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All Journal JURNAL FARMASIMED (JFM) SANITAS: Jurnal Teknologi dan Seni Kesehatan Jurnal Peduli Masyarakat Jurnal Pengabdian kepada Masyarakat Nusantara Jurnal Ilmiah Pharmacy MEDIC MEdical Dedication Studium: Jurnal Pengabdian Kepada Masyarakat Sciences of Pharmacy Sinteza Jurnal Pengabdian Harapan Ibu (JPHI) Journal of Pharmaceutical and Sciences. Indonesian Journal of Cosmetics Bencoolen Journal of Pharmacy
Puspa Dwi Pratiwi
Faculty of Dentistry, University of Indonesia, Jakarta
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Formulasi body scrub dari kombinasi temu putih (Curcuma zedoaria) dan biji kurma (Phoenix dactylifera) Yuliawati, Yuliawati; Elisma, Elisma; Utami, Diah Tri; Pratiwi, Puspa Dwi
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.456

Abstract

Body scrub is a cosmetic form that removes dead skin cells caused by free radicals from various pollutants and ultraviolet (UV) radiation so skin cells become more accessible to regenerate. White turmeric (Curcuma zedoaria) and date seeds (Phoenix dactylifera) are plants that contain bioactive compounds to maintain and nourish the skin and have antioxidant activity. Besides, date seeds also have the potential as exfoliating agents to facilitate the release of dead skin cells. This study aimed to formulate a body scrub containing ethanol extract of white turmeric rhizome and date seed powder with five types of formulas (K+, K-, F1, F2, F3). This type of research is a true experimental, which includes the formulation and stability test. The stability test was conducted with the Cycling test method in 6 cycles (1 cycle for 2x24 hours) at temperatures of -4oC and 40oC and four months for stability at room temperature. Parameters observed include organolepticity, homogeneity, dispersibility, adhesion, pH, and viscosity. The results showed that this body scrub did not show any change in the organoleptic character, homogeneity, spreadability, adhesion, or pH values that met the requirements of a body scrub preparation. Viscosity met the requirement for stability test for room temperature in four months. This study concludes that the combination of ethanol extract of white turmeric rhizome and date seed powder seeds can be formulated to be a body scrub dosage form.
Bahan Tambahan dalam Sediaan Tablet: Review Pratiwi, Puspa Dwi; Citrariana, Shesanthi; Gemantari, Baiq Maylinda
Sinteza Vol. 3 No. 2 (2023): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v3i2.17472

Abstract

Tablets are solid pharmaceutical dosage form without or with suitable excipients by press or compression manufacturing process. The excipient chosen can influence the product performance (physical properties and stability) and bioavailability. All excipients must be optimally selected to get the optimal formula of tablet dosage form. This article review aims to overview of excipient in tablet dosage form and their role in formulating tablet dosage form. this review article was written based on literature studies from electronic databases such as PubMed, ScienceDirect, and Google Scholar which contain related information using keyword in Indonesian or English use article published in 2013-2023. excipients in tablet dosage form are fillers or diluents, disintegrants, lubricants, preservatives, flavors, sweeteners, coloring, and coating agents. These excipients added to tablet dosage form to facilitating the process of manufacture tablet dosage form, increasing stability and effectiveness of active pharmaceutical ingredients in tablet. The conclusion of this review, there are many classification of tablet excipients which is different function to get compendial requirements of tablet dosage form.
Aplikasi Simplex Lattice Design untuk Optimasi Emulgator dalam Krim Minyak Atsiri Kulit Jeruk Manis Pratiwi, Puspa Dwi; Arnas, Deah Lestiana
Sinteza Vol. 4 No. 2 (2024): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i2.26539

