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All Journal HAYATI Journal of Biosciences Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya MANDALA of Health Research Journal of Life Science STOMATOGNATIC- Jurnal Kedokteran Gigi Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Jurnal Fish Protech Amerta Nutrition E-Prodenta Journal of Dentistry Jurnal Impresi Indonesia
Nur Permatasari
Universitas Brawijaya
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Cysteine, Malondyaldehide (MDA) and Glutathione (GSH) Levels in Marasmic Type Malnutrition Cahyani, Dwi Indah; Puryatni, Anik; Permatasari, Nur
Journal of Tropical Life Science Vol 7, No 2 (2017)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.07.02.11

Abstract

Micronutrien deficiency in severe malnutrition will reduce antioxidant capacity that needed for oxidative stress defense. Cysteine, a non-essential amino acid, is one of an important component for reduced glutha-tione (GSH). This study aims to prove the difference between the levels of cysteine, MDA and GSH levels in children with marasmic malnutrition and well-nourished children and prove whether there is a relationship between those parameters. Fiftysix patients participated in this study were grouped into two groups of sam-ples that were marasmic type malnutrition group (28 patients) and control groups that were well nourished group (28 patients). Examination begins with a complete laboratory screening, followed by examination of cysteine, MDA and GSH level. Of the 28 patients included in marasmic type malnutrition group consisting of 15 male patients (53.6%) and 13 female patients (46.4%), while the well-nourished group consisted of 13 male patients (46.4%) and 15 female patients (53.6%). The average age is 54.61±56.35 months in the group of ma-rasmic type malnutrition and 48.25±45.34 months in the well-nourished group. By using the Mann Whitney test, there were significant difference between the levels of cysteine and GSH in marasmic malnutrition and control group (p = 0.000 and p = 0.000 respectively). Spearman correlation test between cysteine and GSH levels, cysteine and MDA levels, MDA and GSH levels in marasmic malnutrition children shows no significant correlation (R = -0.206, p = 0.294; R = -0.036, p = 0.856; R = 0.210, p = 0.284 respectively). In well-nourished group Spearman correlation test between cysteine and GSH levels, cysteine and MDA levels, MDA and GSH levels also shows no significant correlation (R = -0.053, p=0.789; R = -0.146, p = 0.458; R = -0.079, p = 0.688 re-spectively). From this study it can be concluded that there are significant differences of the levels of cysteine and GSH between severe malnutrition groups compared with the control one. But this study shows no signif-icant correlation between the levels of cysteine and GSH levels in marasmic type malnutrition and well-nourished children.
The Effect of Different Orthodontic Force on MMP 9 Expression in a Rat Diabetic Model Maulana, Hafiedz; Hikmah, Nuzulul; Shita, Amandia Dewi permana; Permatasari, Nur; Widyarti, Sri
Journal of Tropical Life Science Vol 4, No 2 (2014)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Orthodontic forces produce alveolar bone and periodontal ligament remodeling that cause tooth movement. Diabetes can increase tissue damage and, therefore, contributes to the process of orthodontic tooth movement. The aim of this study was to determine the effect of differently orthodontic forces on the expression of MMP nine in rat diabetic model. Twenty four male Wistar rats were divided into three groups of control and three groups of treatment streptozotocin-induced diabetes with stratified doses. Application of orthodontic appliance was performed with different forces (10, 20 and 30 grF). Orthodontic appliance was performed on both upper incisors. Immunohistochemical (IHC) analysis was used to observe the expression of MMP 9 and HE (Hematoxylen Eosin) staining to observe the number of fibroblasts. Statistical analysis was carried out using t-test and Spearman correlation analysis to determine the difference of MMP nine expression and number of fibroblasts between groups, and determine the correlation of both. The results showed an increased expression of MMP 9 and decreased of fibroblasts number in diabetic rats, along with increasing magnitude of orthodontic forces. The different orthodontic forces given to diabetic rats affect the expression of MMP 9 and the number of fibroblasts, in which the expression of MMP 9 increased along with the increase of orthodontic forces, both at pressure and tension sides.
POTENSI KARBOKSIMETIL KITOSAN SEBAGAI ANTIKANKER DENGAN PENDEKATAN LABORATORIUM Ibrahim, Moh. Nuh; Widjajanto, Edi; Permatasari, Nur; Sabarudin, Akhmad
Jurnal Fish Protech Vol 1, No 1 (2018): Jurnal Fish Protech, April 2018
Publisher : Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33772/jfp.v1i1.4066

