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All Journal HAYATI Journal of Biosciences Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya MANDALA of Health Research Journal of Life Science STOMATOGNATIC- Jurnal Kedokteran Gigi Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Jurnal Fish Protech Amerta Nutrition E-Prodenta Journal of Dentistry Jurnal Impresi Indonesia Indonesian Health Journal Acta Odontologica Indonesia
Nur Permatasari
Universitas Brawijaya
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Physalis angulata Leaf Ethanol Extract Reduces Oxidative Stress and Improves Endothelial Progenitor Cells in L-NAME-Induced Hypertensive Rats Dian Nugrahenny; Nur Permatasari; Setyawati Soeharto; Indriati Dwi Rahayu; Edwin Widodo; Karyono Mintaroem; Hidayat Sujuti; Retty Ratnawati; Elly Mayangsari; Dicky Faizal Irnandi; Lavina Sofia Ardani; Tika Ardhini Wardoyo; Nathania Bella Claresta; Nura Fattah Cantika Yoga; Adinda Chika Anindita; Niarti Ulan Sari Siarnu; Fardizia Putri Alia
HAYATI Journal of Biosciences Vol. 30 No. 1 (2023): January 2023
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.30.1.81-87

Abstract

This study aimed to evaluate the effects of ciplukan (Physalis angulata L.) leaf ethanol extract on L-NG-nitroarginine methyl ester (L-NAME)-induced hypertensive rats. We randomly divided twenty-five Wistar rats into five groups. The sham group was given a PBS injection. The hypertensive group was injected with L-NAME on days 1 to 28. Three groups of hypertensive rats were given the extract on days 4 to 28. Blood pressure was measured using the tail-cuff method on days 0, 4, 10, and 27. The endothelial progenitor cells (EPCs) in the blood were measured by flow cytometry as a percentage of circulating angiogenic cells (CACs, CD34+/CD309+/CD45+) and endothelial colony-forming cells (ECFCs, CD34+/CD309+/CD45-). Serum NO and MDA levels, as well as serum SOD activity, were measured colorimetrically. Serum TNF-α levels were measured by the ELISA method. The ciplukan leaf extract reduced systolic and diastolic blood pressure, reduced the percentage of EPCs in the blood, increased serum NO levels, reduced MDA levels, increased serum SOD activity, and reduced serum TNF-α levels in L-NAME-induced hypertensive rats. It is concluded that ciplukan ethanol leaf extract exerts protective effects on L-NAME-induced hypertensive rats. These study results can strengthen the scientific basis of using ciplukan leaf ethanol extract to treat hypertension.
Secretory Leukocyte Protease Inhibitor (SLPI) Decreased the Celluler Expression of NF-Kβ and IL-1β on Wound Macrophages of Rattus novergicus Post Tooth Extraction Agustine Hanafi Putri; Abdur Razaq Komaruzzaman; Putri Noerpuspita; Delfi Fitriyani; Nur Permatasari; Edi Widjajanto
Journal of Tropical Life Science Vol. 6 No. 3 (2016)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.06.03.05

Abstract

Prevalence of tooth extraction or dental surgery was 48.5% of all dental care in Indonesia. Tooth extraction carries potential health risks and side effects such as pain, swelling, trismus and dysfunction of the oral cavity during recovery. Secretory leukocyte protease inhibitor (SLPI) is one of innate immunity proteins that can inhibit the activation of macrophages. We are expecting the provision of SLPI can decrease excessive inflammatory response in healing after tooth extraction. This study was to investigate the administration of SLPI on cellular expression of NF-Kβ and IL-1β on wound macrophages of Rattus novergicus post tooth extraction. The research design is in vivo experimental study. In total, 20 rats were randomly divided into four groups (each group n=5) and underwent tooth extraction on left incisor teeth of mandible. One of the groups did not receive SLPI administration (control group) and the socket was stitched after tooth extraction. Meanwhile, the remaining three groups (experimental groups) were given SLPI administration after tooth extraction with three different doses (0.1 µM, 0.5 µM and 2.5 µM, respectively). After SLPI administration, the socket of experimental groups was stitched. The effects of SLPI administration were evaluated by counting at the percentage of NF-Kβ translocation and the expression of expression of IL-1 in macrophages cells of the rat socket using immunohistochemistry analysis. The cellular expression of NF-Kβ and IL-1β were significantly decreased (p < 0.05) on groups with SLPI may decrease cellular expression of NF-Kβ and IL-1β on wound macrophages cells of rats post tooth extraction in a dosedependent manner.
Penyebab Stroke Perspektif Kesehatan Mental Nur Amalia Permatasari
Jurnal Impresi Indonesia Vol. 2 No. 1 (2023): Jurnal Impresi Indonesia
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jii.v2i1.1790