Abstract

In order to obtain a perfect emulsified and stable preparation, choosing the right composition emulsifier is crucial. Formula optimization is needed to determine the best combination of ingredients in formulation process based on evaluation responses. Simplex Lattice Design (SLD) is an experimental design method for mixing materials with the proportion of the total number of materials 1 or 100%. This research was aims to obtained the optimal cream formula using tween 80 and span 80 as emulsifiers and determined their effect on the physical properties of cream preparation. SLD method was used as optimization method with tween 80 and span 80 as independent variables and pH, viscosity, spreadability, and stickiness as responses. The minimum limit for tween 80 and span 80 is 1% (w/v) and the maximum is 9% (w/v) with total 10%. The optimal formula was obtained from consideration of the response by entering the target value to obtain a formula with desirability value close to 1. There are 5 formulas based on SLD recommendations, with a concentration ratio of tween 80 and span 80 9:1 (run 1); 7:3 (run 2); 1:9 (run 3); 5:5 (run 4); and 3:7 (run 5). The relationship between concentration and response value can be explained based on the significance of the model and equations obtained. The optimal formula was the concentration ratio of tween 80 and span 80 8.6:1.34 with a desirability value of 0.953. The conclusion of this research was that SLD can be used to optimize the emulsifier with response predictions close to the results obtained.
FRAP REDUCING ACTIVITY OF PROTIUM JAVANICUM BURM.FIL LEAVES: A SCREENING ANTIOXIDANT POTENCY OF NATURAL COSMETIC INGREDIENT Sulastri, Novi; Gemantari, Baiq Maylinda; Hayaza, Azzam Hafid; Azim, Muhlisun; Hariadi, Puspawan; Pratiwi, Puspa Dwi
Indonesian Journal of Cosmetics Vol. 3 No. 2 (2025): Indonesian Journal of Cosmetics
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/ijcos.v3i2.2373

Abstract

Tenggulun (Protium javanicum Burm.fil) has been traditionally used to treat various ailments such as cough, stomachache, diarrhea, inflammation and headache. The leaves have therapeutic roles in the treatment and prevention of illnesses acting as antibacterial, antidiabetic and antiinflammation agents. It is also reported that tenggulun leaves can be used for insecticides, cosmetics and food additives. This research aimed to determine antioxidant activity by reducing FRAP of the tenggulun leaves methanol extract using Trolox as the standard solution. The result showed that the tenggulun leaves extract contained secondary metabolites of flavonoid and polyphenolic. The extract showed the FRAP reducing activity at 0,008634±0.00043 μmol TE/g DW. These results indicated the ability of tenggulun methanolic extract to reduce Fe (III) into Fe (II) equivalent to Trolox by the presence of secondary metabolites confirmed.
Program Edukasi Kosmetik Aman pada Siswa MAN 1 Kota Jambi Pratiwi, Puspa Dwi; Yuliawati , Yuliawati; Maharini , Indri; Maimum, Maimum; Fitrianingsih, Fitrianingsih; Syamsurizal, Syamsurizal; Pondawinata, Marizki
Jurnal Pengabdian kepada Masyarakat Nusantara Vol. 7 No. 1 (2026): Edisi Januari - April
Publisher : Lembaga Dongan Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Program edukasi kosmetik aman pada siswa MAN 1 Kota Jambi dilaksanakan sebagai upaya meningkatkan pemahaman remaja mengenai pemilihan dan penggunaan produk kosmetik yang memenuhi standar keamanan. Kegiatan ini dilatarbelakangi oleh maraknya peredaran kosmetik ilegal dan kurangnya literasi siswa terkait identifikasi kosmetik berizin edar, kandungan berbahaya, serta risiko kesehatan akibat penggunaan produk yang tidak sesuai. Metode pelaksanaan meliputi pretest, penyuluhan interaktif, demonstrasi cara memeriksa izin BPOM, dan post test untuk menilai peningkatan pengetahuan. Hasil kegiatan menunjukkan adanya peningkatan signifikan pada pemahaman siswa mengenai kriteria kosmetik aman (p <0,001). Selain itu, siswa menunjukkan antusiasme tinggi terkait pemilihan kosmetik yang digunakan untuk sehari-hari. Program ini membuktikan bahwa edukasi yang bersifat aplikatif dan sesuai konteks remaja dapat meningkatkan kesadaran dalam memilih kosmetik yang aman dan legal. Kegiatan ini diharapkan dapat menjadi model edukasi berkelanjutan yang dapat diterapkan di sekolah guna mendukung perilaku penggunaan produk kosmetik yang bertanggung jawab di kalangan remaja.
Uji Aktivitas Sediaan Gel Berbasis Ekstrak Daun Kayu Manis (Cinnamomum burmannii) sebagai Agen Antiinflamasi pada Model Tikus Putih Jantan dengan Induksi Karagenan Kasmadi, Fathnur Sani; Putri, Azelia; Pratiwi, Puspa Dwi; Humaryanto, Humaryanto; Ekaputri, Tia Wida
Jurnal Ilmiah Pharmacy Vol 13, No 1 (2026)
Publisher : Sekolah Tinggi Kesehatan Al-Fatah Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52161/jiphar.v13i1.917