Abstract

Faktor prilaku dan pola makan yang tidak sehat dapat menyebabkan penyakit kanker. Penyakit ini menjadi penyebab utama kematian seluruh dunia.  Kanker dapat terjadi akibat paparan radikal bebas atau disebut ROS salah satu produknya adalah hydrogen peroksida. Ketidakseimbangan ROS dengan antioksidan menyebabkan oxidative stress dan oxidative damage sel tubuh. Untuk itu dibutuhkan antioksidan pencegah terjadinya kanker. Karboksimetil Kitosan dapat menurunkan kadar hydrogen peroksida pada tikus uji setelah dipapar dengan allergen,  melalui gugus aktifnya. Efektivitas Karboksimetil Kitosan ini sangat berpotensi sebagai antikanker.
Evaluation Anxiolytic Effect of Methanol Extract of Ceplukan Leaves (Physalis minima L.) in the Elevated Plus Maze Test through IL-6 Level Changes in Ovariectomized Rats Nurfitria, Siti; Permatasari, Nur; Ratnawati, Retty
Journal of Tropical Life Science Vol 5, No 1 (2015)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.5.1.%x

Abstract

Ceplukan (Physalis minima L.) has long been used to treat various conditions in traditional medicine. This study aims to demonstrate the anxiolytic effects of Methanol Extract of Ceplukan Leaves (MECL) in the Elevated Plus Maze (EPM) test and correlate to IL-6 level of ovariectomized rat brain. Total of 24 Wistar rats were divided into six groups: one normal group, one group of 1 month ovariectomized (ovx), one group of 2 months ovx, three groups of 2 months ovx (each given with MECL 500; 1500 and 2500 mg/kg doses for 1 month). The anxiety-like behavior level was measured by EPM test. After EPM test, the brain was removed to measure level of IL-6 by ELISA. The data were processed and analyzed by one-way ANOVA and Pearson correlation. We found that the MECL-treated rats enter the opened-arm higher than the control rats. It indicates that the MECL-treated rats are less anxious than the control rats. The results also show the decreased of IL-6 level in MECL-treated rats.
Secretory Leukocyte Protease Inhibitor (SLPI) Decreased the Celluler Expression of NF-Kβ and IL-1β on Wound Macrophages of Rattus novergicus Post Tooth Extraction Putri, Agustine Hanafi; Komaruzzaman, Abdur Razaq; Noerpuspita, Putri; Fitriyani, Delfi; Permatasari, Nur; Widjajanto, Edi
Journal of Tropical Life Science Vol 6, No 3 (2016)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.06.03.05

Abstract

Prevalence of tooth extraction or dental surgery was 48.5% of all dental care in Indonesia. Tooth extraction carries potential health risks and side effects such as pain, swelling, trismus and dysfunction of the oral cavity during recovery. Secretory leukocyte protease inhibitor (SLPI) is one of innate immunity proteins that can inhibit the activation of macrophages. We are expecting the provision of SLPI can decrease excessive inflammatory response in healing after tooth extraction. This study was to investigate the administration of SLPI on cellular expression of NF-Kβ and IL-1β on wound macrophages of Rattus novergicus post tooth extraction. The research design is in vivo experimental study. In total, 20 rats were randomly divided into four groups (each group n=5) and underwent tooth extraction on left incisor teeth of mandible. One of the groups did not receive SLPI administration (control group) and the socket was stitched after tooth extraction. Meanwhile, the remaining three groups (experimental groups) were given SLPI administration after tooth extraction with three different doses (0.1 µM, 0.5 µM and 2.5 µM, respectively). After SLPI administration, the socket of experimental groups was stitched. The effects of SLPI administration were evaluated by counting at the percentage of NF-Kβ translocation and the expression of expression of IL-1 in macrophages cells of the rat socket using immunohistochemistry analysis. The cellular expression of NF-Kβ and IL-1β were significantly decreased (p < 0.05) on groups with SLPI may decrease cellular expression of NF-Kβ and IL-1β on wound macrophages cells of rats post tooth extraction in a dosedependent manner.
EffectOf Panax Ginseng Extract For The Increased Number Of Fibroblasts Cells After Tooth Extraction Rizky Hutomo, Ferdian; Permatasari, Nur; Andari Wulan, Kartika
Insisiva Dental Journal: Majalah Kedokteran Gigi Insisiva Vol 1, No 1 (2012)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/di.v1i1.509