Abstract

Pendahuluan: Kesehatan Fisik dipengaruhi dari kesehatan jiwa. Mayoritas masyarakat memiliki prioritas kesehatan secara fisikly seperti makan sehat, olah raga dan pola hidup sehat. Kekeliruan dari aspek perkembangan mental seseorang karena kehidupan lingkungan kurang sehat seperti tidak memiliki jiwa sehat, emosi labil, pemikiran negative, tidak nyaman dan tekanan mental lainnya menyebabkan jiwa kurang sehat. Kondisi demikian mempengaruhi peredaran darah yang tidak lancar. Tujuan: Tujuan penelitian ini untuk memberikan pemahaman secara umum kepada masyarakat untuk mampu memberikan kontribusi keilmuan dalam menjalani pola hidup sehat secara fisik dan psikis. Metode: Metodologi penelitian dengan menggunakan pendekatan kualitatif desain library research. Data diperoleh dari beberapa literature rivewe dan diberikan dukungan informan melalui buku digital maupun elektronik. Hasil: Hasil penelitian menggambarkan bahwa kehidupan sehat layaknya individu yang mampu menciptakan lingkuangan bersih secara fisik dan psikis. Mampu meminimalisir perilaku, pikiran dan sikap negative sebagai usaha sadar memberikan kontribusi terhadap kesehatan mental secara penuh menciptakan suasana bahagia dan meningkatkan kesehatan fisik. Kesimpulan: Upaya demikian salah satu bagian dari tindakan meminimalisir resiko serangan struk. Analisis studi literature memberikan deskripsi umum bahwa kesehatan mental memiliki peran penting dalam meningkatkan aspek kesehatan fisik. Siklus peredaran darah, situasi rileks dan bebas dari tekanan mental dapat membantu individu dalam menjaga kesehatan. Kekuatan mental yang sehat dapat mempengaruhi sugesti positif sehingga membentuk pola kehidupan sehat
Effect of Histatin-1 Proteins to Fibroblasts Growth Factor-2 (FGF2) Concentrate and Fibroblasts Cell Migration on Human Gingival Fibroblast (HGF) Culture Dewi, Ni Ketut Ayu Feriyanti; Permatasari, Nur; Sujuti, Hidayat
Research Journal of Life Science Vol 8, No 2 (2021)
Publisher : Direktorat Riset dan Pengabdian Masyarakat, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.rjls.2021.008.02.4

Abstract

The purpose of this study is to determine the effect of histatin-1 protein increasing the concentration of fibroblast growth factor (FGF2) and fibroblast cell migration in human gingival fibroblast (HGF) culture. The HGF cell culture used was obtained from odontectomy patients and was the result of the 4th passage. Cell culture was divided into 4 groups: HGF control group (without treatment) and treatment groups with 5µM, 10µM, and 20µM concentration of histatin-1 respectively. The amount of fibroblast growth factor 2 (FGF2) was quantified by using ELISA method. In vitro fibroblast cells migration was measured using scratch/wound healing assay method. FGF2 concentration and HGF cell migration were measured at hour 0, 3, 11, 24, and 48. The results of the One Way Anova statistical test difference between FGF 2 (ΔFGF2) at hour 24 showed a value of P = 0.042 (P≤0.05) and HGF cell migration at hour 11 showed a P value = 0.003 (P≤0.05). The conclusion of this study is that Histatin-1 Protein is able to increase the concentration of Fibroblast Growth Factor 2 (FGF2) and the migration of Human Gingival Fibroblast cells.
Effectiveness Of Ciplukan Stem Water Extract (Physalis Minima L.) On Malondialdehyde Levels Of Mandibular Bones Of White Rats (Rattus Norvegicus) Wistar Strain Post Ovariectomy Fadhilah, Nadia; Permatasari, Nur; Widodorini, Trining
Indonesian Health Journal Vol. 4 No. 3 (2025): Indonesian Health Journal
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/ihj.v4i3.808

