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All Journal Indonesian Journal of Medicine The Indonesian Journal of Infectious Diseases PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Ilmiah Kesehatan (JIKA) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Berita Kedokteran Masyarakat The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Gema Lingkungan Kesehatan Jurnal Penyakit Dalam Indonesia Jurnal Pengabdian Masyarakat dan Riset Pendidikan Indonesian Journal of Medical and Pharmaceutical Science
Triyanta Yuli Pramana
Universitas Sebelas Maret
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Other

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LAKI-LAKI 40 TAHUN DENGAN GAMBARAN USG ADENOMYOMATOSUS GALDBLADDER Widyastuti, Retno; Pramana, Triyanta Yuli
Indonesian Journal of Medical and Pharmaceutical Science Vol. 2 No. 2 (2023)
Publisher : Sultan Agung Islamic University of Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijmps.v2i2.126

Abstract

Background: Adenomyomatosus gallbladder (GA) is a benign change of the gallbladder wall characterized by excessive epithelial proliferation associated with hyperplasia of the muscularis propria. This situation causes thickening of the gallbladder, so that the gallbladder comet tail artifact appears on an abdominal ultrasound examination. Methods: A 40-year-old man with complaints of right upper quadrant abdominal pain that is colic and recurrent. The patient was hospitalized twice within a week with the same complaint. Ultrasound examination of the patient's lawsuit against GA. The differential diagnosis of this case is chronic cholecystitis and cholesterosis, as seen from complaints of right quadrant abdominal pain and comet tail ultrasound images. Results: Cholecystectomy in patients is indicated for therapy and histopathological diagnosis. The results of histopathological examination obtained a picture that pointed to chronic cholecystitis. Conclusion: Diagnosis by histopathology is necessary in patients with ultrasound images of comet tail artifacts in the gallbladder to determine the patient's treatment and prognosis.
Pengaruh Suplementasi Ekstrak Kulit Manggis Terhadap Kadar IL-8 dan Limfosit Pada Pasien COVID-19 dengan Cedera Hati Akut Muhammad Zuhdan Fannani; Triyanta Yuli Pramana; Robert Satriyo Budhi Susilo; Susanto, Agung
The Indonesian Journal of Infectious Diseases Vol. 10 No. 1 (2024): The Indonesian Journal of Infectious Diseases
Publisher : Rumah Sakit Penyakit Infeksi Prof Dr. Sulianti Saroso

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32667/ijid.v10i1.187

Abstract

Latar belakang: Hati merupakan organ utama detoksifikasi dan metabolisme tubuh sehingga penting dalam pengobatan COVID-19. Salah satu pengobatan tradisional yang memiliki sifat hepatoprotektif adalah kulit manggis (Garcinia mangostana L.). Tujuan:Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak kulit manggis terhadap kadar IL-8 dan limfosit pada pasien COVID-19. Metode: Penelitian eksperimental ini dilakukan pada pasien positif COVID-19 di RS. Dr. Moewardi Surakarta. Sebanyak 40 pasien COVID-19 dibagi menjadi 2 kelompok: kelompok kontrol (tanpa terapi adjuvant) dan kelompok perlakuan (dengan suplementasi dry powder kapsul ekstrak kulit manggis dosis 3x1200 mg. Setelah 14 hari, pasien diperiksa kadar sitokin proinflamasi (IL-8) dan limfositnya. Data dianalisis menggunakan program SPSS 25.0 dan hasil dianggap bermakna bila nilai p <0,05. Hasil: Penurunan (selisih post-pre) kadar IL-8 kelompok kontrol (76.4 +234.6, 45.3%) lebih rendah secara bermakna daripada kelompok perlakuan (155.2+408.5, 54.3%) dengan p=0.048. Sedangkan peningkatan (selisih pre-post) kadar limfosit kelompok kontrol (2.2± 4.7, 13.9%) lebih rendah secara bermakna dari kelompok perlakuan (8.1±5.8, 50.9%) dengan p=0.001. Kesimpulan: pemberian ekstrak kulit manggis efektif menurunkan kadar IL-8 dan meningkatkan kadar limfosit pada pasien COVID-19 dengan cedera hati akut. Pemberian suplementasi dry kapsul ekstrak kulit manggis dapat menurunkan kadar IL-8 dan meningkatkan kadar limfosit secara bermakna pada pasien COVID-19 dengan cedera hati akut.  
The Effect of TNF-α and FIB-4 Score on Diastolic Dysfunction in Child Pugh C Liver Cirrhosis Karim, Muhammad Yusuf; Pramana, Triyanta Yuli; Sulastomo, Heru; Nurudhin, Arief; Pamungkasari, Eti Poncorini
Gema Lingkungan Kesehatan Vol. 23 No. 4 (2025): Gema Lingkungan Kesehatan
Publisher : Poltekkes Kemenkes Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36568/gelinkes.v23i4.384