Abstract

The process of tooth extraction can lead to injury. One of the factors that influencethe process of wound healing after tooth extraction is the number of fibroblastcells. The content of saponins can increase the number of fibroblasts cells aftertooth extraction. Asian ginseng plants known to contain saponins (ginsenoside).The purpose of this study was to determine the effect of Asian ginseng extract(Panax ginseng extract) for the increased number of fibroblasts cells after toothextraction. The research method used is in vivo experimental design with thedesign methods Randomized Post Test Only Control Group Design. In this studyused twentty male rattus novergicus and divided into four group, consisting ofcontrol group (K1) were not given Asian ginseng extract, treatment groupsnumber one (K2) were given 25mg/Rattus novergicus/day doses of Asianginseng, treatment groups number two (K3) were given 50mg/ Rattusnovergicus/day doses of Asian ginseng, and treatment groups number three (K4)were given 75mg/Rattus novergicus/day doses of Asian ginseng. Histopathologicpreparations used for counting the number of fibroblasts cells. The results ofstatistical tests indicate there are differences in the number of fibroblast cells inRattus novergicus between the four different groups (ANOVA, p 0.05) and thereis a very strong correlation between increasing doses of ginseng extract with anumber of fibroblast cells in Rattus novergicus tooth socket (Pearson, R = 0.915 p0.05). The conclusion of this study is Asian ginseng extract can increase thenumber of fibroblasts in the tooth socket after tooth extraction, it is recommendedthat research about the amount of saponin in Asian Ginseng extract
The Effectiveness Of Tofu Liquid Waste As A Natural Phytoestrogen For Mandibular Bone Of Ovariectomized Rats Meilia Aquina; Nur Permatasari
Insisiva Dental Journal: Majalah Kedokteran Gigi Insisiva Vol 1, No 1 (2012)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/di.v1i1.508

Abstract

Estrogen is a steroid compound that has many benefits for the body's physiology.Hypoestrogenic women could have periodontitis in their mouth. Hormonereplacement therapy (HRT) is a therapy that used to reduce the disturbance causedby estrogen deficiency. However, HRT has many side effects. Theoretical studyshows that isoflavones in tofu liquid waste has an element of a steroid compound.The purpose of this study was to prove the effectiveness of isoflavones in the tofuliquid waste by examining the microscopic structure, estrogen receptor expressionand MDA levels in rat mandibular bone post-ovariectomy. This research methoduse a true experimental laboratory with randomized post test control group design.Twenty-four female wistar rats were divided randomly into six groups, consistedof a group of normal rat that does’nt ovariectomized (C1), 4 weeksovariectomized rats (C2), 8 weeks ovariectomized rats (C3) but no tofu liquidwaste was given, and 8 weeks ovariectomized rats that given tofu liquid waste atthe end of the 4th week of ovariectomy with three different doses (C4 = 1.2, C5 =6; C6 = 12 ml / kg). Histopathological slide used to see the changes resulted in anumber of osteoclasts, osteocytes, periodontal ligament width, alveolar boneheight, the amount of estrogen receptor expression and MDA levels. The resultsof statistical tests show that there is a difference in the rats between six differentgroups (ANOVA, p 0.05) and there is a close relationship between the dose ofthe tofu liquid waste with all parameter. The conclusion of this study is tofuliquid waste could improve the microscopic structure, estrogen receptorexpression and MDA levels in rat mandibular bone post-ovariectomy.
Subchronic Toxicity of the Physalis minima Leaves Setyawati Soeharto; Dian Nugrahenny; Nur Permatasari; Elly Mayangsari
Research Journal of Life Science Vol 5, No 1 (2018)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (315.343 KB) | DOI: 10.21776/ub.rjls.2018.005.01.8