Abstract

Estrogen functions as an antioxidant that can suppress free radicals. Hypoestrogenic conditions will increase oxidative stress. Periodontitis is a disease related to oxidative stress. The occurrence of oxidative stress is characterized by increased levels of malondialdehyde (MDA). Malondialdehyde is commonly used to assess oxidative stress. Phytoestrogens are components of plants that have biological activity similar to estrogen. Ciplukan plants are suspected to be phytoestrogen compounds. Based on theoretical studies, it is suspected that the ciplukan stem contains physalin, which has a similar effect to the action of estrogen. The purpose of this study was to determine the effectiveness of ciplukan stem water extract on the level of malondialdehyde of the mandibular bone in white rats of the post-wistar strain ovariectomy. Twenty-four mice were randomly divided into 6 groups with 4 mice each, namely 3 control groups and 3 treatment groups of mice given an extract dose of 500 mg/kgBB, 1,500 mg/kgBB, and 2,500 mg/kgBB for 4 weeks. MDA levels were calculated by thiobarbituric acid (TBA) test and read with a spectrophotometer, kemudian made MDA work curve. The results showed that the increase in MDA levels could be inhibited by the administration of a dose of 500 mg/kg BB, while a dose of 1500 mg/kg BB 2500 mg/kg BB could improve MDA levels close to normal. There was a strong correlation with a negative direction between the dose of ciplukan stem water extract and the MDA level of the mandibular bone (r=--0.507). The conclusion of this study is that the administration of ciplukan stem water extract can reduce the MDA level of mandibular bone in white rats of wistar strain after oophorectomy.
Pengaruh Gel Kombinasi Ekstrak Jintan Hitam (Nigella sativa L.) dan Kulit Manggis (Garcinia mangostana L.) terhadap Pembentukan Kolagen Penyembuhan Luka Ulkus Traumatikus pada Tikus Wistar (Rattus norvegicus) Zahrah, Annisa Lathifah; Permatasari, Nur
Acta Odontologica Indonesia 2026: June Edition (Article in Press)
Publisher : Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/actodont.29472

Abstract

Ulkus traumatikus merupakan lesi jaringan lunak rongga mulut akibat rusaknya epitel karena trauma. Terapi umum menggunakan triamcinolone acetonide efektif, tetapi berisiko efek samping jangka panjang. Sebagai alternatif, tanaman herbal seperti jintan hitam dan kulit manggis yang mengandung thymoquinone dan xanthone dapat meningkatkan kolagen melalui stimulasi PDGF, TGF-β, dan EGF. Penelitian ini bertujuan untuk mengetahui pengaruh gel kombinasi ekstrak jintan hitam (Nigella sativa L.) dan kulit manggis (Garcinia mangostana L.) terhadap pembentukan kolagen pada penyembuhan ulkus traumatikus tikus Wistar (Rattus norvegicus). Metode Randomized Post Test Only Controlled Group Design dilakukan pada 40 ekor tikus Wistar yang terbagi menjadi 10 kelompok (K-, K+, P1, P2, dan P3) dengan 2 time series (hari ke-6 dan 12). Kolagen pada area ulkus traumatikus mukosa labial rahang bawah tikus Wistar dianalisis dari preparat dengan pewarnaan Masson’s trichrome menggunakan digital slide scanner dengan perbesaran 100x, lalu diuji statistik dengan Independent t-Test dan One-Way ANOVA. Hasil menunjukkan kelompok gel kombinasi memiliki rata-rata luas area kolagen yang lebih tinggi pada hari ke-6 dan 12 dibanding kelompok lain. Dapat disimpulkan bahwa gel kombinasi ekstrak jintan hitam dan kulit manggis berpengaruh terhadap pembentukan kolagen pada penyembuhan ulkus traumatikus tikus Wistar.
EFEKTIVITAS EKSTRAK AIR BATANG CIPLUKAN (Physalis minima L.) TERHADAP KADAR MALONDIALDEHID TULANG MANDIBULA TIKUS PUTIH (Rattus norvegicus) Strain Wistar Pasca Ovariectomy Fadhilah, Nadia; Permatasari, Nur; Widodorini, Trining
E-Prodenta Journal of Dentistry Vol 9 No 2 (2025)
Publisher : Fakultas Kedokteran Gigi UB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.eprodenta.2025.009.02.2

