovianus Fufu Pamella Haryanto Pangkahila, Evangelista Maria Patricia Maria Kurniawati Periskila Abigail Prof. Dr. I Nyoman MS SH. Sirtha Putri Mariani, Putri R. A.T. Kuswardhani Regina Sesilia Noy Retno Widyowati Risha Catra Pradhany Rita Maria Rolles Palilingan Romy Kamaluddin Ronald Suryaprawira S. Indra Lesmana S. Indra Lesmana S. Indra Lesmana Santi Bery Hastuti Sugijanto - Sugijanto - Suryawan, IKW. Susy Purnawati Sutajaya, I.M. Syahmirza Indra Lesmana Tarnajaya, Karnia Taufan Hendra Wirawan Tianing, NW. Tirtayasa, K. Ursula Sulistiani Utama, MB. Redy Valentine Retny Shiajanto Weta, IW. Widianti, I Gusti Ayu Wijaya Surya, I Gede Ngurah Harry Wimpie I Pangkahila Wirawan, IMA. Yoselyn Gunawan Yuliana Ratmawati