Abstract

The study was to evaluate the subchronic toxicity of aqueous extract of Physalis minima leaves in female rats. Eighteen female Wistar rats were orally administered with aqueous extract of P. minima leaves at doses of 90, 270 and 450 mg/kg BW, respectively for 90 days. Six female rats without any treatment were provided as a control group. At the end of the experiment, blood samples were collected for hematological and biochemical (aspartate transaminase/AST, alanine transaminase/ALT, creatinine, urea, glucose, cholesterol, and triglyceride) analyses. The results showed that hematological and biochemical biomarkers were not significantly different in treated groups compared to the control group. It is concluded that the aqueous extract of P. minima leaves do not induce hematologic toxicity, hepatotoxicity and renal toxicity in the subchronic toxicity study.
Aspek Biologis Pergerakan Gigi secara Ortodonsi Muhammad Nurul Amin; Nur Permatasari
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 13 No 1 (2016)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Orthodontic appliance used to correct malocclusion which may include dental abnormalities, jaw relationship abnormalities, growth disorder of bone-forming facial or oral soft tissues disorder. Mechanical force of orthodontic appliance applied to suppress the teeth and periodontal tissue including gingiva, periodontal ligament and alveolar bone. This process involves the alveolar bone remodeling. Orthodontic mechanical force will cause the periodontal area is divided into two areas: pressure and strain area. In the pressure area, mechanical force will stimulate osteoclasts to perform alveolar bone resorption. Whereas strain area, osteoblasts will perform new alveolar bone formation. Orthodontic tooth movement has three phases process. The phase is initial phase, lag phase and postlag phase. The third phase of tooth movement mechanism involving cellular and molecular reactions in the periodontal tissues.
Pektin Dalam Tepung Kesemek Mempengaruhi Kadar Trigliserida Pada Tikus Wistar Jantan Yang Diberi Diet Aterogenik Stefania Widya Setyaningtyas; Nur Permatasari; Annasari Mustafa
Amerta Nutrition Vol. 1 No. 1 (2017): AMERTA NUTRITION
Publisher : Universitas Airlangga, Kampus C, Mulyorejo, Surabaya-60115, East Java, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (742.652 KB) | DOI: 10.20473/amnt.v1i1.2017.38-45