Abstract

Estrogen has function as an antioxidant that can reduce free radicals. Hipoestrogen condition will increase oxidative stress in the body. Periodontitis is one of the diseases associated with oxidative stress. Oxidative stress, characterized by increased levels of malondialdehid (MDA). Malondialdehid is usually used to assess the oxidative stress. Phytoestrogens are plant components that have biological activity of estrogen. Ciplukan is a natural ingredient or plant suspected to be a phytoestrogen compound. The theoretical study results showed that ciplukan stem contained physalin, which have a similar effect to estrogen. The purpose of this study is to determine the effectiveness of ciplukan stem extract on malondialdehyde levels in the rat mandibular bone post ovariectomy. Twenty four rats were randomly divided into 6 groups with each 4 rats, that are 3 control groups and 3 groups treated rats that were given the ciplukan stem extract at the end of the first 5 weeks ovariectomy with three different doses: 500 mg/kg BW (K4), 1.500 mg/kg BW (K5), and 2.500 mg/kg BW (K6) for 4 weeks. MDA levels calculated by thiobarbituric acid (TBA) test and read by a spectrophotometer and MDA standard curve created. The results showed the incease of MDA levels can be inhibited at the dose of 500 mg / kg, while at the dose of 1500 mg/kg BW and 2500 mg/kg BW can restore MDA levels similar to normal. There is a strong correlation between the negative direction doses of ciplukan stem extract with MDA levels in mandibular bone (r = -0.507). The conclusion of this study is the ciplukan stem extract can reduce MDA levels in mandibular bone strain of wistar rats after ovariectomy.
Co-Authors Abdur Razaq Komaruzzaman Adinda Chika Anindita Agustin Iskandar Agustine Hanafi Putri Ahmad Reza Fadhlurrahman, Ahmad Reza Akhmad Sabarudin Amandia Dewi Permana Shita Anik Puryatni Annasari Mustafa Aswin D Baskoro, Aswin D Cahyani, Dwi Indah Citra Tarannita Damayanti, Elok Delfi Fitriyani Devitaningtyas, Nungky Dewi, Ni Ketut Ayu Feriyanti Dian Nugrahenny Dicky Faizal Irnandi Edi Widjajanto Edi Widjajanto Edwin Widodo Fadhilah, Nadia Fardizia Putri Alia Ferdian Rizky Hutomo, Ferdian Fitriyani, Delfi Hafiedz Maulana Happy Kurnia P Hidayat Sujuti Ibrahim, Moh. Nuh Indriati Dwi Rahayu Joko Agus Gunawan Kartika Andari Wulan, Kartika Karyono Mintaroem Khadafi Indrawan Komaruzzaman, Abdur Razaq Lavina Sofia Ardani Loeki Enggar Fitri M Aris Widodo Mayangsari, Elly Meilia Aquina Meilia Aquina, Meilia Mohamad Nur Ibrahim Muhammad Nurul Amin Nathania Bella Claresta Niarti Ulan Sari Siarnu Noerpuspita, Putri Nour Athiroh Abdoes Sjakoer Nura Fattah Cantika Yoga Nuzulul Hikmah Putri Noerpuspita Putri, Agustine Hanafi Retty Ratnawati Retty Ratnawati Setyawati Soeharto Setyawati Soeharto Sidharta, Rudhanton Siti Nurfitria, Siti Sri Widyarti Stefania Widya Setyaningtyas Sudiarto Sudiarto Tika Ardhini Wardoyo Widodorini, Trining Zahrah, Annisa Lathifah