Abstract

Inflamasi merupakan mekanisme pertahanan fisiologis tubuh yang berperan dalam membatasi perluasan kerusakan jaringan, menekan pertumbuhan mikroorganisme patogen, serta memfasilitasi proses perbaikan jaringan yang mengalami cedera akibat suatu kondisi patologis. Proses ini tergolong respon biologis normal sebagai bagian dari sistem proteksi tubuh. Salah satu tanaman yang diketahui memiliki aktivitas dalam penyembuhan luka adalah daun kayu manis, yang dilaporkan mengandung berbagai metabolit sekunder yaitu fenolik, flavonoid, saponin, steroid, dan tanin yang berkontribusi dalam modulasi proses inflamasi. Formulasi ekstrak daun kayu manis dalam bentuk gel bertujuan untuk meningkatkan penetrasi zat aktif kejaringan target serta memberikan efek pendingin (cooling effect) yang mendukung proses penyembuhan inflamasi. Penelitian ini dilakukan untuk mengevaluasi aktivitas antiinflamasi sediaan gel ekstrak daun kayu manis serta menentukan konsentrasi yang paling optimal dalam menghasilkan efek terapeutik. Metode yang digunakan adalah penelitian eksperimental dengan desain post test only control group. Kelompok perlakuan dibagi menjadi 5 yaitu kontrol positif, kontrol negatif, formula I (ekstrak 2,5%), formula II (ekstrak 5%, dan formula III (ekstrak 10%) yang diaplikasikan secara topikal pada area punggung tikus yang telah diinduksi dengan karagenan 1%. Perlakuan dilakukan selama 4 hari parameter yang diamati berupa volume eksudat dan profil diferensiasi leukosit dalam darah. Hasil penelitian menunjukkan bahwa formulasi gel ekstrak daun kayu manis dengan konsentrasi 10% memberikan aktivitas antiinflamasi paling optimal yang dibuktikan dengan mampu menurunkan volume eksudat. Efektivitas terbaik di tunjukkan dengan nilai persen inhibisi inflamasi pada kosentrasi 10% adalah sebesar 89,47%.
Cellophane Membranes In In Vitro Permeation Studies Using Franz Diffusion Cells: A Review Jamin, Nessa Ramawati; Astuti, Novia Tri; Pratiwi, Puspa Dwi
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/4kesna66