Abstract

Background: Moderate hypertriglyceridemia is almost certainly an independent risk factor for cardiovascular disease. Pectin is a kind of soluble fiber that can be used to decrease triglyceride level and it  can be found in fruits such as persimmon. Objective: This research intens to prove the effect of soluble fiber of persimmon flour to decrease triglyceride level. Methods: The search used Post Only Control Group design. Normal diet, atherogenic diet, and atherogenic diet with various amount of dried persimmons were given to 30 subjects, male wistar rats, for 12 weeks. 1.2 g, 2.4 g, and 3.6 g persimmon flour were used as the given amount for every groups. Results: There were significant differences between atherogenic diet group and the other groups of research (p-value<0.001). Compared to normal diet group, atherogenic diet with 1.2 g and 2.4 g persimmon flour resulted unsignificant differences of triglycerides level. But, atherogenic diet with 3,6 g dried persimmon group was different significantly to normal diet groups (p-value=0.036). Both dose of persimmon flour and fat intake affect elevation of tryglyceride level up to 62.5%. Conclusion: The contribution of persimmon flour (Diospyros Kaki L. var Junggo) in inhibitation of the increase of triglyceride serum level on male wistar rats.  The most effective dose is 1.2 g, because the result of the trigliceride level was closest to normal and energy intake was not affected. ABSTRAK Latar belakang : Hipertrigliseridemia kadar sedang hampir pasti merupakan faktor risiko tersendiri untuk penyakit kardiovaskular. Pektin merupakan jenis serat larut air memiliki efek menurunkan trigliserida dan banyak terdapat dalam buah-buahan, salah satunya buah kesemek.Tujuan : Penelitian ini bertujuan menguji efek serat larut air pada tepung kesemek dalam menurunkan kadar trigliserida.Metode : Penelitian dilakukan dengan metode Post Test Only Control Group. Diet normal, diet aterogenik, diet aterogenik + kesemek dengan berbagai jumlah diberikan kepada 30 subyek penelitian, yaitu tikus wistar jantan selama 12 minggu. 1,2 g, 2,4 g, dan 3,6 g tepung kesemek digunakan sebagai intervensi untuk kelompok perlakuan.Hasil : terdapat perbedaan kadar trigliserida yang signifikan antara kelompok diet aterogenik dengan kelompok perlakuan lainnya (p=0,000). Bila dibandingkan dengan kelompok diet normal, perlakuan dengan pemberian tepung kesemek 1,2 g dan 2,4 g menghasilkan kadar trigliserida yang tidak berbeda signifikan, namun jumlah pemberian tepung kesemek 3,6 g berbeda nyata dengan diet normal (p=0,036). Pemberian tepung kesemek dan asupan lemak bersama-sama mempengaruhi pembentukan trigliserida dengan kontribusi sebesar 62,5%.Kesimpulan : Tepung kesemek (Diospyros Kaki L. Var. Junggo) terbukti dapat menghambat peningkatan kadar trigliserida serum pada tikus wistar jantan yang diberi diet aterogenik. Jumlah yang dinilai paling efektif menurunkan trigliserida adalah sebesar 1,2 g, karena pada jumlah tersebut, kadar trigliserida yang dihasilkan paling mendekati normal dan tidak mempengaruhi asupan energi.
Co-Authors Abdur Razaq Komaruzzaman Adinda Chika Anindita Agustin Iskandar Agustine Hanafi Putri Ahmad Reza Fadhlurrahman, Ahmad Reza Akhmad Sabarudin Amandia Dewi Permana Shita Anik Puryatni Annasari Mustafa Aswin D Baskoro, Aswin D Cahyani, Dwi Indah Citra Tarannita Damayanti, Elok Delfi Fitriyani Devitaningtyas, Nungky Dewi, Ni Ketut Ayu Feriyanti Dian Nugrahenny Dicky Faizal Irnandi Edi Widjajanto Edi Widjajanto Edwin Widodo Fardizia Putri Alia Ferdian Rizky Hutomo, Ferdian Fitriyani, Delfi Hafiedz Maulana Happy Kurnia P Hidayat Sujuti Ibrahim, Moh. Nuh Indriati Dwi Rahayu Joko Agus Gunawan Kartika Andari Wulan, Kartika Karyono Mintaroem Khadafi Indrawan Komaruzzaman, Abdur Razaq Lavina Sofia Ardani Loeki Enggar Fitri M Aris Widodo Mayangsari, Elly Meilia Aquina Meilia Aquina, Meilia Mohamad Nur Ibrahim Muhammad Nurul Amin Nathania Bella Claresta Niarti Ulan Sari Siarnu Noerpuspita, Putri Nour Athiroh Abdoes Sjakoer Nura Fattah Cantika Yoga Nuzulul Hikmah Putri Noerpuspita Putri, Agustine Hanafi Retty Ratnawati Retty Ratnawati Setyawati Soeharto Setyawati Soeharto Sidharta, Rudhanton Siti Nurfitria, Siti Sri Widyarti Stefania Widya Setyaningtyas Sudiarto Sudiarto Tika Ardhini Wardoyo