Abstract

Liver cirrhosis is a major global health concern, often complicated by cardiac dysfunction such as diastolic heart failure. Tumor necrosis factor-alpha (TNF-α) and FIB-4 score are widely used biomarkers in cirrhotic patients, but their predictive value for cardiac complications remains unclear. To determine the effect of TNF-α and FIB-4 scores on the severity of diastolic dysfunction in patients with Child-Pugh C liver cirrhosis. This analytical cross-sectional study included 40 Child-Pugh C cirrhotic patients. Serum TNF-α levels were measured using ELISA. Diastolic function was evaluated using echocardiography. Ordinal logistic regression was used to analyze the association between TNF-α, FIB-4, and diastolic dysfunction grades. The majority of participants had moderate (65.0%) or severe (35.0%) chronic inflammation based on TNF-α levels, with a median TNF-α of 45.52 pg/mL. Significant liver fibrosis (FIB-4 >3.25) was observed in 82.5% of participants. Grade I diastolic dysfunction was the most prevalent (52.5%). TNF-α levels were significantly associated with the degree of diastolic dysfunction (p=0.042), whereas FIB-4 scores showed no significant correlation (p=0.533). Elevated TNF-α is strongly associated with worsening diastolic dysfunction in Child-Pugh C cirrhosis, suggesting its role in systemic inflammation and myocardial injury. In contrast, the FIB-4 index may not reflect cardiac involvement in advanced cirrhosis. TNF-α may serve as a potential biomarker for cardiovascular risk stratification in cirrhotic patients, supporting early intervention and integrated care approaches.
Vitamin D3 on Oxidative Stress Markers and Blood Pressure in a UUO Rat Model of Chronic Kidney Disease Wibowo, Yogo Pardi; Susanto, Agung; Wijaya, Bayu Basuki; Pamungkasari, Eti Poncorini; Pramana, Triyanta Yuli
Jurnal Ilmiah Kesehatan (JIKA) Vol. 7 No. 3 (2025): Volume 7 Nomor 3 Desember 2025
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v7i3.1431

Abstract

Chronic kidney disease (CKD) is a major global health burden, with oxidative stress and hypertension contributing significantly to its progression. Although vitamin D3 is known for its pleiotropic effects, its influence on oxidative stress markers in obstructive nephropathy remains unclear. This study evaluated the effect of vitamin D3 supplementation on blood pressure, malondialdehyde (MDA) levels, and superoxide dismutase (SOD) activity in a rat model of CKD induced by Unilateral Ureteral Obstruction (UUO). In this experimental post-test-only control group study, 30 male white rats (Rattus norvegicus) were randomly assigned to five groups (n = 6 per group) following UUO induction: one control group (placebo) and four treatment groups receiving graded oral doses of vitamin D3 (36, 72, and 108 IU/rat) daily for 14 days. Blood pressure was measured using the tail-cuff method, and serum MDA levels and SOD activity were analyzed at the end of the treatment period. Vitamin D3 supplementation produced significant, dose-dependent improvements in all parameters (p-value < 0,01). Compared with controls, treated groups showed lower blood pressure, reduced MDA levels, and increased SOD activity. The highest dose (108 IU/rat) demonstrated the greatest reduction in oxidative stress and blood pressure. This study aimed to evaluate whether vitamin D3 supplementation ameliorates hypertension and oxidative stress in UUO-induced CKD in rats, supporting its potential as an adjunctive strategy to slow CKD progression. Further studies are required to confirm clinical applicability.
Co-Authors Abd. Rasyid Syamsuri Adhyaksari, Apriliana Ambar Mudigdo Ambar Mudigdo Ari Prasetyo Arief Nurudhin Brian Wasita Budi S, R. Satriyo C Rinaldi A Lesmana Dadang Makmun Darmayani, Aritantri Darmayani, Aritantri Dharma, IGN Surya Diana Sunardi Didik Prasetyo Dwi Adhi Nugraha E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Eti Poncorini Pamungkasari Gunawan, Timotheus A. Hanif, Muhammad Ifham Hasan Maulahela Ikhwan Rinaldi Jati, Agus Juferdy Kurniawan Karim, Muhammad Yusuf Lee, See Young Michael Tantoro Harnomo Muhammad Zuhdan Fannani Notonugroho, Anung Oyong Oyong Paulus Kusnanto Purwita Wijaya Laksmi Ranty, Stefanus Satrio Ratanachu-ek, Thawee Retno Widyastuti, Retno Robert Satriyo Budhi Susilo ROCHIMA RIDHA HIDAYAH Rudy Hidayat S.R, Brillian Van Fito Sepmeitutu, Iwandheny Sholihah, Mentari Maratus Sulastomo, Heru Susanto, Agung Wibowo, Yogo Pardi Wijaya, Bayu Basuki Wildan Nur