Abstract

Transdermal drug delivery systems require permeation evaluation to ensure the effectiveness and safety of formulations before clinical application. In vitro permeation testing using the Franz diffusion cell is a widely used method in the early stages of formulation development, as it can describe the drug release and diffusion profile in a controlled manner. One of the synthetic membranes commonly utilized in this system is the cellophane membrane, which is semipermeable, easily obtainable, and provides more reproducible testing conditions compared to biological membranes. This article aims to review the use of cellophane membranes in in vitro permeation studies using Franz diffusion cells and to analyze the parameters reported in the results. The method employed is a literature review conducted through Google Scholar using keywords related to cellophane membranes, Franz diffusion, and in vitro permeation within the period of 2021–2026. The review results indicate that cellophane membranes are used in various dosage forms such as gels, transdermal patches, emulgels, vesicular systems, nanosponges, and solid lipid nanoparticles, with testing conditions generally involving phosphate buffer pH 6.8–7.4 at temperatures of 32–37°C and sampling times up to 24 hours or longer. The most frequently reported parameters include percentage of cumulative drug release, cumulative amount of drug permeated, and flux values. Permeation enhancement is generally influenced by formulation composition, the addition of enhancers, and the type of delivery system used.
Green-Synthesized Silver Nanoparticles Using Erythrina subumbrans Leaf Extract: Optimization and Antibacterial Activity Maharini, Indri; Utami, Karen Putri; Rachmawati, Lilis; Fitrianingsih, Fitrianingsih; Pratiwi, Puspa Dwi
Sciences of Pharmacy Volume 5 Issue 2
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0502580

Abstract

The high prevalence of acne and increasing antibiotic resistance necessitate the development of sustainable antimicrobial agents. This study investigated the green synthesis of silver nanoparticles (AgNPs) using Erythrina subumbrans (Hassk.) Merr. leaf extract as a natural bioreductant and stabilizer. The primary objective was to optimize the synthesis process and evaluate the antibacterial efficacy of the resulting nanoparticles specifically against Propionibacterium acnes. Physicochemical and structural characterization were performed using spectroscopic and microscopic techniques to confirm the formation and stability of the nanoparticles. The results successfully demonstrated the synthesis of crystalline, nanoscale AgNPs with plant-derived functional groups facilitating their stabilization. Analytical data indicated a relatively uniform particle size distribution, spherical morphology, and favorable surface characteristics, suggesting high suitability for biomedical integration. Significantly, the synthesized AgNPs exhibited potent antibacterial activity against P. acnes. The underlying mechanism of action is attributed to the disruption of bacterial cell membranes, induction of intracellular reactive oxygen species, and subsequent interference with vital cellular functions. Utilizing E. subumbrans extract offers an eco-friendly, cost-effective, and sustainable alternative to conventional chemical synthesis, reducing the reliance on toxic reagents. These findings highlight the significant potential of plant-mediated AgNPs as innovative antimicrobial agents for dermatological applications. This research provides a robust foundation for the advancement of nanotechnology-based topical treatments. Consequently, further investigation into pharmaceutical formulation development, comprehensive safety assessments, and clinical efficacy trials is highly recommended to establish E. subumbrans-mediated silver nanoparticles as viable therapeutic solutions for managing acne and other skin-related infections in the future.
Co-Authors Amalia Rani, Amalia Angraini, Resti Indah Arnas, Deah Lestiana Baiq Maylinda Gemantari Citrariana, Shesanthi Damayani, Mira Ovita Diah Riski Gusti Dominica, Dwi Ekaputri, Tia Wida Elisma Elisma Faradina Aghadiati Fitrianingsih Fitrianingsih Hayaza, Azzam Hafid Humaryanto, Humaryanto Jamin, Nessa Ramawati M. Rifqi Efendi Maharini , Indri Maharini, Indri Muhammad Syukri Muhlisun Azim Neldi, Vina Novia Tri Astuti Novia, Ria Pondawinata, Marizki Puspawan Hariadi Putri, Azelia Rachmawati, Lilis Rizki, Nanda Putri Sadli, Nurul Kamilah Sani K, Fathnur Santi Perawati, Santi Sitanggang, Sarah Dianora Sulastri, Novi Syamsurizal - - Uce Lestari Utami, Diah Tri Utami, Karen Putri Yuliawati Yuliawati , Yuliawati